Titre : Déméthylation

Déméthylation : Questions médicales fréquentes

Termes MeSH sélectionnés :

Early Detection of Cancer
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Déméthylation : Questions médicales les plus fréquentes", "headline": "Déméthylation : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Déméthylation : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-01-25", "dateModified": "2025-04-19", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Déméthylation" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Désalkylation", "url": "https://questionsmedicales.fr/mesh/D003640", "about": { "@type": "MedicalCondition", "name": "Désalkylation", "code": { "@type": "MedicalCode", "code": "D003640", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "G03.219" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Déméthylation de l'ADN", "alternateName": "DNA Demethylation", "url": "https://questionsmedicales.fr/mesh/D000073399", "about": { "@type": "MedicalCondition", "name": "Déméthylation de l'ADN", "code": { "@type": "MedicalCode", "code": "D000073399", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "G03.219.500.500" } } } ], "about": { "@type": "MedicalCondition", "name": "Déméthylation", "alternateName": "Demethylation", "code": { "@type": "MedicalCode", "code": "D000073398", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Samuel E Ross", "url": "https://questionsmedicales.fr/author/Samuel%20E%20Ross", "affiliation": { "@type": "Organization", "name": "Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia." } }, { "@type": "Person", "name": "Ozren Bogdanovic", "url": "https://questionsmedicales.fr/author/Ozren%20Bogdanovic", "affiliation": { "@type": "Organization", "name": "Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia." } }, { "@type": "Person", "name": "Yaxin Xiong", "url": "https://questionsmedicales.fr/author/Yaxin%20Xiong", "affiliation": { "@type": "Organization", "name": "Department of Environmental Sciences, University of California, Riverside, California 92521, United States." } }, { "@type": "Person", "name": "Qingyang Shi", "url": "https://questionsmedicales.fr/author/Qingyang%20Shi", "affiliation": { "@type": "Organization", "name": "Department of Environmental Sciences, University of California, Riverside, California 92521, United States." } }, { "@type": "Person", "name": "Daniel Schlenk", "url": "https://questionsmedicales.fr/author/Daniel%20Schlenk", "affiliation": { "@type": "Organization", "name": "Department of Environmental Sciences, University of California, Riverside, California 92521, United States." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "A nomogram and risk classification system predicting esophageal stricture after endoscopic submucosal dissection of a large area for early esophageal cancer.", "datePublished": "2022-12-19", "url": "https://questionsmedicales.fr/article/36537007", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1002/jso.27172" } }, { "@type": "ScholarlyArticle", "name": "Affordable Care Act Medicaid Expansion is Associated With Increased Utilization of Minimally Invasive Lung Resection for Early Stage Lung Cancer.", "datePublished": "2022-11-07", "url": "https://questionsmedicales.fr/article/36341749", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1177/00031348221138081" } }, { "@type": "ScholarlyArticle", "name": "Serum-derived piR-hsa-164586 of extracellular vesicles as a novel biomarker for early diagnosis of non-small cell lung cancer.", "datePublished": "2022-09-28", "url": "https://questionsmedicales.fr/article/36249068", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3389/fonc.2022.850363" } }, { "@type": "ScholarlyArticle", "name": "The influence of body mass index on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in women with early-stage breast cancer.", "datePublished": "2022-08-16", "url": "https://questionsmedicales.fr/article/35974240", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1007/s10549-022-06681-6" } }, { "@type": "ScholarlyArticle", "name": "The Role of Surgical Axillary Staging Prior to Immediate Breast Reconstruction in the Era of De-Escalation of Axillary Management in Early Breast Cancer.", "datePublished": "2022-08-04", "url": "https://questionsmedicales.fr/article/36013232", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3390/jpm12081283" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Métabolisme", "item": "https://questionsmedicales.fr/mesh/D008660" }, { "@type": "ListItem", "position": 3, "name": "Désalkylation", "item": "https://questionsmedicales.fr/mesh/D003640" }, { "@type": "ListItem", "position": 4, "name": "Déméthylation", "item": "https://questionsmedicales.fr/mesh/D000073398" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Déméthylation - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Déméthylation", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-12", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Déméthylation", "description": "Comment diagnostiquer une déméthylation anormale ?\nQuels marqueurs sont utilisés pour la déméthylation ?\nQuels tests sanguins peuvent indiquer une déméthylation ?\nLa biopsie est-elle nécessaire pour diagnostiquer la déméthylation ?\nQuels symptômes peuvent alerter sur une déméthylation ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=1000#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Déméthylation", "description": "Quels symptômes sont associés à la déméthylation ?\nLa déméthylation peut-elle causer des maladies ?\nY a-t-il des signes cliniques de déméthylation ?\nLes symptômes varient-ils selon l'âge ?\nLa déméthylation affecte-t-elle le système immunitaire ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=1000#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Déméthylation", "description": "Comment prévenir la déméthylation ?\nLes suppléments peuvent-ils aider ?\nLe stress influence-t-il la déméthylation ?\nL'exercice physique a-t-il un impact ?\nLes toxines environnementales jouent-elles un rôle ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=1000#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Déméthylation", "description": "Quels traitements existent pour la déméthylation ?\nLa nutrition peut-elle influencer la déméthylation ?\nLes thérapies épigénétiques sont-elles efficaces ?\nPeut-on prévenir la déméthylation par des médicaments ?\nLes traitements sont-ils personnalisés ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=1000#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Déméthylation", "description": "Quelles complications peuvent survenir ?