Quels sont les risques pour la santé liés aux TAL ?
Des risques pour la santé peuvent survenir si les TAL provoquent des effets indésirables non prévus.
Risques pour la santéProtéinesBiotechnologie
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Effecteurs de type activateur de transcription : Questions médicales les plus fréquentes",
"headline": "Effecteurs de type activateur de transcription : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Effecteurs de type activateur de transcription : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-20",
"dateModified": "2025-04-16",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Effecteurs de type activateur de transcription"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Facteurs de virulence",
"url": "https://questionsmedicales.fr/mesh/D037521",
"about": {
"@type": "MedicalCondition",
"name": "Facteurs de virulence",
"code": {
"@type": "MedicalCode",
"code": "D037521",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D23.946.896"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Effecteurs de type activateur de transcription",
"alternateName": "Transcription Activator-Like Effectors",
"code": {
"@type": "MedicalCode",
"code": "D000071336",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Doron Teper",
"url": "https://questionsmedicales.fr/author/Doron%20Teper",
"affiliation": {
"@type": "Organization",
"name": "Citrus Research and Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, 700 Experiment Station Road, Lake Alfred, FL 33850, U.S.A."
}
},
{
"@type": "Person",
"name": "Nian Wang",
"url": "https://questionsmedicales.fr/author/Nian%20Wang",
"affiliation": {
"@type": "Organization",
"name": "Citrus Research and Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, 700 Experiment Station Road, Lake Alfred, FL 33850, U.S.A."
}
},
{
"@type": "Person",
"name": "Josh Tycko",
"url": "https://questionsmedicales.fr/author/Josh%20Tycko",
"affiliation": {
"@type": "Organization",
"name": "Department of Genetics, Stanford University, Stanford, CA 94305, USA."
}
},
{
"@type": "Person",
"name": "Michael C Bassik",
"url": "https://questionsmedicales.fr/author/Michael%20C%20Bassik",
"affiliation": {
"@type": "Organization",
"name": "Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: bassik@stanford.edu."
}
},
{
"@type": "Person",
"name": "Lacramioara Bintu",
"url": "https://questionsmedicales.fr/author/Lacramioara%20Bintu",
"affiliation": {
"@type": "Organization",
"name": "Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. Electronic address: lbintu@stanford.edu."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Differences in a Musician's Advantage for Speech-in-Speech Perception Based on Age and Task.",
"datePublished": "2023-02-02",
"url": "https://questionsmedicales.fr/article/36729698",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1044/2022_JSLHR-22-00259"
}
},
{
"@type": "ScholarlyArticle",
"name": "Lilliput: speech perception in speech-weighted noise and in quiet in young children.",
"datePublished": "2022-06-22",
"url": "https://questionsmedicales.fr/article/35732012",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1080/14992027.2022.2086491"
}
},
{
"@type": "ScholarlyArticle",
"name": "Towards a somatosensory theory of speech perception.",
"datePublished": "2022-11-23",
"url": "https://questionsmedicales.fr/article/36416451",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1152/jn.00381.2022"
}
},
{
"@type": "ScholarlyArticle",
"name": "Online Ternary Classification of Covert Speech by Leveraging the Passive Perception of Speech.",
"datePublished": "2023-07-31",
"url": "https://questionsmedicales.fr/article/37522623",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1142/S012906572350048X"
}
},
{
"@type": "ScholarlyArticle",
"name": "Sensorimotor foundations of speech perception in infancy.",
"datePublished": "2023-06-09",
"url": "https://questionsmedicales.fr/article/37302917",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.tics.2023.05.007"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Facteurs biologiques",
"item": "https://questionsmedicales.fr/mesh/D001685"
},
{
"@type": "ListItem",
"position": 3,
"name": "Toxines biologiques",
"item": "https://questionsmedicales.fr/mesh/D014118"
},
{
"@type": "ListItem",
"position": 4,
"name": "Facteurs de virulence",
"item": "https://questionsmedicales.fr/mesh/D037521"
},
{
"@type": "ListItem",
"position": 5,
"name": "Effecteurs de type activateur de transcription",
"item": "https://questionsmedicales.fr/mesh/D000071336"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Effecteurs de type activateur de transcription - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Effecteurs de type activateur de transcription",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-09",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Effecteurs de type activateur de transcription",
