Cognitive Dysfunction in Migraineurs.
Background and Objectives: Migraines are one of the most common types of primary headaches in neurology. Many studies to date have investigated cognitive impairment in migraineurs, but the results are...
Syk kinase : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une dysfonction de la Syk kinase ?
Des tests génétiques et des analyses de sang peuvent aider à diagnostiquer des anomalies.
#2
Quels tests sont utilisés pour évaluer l'activité de la Syk kinase ?
Des tests enzymatiques et des dosages de protéines spécifiques sont utilisés.
#3
Y a-t-il des biomarqueurs associés à la Syk kinase ?
Oui, des biomarqueurs comme le phospho-Syk peuvent indiquer son activation.
#4
Quels symptômes peuvent indiquer un problème avec la Syk kinase ?
Des symptômes immunitaires ou inflammatoires peuvent suggérer une dysfonction.
#5
La Syk kinase est-elle impliquée dans des maladies spécifiques ?
Oui, elle est liée à des maladies auto-immunes et des cancers.
Symptômes 5
#1
Quels symptômes sont liés à une activation excessive de la Syk kinase ?
Une activation excessive peut entraîner des inflammations et des douleurs articulaires.
#2
La Syk kinase affecte-t-elle le système immunitaire ?
Oui, elle joue un rôle clé dans la régulation des réponses immunitaires.
#3
Quels signes cliniques peuvent indiquer une dysfonction de la Syk kinase ?
Des signes comme des infections fréquentes ou des réactions allergiques peuvent apparaître.
#4
Les troubles de la Syk kinase provoquent-ils des symptômes neurologiques ?
Des études suggèrent un lien potentiel, mais des recherches supplémentaires sont nécessaires.
#5
Y a-t-il des symptômes associés à des inhibiteurs de la Syk kinase ?
Des effets secondaires comme des nausées ou des infections peuvent survenir.
Prévention 5
#1
Peut-on prévenir les dysfonctionnements de la Syk kinase ?
Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir la santé immunitaire.
#2
Y a-t-il des mesures préventives pour les maladies liées à la Syk kinase ?
Éviter les facteurs de risque comme le tabagisme peut réduire les maladies associées.
#3
Les vaccinations influencent-elles la Syk kinase ?
Oui, certaines vaccinations peuvent moduler l'activité de la Syk kinase dans le système immunitaire.
#4
Comment le stress affecte-t-il la Syk kinase ?
Le stress chronique peut altérer la signalisation de la Syk kinase, affectant l'immunité.
#5
L'exercice physique influence-t-il la Syk kinase ?
Oui, l'exercice régulier peut améliorer la fonction immunitaire et la signalisation de Syk.
Traitements 5
#1
Quels traitements ciblent la Syk kinase ?
Des inhibiteurs de Syk sont utilisés pour traiter certaines maladies auto-immunes.
#2
Les traitements de la Syk kinase sont-ils efficaces ?
Oui, ils montrent des résultats prometteurs dans le contrôle des maladies inflammatoires.
#3
Quels médicaments inhibent la Syk kinase ?
Des médicaments comme le fostamatinib sont des inhibiteurs spécifiques de Syk.
#4
Y a-t-il des effets secondaires des traitements de la Syk kinase ?
Oui, des effets comme des troubles gastro-intestinaux et des infections peuvent survenir.
#5
Comment les traitements de la Syk kinase sont-ils administrés ?
Ils peuvent être administrés par voie orale ou intraveineuse, selon le médicament.
Complications 5
#1
Quelles complications peuvent survenir avec une dysfonction de la Syk kinase ?
Des complications comme des infections récurrentes et des maladies auto-immunes peuvent survenir.
#2
La Syk kinase est-elle liée à des cancers ?
Oui, une activation anormale de Syk est associée à certains types de cancers.
#3
Quels risques sont associés aux inhibiteurs de la Syk kinase ?
Les inhibiteurs peuvent augmenter le risque d'infections et de troubles hématologiques.
#4
Les complications de la Syk kinase affectent-elles la qualité de vie ?
Oui, les complications peuvent gravement affecter la qualité de vie des patients.
#5
Y a-t-il des complications neurologiques liées à la Syk kinase ?
Des recherches sont en cours pour explorer les liens entre Syk et des troubles neurologiques.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour les maladies liées à la Syk kinase ?
Des facteurs comme l'âge, le sexe et des antécédents familiaux peuvent influencer le risque.
#2
Le tabagisme affecte-t-il la Syk kinase ?
Oui, le tabagisme peut altérer la signalisation de la Syk kinase et augmenter les risques de maladies.
#3
L'alimentation influence-t-elle la Syk kinase ?
Une alimentation riche en antioxydants peut aider à réguler l'activité de la Syk kinase.