\nLa déméthylation est-elle réversible ?\nQuels risques sont associés à la déméthylation ?\nLa déméthylation peut-elle affecter la fertilité ?\nY a-t-il des effets à long terme ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=1000#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Déméthylation", "description": "Quels sont les facteurs de risque de déméthylation ?\nL'hérédité joue-t-elle un rôle ?\nLes maladies chroniques augmentent-elles le risque ?\nLe mode de vie influence-t-il la déméthylation ?\nLes infections peuvent-elles affecter la déméthylation ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=1000#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une déméthylation anormale ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses de l'ADN peuvent révéler des modifications de méthylation." } }, { "@type": "Question", "name": "Quels marqueurs sont utilisés pour la déméthylation ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les marqueurs épigénétiques comme 5-méthylcytosine sont souvent analysés." } }, { "@type": "Question", "name": "Quels tests sanguins peuvent indiquer une déméthylation ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de métabolites et d'ADN circulant peuvent fournir des indices." } }, { "@type": "Question", "name": "La biopsie est-elle nécessaire pour diagnostiquer la déméthylation ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Une biopsie peut être nécessaire pour des analyses plus précises des tissus." } }, { "@type": "Question", "name": "Quels symptômes peuvent alerter sur une déméthylation ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes variés comme des troubles neurologiques ou des cancers peuvent survenir." } }, { "@type": "Question", "name": "Quels symptômes sont associés à la déméthylation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent inclure des troubles cognitifs, des anomalies de croissance et des cancers." } }, { "@type": "Question", "name": "La déméthylation peut-elle causer des maladies ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle est liée à des maladies comme le cancer et des troubles génétiques." } }, { "@type": "Question", "name": "Y a-t-il des signes cliniques de déméthylation ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des signes cliniques peuvent inclure des changements de comportement et des anomalies physiques." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent se manifester différemment selon l'âge et le développement." } }, { "@type": "Question", "name": "La déméthylation affecte-t-elle le système immunitaire ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut altérer la réponse immunitaire, augmentant le risque d'infections." } }, { "@type": "Question", "name": "Comment prévenir la déméthylation ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir la déméthylation." } }, { "@type": "Question", "name": "Les suppléments peuvent-ils aider ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments comme l'acide folique peuvent soutenir la méthylation." } }, { "@type": "Question", "name": "Le stress influence-t-il la déméthylation ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter les mécanismes de méthylation." } }, { "@type": "Question", "name": "L'exercice physique a-t-il un impact ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "L'exercice régulier peut améliorer la santé épigénétique et la méthylation." } }, { "@type": "Question", "name": "Les toxines environnementales jouent-elles un rôle ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certaines toxines peut perturber les mécanismes de méthylation." } }, { "@type": "Question", "name": "Quels traitements existent pour la déméthylation ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des thérapies géniques et des médicaments ciblés." } }, { "@type": "Question", "name": "La nutrition peut-elle influencer la déméthylation ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains nutriments comme l'acide folique peuvent moduler la méthylation." } }, { "@type": "Question", "name": "Les thérapies épigénétiques sont-elles efficaces ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Elles montrent un potentiel prometteur dans le traitement de certains cancers." } }, { "@type": "Question", "name": "Peut-on prévenir la déméthylation par des médicaments ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des inhibiteurs spécifiques peuvent être utilisés pour prévenir la déméthylation." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent des cancers, des troubles neurologiques et des maladies auto-immunes." } }, { "@type": "Question", "name": "La déméthylation est-elle réversible ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines modifications peuvent être réversibles, mais pas toutes." } }, { "@type": "Question", "name": "Quels risques sont associés à la déméthylation ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les risques incluent des maladies chroniques et des troubles de développement." } }, { "@type": "Question", "name": "La déméthylation peut-elle affecter la fertilité ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut influencer la fertilité en altérant la fonction reproductive." } }, { "@type": "Question", "name": "Y a-t-il des effets à long terme ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Des effets à long terme peuvent inclure des prédispositions à diverses maladies." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque de déméthylation ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent l'alimentation, le stress, et l'exposition à des toxines." } }, { "@type": "Question", "name": "L'hérédité joue-t-elle un rôle ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des facteurs génétiques peuvent influencer la déméthylation." } }, { "@type": "Question", "name": "Les maladies chroniques augmentent-elles le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Certaines maladies chroniques peuvent augmenter le risque de déméthylation." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il la déméthylation ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie malsain peut favoriser la déméthylation." } }, { "@type": "Question", "name": "Les infections peuvent-elles affecter la déméthylation ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections peuvent perturber les mécanismes de méthylation." } } ] } ] }

Sources (10000 au total)

A nomogram and risk classification system predicting esophageal stricture after endoscopic submucosal dissection of a large area for early esophageal cancer.

