Titre : Test pharmacogénomique

Test pharmacogénomique : Questions médicales fréquentes

Termes MeSH sélectionnés :

Randomized Controlled Trials as Topic
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des symptômes ?\nPeut-on avoir des symptômes sans test ?\nLes symptômes varient-ils selon les gènes ?\nLes tests peuvent-ils aider à diagnostiquer des maladies ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Test pharmacogénomique", "description": "Les tests peuvent-ils prévenir des effets secondaires ?\nComment intégrer les tests dans la prévention ?\nLes tests sont-ils recommandés pour tous ?\nPeut-on se préparer à un test ?\nLes tests peuvent-ils réduire les coûts de santé ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Test pharmacogénomique", "description": "Comment les tests influencent-ils les traitements ?\nPeut-on éviter des traitements grâce aux tests ?\nLes tests sont-ils utilisés pour tous les médicaments ?\nLes résultats des tests sont-ils toujours clairs ?\nLes tests peuvent-ils changer en cours de traitement ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Test pharmacogénomique", "description": "Quelles complications peuvent survenir sans test ?\nLes tests peuvent-ils prévenir des complications ?\nLes complications sont-elles toujours évitables ?\nComment gérer les complications liées aux médicaments ?\nLes complications peuvent-elles affecter le traitement futur ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Test pharmacogénomique", "description": "Quels facteurs de risque influencent les tests ?\nLes facteurs environnementaux jouent-ils un rôle ?\nLes facteurs de risque sont-ils les mêmes pour tous ?\nComment évaluer les facteurs de risque ?\nLes facteurs de risque peuvent-ils changer ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Qu'est-ce qu'un test pharmacogénomique ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "C'est un test qui analyse les gènes pour prédire la réponse aux médicaments." } }, { "@type": "Question", "name": "Quand est-il recommandé de faire un test ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Il est recommandé avant de commencer un traitement médicamenteux, surtout pour certains médicaments." } }, { "@type": "Question", "name": "Quels types de médicaments sont concernés ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Les médicaments pour le cancer, les antidépresseurs et les anticoagulants sont souvent testés." } }, { "@type": "Question", "name": "Comment se déroule un test ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Un échantillon de sang ou de salive est prélevé et analysé en laboratoire." } }, { "@type": "Question", "name": "Les tests sont-ils fiables ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, mais leur précision dépend de la qualité du laboratoire et des gènes analysés." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un besoin de test ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des effets secondaires graves ou une réponse inefficace au traitement peuvent le justifier." } }, { "@type": "Question", "name": "Les tests peuvent-ils prédire des symptômes ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent aider à anticiper des réactions indésirables à certains médicaments." } }, { "@type": "Question", "name": "Peut-on avoir des symptômes sans test ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains symptômes peuvent survenir sans lien avec la génétique ou les médicaments." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon les gènes ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les variations génétiques peuvent influencer la gravité et la nature des symptômes." } }, { "@type": "Question", "name": "Les tests peuvent-ils aider à diagnostiquer des maladies ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Indirectement, en identifiant des prédispositions génétiques à certaines maladies." } }, { "@type": "Question", "name": "Les tests peuvent-ils prévenir des effets secondaires ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils aident à choisir des médicaments moins susceptibles de provoquer des effets indésirables." } }, { "@type": "Question", "name": "Comment intégrer les tests dans la prévention ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "En les utilisant lors de la prescription de médicaments pour anticiper les réactions." } }, { "@type": "Question", "name": "Les tests sont-ils recommandés pour tous ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Non, ils sont surtout recommandés pour les personnes avec des antécédents médicaux complexes." } }, { "@type": "Question", "name": "Peut-on se préparer à un test ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Il est conseillé de discuter de l'historique médical et des médicaments en cours avec le médecin." } }, { "@type": "Question", "name": "Les tests peuvent-ils réduire les coûts de santé ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en évitant des traitements inefficaces et des hospitalisations dues à des effets secondaires." } }, { "@type": "Question", "name": "Comment les tests influencent-ils les traitements ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Ils permettent de personnaliser les traitements en fonction de la réponse génétique." } }, { "@type": "Question", "name": "Peut-on éviter des traitements grâce aux tests ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en identifiant les médicaments susceptibles de provoquer des effets indésirables." } }, { "@type": "Question", "name": "Les tests sont-ils utilisés pour tous les médicaments ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Non, ils sont principalement utilisés pour certains médicaments à haut risque." } }, { "@type": "Question", "name": "Les résultats des tests sont-ils toujours clairs ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Pas toujours, certains résultats peuvent être ambigus et nécessiter une interprétation." } }, { "@type": "Question", "name": "Les tests peuvent-ils changer en cours de traitement ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests supplémentaires peuvent être nécessaires si le traitement échoue." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir sans test ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des effets secondaires graves ou des traitements inefficaces peuvent survenir." } }, { "@type": "Question", "name": "Les tests peuvent-ils prévenir des complications ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en identifiant les patients à risque de réactions indésirables aux médicaments." } }, { "@type": "Question", "name": "Les complications sont-elles toujours évitables ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Non, certaines complications peuvent survenir malgré un test pharmacogénomique." } }, { "@type": "Question", "name": "Comment gérer les complications liées aux médicaments ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "En ajustant le traitement selon les résultats des tests et en surveillant les effets." } }, { "@type": "Question", "name": "Les complications peuvent-elles affecter le traitement futur ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent influencer les choix de médicaments dans le futur." } }, { "@type": "Question", "name": "Quels facteurs de risque influencent les tests ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'hérédité, les antécédents médicaux et les traitements antérieurs sont des facteurs clés." } }, { "@type": "Question", "name": "Les facteurs environnementaux jouent-ils un rôle ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'environnement peut interagir avec la génétique et influencer la réponse aux médicaments." } }, { "@type": "Question", "name": "Les facteurs de risque sont-ils les mêmes pour tous ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Non, ils varient selon les individus et leurs antécédents médicaux." } }, { "@type": "Question", "name": "Comment évaluer les facteurs de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Par une évaluation médicale complète et des tests génétiques appropriés." } }, { "@type": "Question", "name": "Les facteurs de risque peuvent-ils changer ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent évoluer avec le temps et les traitements reçus." } } ] } ] }

