Titre : Protéines MutS

Protéines MutS : Questions médicales fréquentes

Termes MeSH sélectionnés :

Interviews as Topic
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"ScholarlyArticle", "name": "Corrigendum to \"Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity\" [Heliyon 10(11) 15th June 2024, e31671].", "datePublished": "2024-06-21", "url": "https://questionsmedicales.fr/article/39185498", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.heliyon.2024.e33351" } }, { "@type": "ScholarlyArticle", "name": "Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility.", "datePublished": "2023-06-14", "url": "https://questionsmedicales.fr/article/37314941", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1021/acs.jmedchem.3c00519" } }, { "@type": "ScholarlyArticle", "name": "Study 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"https://questionsmedicales.fr/mesh/D000074080?mesh_terms=Interviews+as+Topic&page=725#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Protéines MutS", "description": "Quels sont les symptômes d'une mutation de MutS ?\nLes symptômes sont-ils toujours présents ?\nComment les symptômes varient-ils selon les individus ?\nLes symptômes peuvent-ils apparaître tardivement ?\nY a-t-il des symptômes associés à d'autres maladies ?", "url": "https://questionsmedicales.fr/mesh/D000074080?mesh_terms=Interviews+as+Topic&page=725#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Protéines MutS", "description": "Comment prévenir les cancers liés à MutS ?\nLes changements de mode de vie aident-ils ?\nLes tests génétiques sont-ils recommandés ?\nY a-t-il des recommandations alimentaires ?\nLes vaccinations peuvent-elles aider ?", "url": "https://questionsmedicales.fr/mesh/D000074080?mesh_terms=Interviews+as+Topic&page=725#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Protéines MutS", "description": "Quels traitements sont disponibles pour les cancers liés à MutS ?\nLa thérapie génique est-elle une option ?\nComment la surveillance est-elle effectuée ?\nY a-t-il des traitements préventifs ?\nLes traitements ciblés sont-ils efficaces ?", "url": "https://questionsmedicales.fr/mesh/D000074080?mesh_terms=Interviews+as+Topic&page=725#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Protéines MutS", "description": "Quelles complications peuvent survenir avec MutS ?\nLes complications sont-elles réversibles ?\nComment les complications affectent-elles la qualité de vie ?\nY a-t-il des complications psychologiques ?\nLes complications peuvent-elles être prévenues ?", "url": "https://questionsmedicales.fr/mesh/D000074080?mesh_terms=Interviews+as+Topic&page=725#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Protéines MutS", "description": "Quels sont les principaux facteurs de risque liés à MutS ?\nL'âge est-il un facteur de risque ?\nLe sexe influence-t-il le risque ?\nLes habitudes de vie jouent-elles un rôle ?\nY a-t-il des facteurs environnementaux à considérer ?", "url": "https://questionsmedicales.fr/mesh/D000074080?mesh_terms=Interviews+as+Topic&page=725#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une déficience en protéines MutS ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques peuvent identifier des mutations dans les gènes codant pour MutS." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer l'activité des protéines MutS ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de réparation de l'ADN in vitro peuvent mesurer l'activité des protéines MutS." } }, { "@type": "Question", "name": "Les biopsies peuvent-elles aider au diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des biopsies tumorales peuvent révéler des anomalies dans les protéines MutS." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème avec MutS ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes de cancer héréditaire peuvent suggérer une déficience en MutS." } }, { "@type": "Question", "name": "Y a-t-il des marqueurs biologiques associés à MutS ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des niveaux anormaux de certains biomarqueurs peuvent indiquer une dysfonction de MutS." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une mutation de MutS ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les mutations peuvent entraîner des cancers, notamment le cancer colorectal héréditaire." } }, { "@type": "Question", "name": "Les symptômes sont-ils toujours présents ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Non, certains individus porteurs de mutations peuvent ne pas présenter de symptômes visibles." } }, { "@type": "Question", "name": "Comment les symptômes varient-ils selon les individus ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent varier en fonction de l'âge et de l'historique familial." } }, { "@type": "Question", "name": "Les symptômes peuvent-ils apparaître tardivement ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains cancers liés à MutS peuvent se développer plus tard dans la vie." } }, { "@type": "Question", "name": "Y a-t-il des symptômes associés à d'autres maladies ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes similaires peuvent être observés dans d'autres syndromes de cancer héréditaire." } }, { "@type": "Question", "name": "Comment prévenir les cancers liés à MutS ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention inclut des dépistages réguliers et des conseils génétiques pour les familles." } }, { "@type": "Question", "name": "Les changements de mode de vie aident-ils ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sain peut réduire le risque de cancer, même avec des mutations." } }, { "@type": "Question", "name": "Les tests génétiques sont-ils recommandés ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les tests génétiques peuvent aider à identifier les individus à risque élevé." } }, { "@type": "Question", "name": "Y a-t-il des recommandations alimentaires ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation riche en fibres et en antioxydants est conseillée pour la prévention." } }, { "@type": "Question", "name": "Les vaccinations peuvent-elles aider ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Certaines vaccinations, comme contre le HPV, peuvent réduire le risque de cancers associés." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les cancers liés à MutS ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent la chirurgie, la chimiothérapie et l'immunothérapie." } }, { "@type": "Question", "name": "La thérapie génique est-elle une option ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "La thérapie génique est en recherche, mais pas encore une option standard pour MutS." } }, { "@type": "Question", "name": "Comment la surveillance est-elle effectuée ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Une surveillance régulière par des examens endoscopiques est recommandée pour les porteurs." } }, { "@type": "Question", "name": "Y a-t-il des traitements préventifs ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des interventions chirurgicales prophylactiques peuvent être envisagées pour réduire le risque." } }, { "@type": "Question", "name": "Les traitements ciblés sont-ils efficaces ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements ciblés sont en développement et montrent des résultats prometteurs." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec MutS ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent un risque accru de divers cancers et des syndromes associés." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes." } }, { "@type": "Question", "name": "Comment les complications affectent-elles la qualité de vie ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les complications peuvent réduire la qualité de vie en raison des traitements et des symptômes." } }, { "@type": "Question", "name": "Y a-t-il des complications psychologiques ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le diagnostic de mutations MutS peut entraîner de l'anxiété et du stress." } }, { "@type": "Question", "name": "Les complications peuvent-elles être prévenues ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Une surveillance régulière et des interventions précoces peuvent aider à prévenir certaines complications." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque liés à MutS ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux de cancer et les mutations génétiques sont des facteurs clés." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque de cancer augmente avec l'âge, surtout chez les porteurs de mutations MutS." } }, { "@type": "Question", "name": "Le sexe influence-t-il le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Certaines mutations peuvent avoir un impact différent selon le sexe, affectant le risque de cancer." } }, { "@type": "Question", "name": "Les habitudes de vie jouent-elles un rôle ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des habitudes de vie malsaines peuvent augmenter le risque de cancer chez les porteurs." } }, { "@type": "Question", "name": "Y a-t-il des facteurs environnementaux à considérer ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certains agents cancérigènes peut augmenter le risque chez les porteurs de MutS." } } ] } ] }