Esophageal stricture is a troublesome adverse effect of endoscopic submucosal dissection (ESD) for early esophageal cancer. However, risk factors of post-ESD esophageal stricture formation are incompr... Patients who underwent ESD for early esophageal cancer between 2014 and 2021 at the Beijing Friendship Hospital, Capital Medical University, were recruited. A nomogram and risk classification system w... Stricture formed in 36 patients, while stricture was not observed in the remaining 112 patients. Operative time (odds ratio [OR]: 1.01; 95% confidence interval [CI]: 1.00-1.01; p < 0.01); lesions >3/4... We developed a nomogram and risk stratification system to predict post-ESD esophageal stricture using three independent risk factors....

Affordable Care Act Medicaid Expansion is Associated With Increased Utilization of Minimally Invasive Lung Resection for Early Stage Lung Cancer.

Minimally invasive lung resection (MILR) is underutilized in the United States. Under the Affordable Care Act (ACA), 39 states adopted Medicaid expansion, while 12 did not. Although Medicaid expansion... The National Cancer Database was queried for adult patients from 2010 to 2018 with cT1/2N0M0 non-small cell lung cancer who received surgical resection by wedge, segmentectomy, or lobectomy. Patients ... There were 41,439 patients who met inclusion criteria: 20,446 (49.3%) in expansion states and 20,993 (50.7%) in non-expansion states. Multivariable DID analysis showed that Medicaid expansion was asso... Although Medicaid expansion was associated with increased utilization of MILR for early stage lung cancer, the treatment effect was modest. This suggests that barriers in access to MILR are larger tha...

The influence of body mass index on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in women with early-stage breast cancer.

To investigate the influence of body mass index (BMI) on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in early breast cancer patients.... Early-stage breast cancer patients who received (neo)adjuvant weekly paclitaxel 80 mg/m... Four hundred (400) patients were included in this study; 200 (50%) lean, 125 (31%) overweight, and 75 (19%) obese patients. The adjusted odds ratio to receive RDI < 85% for BMI was 1.02 (p value, .263... BMI did not significantly influence the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy. Therefore, the results of this study align with current guideline recommendations o...

Early Prediction of Planning Adaptation Requirement Indication Due to Volumetric Alterations in Head and Neck Cancer Radiotherapy: A Machine Learning Approach.

During RT cycles, the tumor response pattern could affect tumor coverage and may lead to organs at risk of overdose. As such, early prediction of significant volumetric changes could therefore reduce ... CBCT images from 40 HN cancer patients were collected weekly during RT treatment. From the obtained images, the Clinical Target Volume (CTV) and Parotid Glands (PG) regions of interest were utilized t... The proposed framework was able to achieve 0.90 classification performance accuracy while detecting a small subset of discriminative characteristics from the 1st week of RT. The selected features were... The use of machine learning algorithms offers promising perspectives for fast and reliable early prediction of large volumetric deviations as a result of RT treatment, exploiting hidden patterns in th...

Novel Signatures Based on the Lymphocyte-to-C-Reactive Protein Ratio Predict the Prognosis of Patients with Early Breast Cancer: A Retrospective Study.

The value of the lymphocyte-to-C-reactive protein (CRP) ratio (LCR) in early breast cancer (BC) is unclear. We explored the correlation between the LCR and survival of patients with early BC and estab... In this retrospective study, we randomized 623 patients with early-stage BC diagnosed in December 2010 to October 2012 at the Sun Yat-sen University Cancer Center to training and verification datasets... The LCR, lymphatic vessel invasion (LVI), progesterone receptor (PR) status, and Ki67 index were independent prognostic factors of OS. And the LCR and LVI are associated to DFS too. High LCR was assoc... The LCR was a significant prognostic predictor of OS and DFS in early BC. The LCR-based prognostic signatures could be a useful tool for individualized therapeutic guidance....

Metabolism-Related Gene Expression in Circulating Tumor Cells from Patients with Early Stage Non-Small Cell Lung Cancer.

Metabolic reprogramming is now characterized as one of the core hallmarks of cancer, and it has already been shown that the altered genomic profile of metabolically rewired cancer cells can give valua... We first developed and analytically validated highly sensitive RT-qPCR assays for the quantification of... An overexpression of MRGs was observed at a high frequency in the CTCs isolated from early NSCLC patients, thereby supporting the role of MRGs in metastatic processes. The glycolytic and mesenchymal s...