"description": "Comment identifier les effecteurs TAL dans un échantillon ?\nQuels tests sont utilisés pour détecter les TAL ?\nLes TAL peuvent-ils être détectés par imagerie ?\nQuels marqueurs sont associés aux TAL ?\nPeut-on utiliser des anticorps pour détecter les TAL ?",
"url": "https://questionsmedicales.fr/mesh/D000071336?mesh_terms=Speech+Perception#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Effecteurs de type activateur de transcription",
"description": "Quels sont les effets des TAL sur les cellules ?\nLes TAL provoquent-ils des symptômes cliniques ?\nComment les TAL affectent-ils les plantes ?\nLes TAL sont-ils liés à des maladies ?\nLes TAL affectent-ils le métabolisme cellulaire ?",
"url": "https://questionsmedicales.fr/mesh/D000071336?mesh_terms=Speech+Perception#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Effecteurs de type activateur de transcription",
"description": "Comment prévenir les effets indésirables des TAL ?\nLes TAL peuvent-ils être utilisés de manière préventive ?\nQuelles mesures de sécurité sont nécessaires lors de l'utilisation des TAL ?\nLes TAL nécessitent-ils une réglementation spécifique ?\nComment évaluer l'impact environnemental des TAL ?",
"url": "https://questionsmedicales.fr/mesh/D000071336?mesh_terms=Speech+Perception#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Effecteurs de type activateur de transcription",
"description": "Les TAL sont-ils utilisés en thérapie génique ?\nComment les TAL sont-ils appliqués en biotechnologie ?\nLes TAL peuvent-ils être utilisés pour traiter des cancers ?\nQuels sont les avantages des TAL en médecine ?\nLes TAL sont-ils sûrs pour l'utilisation humaine ?",
"url": "https://questionsmedicales.fr/mesh/D000071336?mesh_terms=Speech+Perception#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Effecteurs de type activateur de transcription",
"description": "Quelles complications peuvent survenir avec l'utilisation des TAL ?\nLes TAL peuvent-ils provoquer des réactions immunitaires ?\nComment gérer les complications liées aux TAL ?\nLes TAL peuvent-ils affecter la biodiversité ?\nQuelles sont les préoccupations éthiques liées aux TAL ?",
"url": "https://questionsmedicales.fr/mesh/D000071336?mesh_terms=Speech+Perception#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Effecteurs de type activateur de transcription",
"description": "Quels facteurs augmentent les risques liés aux TAL ?\nLes TAL sont-ils plus risqués dans certaines applications ?\nComment évaluer les risques des TAL en recherche ?\nLes TAL sont-ils associés à des risques environnementaux ?\nQuels sont les risques pour la santé liés aux TAL ?",
"url": "https://questionsmedicales.fr/mesh/D000071336?mesh_terms=Speech+Perception#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment identifier les effecteurs TAL dans un échantillon ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'identification se fait par PCR, séquençage ou techniques de biologie moléculaire."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour détecter les TAL ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de PCR en temps réel et des analyses de séquençage sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Les TAL peuvent-ils être détectés par imagerie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, les TAL sont des protéines et nécessitent des méthodes moléculaires pour leur détection."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont associés aux TAL ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs génétiques spécifiques aux TAL peuvent être utilisés pour leur identification."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des anticorps pour détecter les TAL ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anticorps spécifiques peuvent être utilisés dans des tests immunologiques."
}
},
{
"@type": "Question",
"name": "Quels sont les effets des TAL sur les cellules ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les TAL modifient l'expression génique, influençant la croissance et la différenciation cellulaire."
}
},
{
"@type": "Question",
"name": "Les TAL provoquent-ils des symptômes cliniques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les TAL eux-mêmes ne provoquent pas de symptômes, mais leurs effets peuvent influencer la santé cellulaire."
}
},
{
"@type": "Question",
"name": "Comment les TAL affectent-ils les plantes ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent induire des réponses de défense ou des modifications de croissance chez les plantes."
}
},
{
"@type": "Question",
"name": "Les TAL sont-ils liés à des maladies ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être impliqués dans des maladies en modifiant l'expression de gènes associés."
}
},
{
"@type": "Question",
"name": "Les TAL affectent-ils le métabolisme cellulaire ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, en régulant des gènes clés, les TAL peuvent influencer le métabolisme cellulaire."
