Titre : Déméthylation

Déméthylation : Questions médicales fréquentes

Termes MeSH sélectionnés :

Early Detection of Cancer
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Déméthylation : Questions médicales les plus fréquentes", "headline": "Déméthylation : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Déméthylation : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-01-25", "dateModified": "2025-04-19", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Déméthylation" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Désalkylation", "url": "https://questionsmedicales.fr/mesh/D003640", "about": { "@type": "MedicalCondition", "name": "Désalkylation", "code": { "@type": "MedicalCode", "code": "D003640", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "G03.219" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Déméthylation de l'ADN", "alternateName": "DNA Demethylation", "url": "https://questionsmedicales.fr/mesh/D000073399", "about": { "@type": "MedicalCondition", "name": "Déméthylation de l'ADN", "code": { "@type": "MedicalCode", "code": "D000073399", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "G03.219.500.500" } } } ], "about": { "@type": "MedicalCondition", "name": "Déméthylation", "alternateName": "Demethylation", "code": { "@type": "MedicalCode", "code": "D000073398", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Samuel E Ross", "url": "https://questionsmedicales.fr/author/Samuel%20E%20Ross", "affiliation": { "@type": "Organization", "name": "Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia." } }, { "@type": "Person", "name": "Ozren Bogdanovic", "url": "https://questionsmedicales.fr/author/Ozren%20Bogdanovic", "affiliation": { "@type": "Organization", "name": "Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia." } }, { "@type": "Person", "name": "Yaxin Xiong", "url": "https://questionsmedicales.fr/author/Yaxin%20Xiong", "affiliation": { "@type": "Organization", "name": "Department of Environmental Sciences, University of California, Riverside, California 92521, United States." } }, { "@type": "Person", "name": "Qingyang Shi", "url": "https://questionsmedicales.fr/author/Qingyang%20Shi", "affiliation": { "@type": "Organization", "name": "Department of Environmental Sciences, University of California, Riverside, California 92521, United States." } }, { "@type": "Person", "name": "Daniel Schlenk", "url": "https://questionsmedicales.fr/author/Daniel%20Schlenk", "affiliation": { "@type": "Organization", "name": "Department of Environmental Sciences, University of California, Riverside, California 92521, United States." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "DNA Methylation in the Fields of Prenatal Diagnosis and Early Detection of Cancers.", "datePublished": "2023-07-20", "url": "https://questionsmedicales.fr/article/37511475", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3390/ijms241411715" } }, { "@type": "ScholarlyArticle", "name": "A Liquid Biopsy Signature for the Early Detection of Gastric Cancer in Patients.", "datePublished": "2023-03-07", "url": "https://questionsmedicales.fr/article/36894035", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1053/j.gastro.2023.02.044" } }, { "@type": "ScholarlyArticle", "name": "Early detection of cancer therapy cardiotoxicity by radionuclide angiography: An update.", "datePublished": "2023-02-28", "url": "https://questionsmedicales.fr/article/36855007", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1007/s12350-023-03202-w" } }, { "@type": "ScholarlyArticle", "name": "Optimal age to stop prostate cancer screening and early detection.", "datePublished": "2023-08-19", "url": "https://questionsmedicales.fr/article/37598870", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.jcpo.2023.100443" } }, { "@type": "ScholarlyArticle", "name": "Serum IgG N-glycans enable early detection and early relapse prediction of colorectal cancer.", "datePublished": "2022-10-03", "url": "https://questionsmedicales.fr/article/36121650", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1002/ijc.34298" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Métabolisme", "item": "https://questionsmedicales.fr/mesh/D008660" }, { "@type": "ListItem", "position": 3, "name": "Désalkylation", "item": "https://questionsmedicales.fr/mesh/D003640" }, { "@type": "ListItem", "position": 4, "name": "Déméthylation", "item": "https://questionsmedicales.fr/mesh/D000073398" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Déméthylation - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Déméthylation", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-07", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Déméthylation", "description": "Comment diagnostiquer une déméthylation anormale ?\nQuels marqueurs sont utilisés pour la déméthylation ?\nQuels tests sanguins peuvent indiquer une déméthylation ?\nLa biopsie est-elle nécessaire pour diagnostiquer la déméthylation ?\nQuels symptômes peuvent alerter sur une déméthylation ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Déméthylation", "description": "Quels symptômes sont associés à la déméthylation ?\nLa déméthylation peut-elle causer des maladies ?\nY a-t-il des signes cliniques de déméthylation ?\nLes symptômes varient-ils selon l'âge ?\nLa déméthylation affecte-t-elle le système immunitaire ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Déméthylation", "description": "Comment prévenir la déméthylation ?\nLes suppléments peuvent-ils aider ?\nLe stress influence-t-il la déméthylation ?\nL'exercice physique a-t-il un impact ?\nLes toxines environnementales jouent-elles un rôle ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Déméthylation", "description": "Quels traitements existent pour la déméthylation ?\nLa nutrition peut-elle influencer la déméthylation ?\nLes thérapies épigénétiques sont-elles efficaces ?\nPeut-on prévenir la déméthylation par des médicaments ?\nLes traitements sont-ils personnalisés ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Déméthylation", "description": "Quelles complications peuvent survenir ?\nLa déméthylation est-elle réversible ?\nQuels risques sont associés à la déméthylation ?\nLa déméthylation peut-elle affecter la fertilité ?