Titre : Protéogénomique

Protéogénomique : Questions médicales fréquentes

Termes MeSH sélectionnés :

Subtalar Joint
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Protéogénomique", "description": "Quelles complications peuvent survenir en cas d'anomalies protéiques ?\nLes maladies cardiovasculaires sont-elles liées à la protéogénomique ?\nComment la protéogénomique aide-t-elle à comprendre les complications ?\nLes complications liées à la protéogénomique sont-elles évitables ?\nPeut-on prédire des complications grâce à la protéogénomique ?", "url": "https://questionsmedicales.fr/mesh/D000071696?mesh_terms=Subtalar+Joint&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Protéogénomique", "description": "Quels sont les principaux facteurs de risque identifiés par la protéogénomique ?\nLa protéogénomique peut-elle identifier des risques environnementaux ?\nLes habitudes de vie influencent-elles les facteurs de risque protéogénomiques ?\nComment la génétique influence-t-elle les facteurs de risque ?\nPeut-on modifier les facteurs de risque grâce à la protéogénomique ?", "url": "https://questionsmedicales.fr/mesh/D000071696?mesh_terms=Subtalar+Joint&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment la protéogénomique aide-t-elle au diagnostic des maladies ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Elle permet d'identifier des biomarqueurs protéiques spécifiques pour un diagnostic plus précis." } }, { "@type": "Question", "name": "Quels tests sont utilisés en protéogénomique ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des techniques comme la spectrométrie de masse et l'électrophorèse sont couramment utilisées." } }, { "@type": "Question", "name": "La protéogénomique peut-elle détecter des cancers ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle aide à identifier des protéines spécifiques associées à différents types de cancers." } }, { "@type": "Question", "name": "Quels échantillons sont analysés en protéogénomique ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des échantillons de tissus, de sang ou de fluides biologiques sont souvent analysés." } }, { "@type": "Question", "name": "La protéogénomique est-elle utilisée en médecine personnalisée ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle permet d'adapter les traitements en fonction du profil protéique du patient." } }, { "@type": "Question", "name": "Quels symptômes peuvent être liés à des anomalies protéiques ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes variés comme la fatigue, la douleur ou des troubles neurologiques peuvent survenir." } }, { "@type": "Question", "name": "Les maladies auto-immunes sont-elles étudiées en protéogénomique ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la protéogénomique aide à comprendre les mécanismes sous-jacents des maladies auto-immunes." } }, { "@type": "Question", "name": "Comment les protéines affectent-elles les symptômes ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Les protéines peuvent influencer des voies biologiques, entraînant divers symptômes cliniques." } }, { "@type": "Question", "name": "Les symptômes de maladies métaboliques sont-ils liés à la protéogénomique ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des déséquilibres protéiques peuvent contribuer à des symptômes de maladies métaboliques." } }, { "@type": "Question", "name": "Peut-on prédire des symptômes grâce à la protéogénomique ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des modèles prédictifs basés sur des profils protéiques peuvent anticiper certains symptômes." } }, { "@type": "Question", "name": "La protéogénomique peut-elle aider à la prévention des maladies ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle permet d'identifier des facteurs de risque protéiques pour des interventions précoces." } }, { "@type": "Question", "name": "Quels facteurs de risque sont identifiés par la protéogénomique ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs comme des niveaux anormaux de certaines protéines peuvent indiquer un risque accru." } }, { "@type": "Question", "name": "Comment la protéogénomique influence-t-elle les programmes de dépistage ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Elle permet de cibler des populations à risque pour des dépistages plus efficaces." } }, { "@type": "Question", "name": "Peut-on prévenir des maladies grâce à des interventions protéogénomiques ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des interventions basées sur des profils protéiques peuvent réduire le risque de maladies." } }, { "@type": "Question", "name": "La nutrition peut-elle être influencée par la protéogénomique ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle aide à adapter les régimes alimentaires en fonction des besoins protéiques individuels." } }, { "@type": "Question", "name": "La protéogénomique influence-t-elle les traitements ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle permet de développer des thérapies ciblées basées sur le profil protéique des patients." } }, { "@type": "Question", "name": "Quels types de traitements sont développés grâce à la protéogénomique ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements biologiques, comme les anticorps monoclonaux, sont souvent développés." } }, { "@type": "Question", "name": "La protéogénomique aide-t-elle à la résistance aux médicaments ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle identifie des mécanismes de résistance, permettant d'ajuster les traitements." } }, { "@type": "Question", "name": "Les traitements peuvent-ils être personnalisés grâce à la protéogénomique ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des profils protéiques individuels." } }, { "@type": "Question", "name": "Quels médicaments sont influencés par la protéogénomique ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments anticancéreux et des immunothérapies sont souvent influencés par cette approche." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir en cas d'anomalies protéiques ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme des troubles métaboliques ou des maladies dégénératives peuvent survenir." } }, { "@type": "Question", "name": "Les maladies cardiovasculaires sont-elles liées à la protéogénomique ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des profils protéiques spécifiques peuvent être associés à un risque accru de maladies cardiovasculaires." } }, { "@type": "Question", "name": "Comment la protéogénomique aide-t-elle à comprendre les complications ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Elle permet d'analyser les interactions entre gènes et protéines, révélant des mécanismes de complications." } }, { "@type": "Question", "name": "Les complications liées à la protéogénomique sont-elles évitables ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être évitées par des interventions précoces basées sur des analyses protéiques." } }, { "@type": "Question", "name": "Peut-on prédire des complications grâce à la protéogénomique ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des modèles prédictifs basés sur des données protéomiques peuvent anticiper des complications." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque identifiés par la protéogénomique ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs comme l'âge, l'hérédité et des niveaux protéiques anormaux sont souvent identifiés." } }, { "@type": "Question", "name": "La protéogénomique peut-elle identifier des risques environnementaux ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut révéler comment des facteurs environnementaux influencent les profils protéiques." } }, { "@type": "Question", "name": "Les habitudes de vie influencent-elles les facteurs de risque protéogénomiques ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des habitudes comme l'alimentation et l'exercice peuvent modifier les niveaux protéiques." } }, { "@type": "Question", "name": "Comment la génétique influence-t-elle les facteurs de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "La génétique détermine la production de certaines protéines, influençant ainsi le risque de maladies." } }, { "@type": "Question", "name": "Peut-on modifier les facteurs de risque grâce à la protéogénomique ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des interventions ciblées peuvent aider à modifier les niveaux protéiques et réduire les risques." } } ] } ] }