}
},
{
"@type": "Question",
"name": "Comment prévenir les effets indésirables des TAL ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une évaluation rigoureuse des TAL avant leur utilisation est essentielle pour prévenir les effets indésirables."
}
},
{
"@type": "Question",
"name": "Les TAL peuvent-ils être utilisés de manière préventive ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être utilisés pour renforcer la résistance des plantes aux maladies, par exemple."
}
},
{
"@type": "Question",
"name": "Quelles mesures de sécurité sont nécessaires lors de l'utilisation des TAL ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des protocoles de sécurité en laboratoire et des évaluations de risque sont nécessaires."
}
},
{
"@type": "Question",
"name": "Les TAL nécessitent-ils une réglementation spécifique ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, leur utilisation en biotechnologie et en médecine est soumise à des réglementations strictes."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'impact environnemental des TAL ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études d'impact environnemental doivent être réalisées avant leur déploiement dans la nature."
}
},
{
"@type": "Question",
"name": "Les TAL sont-ils utilisés en thérapie génique ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les TAL sont utilisés pour cibler et modifier des gènes dans des thérapies géniques."
}
},
{
"@type": "Question",
"name": "Comment les TAL sont-ils appliqués en biotechnologie ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils sont utilisés pour créer des plantes génétiquement modifiées et pour la recherche génétique."
}
},
{
"@type": "Question",
"name": "Les TAL peuvent-ils être utilisés pour traiter des cancers ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études explorent leur utilisation pour cibler des gènes spécifiques dans les cellules cancéreuses."
}
},
{
"@type": "Question",
"name": "Quels sont les avantages des TAL en médecine ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils permettent une modification précise de l'ADN, offrant des possibilités de traitement ciblé."
}
},
{
"@type": "Question",
"name": "Les TAL sont-ils sûrs pour l'utilisation humaine ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études sont en cours pour évaluer leur sécurité et leur efficacité dans des applications cliniques."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec l'utilisation des TAL ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets hors cible sur d'autres gènes peuvent survenir, entraînant des complications."
}
},
{
"@type": "Question",
"name": "Les TAL peuvent-ils provoquer des réactions immunitaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des réactions immunitaires peuvent se produire si le système immunitaire reconnaît les TAL comme étrangers."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées aux TAL ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surveillance étroite et des ajustements dans les protocoles d'utilisation peuvent aider."
}
},
{
"@type": "Question",
"name": "Les TAL peuvent-ils affecter la biodiversité ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, leur utilisation peut avoir des impacts sur la biodiversité, nécessitant une évaluation."
}
},
{
"@type": "Question",
"name": "Quelles sont les préoccupations éthiques liées aux TAL ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les préoccupations incluent les effets sur l'environnement et la modification génétique des organismes."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent les risques liés aux TAL ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'utilisation inappropriée ou non réglementée des TAL peut augmenter les risques associés."
}
},
{
"@type": "Question",
"name": "Les TAL sont-ils plus risqués dans certaines applications ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, leur utilisation dans des organismes vivants peut présenter des risques plus élevés."
}
},
{
"@type": "Question",
"name": "Comment évaluer les risques des TAL en recherche ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des études de sécurité et des évaluations de risque doivent être menées avant l'utilisation."
}
},
{
"@type": "Question",
"name": "Les TAL sont-ils associés à des risques environnementaux ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, leur introduction dans l'environnement peut avoir des conséquences imprévues."
}
},
{
"@type": "Question",
"name": "Quels sont les risques pour la santé liés aux TAL ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des risques pour la santé peuvent survenir si les TAL provoquent des effets indésirables non prévus."
}
}
]
}
]
}
Citrus Research and Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, 700 Experiment Station Road, Lake Alfred, FL 33850, U.S.A.
Publications dans "Effecteurs de type activateur de transcription" :
Citrus Research and Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, 700 Experiment Station Road, Lake Alfred, FL 33850, U.S.A.
Publications dans "Effecteurs de type activateur de transcription" :
Citrus Research and Education Center, Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, 700 Experiment Station Road, Lake Alfred, FL 33850, U.S.A.
Publications dans "Effecteurs de type activateur de transcription" :
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota. Electronic address: maher@mayo.edu.
Publications dans "Effecteurs de type activateur de transcription" :
This study investigates the debate that musicians have an advantage in speech-in-noise perception from years of targeted auditory training. We also consider the effect of age on any such advantage, co...