Sources (10000 au total)

Efficacy of Sternum Guard vs. bone wax in post-cardiac surgery patients: a randomized controlled trial.

Median sternotomy offers the main access during cardiac surgery. However, a surgical site infection (SSI) of the sternum is a distressing complication following this procedure. The incidence of postop... This single-blinded, single center randomized controlled trial comprised 414 adult patients who underwent cardiac surgery. The postoperative outcomes assessed were SSI and the quantity of blood lost f... The superficial SSI prevalence in the Sternum Guard group was lower than that in the bone wax group (2.9% vs. 8.2%, respectively; P=0.018). The incidence of deep SSI was also lower in the Sternum Guar... Sternum Guard (Vygon) had a significantly lower incidence of postoperative infection and bleeding from the sternum compared to bone wax....

Efficacy of Virtual Visitation in ICU During COVID-19 Pandemic: The ICU Visits Randomized Controlled Trial.

This study aimed to demonstrate the impact of virtual visits on the satisfaction of family members and the anxiety and depression of patients in the ICU during the COVID-19 pandemic.... A single-center, randomized controlled trial.... This study was conducted from July 2021 to May 2022, in the Seoul National University Hospital.... A total of 40 patients eligible for virtual visitation whose Richmond Agitation-Sedation Scale score was -2 or above were recruited and randomized into virtual visitation and usual care groups.... Virtual visitation began on the first day after ICU admission and continued until ICU discharge, lasting for a maximum of 7 days.... The primary outcome was the satisfaction level of the family members with care and decision-making in the ICU, assessed using the Family Satisfaction-ICU (FS-ICU) 24-survey questionnaire. Secondary ou... In the COVID-19 pandemic era, virtual visits to ICU patients helped reduce depression and anxiety levels of patients and increase the satisfaction of their family members. Enhancing access to virtual ...

Feasibility and effectiveness of cardiac telerehabilitation for older adults with coronary heart disease: A pilot randomized controlled trial.

Cardiac rehabilitation is a beneficial multidisciplinary treatment of exercise promotion, patient education, risk factor management, and psychosocial counseling for people with coronary heart disease ... The study randomized 43 older adults (84 % males) to the 12-week CTR intervention or standard of care. Guided by Social Cognitive Theory, participants received individualized in-person assessment and ... Participants in the CTR intervention group showed significant improvement in daily steps (T1: β = 4126.58, p = 0.001; T2: β = 5285, p = 0.01) and health-promoting lifestyle profile (T1: β = 23.26,... The CTR is feasible, safe and effective in improving physical activity and healthy behaviors in older adults with CHD. Considering the variation in individual cardiovascular risk factors, full-scale R...

Efficacy of the mHealth-Based Exercise Intervention re.flex for Patients With Knee Osteoarthritis: Pilot Randomized Controlled Trial.

