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Composés hétérocycliques
Composés hétérocycliques à cycles fusionnés
Composés hétérobicycliques
Purines
Roscovitine
Roscovitine : Questions médicales fréquentes
Diagnostic
2
Roscovitine
Inhibiteurs de kinases
Symptômes
2
Effets secondaires
Nausées
Symptômes neurologiques
Doses
Prévention
2
Prévention du cancer
Roscovitine
Alimentation saine
Exercice physique
Traitements
2
Traitement du cancer
Roscovitine
Prolifération cellulaire
Apoptose
Complications
2
Complications
Troubles hématologiques
Interactions médicamenteuses
Effets indésirables
Facteurs de risque
2
Antécédents médicaux
Maladies hépatiques
Personnes âgées
Tolérance médicamenteuse
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 14/03/2026
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
ManRos Therapeutics, Presqu'île de Perharidy, 29680 Roscoff, France.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, People's Republic of China.
Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR, People's Republic of China.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Experimental Oncology Laboratory, Universidade Federal Do Ceará, Fortaleza, CE, Brazil.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Experimental Oncology Laboratory, Universidade Federal Do Ceará, Fortaleza, CE, Brazil.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Animal Biotechnology, Universidade Federal Rural Do Semi-Árido, Av. Francisco Mota, 572, Mossoró, RN, 59625-900, Brazil. alexsandra.pereira@ufersa.edu.br.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
EA 3878, GETBO, Université de Bretagne Occidentale, F-29200 Brest, France.
CHRU de Brest, Service de Biochimie et de Pharmaco-Toxicologie, Hôpital de la Cavale Blanche, F-29200 Brest, France.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Centre d'Investigation Clinique, INSERM CIC-1412, Hôpital de la Cavale Blanche, CHRU Brest, 29609 Brest CEDEX, France.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
ManRos Therapeutics, Hôtel de Recherche, Centre de Perharidy, F-29680, Roscoff, France.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine, Tai'an, China.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine, Tai'an, China.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine, Tai'an, China.
College of Life Science, North Agricultural University, Harbin, China.
Publications dans "Roscovitine" :
2 publications dans cette catégorie
Affiliations :
EFS, Université de Bretagne Occidentale, Inserm UMR 1078, GGB, Brest, France.
Publications dans "Roscovitine" :
The effects of oocyte activation with a Ca ionophore and roscovitine (Ca+R), a selective inhibitor of M-phase promoting factor, on unfertilized oocytes after intracytoplasmic sperm injection (ICSI) or...
Oocytes without pronuclei at 18 hours after ICSI were judged to be unfertilized and were exposed to the Ca ionophore A23187 (5 ?M) with or without roscovitine (50 ?M). The activation rate was measured...
At 18 hours, the activation rates in the control, Ca ionophore, and Ca+R groups were 3.5% (4/112), 26.9% (7/26), and 32.1% (17/53), respectively. The activation rate of the Ca+R group was significantl...
Sequential treatment with an Ca ionophore and roscovitine activates oocytes that remain unfertilized after ICSI. In TESE-ICSI, the activation rate tended to be increased by the co-administration of ro...
The most frequent cause of endogenous hypercortisolism is Cushing disease (CD), a devastating condition associated with severe comorbidities and high mortality. Effective tumor-targeting therapeutics ...
Search in PubMed with key words "corticotroph" and "Cushing's disease" plus the name of the mentioned therapeutic agent and in associated references of the obtained papers. Additionally, potential the...
At present, the tumor-targeted pharmacological therapy of CD is concentrated on dopamine agonists (cabergoline) and somatostatin analogs (pasireotide) with varying efficacy, escape from response, and ...
For many patients with CD, effective tumor-targeted pharmacological therapy is still lacking. Coordinated efforts are pivotal in establishing efficacy and safety of novel therapeutics in this rare but...
Preclinical studies show seliciclib (R-roscovitine) suppresses neoplastic corticotroph proliferation and pituitary adrenocorticotrophic hormone (ACTH) production....
To evaluate seliciclib as an effective pituitary-targeting treatment for patients with Cushing disease (CD)....
Two prospective, open-label, phase 2 trials, conducted at a tertiary referral pituitary center, included adult patients with de novo, persistent, or recurrent CD who received oral seliciclib 400 mg tw...
Sixteen patients were consented and 9 were treated. Mean UFC decreased by 42%, from 226.4 ± 140.3 µg/24 hours at baseline to 131.3 ± 114.3 µg/24 hours by study end. Longitudinal model showed significa...
Seliciclib may directly target pituitary corticotrophs in CD and reverse hypercortisolism. Potential liver toxicity of seliciclib resolves with treatment withdrawal. The lowest effective dose requires...
Targeted biologic therapies demonstrate similar efficacies in rheumatoid arthritis despite distinct mechanisms of action. They also exhibit a ceiling effect, with 10% to 20% of patients achieving remi...
TRAFIC is a non-commercial, multi-center, rolling phase Ib/IIa trial investigating the safety, tolerability, and efficacy of seliciclib in patients with moderate to severe rheumatoid arthritis receivi...
The study has been reviewed and approved by the North East - Tyne & Wear South Research Ethics Committee (reference 14/NE/1075) and the Medicines and Healthcare Products Regulatory Agency (MHRA), Unit...
ISRCTN, ISRCTN36667085. Registered on September 26, 2014; http://www.isrctn.com/ISRCTN36667085Current protocol version: Protocol version 11.0 (March 21, 2019)....
The oncogenic transcription factor B-Myb is an essential regulator of late cell cycle genes whose activation by phosphorylation is still poorly understood. We describe a stepwise phosphorylation mecha...
Fibroblast cycle synchronization in G...
Cystic fibrosis (CF) is characterized by chronic bacterial infections and heightened inflammation. Widespread ineffective antibiotic use has led to increased isolation of drug resistant bacterial stra...
The puma population is constantly decreasing, and cloning by somatic cell nuclear transfer can be used to conserve the species. One of the factors determining the success of the development of cloned ...
A series of 16 novel spirooxindole analogs 8a-p were designed and constructed via cost-effective single-step multicomponent [3+2] cycloaddition reaction of azomethine ylide (AY) generated in situ from...
Cyclin-dependent kinase 2 (CDK2) is a vital protein for controlling cell cycle progression that is critically associated with various malignancies and its inhibition could offer a convenient therapeut...