Participants (ranging in age from 18 to 66 years) included 29 musicians and 26 nonmusicians. They completed two tasks varying in attentional demands: (a) a selective attention task where listeners ide...
Results show that increasing differences in...
Overall, we find support for a hybrid...
https://doi.org/10.23641/asha.21956777....
The aim of this study was to develop an open-set word recognition task in speech-weighted noise and in quiet for young children and examine age effects for open versus closed response formats....
Dutch monosyllabic words were presented in quiet and in stationary speech-weighted noise to 4- and 5-year-old children as well as to young adults in an open-set response format. Additionally, performa...
More than 200 children and 50 adults with normal hearing participated in the various validation phases....
Average fitted speech reception thresholds (50%) yielded an age effect between 4-year and 5-year olds (and adults), both in speech-weighted noise and in quiet. The closed-set format yielded lower (bet...
The same materials reveal performance differences between 4 and 5 years of age (and adults), both in quiet and speech-weighted noise using an open-set response format. This relatively small yet signif...
Speech perception is known to be a multimodal process, relying not only on auditory input but also on the visual system and possibly on the motor system as well. To date there has been little work on ...
Brain-computer interfaces (BCIs) provide communicative alternatives to those without functional speech. Covert speech (CS)-based BCIs enable communication simply by thinking of words and thus have int...
The perceptual system for speech is highly organized from early infancy. This organization bootstraps young human learners' ability to acquire their native speech and language from speech input. Here,...
Beyond hallmark production deficits characterizing childhood apraxia of speech (CAS), largely attributed to disruption(s) in speech motor planning, children with CAS often present with co-occurring sp...
This tutorial summarizes the current literature on speech perception and how it relates to speech production, language, and reading abilities for children with CAS. We include case illustrations that ...
Although speech perception difficulties do not seem to be a core deficit of CAS, they are strongly linked to language difficulties, which are highly prevalent among children with CAS. Speech perceptio...
Children with CAS who have co-occurring language difficulties likely also demonstrate speech perception deficits, which puts them at heightened risk for reading difficulties and struggles with academi...
Investigate if speech perception skills can differentiate school children with Specific Reading Disorders (SRD) with and without Persistent Speech Sound Disorders (PSSD)....
80 children, regularly enrolled in the 2nd (N=1), 3rd (N=28), 4th (N=29), 5th (N=15) and 6th (N=7) grades participated in the study. Control Group (CG) (N=48): no complaints, no speech alteration; and...
Control and RGI showed higher correct answer scores than RGII. There was no difference between the correct answer distributions of the Control and RGI, and RGI and RGII in the test of DNPLS and the nu...
The ability to discriminate non-words enabled the differentiated between school-aged children with SRD associated with PSSD and typical children, thus characterizing this group for presenting a number...
Sensory gating is the cortical phenomenon that involves selective inhibition of responses to task-irrelevant stimuli. Perceiving speech in noise, a situation commonly encountered by humans, requires t...
An observational research following a correlational design was conducted on 10 neurotypical individuals. Auditory sensory gating was assessed using a conditioning-testing paradigm for tone and speech ...
Differences were observed in the gating index of the P2 peaks of speech and tone pairs. A significant relationship between SPiN and the auditory sensory gating of the P2 peak of the speech-evoked cort...
The results of this preliminary investigation indicate an association between the sensory gating mechanism and neurotypical individuals' ability to perceive speech in noise....
To analyze the performance of auditory speech perception (PF) after cochlear implant (CI) replacement surgery and associations with age, times of use of the first CI, deprivation, recovery and use of ...
The retrospective study analyzed the medical records of 68 participants reimplanted from 1990 to 2016, and evaluated with PF performance tests, considering as a reference, the greater auditory capacit...
Most were children with hearing loss due to idiopathic causes and meningitis. Abrupt stoppage of operation was the most common cause for device replacement. Most cases recovered and maintained or cont...
Periodic programming and replacement of the device when indicated are fundamental for the maintenance of auditory functions. Being young and having longer use of implants represent advantages for the ...
Individuals with autism spectrum disorder (ASD) exhibit atypical speech-in-noise (SiN) perception, but the scope of these impairments has not been clearly defined. We conducted a systematic review of ...