#4
Le stress est-il un facteur de risque pour la Syk kinase ?
Oui, le stress chronique peut exacerber les dysfonctionnements de la Syk kinase.
#5
Y a-t-il des prédispositions génétiques liées à la Syk kinase ?
Certaines variations génétiques peuvent augmenter le risque de dysfonctionnement de Syk.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 26/04/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Andy Pike
4 publications dans cette catégorie
Affiliations :
- DMPK (A.P., R.M., B.J.) and Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom andrew.pike@astrazeneca.com.
Publications dans "Syk kinase" :
-
Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs.
Drug metabolism and disposition: the biological fate of chemicals 2021-06-16
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Antonella Pantaleo
3 publications dans cette catégorie
Affiliations :
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Publications dans "Syk kinase" :
-
Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in
Antioxidants (Basel, Switzerland) 2020-08-14
-
Signaling Response to Transient Redox Stress in Human Isolated T Cells: Molecular Sensor Role of Syk Kinase and Functional Involvement of IL2 Receptor and L-Selectine.
Sensors (Basel, Switzerland) 2020-01-14
-
Syk Inhibitors: New Computational Insights into Their Intraerythrocytic Action in
International journal of molecular sciences 2020-09-23
Jinhua Wang
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Publications dans "Syk kinase" :
-
The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations.
Journal of cellular and molecular medicine 2020-01-14
-
A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas.
Blood advances
-
Inhibition of the deubiquitinase USP10 induces degradation of SYK.
British journal of cancer 2020-02-04
Jae Youl Cho
3 publications dans cette catégorie
Affiliations :
- Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Biocosmetics, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: jaecho@skku.edu.
Publications dans "Syk kinase" :
-
Millingtonia hortensis L.f. ethanol extract exerts in vivo and in vitro anti-inflammatory activities through inhibition of Syk kinase in NF-κB pathway.
Journal of ethnopharmacology 2024-05-21
-
Cocculus hirsutus ameliorates gastric and lung injuries by suppressing Src/Syk.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021-09-27
-
Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages.
Frontiers in immunology 2021-12-23
Bernard Barlaam
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Cambridge, United Kingdom. Electronic address: Bernard.barlaam2@astrazeneca.com.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Scott Boiko
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Hannah Dry
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Lakshmaiah Gingipalli
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Sameer Kawatkar
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Jon Read
3 publications dans cette catégorie
Affiliations :
- Discovery Sciences, AstraZeneca, Cambridge, United Kingdom.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Qibin Su
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Peng Wang
3 publications dans cette catégorie
Affiliations :
- Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, PR China.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Scott D Edmondson
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Kohei Kume
2 publications dans cette catégorie
Affiliations :
- Center of Molecular and Cellular Oncology, Yale University, New Haven, CT 06511, USA.
Publications dans "Syk kinase" :
-
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies.
Cellular signalling 2022-04-07
-
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Molecular cell 2021-04-19
Markus Müschen
2 publications dans cette catégorie
Affiliations :
- Center of Molecular and Cellular Oncology, Yale University, New Haven, CT 06511, USA; Department of Immunobiology, Yale University, CT 06520, USA. Electronic address: markus.muschen@yale.edu.
Publications dans "Syk kinase" :
-
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies.
Cellular signalling 2022-04-07
-
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Molecular cell 2021-04-19
Helen T Hobbs
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, California, USA.
- Department of Biomedical Engineering, University of California, Irvine, California, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
Neel H Shah
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, Columbia University, New York, New York, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
Susan Marqusee
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, California, USA.
- Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.
- California Institute for Quantitative Biosciences, University of California, Berkeley, California, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
John Kuriyan
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, California, USA.
- Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.
- California Institute for Quantitative Biosciences, University of California, Berkeley, California, USA.
- Howard Hughes Medical Institute, University of California, Berkeley, California, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
Ioannis Tsamesidis
2 publications dans cette catégorie
Affiliations :
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
- UMR 152 Pharma-Dev, Université de Toulouse, IRD, UPS, 31000 Toulouse, France.
Publications dans "Syk kinase" :
-
Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in
Antioxidants (Basel, Switzerland) 2020-08-14
-
Syk Inhibitors: New Computational Insights into Their Intraerythrocytic Action in
International journal of molecular sciences 2020-09-23
Sources (10000 au total)
Postoperative cognitive dysfunction: a concept analysis.
Post-operative cognitive dysfunction (POCD) is a concern for clinicians that often presents post-surgery where generalized anesthesia has been used. Its prevalence ranges from 36.6% in young adults to... The reporting of our review was guided by the PRISMA statement and the 6-step evolutionary approach to concept analysis developed by Rodgers. Three databases, including Medline, CINAHL, and Web of Sci... POCD was defined with varying severities ranging from subtle-to-extensive cognitive changes (1) affecting single or multiple cognitive domains that manifest following major surgery (2), is transient a... This review resulted in a refined definition and comprehensive analysis of POCD that can be useful to both researchers and clinicians. Future research is needed to refine the operational definitions o...
