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"description": "Quels sont les principaux facteurs de risque identifiés par la protéogénomique ?\nLa protéogénomique peut-elle identifier des risques environnementaux ?\nLes habitudes de vie influencent-elles les facteurs de risque protéogénomiques ?\nComment la génétique influence-t-elle les facteurs de risque ?\nPeut-on modifier les facteurs de risque grâce à la protéogénomique ?",
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"@type": "Question",
"name": "Comment la protéogénomique aide-t-elle au diagnostic des maladies ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet d'identifier des biomarqueurs protéiques spécifiques pour un diagnostic plus précis."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés en protéogénomique ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques comme la spectrométrie de masse et l'électrophorèse sont couramment utilisées."
}
},
{
"@type": "Question",
"name": "La protéogénomique peut-elle détecter des cancers ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à identifier des protéines spécifiques associées à différents types de cancers."
}
},
{
"@type": "Question",
"name": "Quels échantillons sont analysés en protéogénomique ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des échantillons de tissus, de sang ou de fluides biologiques sont souvent analysés."
}
},
{
"@type": "Question",
"name": "La protéogénomique est-elle utilisée en médecine personnalisée ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle permet d'adapter les traitements en fonction du profil protéique du patient."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent être liés à des anomalies protéiques ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes variés comme la fatigue, la douleur ou des troubles neurologiques peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles étudiées en protéogénomique ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la protéogénomique aide à comprendre les mécanismes sous-jacents des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Comment les protéines affectent-elles les symptômes ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les protéines peuvent influencer des voies biologiques, entraînant divers symptômes cliniques."
}
},
{
"@type": "Question",
"name": "Les symptômes de maladies métaboliques sont-ils liés à la protéogénomique ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres protéiques peuvent contribuer à des symptômes de maladies métaboliques."
}
},
{
"@type": "Question",
"name": "Peut-on prédire des symptômes grâce à la protéogénomique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des modèles prédictifs basés sur des profils protéiques peuvent anticiper certains symptômes."
}
},
{
"@type": "Question",
"name": "La protéogénomique peut-elle aider à la prévention des maladies ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle permet d'identifier des facteurs de risque protéiques pour des interventions précoces."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont identifiés par la protéogénomique ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme des niveaux anormaux de certaines protéines peuvent indiquer un risque accru."
}
},
{
"@type": "Question",
"name": "Comment la protéogénomique influence-t-elle les programmes de dépistage ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet de cibler des populations à risque pour des dépistages plus efficaces."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir des maladies grâce à des interventions protéogénomiques ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des interventions basées sur des profils protéiques peuvent réduire le risque de maladies."
}
},
{
"@type": "Question",
"name": "La nutrition peut-elle être influencée par la protéogénomique ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à adapter les régimes alimentaires en fonction des besoins protéiques individuels."
}
},
{
"@type": "Question",
"name": "La protéogénomique influence-t-elle les traitements ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle permet de développer des thérapies ciblées basées sur le profil protéique des patients."
}
},
{
"@type": "Question",
"name": "Quels types de traitements sont développés grâce à la protéogénomique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements biologiques, comme les anticorps monoclonaux, sont souvent développés."
}
},
{
"@type": "Question",
"name": "La protéogénomique aide-t-elle à la résistance aux médicaments ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle identifie des mécanismes de résistance, permettant d'ajuster les traitements."
}
},
{
"@type": "Question",
"name": "Les traitements peuvent-ils être personnalisés grâce à la protéogénomique ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des profils protéiques individuels."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont influencés par la protéogénomique ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments anticancéreux et des immunothérapies sont souvent influencés par cette approche."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir en cas d'anomalies protéiques ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des troubles métaboliques ou des maladies dégénératives peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles liées à la protéogénomique ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des profils protéiques spécifiques peuvent être associés à un risque accru de maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Comment la protéogénomique aide-t-elle à comprendre les complications ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet d'analyser les interactions entre gènes et protéines, révélant des mécanismes de complications."
}
},
{
"@type": "Question",
"name": "Les complications liées à la protéogénomique sont-elles évitables ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être évitées par des interventions précoces basées sur des analyses protéiques."