Sources (7253 au total)

Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility.

An unmet medical need remains for patients suffering from dry eye disease (DED). A fast-acting, better-tolerated noncorticosteroid anti-inflammatory eye drop could improve patient outcomes and quality...

Study protocol for a phase 1, randomised, double-blind, placebo-controlled study to investigate the safety, tolerability and pharmacokinetics of ascending topical doses of TCP-25 applied to epidermal suction blister wounds in healthy male and female volunteers.

TCP-25 gel is intended for use in treatment of wound infection and inflammation. Current local therapies for wounds have limited efficacy to prevent infections and there are no wound treatments availa... A randomised, double-blinded, first-in-human study was designed to evaluate the safety, tolerability and potential systemic exposure of three increasing doses of the TCP-25 gel applied topically on su... The study will be performed in accordance with ethical principles consistent with the Declaration of Helsinki, ICH/GCPE6 (R2), European Union Clinical Trials Directive and applicable local regulatory ... NCT05378997....

High-Throughput Proteomic Analysis of Human Dermal Fibroblast Response to Different Blood Derivatives: Autologous Topical Serum Derived from Plasma Rich in Growth Factors (PRGF) versus Leukocyte- and Platelet-Rich Plasma (L-PRP).

Platelet-rich plasma (PRP) is nowadays used in the treatment of different types of cutaneous lesions. However, different compositions can influence clinical outcomes. Among them, the inclusion of leuk...

Association between the starting age of non-parental Early Childhood Education and Care (ECEC), and psycho-social problems in adolescence in West and East Germany - a natural experiment using data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS).

The study aimed to investigate the association between the start age of non-parental Early Childhood Education and Care (ECEC) and psycho-social problems in adolescence. The similarities and differenc... Our sample consisted of 1022 children (621 from West Germany, 401 from East Germany) aged 3-4 years at wave 2003-2006 that were followed up to wave 2014-2017 as adolescents (mean ± SD age = 14.4 ± 0.0... Those who started ECEC between 2 and 3 years old (reference) had the lowest scores of psycho-social problems in the whole Germany and in West Germany in adolescence. In comparison, those who started E... The results suggest that if children start ECEC older than 3 years or younger than 2 years, more attention needs to be given to internalizing or externalizing psycho-social problems respectively. The ...

Improved treatment satisfaction with once-weekly insulin icodec compared with once-daily basal insulin in individuals with type 2 diabetes: An analysis of patient-reported outcomes and participant interviews from ONWARDS 2 and 5 and a physician survey from ONWARDS 1.