Sources (10000 au total)

The optimal procedure for lateral column lengthening calcaneal osteotomy according to anatomical patterns of the subtalar joint: an anatomical study in the Chinese population.

Lateral column lengthening calcaneal osteotomy is a powerful procedure for correcting forefoot abduction in flatfoot deformity. However, it involves the risk of damaging articular facets of the subtal... A total of 72 ft from 70 fresh frozen cadavers were obtained from the Department of Anatomy of Central South University. For each foot, soft tissues were surgically removed from the bones, and the cal... Out of the 72 ft, 36.1% had separated anterior and middle facets in the calcaneus, and 63.8% had partly or completely fused anterior and middle facets. In the calcanei with discrete facets, the mean d... The anatomy of the subtalar joint presents significant individual variations in the Chinese population. Calcanei with partly or completely fused anterior and middle facets were observed in nearly two ...

Factors influencing successful bone union of isolated subtalar arthrodesis for posttraumatic subtalar arthritis: a multicenter case series.

The purpose of this study was to find the factors influencing successful bone union for isolated subtalar arthrodesis in posttraumatic subtalar arthritis following calcaneal fracture.... We retrospectively analyzed the rate of successful bone union of 119 cases of isolated subtalar arthrodesis for posttraumatic subtalar arthritis performed at five university hospitals between January ... There were 77 (64.7%) cases of successful bone union, 11 (9.2%) cases of delayed union, 8 (6.7%) cases of questionable union, and 23 (19.3%) cases of nonunion. Use of fully threaded screws was 5.90 ti... Use of fully threaded screws, autograft, and two screws compared to a single screw were the factors associated with successful bone union within six postoperative months after subtalar arthrodesis for...

Increased ankle pain after total knee arthroplasty is associated with a preoperative lateralized gait and talar tilt, but not with ankle laxity or the range of motion of the subtalar joint.