}
},
{
"@type": "Question",
"name": "Peut-on prédire des complications grâce à la protéogénomique ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des modèles prédictifs basés sur des données protéomiques peuvent anticiper des complications."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque identifiés par la protéogénomique ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme l'âge, l'hérédité et des niveaux protéiques anormaux sont souvent identifiés."
}
},
{
"@type": "Question",
"name": "La protéogénomique peut-elle identifier des risques environnementaux ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut révéler comment des facteurs environnementaux influencent les profils protéiques."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie influencent-elles les facteurs de risque protéogénomiques ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme l'alimentation et l'exercice peuvent modifier les niveaux protéiques."
}
},
{
"@type": "Question",
"name": "Comment la génétique influence-t-elle les facteurs de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "La génétique détermine la production de certaines protéines, influençant ainsi le risque de maladies."
}
},
{
"@type": "Question",
"name": "Peut-on modifier les facteurs de risque grâce à la protéogénomique ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des interventions ciblées peuvent aider à modifier les niveaux protéiques et réduire les risques."
}
}
]
}
]
}
Muscular overuse injuries are a common health issue in elite athletes. Changes in the muscular microenvironment can be depicted by Diffusion Tensor Imaging (DTI). We hypothesize that the biomechanics ...
Twenty-two male elite rowers (12 sweep, 10 scull rowers) with a mean age of 15.8 ± 1.2 years underwent 3-Tesla MRI of the lumbar spine 6 hours after cessation of training. Apparent diffusion coefficie...
ADC values in the erector spinae and multifidus muscle were significantly higher (p = 0.039) and FA values significantly lower (p < 0.001) in sweep rowers compared to scull rowers. There was no signif...
Our DTI results show that lumbar spine muscle diffusivity is higher in sweep rowers than in scull rowers. Altered muscle diffusivity is suggestive of microscopic tissue disruption and might be attribu...
To compare the performance of 3.0 T magnetic resonance diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) in evaluation of the degree of tubulointerstitial damage and renal function i...
Both DKI and DTI were performed in 40 IgAN patients and 17 healthy volunteers. IgAN patients were divided into two groups according to tubulointerstitial lesion score: Mild injury group, n = 24; Moder...
Cortical MK, Kr, Da and parenchymal Ka significantly differed among three groups (P < 0.05). Cortical MK, Kr, Ka were negatively correlated with estimated glomerular filtration rate (eGFR) (MK: r = - ...
Compared with DTI, DKI was more sensitive and accurate to probe the renal function and the tubulointerstitial damage of IgAN, especially the mild tubulointerstitial damage....
The current study aims to explore the correlation between the Diffusion Tensor Imaging (DTI) indices and neurological status of individuals with TB spine with neurological deficit (TBSND). Further, fa...
The current study included 51 individuals with TBSND undergoing posterior instrumentation and posterolateral decompression. All individuals underwent DTI scanning at the site of compression and at a n...
The FA values at the compressed segment were significantly lower while the ADC values were significantly higher when compared with the non-compressed levels. Pre-operative motor and total neurological...
Higher FA indices along with lower age constitute independent predictors for faster neurological recovery following decompression. FA values correlate with the neurological status of individuals with ...
Childhood cerebral adrenoleukodystrophy (C-ALD) is a severe inflammatory demyelinating disease that must be treated at an early stage to prevent permanent brain injury and neurocognitive decline. In s...
In this retrospective cohort study, we analyzed high-resolution anatomical MRI, DTI, and neurocognitive assessments from boys with C-ALD undergoing HCT at the University of Minnesota between 2011 and ...
Among patients with NL-ALD (n = 14), stable or increasing FA, stable AD, and stable or decreasing RD and MD were generally observed during the 1-year study period across all ROIs. In comparison, patie...
DTI was sensitive to lesion presence and severity as well as clinical neurocognitive effects of C-ALD. DTI metrics quantify C-ALD even at an early stage....
Diffusion tensor imaging (DTI) techniques are being studied as a possible diagnostic and predictive tool for the evaluation of cervical spinal cord disease. This systematic review aims to evaluate the...
A search in the PubMed, Scopus, Web of Science and Ovid electronic databases was conducted for articles published between January 1990 and February 2022 that related to the repeatability and reproduci...