\nY a-t-il des effets à long terme ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Déméthylation", "description": "Quels sont les facteurs de risque de déméthylation ?\nL'hérédité joue-t-elle un rôle ?\nLes maladies chroniques augmentent-elles le risque ?\nLe mode de vie influence-t-il la déméthylation ?\nLes infections peuvent-elles affecter la déméthylation ?", "url": "https://questionsmedicales.fr/mesh/D000073398?mesh_terms=Early+Detection+of+Cancer&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une déméthylation anormale ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses de l'ADN peuvent révéler des modifications de méthylation." } }, { "@type": "Question", "name": "Quels marqueurs sont utilisés pour la déméthylation ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les marqueurs épigénétiques comme 5-méthylcytosine sont souvent analysés." } }, { "@type": "Question", "name": "Quels tests sanguins peuvent indiquer une déméthylation ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de métabolites et d'ADN circulant peuvent fournir des indices." } }, { "@type": "Question", "name": "La biopsie est-elle nécessaire pour diagnostiquer la déméthylation ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Une biopsie peut être nécessaire pour des analyses plus précises des tissus." } }, { "@type": "Question", "name": "Quels symptômes peuvent alerter sur une déméthylation ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes variés comme des troubles neurologiques ou des cancers peuvent survenir." } }, { "@type": "Question", "name": "Quels symptômes sont associés à la déméthylation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent inclure des troubles cognitifs, des anomalies de croissance et des cancers." } }, { "@type": "Question", "name": "La déméthylation peut-elle causer des maladies ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle est liée à des maladies comme le cancer et des troubles génétiques." } }, { "@type": "Question", "name": "Y a-t-il des signes cliniques de déméthylation ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des signes cliniques peuvent inclure des changements de comportement et des anomalies physiques." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent se manifester différemment selon l'âge et le développement." } }, { "@type": "Question", "name": "La déméthylation affecte-t-elle le système immunitaire ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut altérer la réponse immunitaire, augmentant le risque d'infections." } }, { "@type": "Question", "name": "Comment prévenir la déméthylation ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir la déméthylation." } }, { "@type": "Question", "name": "Les suppléments peuvent-ils aider ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments comme l'acide folique peuvent soutenir la méthylation." } }, { "@type": "Question", "name": "Le stress influence-t-il la déméthylation ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter les mécanismes de méthylation." } }, { "@type": "Question", "name": "L'exercice physique a-t-il un impact ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "L'exercice régulier peut améliorer la santé épigénétique et la méthylation." } }, { "@type": "Question", "name": "Les toxines environnementales jouent-elles un rôle ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certaines toxines peut perturber les mécanismes de méthylation." } }, { "@type": "Question", "name": "Quels traitements existent pour la déméthylation ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des thérapies géniques et des médicaments ciblés." } }, { "@type": "Question", "name": "La nutrition peut-elle influencer la déméthylation ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains nutriments comme l'acide folique peuvent moduler la méthylation." } }, { "@type": "Question", "name": "Les thérapies épigénétiques sont-elles efficaces ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Elles montrent un potentiel prometteur dans le traitement de certains cancers." } }, { "@type": "Question", "name": "Peut-on prévenir la déméthylation par des médicaments ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des inhibiteurs spécifiques peuvent être utilisés pour prévenir la déméthylation." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent des cancers, des troubles neurologiques et des maladies auto-immunes." } }, { "@type": "Question", "name": "La déméthylation est-elle réversible ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines modifications peuvent être réversibles, mais pas toutes." } }, { "@type": "Question", "name": "Quels risques sont associés à la déméthylation ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les risques incluent des maladies chroniques et des troubles de développement." } }, { "@type": "Question", "name": "La déméthylation peut-elle affecter la fertilité ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut influencer la fertilité en altérant la fonction reproductive." } }, { "@type": "Question", "name": "Y a-t-il des effets à long terme ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Des effets à long terme peuvent inclure des prédispositions à diverses maladies." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque de déméthylation ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent l'alimentation, le stress, et l'exposition à des toxines." } }, { "@type": "Question", "name": "L'hérédité joue-t-elle un rôle ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des facteurs génétiques peuvent influencer la déméthylation." } }, { "@type": "Question", "name": "Les maladies chroniques augmentent-elles le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Certaines maladies chroniques peuvent augmenter le risque de déméthylation." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il la déméthylation ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie malsain peut favoriser la déméthylation." } }, { "@type": "Question", "name": "Les infections peuvent-elles affecter la déméthylation ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections peuvent perturber les mécanismes de méthylation." } } ] } ] }

