Test pharmacogénomique : Questions médicales fréquentes
Nom anglais: Pharmacogenomic Testing
Descriptor UI:D000071185
Tree Number:N02.421.726.233.221.500
Termes MeSH sélectionnés :
Randomized Controlled Trials as Topic
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"name": "Diagnostic",
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"description": "Qu'est-ce qu'un test pharmacogénomique ?\nQuand est-il recommandé de faire un test ?\nQuels types de médicaments sont concernés ?\nComment se déroule un test ?\nLes tests sont-ils fiables ?",
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"description": "Quels symptômes peuvent indiquer un besoin de test ?\nLes tests peuvent-ils prédire des symptômes ?\nPeut-on avoir des symptômes sans test ?\nLes symptômes varient-ils selon les gènes ?\nLes tests peuvent-ils aider à diagnostiquer des maladies ?",
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"description": "Les tests peuvent-ils prévenir des effets secondaires ?\nComment intégrer les tests dans la prévention ?\nLes tests sont-ils recommandés pour tous ?\nPeut-on se préparer à un test ?\nLes tests peuvent-ils réduire les coûts de santé ?",
"url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=998#section-prévention"
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"headline": "Traitements sur Test pharmacogénomique",
"description": "Comment les tests influencent-ils les traitements ?\nPeut-on éviter des traitements grâce aux tests ?\nLes tests sont-ils utilisés pour tous les médicaments ?\nLes résultats des tests sont-ils toujours clairs ?\nLes tests peuvent-ils changer en cours de traitement ?",
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"description": "Quelles complications peuvent survenir sans test ?\nLes tests peuvent-ils prévenir des complications ?\nLes complications sont-elles toujours évitables ?\nComment gérer les complications liées aux médicaments ?\nLes complications peuvent-elles affecter le traitement futur ?",
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"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Test pharmacogénomique",
"description": "Quels facteurs de risque influencent les tests ?\nLes facteurs environnementaux jouent-ils un rôle ?\nLes facteurs de risque sont-ils les mêmes pour tous ?\nComment évaluer les facteurs de risque ?\nLes facteurs de risque peuvent-ils changer ?",
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"@type": "Question",
"name": "Qu'est-ce qu'un test pharmacogénomique ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "C'est un test qui analyse les gènes pour prédire la réponse aux médicaments."
}
},
{
"@type": "Question",
"name": "Quand est-il recommandé de faire un test ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est recommandé avant de commencer un traitement médicamenteux, surtout pour certains médicaments."
}
},
{
"@type": "Question",
"name": "Quels types de médicaments sont concernés ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les médicaments pour le cancer, les antidépresseurs et les anticoagulants sont souvent testés."
}
},
{
"@type": "Question",
"name": "Comment se déroule un test ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un échantillon de sang ou de salive est prélevé et analysé en laboratoire."
}
},
{
"@type": "Question",
"name": "Les tests sont-ils fiables ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, mais leur précision dépend de la qualité du laboratoire et des gènes analysés."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un besoin de test ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets secondaires graves ou une réponse inefficace au traitement peuvent le justifier."
}
},
{
"@type": "Question",
"name": "Les tests peuvent-ils prédire des symptômes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent aider à anticiper des réactions indésirables à certains médicaments."
}
},
{
"@type": "Question",
"name": "Peut-on avoir des symptômes sans test ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains symptômes peuvent survenir sans lien avec la génétique ou les médicaments."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon les gènes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les variations génétiques peuvent influencer la gravité et la nature des symptômes."
}
},
{
"@type": "Question",
"name": "Les tests peuvent-ils aider à diagnostiquer des maladies ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, en identifiant des prédispositions génétiques à certaines maladies."
}
},
{
"@type": "Question",
"name": "Les tests peuvent-ils prévenir des effets secondaires ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils aident à choisir des médicaments moins susceptibles de provoquer des effets indésirables."
}
},
{
"@type": "Question",
"name": "Comment intégrer les tests dans la prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "En les utilisant lors de la prescription de médicaments pour anticiper les réactions."
}
},
{
"@type": "Question",
"name": "Les tests sont-ils recommandés pour tous ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils sont surtout recommandés pour les personnes avec des antécédents médicaux complexes."
}
},
{
"@type": "Question",
"name": "Peut-on se préparer à un test ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est conseillé de discuter de l'historique médical et des médicaments en cours avec le médecin."
