Quels facteurs de risque sont étudiés avec les A549 ?
Des facteurs comme le tabagisme, l'exposition à des agents chimiques et la pollution.
Facteurs de risquePollution
#2
Les A549 aident-elles à identifier des facteurs génétiques ?
Elles peuvent être utilisées pour étudier l'expression génique liée à des prédispositions au cancer.
Facteurs génétiquesExpression génique
#3
Comment les A549 sont-elles utilisées pour étudier l'environnement ?
Elles permettent d'évaluer l'impact des toxines environnementales sur les cellules pulmonaires.
Toxines environnementalesImpact environnemental
#4
Peut-on étudier l'alimentation avec les A549 ?
Indirectement, elles peuvent être utilisées pour explorer l'impact des nutriments sur le cancer.
AlimentationNutriments
#5
Les A549 sont-elles utiles pour étudier le stress oxydatif ?
Oui, elles sont souvent utilisées pour examiner les effets du stress oxydatif sur les cellules.
Stress oxydatifCellules
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"@type": "Question",
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"position": 3,
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"position": 5,
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"@type": "Question",
"name": "Quels symptômes sont associés aux cellules A549 ?",
"position": 6,
"acceptedAnswer": {
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"text": "Les cellules A549 ne présentent pas de symptômes, car elles sont in vitro."
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"@type": "Question",
"name": "Les cellules A549 peuvent-elles simuler des symptômes humains ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier des symptômes liés aux maladies pulmonaires."
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"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre les symptômes du cancer ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier la réponse des cellules tumorales aux traitements et aux facteurs de croissance."
}
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"@type": "Question",
"name": "Les cellules A549 montrent-elles des signes de stress cellulaire ?",
"position": 9,
"acceptedAnswer": {
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"text": "Oui, elles peuvent montrer des signes de stress en réponse à des agents cytotoxiques."
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"position": 10,
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"@type": "Question",
"name": "Les cellules A549 aident-elles à la prévention du cancer ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, elles sont utilisées pour étudier les mécanismes de la carcinogenèse."
}
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"@type": "Question",
"name": "Comment les A549 contribuent-elles à la recherche préventive ?",
"position": 12,
"acceptedAnswer": {
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"text": "Elles permettent d'identifier des biomarqueurs et des cibles pour la prévention du cancer."
}
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"@type": "Question",
"name": "Peut-on utiliser les A549 pour étudier des facteurs de risque ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont utilisées pour étudier l'impact de divers facteurs environnementaux sur le cancer."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utiles pour la recherche sur le tabagisme ?",
"position": 14,
"acceptedAnswer": {
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"text": "Oui, elles sont souvent utilisées pour étudier les effets du tabagisme sur les cellules pulmonaires."
}
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"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre la prévention des maladies ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'explorer les mécanismes de protection et les interventions préventives."
}
},
{
"@type": "Question",
"name": "Quels traitements sont testés sur les cellules A549 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements anticancéreux et les thérapies ciblées sont souvent testés sur ces cellules."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utilisées pour des essais cliniques ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elles sont utilisées pour des études précliniques et non pour des essais cliniques directs."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à développer de nouveaux traitements ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'évaluer l'efficacité et la toxicité des nouveaux composés thérapeutiques."
}
},
{
"@type": "Question",
"name": "Les cellules A549 peuvent-elles prédire la réponse au traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent fournir des indications sur la réponse aux traitements, mais ne sont pas définitives."
}
},
{
"@type": "Question",
"name": "Quels agents sont souvent testés sur les A549 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des agents chimiothérapeutiques comme le cisplatine et des inhibiteurs de tyrosine kinase."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent être étudiées avec les A549 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier les complications liées aux traitements du cancer et aux métastases."
}
},
{
"@type": "Question",
"name": "Les A549 peuvent-elles simuler des complications pulmonaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont utilisées pour modéliser des complications comme la fibrose pulmonaire."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre les complications du cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier les interactions entre les cellules tumorales et le microenvironnement."
}
},
{
"@type": "Question",
"name": "Peut-on étudier la résistance aux traitements avec les A549 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour comprendre les mécanismes de résistance aux traitements."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles impliquées dans des complications métaboliques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier les effets métaboliques des traitements anticancéreux."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont étudiés avec les A549 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme le tabagisme, l'exposition à des agents chimiques et la pollution."
}
},
{
"@type": "Question",
"name": "Les A549 aident-elles à identifier des facteurs génétiques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier l'expression génique liée à des prédispositions au cancer."
}
},
{
"@type": "Question",
"name": "Comment les A549 sont-elles utilisées pour étudier l'environnement ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'évaluer l'impact des toxines environnementales sur les cellules pulmonaires."
}
},
{
"@type": "Question",
"name": "Peut-on étudier l'alimentation avec les A549 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, elles peuvent être utilisées pour explorer l'impact des nutriments sur le cancer."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utiles pour étudier le stress oxydatif ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour examiner les effets du stress oxydatif sur les cellules."
}
}
]
}
]
}
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: taolm@ecust.edu.cn.
Will Rogers Institute Pulmonary Research Center and Hastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Will Rogers Institute Pulmonary Research Center and Hastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Physiology and Neurosciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Sonny Astani Department of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Will Rogers Institute Pulmonary Research Center and Hastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Mork Family Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Individuals with borderline personality disorder (BPD) or antisocial personality disorder (ASPD) are overrepresented in forensic settings. Yet, despite the burden these disorders place on healthcare a...