Sources (10000 au total)

A Liquid Biopsy Signature for the Early Detection of Gastric Cancer in Patients.

Diagnosing gastric cancer (GC) while the disease remains eligible for surgical resection is challenging. In view of this clinical challenge, novel and robust biomarkers for early detection thus improv... The present 3-step study incorporated data from 2141 patients, including 888 with GC, 158 with chronic atrophic gastritis, 193 with intestinal metaplasia, 501 healthy donors, and 401 with other gastro... In discovery phase, one LR (GClnc1) was found to be up-regulated in both tissue and circulating EV samples with an area under the curve (AUC) of 0.9369 (95% confidence interval [CI], 0.9073-0.9664) fo... EV-derived GClnc1 serves as a circulating biomarker for the early detection of GC, thus providing opportunities for curative surgery and improved survival outcomes....

Optimal age to stop prostate cancer screening and early detection.

Prostate Cancer screening should be discontinued at older ages because competing mortality risks eventually dominate the risk of Prostate Cancer and harms exceed benefits. We explored the Prostate Can... We applied Bellman Equations to formulate the net benefits biopsy and "do nothing". Using difference between the net benefits of two alternatives, we calculated the stopping age. The cancer states wer... Our results suggested that Prostate Cancer screening stopping ages from the patient, healthcare system, and social were 70, 68, and 68 respectively. The univariate sensitivity analysis showed that the... Men should not be screened for Prostate Cancer beyond 70 years old, as this results in the net benefit of "do nothing" above the biopsy. Nevertheless, this finding needs to be further studied with mor...

Ovarian Cancer-Self Assessment: An Innovation for Early Detection and Risk Assessment of Ovarian Cancer.

The modality to detect ovarian cancer at an early stage is very limited. Early diagnosis determines the prognosis. This study aimed to develop a risk assessment tool for early detection of ovarian can... This study was carried out as a cohort study of patients diagnosed with suspected ovarian tumors undergoing cytoreduction operation at Hasan Sadikin Hospital, Bandung, from December 2019 to September ... In total, 115 patients included in this study. The differences were statistically significant in terms of the six variables (abdominal bloating, nausea/vomiting, decreased of appetite, fullness, menst... Risk assessments based on ovarian cancer self-assessment unfortunately were not comparable to postoperative histopathology as a single predictor. Ten variables in ovarian cancer artificial intelligenc...

Integration of multiomics features for blood-based early detection of colorectal cancer.

Early detection of colorectal cancer (CRC) significantly enhances patient outcomes. Conventional CRC screening tools, like endoscopy and stool-based tests, have constraints due to their invasiveness o... In this research, we harnessed the Mutation Capsule Plus (MCP) technology to profile an array of genomic characteristics from cfDNA procured from a single blood draw. This profiling encompassed DNA me... This model was subsequently validated in another cohort comprising 89 CRC patients and 95 healthy controls. Remarkably, the model achieved an area under the curve (AUC) of 0.981 (95% confidence interv... Our findings underscore the clinical potential of our multiomics liquid biopsy test, indicating its prospective role as a noninvasive method for early-stage CRC detection. This multiomics approach hol...

Prospective cohort for early detection of liver cancer (Pearl): a study protocol.

Hepatocellular carcinoma (HCC) is the fastest-rising and fourth most common cause of cancer death worldwide. Liver cirrhosis is the largest underlying risk factor for HCC. Therefore, patients with cir... This is a UK-based prospective, longitudinal, diagnostic, prognostic, multicentre, non-CTIMP study. Aiming to recruit 3000 patients with liver cirrhosis without a HCC diagnosis, the Pearl cohort will ... Ethical approval has been granted by REC and the trial is registered on ClinicalTrials.gov. The results will be published in peer-reviewed journals and presented at relevant meetings.... NCT05541601....