The ONWARDS phase 3a clinical trials evaluated once-weekly insulin icodec (icodec) versus once-daily basal insulin in type 2 diabetes. This analysis investigated the treatment-related experiences of p... Patient-reported outcomes were only collected during ONWARDS 5 (icodec with a dosing guide app vs. once-daily basal analogues) and 2 (icodec vs. once-daily insulin degludec). ONWARDS 1 (icodec vs. onc... In ONWARDS 5 and 2, there was a statistically significantly greater increase in total treatment satisfaction from baseline to end of treatment for icodec/icodec with app versus once-daily comparators,... These results demonstrate improved treatment satisfaction with, and strong preferences for, once-weekly versus once-daily basal insulin. Treatment convenience and willingness to continue and recommend... ONWARDS 1: NCT04460885; ONWARDS 2: NCT04770532; ONWARDS 5: NCT04760626....

A Randomized Single-Blinded Phase II Trial Comparing Efficacy and Quality of Life of Topical Aloe Vera Gel Plus Urea Cream Versus Urea Cream Alone for Prevention of Hand Foot Syndrome in Cancer Patients Receiving Capecitabine.

Capecitabine has been widely prescribed to treat various cancers. The hand foot syndrome (HFS) is the most troublesome adverse effect. Urea cream has been pre-emptively co-prescribed, even though its ... The investigators conducted a randomized single-blinded phase II study. The participants were randomized 1:1 to receive the combination of aloe vera gel and 10% urea cream (n = 30), the experimental A... Most of the participants had rectal cancer (A+U: 43.3%; U: 41.9%). In the A+U group, 86.7% had grade 0-1 HFS and 13.3% had grade 2-3 HFS. In the U group, 64.5% had grade 0-1 HFS and 35.5% had grade 2-... Combination of aloe vera gel and 10% urea cream ameliorated the severity of HFS in participants taking capecitabine; however, no significant difference in DLQI between the groups was demonstrated....

Study protocol of a single-arm phase 2 study evaluating the preventive effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in colorectal cancer patients receiving adjuvant chemotherapy with capecitabine plus oxaliplatin (T-CRACC study).

Clinical evidence of the preventive effectiveness of medium-class topical corticosteroids for capecitabine-induced hand foot syndrome (HFS) is limited. Although the pathogenesis and mechanism of HFS a... This is a single-center, single-arm, phase 2 study. Patients with colorectal cancer scheduled to receive adjuvant chemotherapy with capecitabine plus oxaliplatin are enrolled, and topical hydrocortiso... This study is expected to contribute to the establishment of new supportive care for preventing HFS, not only for colorectal cancer patients receiving adjuvant chemotherapy, but also for various cance... This trial was registered in the Japan Registry of Clinical Trials (jRCT) as jRCTs031220002. Registered 5 April 2022, https://jrct.niph.go.jp/search Protocol version V.1.0, 16 February 2022....

The safety and effectiveness of low-level light therapy (LLLT) with light-emitting diode (LED) bed system and a novel topical anti-cellulite gel on grades 1-2 thigh/buttock cellulite: a randomized, comparative-controlled split-thigh/buttock IRB study.

Cellulite of the upper lateral and posterior thighs and lower buttocks represents a common unwanted condition.... The author sought to comparea LLLT-LED bed therapy and a novel topical anti-cellulite gel on one thigh/buttock cellulite vs light therapy for cellulite to the opposite side.... Eight healthy female subjects were randomly treated with a LLLT-LED bed twice weekly for 20 minutes in prone/supine positions with twice daily application of a novel anti-cellulite gel to one randomiz... At the end of the 3-month trial, skin elasticity increased after combined therapy on one thigh but decreased with only LLLT-LED bed treatments on the opposite thigh. Thighs treated with active gel and... The use of LLLT-LED bed therapy and an anti-cellulite gel demonstrated an efficient alternative in the treatment of cellulite-involved thighs/buttocks over similarly affected thighs/buttocks that were...

Comparison of the effect of combined usage of povidone-iodine irrigation and topical vancomycin powder to the use of povidone-iodine irrigation alone on the periprosthetic joint infection incidence rate in patients undergoing primary total hip and knee arthroplasty: a protocol for multicenter prospective randomized clinical trial.

With the increasing number of joint replacement surgeries, periprosthetic joint infection (PJI) has become a significant concern in orthopedic practice, making research on PJI prevention paramount. Th... The prospective randomized clinical trial will be conducted in two independent voivodeship hospitals with extensive experience in lower limb arthroplasties. The studied material will comprise 840 pati... A randomized clinical trial comparing the effect of combined usage of povidone-iodine irrigation and vancomycin powder to the use of povidone-iodine irrigation alone in preventing PJIs after primary a... ClinicalTrials.gov NCT05972603 . Registered on 2 August 2023....