}
},
{
"@type": "Question",
"name": "Les tests peuvent-ils réduire les coûts de santé ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, en évitant des traitements inefficaces et des hospitalisations dues à des effets secondaires."
}
},
{
"@type": "Question",
"name": "Comment les tests influencent-ils les traitements ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils permettent de personnaliser les traitements en fonction de la réponse génétique."
}
},
{
"@type": "Question",
"name": "Peut-on éviter des traitements grâce aux tests ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, en identifiant les médicaments susceptibles de provoquer des effets indésirables."
}
},
{
"@type": "Question",
"name": "Les tests sont-ils utilisés pour tous les médicaments ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils sont principalement utilisés pour certains médicaments à haut risque."
}
},
{
"@type": "Question",
"name": "Les résultats des tests sont-ils toujours clairs ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Pas toujours, certains résultats peuvent être ambigus et nécessiter une interprétation."
}
},
{
"@type": "Question",
"name": "Les tests peuvent-ils changer en cours de traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests supplémentaires peuvent être nécessaires si le traitement échoue."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir sans test ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets secondaires graves ou des traitements inefficaces peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les tests peuvent-ils prévenir des complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, en identifiant les patients à risque de réactions indésirables aux médicaments."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles toujours évitables ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certaines complications peuvent survenir malgré un test pharmacogénomique."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées aux médicaments ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "En ajustant le traitement selon les résultats des tests et en surveillant les effets."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles affecter le traitement futur ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent influencer les choix de médicaments dans le futur."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque influencent les tests ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'hérédité, les antécédents médicaux et les traitements antérieurs sont des facteurs clés."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux jouent-ils un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'environnement peut interagir avec la génétique et influencer la réponse aux médicaments."
}
},
{
"@type": "Question",
"name": "Les facteurs de risque sont-ils les mêmes pour tous ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils varient selon les individus et leurs antécédents médicaux."
}
},
{
"@type": "Question",
"name": "Comment évaluer les facteurs de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Par une évaluation médicale complète et des tests génétiques appropriés."
}
},
{
"@type": "Question",
"name": "Les facteurs de risque peuvent-ils changer ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent évoluer avec le temps et les traitements reçus."
}
}
]
}
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To examine short-term (i.e., postintervention) outcomes from a randomized controlled trial comparing a school-based telehealth-delivered depression prevention program, Interpersonal Psychotherapy-Adol...
Adolescents (...
Hierarchical linear models showed that adolescents reported significant reductions in depression symptoms and impairment across conditions. IPT-AST adolescents reported significantly greater reduction...
Results support telehealth-delivered IPT-AST as a promising intervention for improving short-term outcomes among adolescents with depression symptoms but without a depression diagnosis. (PsycInfo Data...
Ciprofol, a recently developed anesthetic agent, is not inferior to propofol in terms of efficacy and safety. However, most previous clinical experience with ciprofol was based on a robust population....
This prospective randomized controlled trial included patients with frailty undergoing elective general anesthesia for gynecological surgery. Frailty was assessed using the modified frailty index. The...
Among the 69 enrolled patients with frailty, 67 were included in the final analysis. The success rate of anesthesia induction was 100% in both groups. The lowest SBP was significantly higher in the ci...
The results of this study suggest that the efficacy of ciprofol for inducing general anesthesia in patients with frailty is comparable to that of propofol, with more stable hemodynamics....
The trial was registered, before patient enrollment, in the Chinese Clinical Trial Registry ( www.chictr.org.cn ) (Clinical trial number: ChiCTR2300075271; https://www.chictr.org.cn/showproj.html?proj...
The current pilot randomized controlled trial evaluated the acceptability, feasibility, and preliminary efficacy of a mental health promotion intervention for college students based on trauma-focused ...
Digital therapeutics (DTx) intervention is an emerging therapy for the treatment and long-term management of hypertension. We aim to systematically evaluate the overall effect of DTx intervention on i...
To examine the effects of a sport-based exercise therapy program combined with usual care (sET+UC) compared with usual care alone (UC) on health-related quality of life, upper limb motor control, func...
Single-blind, parallel-group, randomized controlled trial....
Rehabilitation center....