Borderline personality disorder (BPD) is a complex condition marked by heterogeneity. People with BPD have a profusion of symptoms spread across various levels of lived experience, such as identity, a...
Low personal agency is the concept of attributing successes and failures to external factors rather than personal characteristics. Previous research supported links between low personal agency and sym...
Patients (N = 57, age 18-72, 91.5% female) were assessed at intake, after three months of DBT treatment, and 12 months follow up on measures of symptoms and personal agency. Three separate measures we...
Mixed model analyses found BPD symptoms significantly reduced as a result of DBT treatment and were maintained at follow-up. However, 47% of participants continued to meet BPD criteria 12 months later...
Despite the reductions in BPD symptomology, personal agency did not significantly change over time. Those with lower agency at intake continued to do more poorly at follow up. We speculate that poor o...
The goal of this study was to evaluate specific characteristics associated with hopelessness, potentially correlated with coping strategies, sensory profile, and alexithymia in patients with borderlin...
Two hundred twenty-four (N=224) inpatients completed a clinical interview with administration of the Beck Hopelessness Scale (BHS), the Adolescent/Adult Sensory Profile (AASP), the Coping Orientation ...
Hopelessness was significantly associated with female gender, more hospitalizations, current suicidal ideation, number of suicide attempts, current and lifetime medication abuse, and alcohol misuse. F...
Hopelessness in BPD was associated with higher severity of illness, alternative process sensory input from the environment, reduced ability to cope with stressful events, and alexithymia. Therefore, a...
Among people with a diagnosis of borderline personality disorder (BPD) who are engaged in clinical care, prescription rates of psychotropic medications are high, despite the fact that medication use i...
To assess the effects of pharmacological treatment for people with BPD....
For this update, we searched CENTRAL, MEDLINE, Embase, 14 other databases and four trials registers up to February 2022. We contacted researchers working in the field to ask for additional data from p...
Randomised controlled trials comparing pharmacological treatment to placebo, other pharmacologic treatments or a combination of pharmacologic treatments in people of all ages with a formal diagnosis o...
At least two review authors independently selected trials, extracted data, assessed risk of bias using Cochrane's risk of bias tool and assessed the certainty of the evidence using the GRADE approach....
We included 46 randomised controlled trials (2769 participants) in this review, 45 of which were eligible for quantitative analysis and comprised 2752 participants with BPD in total. This is 18 more t...
This review included 18 more trials than the 2010 version, so larger meta-analyses with more statistical power were feasible. We found mostly very low-certainty evidence that medication may result in ...
People diagnosed with borderline personality disorder (BPD) frequently present to healthcare services in crisis, often with suicidal thoughts or actions. Despite this, little is known about what const...
To assess the effects of crisis interventions in adults diagnosed with BPD in any setting....
We searched CENTRAL, MEDLINE, Embase, nine other databases and three trials registers up to January 2022. We also checked reference lists, handsearched relevant journal archives and contacted experts ...
Randomised controlled trials (RCTs) comparing crisis interventions with usual care, no intervention or waiting list, in adults of any age diagnosed with BPD....
We used standard methodological procedures expected by Cochrane....
We included two studies with 213 participants. One study (88 participants) was a feasibility RCT conducted in the UK that examined the effects of joint crisis plans (JCPs) plus treatment as usual (TAU...
A comprehensive search of the literature revealed very little RCT-based evidence to inform the management of acute crises in people diagnosed with BPD. We included two studies of two very different ty...
The progressively improving understanding of the borderline personality disorder (BPD) has led to an increased interest in the better clarification of the integrated role of biological and psychosocia...
A growing body of research has shown that people with a wide range of psychiatric disorders, including depression, present with alterations of the gut microbiota, although it is unclear if differences...
Twenty-four unmedicated patients and twenty-one age- and sex-matched healthy controls were recruited. Stool samples were frozen at -80 °C within ten minutes after defecation. The V4 region of bacteria...
There was no significant difference in alpha- and beta-diversity between patients and controls. However, the Bacteroidetes/Firmicutes-ratio was higher in patients, approaching significance (p = 0.06, ...
Differences in the taxonomic composition may indicate a potential dysbiosis among SCFA-producing bacteria in BPD. Future research is warranted to replicate these findings in independent and larger sam...
Previous research has emphasized the importance of therapists giving Routine Outcome Monitoring (ROM) feedback to their patients. It has been shown that several factors influence therapists' tendency ...
In this qualitative study, using a semi-structured interview followed by thematic analysis using Atlas.ti, we focused on experiences of therapists and patients with a disorder specific ROM instrument:...
Qualitative analysis revealed that patients experienced benefits of ROM using the BPDSI-IV. Patients gained more insight in and recognition of their borderline personality disorder symptoms. They also...
Experiences of both patients and therapists with the BPDSI-IV were positive. It seems to be valuable and promising for healthcare institutions to evaluate treatment with a disorder specific ROM instru...
It has been suggested that the diagnosis of borderline personality disorder (BPD) is associated with particularly stigmatizing connotations, particularly among mental health professionals. The goal of...
A systematic search was carried out using MEDLINE Complete, CINAHL Complete, PsychoINFO, PsychARTICLES, Scopus, Social Sciences Citation Index, and Academic Search Complete. Study quality was rated us...
This review included 37 papers involving an estimated 8196 participants: 21 cross-sectional survey studies, 5 studies assessing training workshops, 5 studies assessing countertransference, and 6 exper...
Negative attitudes toward BPD continue to be a problem to differing degrees among clinical staff. Although this issue is most prominent among psychiatric nurses, the results of this review highlight e...