Exercise therapy is recommended by international guidelines as a core treatment for patients with knee osteoarthritis. However, there is a significant gap between recommendations and practice in healt... This study aims to evaluate the efficacy of a 12-week fully automated app-based exercise intervention with and without a supporting knee brace on health-related outcomes, performance measures, and adh... This closed user group trial included participants with moderate to severe unicondylar painful knee osteoarthritis. Randomization was 1:1:2 into an intervention group (IG) with 2 subgroups (app-based ... A total of 61 participants were included (IG: n=30, 49%; CG: n=31, 51%; male: n=31, 51%; female: n=30, 49%; mean age 62.9, SD 8.5 years; mean BMI 27.7, SD 4.5 kg/m... Individuals with knee osteoarthritis undergoing a 12-week sensor-assisted app-based exercise intervention with or without an additional knee brace experienced clinically meaningful treatment effects r... German Clinical Trials Register (DRKS) DRKS00023269; https://drks.de/search/de/trial/DRKS00023269....

Effect of Raloxifene Treatment on Apolipoproteins and Lipoprotein(a) Concentrations in Postmenopausal Women: A Meta-Analysis of Randomized Controlled Trials.

Although various randomized controlled trials (RCTs) have evaluated the effect of raloxifene on apolipoproteins and lipoprotein(a) concentrations in postmenopausal women, the results have been inconsi... Two independent researchers systematically searched the scientific literature (including PubMed/Medline, Scopus, Web of Science, and EMBASE) for English-language randomized controlled trials (RCTs) pu... The present meta-analysis incorporated 12 publications with 14 RCT arms. The comprehensive outcomes derived from the random-effects model revealed a statistically significant increase in ApoA-I (WMD: ... The current meta-analysis of RCTs demonstrates that treatment with raloxifene reduces ApoB and Lp(a) levels while increasing ApoA-I levels in postmenopausal women. Since these effects on lipid compone...

Can Bisphosphonate Therapy Reduce Overall Mortality in Patients With Osteoporosis? A Meta-analysis of Randomized Controlled Trials.

For patients with osteoporosis, bisphosphonate therapy can reduce the risk of fractures, but its effect on reducing mortality remains unclear. Previous studies on this topic have produced conflicting ... In a large meta-analysis of placebo-controlled randomized controlled trials (RCTs), we asked: (1) Does bisphosphonate use reduce mortality? (2) Is there a subgroup effect based on whether different bi... We conducted a systematic review using multiple databases, including Embase, Web of Science, Medline (via PubMed), Cochrane Library, and ClinicalTrials.gov, with each database searched up to November ... The use of bisphosphonates did not reduce the overall risk of mortality in patients with osteoporosis (risk ratio 0.95 [95% CI 0.88 to 1.03]). Subgroup analyses involving different bisphosphonate drug... Based on our comprehensive meta-analysis, there is high-quality evidence suggesting that bisphosphonate therapy for patients with osteoporosis does not reduce the overall risk of mortality despite its... Level I, therapeutic study....

Analgesic effectiveness of methoxyflurane inhaler during genicular nerve block in knee osteoarthritis: a randomized controlled trial.

Up to 30% of patients with knee osteoarthritis (KOA) have evidence of sensitization, with a similar proportion experiencing severe pain during procedures. Most patients with KOA are elderly and often ... 42 adults with refractory KOA were randomized into two groups. Methoxyflurane group received a self-titrated methoxyflurane inhaler with local anesthesia whereas lidocaine group received local anesthe... 42 patients with a mean age of 66±12 years participated in this study. There were no significant baseline differences. During the procedure, the methoxyflurane group experienced a significantly greate... A methoxyflurane inhaler combined with local anesthesia provided better procedural pain control than local anesthesia alone with no observable differences in adverse effects. Future studies evaluating...

Comparing the hemodynamic effects of ketamine versus fentanyl bolus in patients with septic shock: a randomized controlled trial.

Ketamine and fentanyl are commonly used for sedation and induction of anesthesia in critically ill patients. This study aimed to compare the hemodynamic effects of ketamine versus fentanyl bolus in pa... This randomized controlled trial included mechanically ventilated adults with septic shock receiving sedation. Patients were randomized to receive either 1 mg/kg ketamine bolus or 1 mcg/kg fentanyl bo... Eighty-six patients were analyzed. The median (quartiles) delta CO 6 min after drug injection was 71(37, 116)% in the ketamine group versus - 31(- 43, - 12)% in the fentanyl group, P value < 0.001. Th... In patients with septic shock, ketamine bolus was associated with higher CO and SV compared to fentanyl bolus.... Date of registration: 24/07/2023.... gov Identifier: NCT05957302. URL: https://clinicaltrials.gov/study/NCT05957302 ....