Hypertension, Neurovascular Dysfunction, and Cognitive Impairment.
Hypertension affects a significant proportion of the adult and aging population and represents an important risk factor for vascular cognitive impairment and late-life dementia. Chronic high blood pre...
Microvascular Dysfunction as a Possible Link Between Heart Failure and Cognitive Dysfunction.
Microvascular function in the brain and heart may play an important role in the course of patients with heart failure (HF), but its relationship with ventricular and cognitive function is not well und... In healthy controls and symptomatic patients with HF (New York Heart Association functional class II or III), we used oxygenation-sensitive magnetic resonance imaging during a standardized breathing m... Twenty patients with HF (age 64.4±8.3 years; 50% female sex), and 21 healthy controls (age 55.0±5.1 years; 62% female sex) were included in the analysis. In patients with HF, cerebral oxygenation rese... Our results indicate that heart failure is an independent predictor of coronary and cerebral microvascular dysfunction as defined by a reduced response to a vasodilatory breathing maneuver. This impai...
Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke.
The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive dysfunction after basal ganglia stroke, and factors affecting total MoCA score were examined.... Data were retrospectively analyzed for 30 patients with basal ganglia intracerebral hemorrhage or basal ganglia cerebral infarction, who were admitted to The Second Affiliated Hospital of Fujian Tradi... Univariate linear regression showed that the total MoCA score was significantly associated with sex, age, executive function, naming, attention, abstract generalization ability, memory ability, and vi... We showed that the MoCA test can be used for patients with basal ganglia stroke. The total MoCA score of basal ganglia stroke was significantly associated with impairments in executive function, namin...
Sleep-Related Changes Prior to Cognitive Dysfunction.
The aim of this review is to summarize the current evidence on the relationship between sleep and cognition and present available data reporting the impact that sleep alterations may have on cognitive... Research findings support the idea that sleep is involved in cognitive processes and that altered sleep homeostasis or circadian rhythms may lead to clinical and biochemical changes associated with co...
Cognitive dysfunction following COVID-19 infection.
The coronavirus (COVID-19) pandemic is still evolving, causing hundreds of millions of infections around the world. The long-term sequelae of COVID-19 and neurologic syndromes post COVID remain poorly...
Vestibular Migraine: Cognitive Dysfunction, Mobility, Falls.
Recent evidence has shown that vestibular migraine is strongly associated with cognitive difficulties. However, limited data exist on real-world effects of that dysfunction. The objective of this stud... Randomized, population-based survey study of US adults.... We generated a case definition approximating probable vestibular migraine based on Bárány Society criteria and validated that definition in a tertiary care vestibular clinic.... Adult respondents to the 2016 NHIS, which queries a representative sample of the civilian, noninstitutionalized US population.... Diagnostic.... We evaluated incidence of self-reported cognitive dysfunction with vestibular migraine and whether individuals were more likely to have impaired mobility, falls, and work absenteeism than those withou... Among individuals with vestibular migraine, 40% reported "some" and 12% reported "a lot" of difficulty thinking versus 13% and 2% of those without vestibular migraine, respectively. Vestibular migrain... Our findings indicate vestibular migraine is not only associated with cognitive dysfunction, but they are together associated with mobility issues, fall risk, and work absenteeism....
The role of epigenetic modification in postoperative cognitive dysfunction.
With the ageing of the population, the health problems of elderly individuals have become particularly important. Through a large number of clinical studies and trials, it has been confirmed that elde...
Visuospatial Cognitive Dysfunction in Patients with Vestibular Loss.
To characterize visuospatial and nonvisuospatial cognitive domains affected by vestibular loss and determine whether patient-reported outcomes measures (PROMs) correlate with performance on neuropsych... Cross-sectional study.... University-based tertiary medical center.... Sixty-nine age-matched subjects: 25 patients with bilateral vestibular loss (BVL), 14 patients with unilateral vestibular loss (UVL), and 30 normal controls (NC).... Neuropsychological tests used to assess visuospatial and auditory short-term and working memory, number magnitude representation, executive function, and attention. Validated PROMs used to evaluate qu... Performance on neuropsychological tests and scores on PROM surveys.... BVL and UVL patients performed significantly worse than NC subjects on tasks requiring visuospatial representation compared with NC subjects ( p < 0.01). BVL patients demonstrated decreased performanc... Patients with vestibular loss exhibit impairments in tasks requiring visuospatial representation but perform similarly to NC subjects in tasks of auditory working memory, executive function, or attent...