A total of 11 studies were included and assessed for different characteristics, including sample size,(3-34) re-test time interval (<1 h to >3 months), test-retest reproducibility scores and acquisiti...
This study revealed that the application of DTI and its related measures in a clinical setting in the assessment of cervical spinal cord changes is feasible and reproducible. However, cervical spinal ...
DTI with its parametric maps provide broad evaluation of the tissue structure of axonal white matter and are being studied as a possible diagnostic and predictive tool for the assessment of cervical s...
The method of diffusion tensor image analysis along the perivascular space (DTI-ALPS) was gathering attention to evaluate the brain's glymphatic function or interstitial fluid dynamics. However, to th...
This study included 23 participants, including 2 with Alzheimer's disease, 15 with mild cognitive impairment, and 6 with cognitive normals. Scan and rescan data of diffusion magnetic resonance images ...
The absolute difference in ALPS-index values between scan and rescan was larger in the ALPS index than in the vALPS index by approximately 0.6% as the relative difference. Cohen's d for the left and r...
The vALPS index based on DTI-ALPS maintaining tensor vector orientation information has higher reproducibility than the ALPS index. This result encourages a multisite study on the ALPS index with a la...
The aim was to compare the diffusion tensor imaging (DTI) indices derived from human hearts between 1.5 T and 3.0 T scanners. Additionally, the reproducibility of DTI indices was assessed between 1.5 ...
A total of 18 ex-vivo hearts were derived from patients who underwent heart transplantation. The DTI schemes were performed at 1.5 T and 3.0 T, respectively. Then, the same slices from each ex-vivo he...
No significant differences (all P > 0.05) were found in the DTI indices between 1.5 T and 3.0 T scanners. Interestingly, the ICC of all DTI indices was relatively lower with a low b-value. The reprodu...
The DTI indices of ex-vivo human hearts between 1.5 T and 3.0 T scanners had no significant differences. The consistency of DTI indices needed caution using a low b-value with different field strength...
The aim of this study was to evaluate brain connectivity by diffusion tensor imaging (DTI) in schizophrenia patients with clozapine-induced obsessive compulsive symptoms (OCS)....
Eighteen schizophrenia patients, nine of which had clozapine-induced OCS (Clz-OCS (+)), 9 without OCS (Clz-OCS (-)) and 9 healthy controls were included. Psychopathology was evaluated with Positive an...
Tract-Based Spatial Statistics based comparison of DTI revealed lower fractional anisotropy in the genu of corpus callosum (CC), right cingulum, left frontal white matter (WM) in the Clz-OCS (+) group...
WM integrity in several pathways such as cortico-striato-thalamo-cortical circuitry and orbito-frontal tracts seems to be affected differently in patients with Clz-OCS (+). Different neuroplastic effe...
Globally, suicide represents the second leading cause of death in young people aged 15-29 years for both sexes, after traffic accidents. Suicide occurs not only in high-income countries, in high-incom...
This review was conducted on studies focused on white matter alterations in people who have attempted or thought about suicide. We searched PubMed and Scopus databases and screened references of inclu...
White matter alterations in suicidal behaviors were found in the prefrontal cortex, orbitofrontal cortex, internal capsule, corpus callosum, and default mode networks, which are critical cerebral area...
White matter alteration in cerebral areas involving high cognitive process and emotional regulation to confer a heightened vulnerability for suicidal behavior. Suicide is a complex process ranging fro...
To assess the diagnostic accuracy of diffusion tensor imaging (DTI) in the characterization of hepatic focal lesions (HFLs) and compare it to diffusion-weighted imaging (DWI)....
Prospective analysis was done for 49 patients (23 male and 26 female) with 74 HFLs who underwent dynamic MRI, DWI, and DTI. Apparent diffusion coefficient (ADC) values from DWI, fractional anisotropy ...
The ADC, MD, and FA at cutoff values of ≤ 1.17 × 10...
MD and FA of DTI are non-invasive, very good, and excellent discriminators superior to ADC measured by DWI for the differentiation of HFLs....
• The ADC, MD, and FA at cutoff values of ≤ 1.17 × 10...