Total knee arthroplasty (TKA) may provoke ankle symptoms. The aim of this study was to validate the impact of the preoperative mechanical tibiofemoral angle (mTFA), the talar tilt (TT) on ankle sympto... Patients who underwent TKA from September 2020 to September 2021 were prospectively included. Inclusion criteria were primary end-stage osteoarthritis (Kellgren-Lawrence stage IV) of the knee. Exclusi... A total of 69 patients (varus n = 45; valgus n = 24) underwent TKA and completed the postoperative follow-up visit. Of these, 16 patients (23.2%) reported the onset or progression of ankle symptoms. V... Approximately one-quarter of the patients developed ankle pain after TKA. If patients complain about ankle symptoms after TKA, standing radiographs of the ankle and a gait analysis could help in detec...

Short term efficacy of subtalar arthroscopy combined with medial calcaneal-talar joint distraction in minimally invasive treatment of diabetic patients with calcaneal fractures: a retrospective study.

The surgical treatment and management of postoperative soft tissue complications in diabetic patients with displaced calcaneal fractures are still controversial. We aimed to evaluate the short-term ef... The clinical data of 52 diabetic patients diagnosed with Sanders II or III calcaneal fractures from March 2016 to August 2020 were followed up and analyzed. There were 23 patients of type II and 29 pa... 52 patients were followed up for 23.7 ± 3.2 months (range: 20-28 months) without incision-related complications. Calcaneal radiographic parameters (length, width, height, Böhler/Gissane angle) were im... Preoperative ultrasonic locating LCB of the sural nerve and arthroscopic percutaneous minimally invasive screw fixation of Sanders II and III calcaneal fractures with the assistance of calcaneal-talar...

Comparative analysis of clinical outcomes of talocalcaneal coalition resection: subtalar joint middle and posterior facet involvement versus isolated posterior facet involvement - a retrospective cohort study.

Despite coalition resection being the preferred treatment for talocalcaneal coalition (TCC), postoperative complications, suboptimal functional recovery, and recurrence risks remain challenges. Althou... We conducted a retrospective study on 115 patients who underwent coalition resection surgery due to symptomatic TCC between November 2009 and February 2023. According to preoperative CT scan results, ... 69 patients meeting the inclusion criteria were included, with 30 patients in the P-type group and 39 in the MP-type group. There were no statistically significant differences between the two groups i... Even with complete coalition resection during surgery and rehabilitation following standardized protocols, the surgical outcomes in MP-type TCC patients are still inferior to those in P-type patients....

Subtalar Arthrodesis in Patients With Prior Tibiotalar Arthrodesis for Posttraumatic Osteoarthritis.

The tibiotalar arthrodesis for end-stage ankle osteoarthritis is a surgical procedure that leads to a modification of the kinematics of the adjacent joints and may result in the development of seconda... Between September 2010 and October 2021, 15 arthrodeses of the subtalar joint with screw fixation were performed in 14 patients, with a fusion of the ipsilateral tibiotalar joint. Fourteen of 15 cases... Twelve of the 15 subtalar arthrodeses (80%) fused at the first attempt with an average fusion time of 4.7 months.... In this limited retrospective case series, compared to the fusion rate of isolated subtalar arthrodesis reported in the literature, the rate of subtalar fusion in the presence of an ipsilateral tibiot... Level IV, retrospective case series....

Subtalar Arthrodesis Union Rates With and Without Adjacent Ankle Arthrodesis.

Subtalar arthrodesis is the surgical procedure commonly performed to treat subtalar arthritis. Subtalar arthrodesis may have a higher nonunion rate if there is a preexisting adjacent joint arthrodesis... A retrospective cohort study of consecutive patients that underwent a subtalar arthrodesis in a single center between 2010 and 2020. The primary outcome of union was determined based on bridging callu... Eighteen patients had an adjacent ankle arthrodesis and 53 patients did not. The successful subtalar arthrodesis union rate in those with a preexisting ankle joint arthrodesis (44.4%) was approximatel... In our study, we found that patients undergoing a subtalar arthrodesis with an adjacent ankle arthrodesis have a significantly increased risk of nonunion compared with those undergoing a subtalar arth...