Twenty-three adults with ABI (82.6% stroke; 17 males; mean age of 59.6±10.3 yr) INTERVENTION: Participants received either sET+UC (n=11) or UC (n=12). The sET+UC group received sixteen 60-minute sessi...
Primary outcome measures were health-related quality of life (Short Form-36, SF-36) and upper limb motor control (Fugl Meyer-Upper Extremity; FM-UE), while the secondary included functional capacity (...
Significant differences were found in all outcome analyses at post-intervention when comparing between groups. The sET+UC group showed significant improvements in both the physical (p=.027, r=.46) and...
This study shows that a sport-based exercise therapy program combined with usual care can effectively improve all the aforementioned outcomes measures in ABI population. Further research with larger s...
In addition to attention and hyperactivity problems, children with attention deficit hyperactivity disorder (ADHD) have poorer organizational skills needed to manage time and materials. This study exa...
This was a prospective, randomized controlled trial. Between September 2023 and January 2024, 70 children with a diagnosis of ADHD and at least one domain of executive dysfunction (EF) were divided in...
The mean age of the children was 8.33 ± 1.62 years. A total of 66 children completed the intervention and follow-up, 32 in the conventional group and 34 in the OST group. There were no differences bet...
OST can further improve organizational skills in daily life in children with ADHD while improving core symptoms of attention deficit in addition to conventional treatment. The effect of OST on BRIEF i...
The randomized controlled trial registration number was ChiCTR2300075744....
Vital pulp therapy (VPT) is recommended as an alternative treatment to root canal therapy (RCT) for management of teeth with carious pulp exposure. This randomized clinical trial aimed to compare the ...
A total of 160 mature molar teeth with IP were randomly divided into two treatment groups. The FP group (test group) was treated with FP using iRoot BP Plus by an endodontist, the RCT group (control g...
FP and RCT had comparable success rates (Clinical, 97.3% vs. 98.6%; radiographic, 93.3% vs. 94.6%) (P > 0.05). Pain levels decreased over time from day 1 to day 7 postoperative in both groups, and the...
FP could be an appropriate alternative treatment for management of mature teeth with IP in short follow-up....
The trial was registered in Chinese Clinical Trial Registry (ChiCTR2200063380 at 05/09/2022)....
Managing postoperative setting, regarding pain and anxiety after cesarean delivery is crucial for the mother's recovery, her emotional well-being, mother-infant bonding and initiating breastfeeding. A...
This was a monocentric randomized controlled double-blind trial conducted over a period of five months during 2023. A hundred women undergoing c-sections under spinal anesthesia were enrolled and rand...
A total of 100 women were included (50 women in each group aromatherapy and the placebo group). The two groups were comparable regarding baseline characteristics and pre-intervention parameters with n...
Aromatherapy using Lavender essential oil is effective in reducing pain and anxiety after cesarean delivery without adverse effects....
Zinc deficiency is highly prevalent in HD patients. On the other hand, it remains unknown about the role of zinc in their nutritional status....
We conducted an open-label randomized controlled trial. We investigated (i) the relationship between serum zinc levels and body composition and (ii) the effects of zinc supplementation on the composit...
Serum zinc levels were significantly correlated with body fat weight (p < 0.01), but not with nonfat tissue weight. Multiple regression analyses demonstrated that serum zinc levels were a significant ...
Our findings indicate that zinc deficiency plays an important role in fat metabolism in HD patients with its deficiency....
The aim of this systematic review and meta-analysis was to assess whether earlier discharge from hospital after cesarean delivery (CD) affects the rate of maternal readmission....
The research was conducted using PubMed, Embase, Web of Sciences, Scopus, ClinicalTrials.gov and the Cochrane Central Register of Controlled Trials as electronic databases, from the inception of each ...
Selection criteria included only RCTs comparing the effect of earlier vs later hospital discharge after CD....
The primary outcome was the rate of maternal readmission. The summary measures were reported as relative risk (RR) or as mean difference (MD) with 95% confidence intervals (CI) using the random effect...
Seven RCTs including 4,267 individuals, of which 2,125 (49.8%) randomized in the early discharge and 2,142 (50.2%) in the late discharge group were included. There was no difference between the two gr...
There is no increase in the rate of maternal readmission following early hospital discharge at 24-28 hours as opposed to later hospital discharge after a CD. The rates of neonatal readmission and neon...