Titre : alpha-1-Antitrypsine

alpha-1-Antitrypsine : Questions médicales fréquentes

Termes MeSH sélectionnés :

Practice Guidelines as Topic
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alpha-1-antitrypsine ?\nQuels tests génétiques sont utilisés pour le diagnostic ?\nLe diagnostic nécessite-t-il une biopsie hépatique ?\nQuels examens d'imagerie sont recommandés ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=4#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur alpha-1-Antitrypsine", "description": "Quels sont les symptômes pulmonaires du déficit ?\nY a-t-il des symptômes hépatiques associés ?\nLes symptômes varient-ils selon l'âge ?\nComment les symptômes évoluent-ils avec le temps ?\nLes symptômes sont-ils similaires à d'autres maladies ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=4#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur alpha-1-Antitrypsine", "description": "Peut-on prévenir le déficit en alpha-1-antitrypsine ?\nQuelles habitudes de vie peuvent aider ?\nLe vaccin contre la grippe est-il recommandé ?\nDes conseils nutritionnels sont-ils utiles ?\nLe suivi médical régulier est-il important ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=4#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur alpha-1-Antitrypsine", "description": "Quel est le traitement principal pour le déficit ?\nDes médicaments sont-ils prescrits pour les symptômes ?\nLa chirurgie est-elle une option de traitement ?\nY a-t-il des traitements expérimentaux disponibles ?\nComment la physiothérapie aide-t-elle ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=4#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur alpha-1-Antitrypsine", "description": "Quelles sont les complications pulmonaires possibles ?\nLe déficit peut-il causer des maladies hépatiques ?\nY a-t-il un risque accru de cancer ?\nComment le déficit affecte-t-il la qualité de vie ?\nLes complications sont-elles réversibles ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=4#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur alpha-1-Antitrypsine", "description": "Quels sont les facteurs de risque génétiques ?\nLe tabagisme est-il un facteur de risque ?\nL'exposition à des polluants est-elle préoccupante ?\nL'âge influence-t-il le risque de complications ?\nLes infections respiratoires fréquentes sont-elles un facteur ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=4#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer un déficit en alpha-1-antitrypsine ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un test sanguin mesure le niveau d'alpha-1-antitrypsine pour confirmer le déficit." } }, { "@type": "Question", "name": "Quels symptômes indiquent un déficit en alpha-1-antitrypsine ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Essoufflement, toux chronique et maladies hépatiques peuvent indiquer un déficit." } }, { "@type": "Question", "name": "Quels tests génétiques sont utilisés pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques identifient les mutations du gène SERPINA1 responsables du déficit." } }, { "@type": "Question", "name": "Le diagnostic nécessite-t-il une biopsie hépatique ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Une biopsie hépatique peut être réalisée si des lésions hépatiques sont suspectées." } }, { "@type": "Question", "name": "Quels examens d'imagerie sont recommandés ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Une échographie ou un scanner peut être utilisé pour évaluer l'état du foie et des poumons." } }, { "@type": "Question", "name": "Quels sont les symptômes pulmonaires du déficit ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent essoufflement, toux persistante et infections respiratoires fréquentes." } }, { "@type": "Question", "name": "Y a-t-il des symptômes hépatiques associés ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, jaunisse, fatigue, et douleurs abdominales peuvent indiquer des problèmes hépatiques." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent apparaître dès l'enfance ou à l'âge adulte, selon la gravité." } }, { "@type": "Question", "name": "Comment les symptômes évoluent-ils avec le temps ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent s'aggraver progressivement, surtout sans traitement approprié." } }, { "@type": "Question", "name": "Les symptômes sont-ils similaires à d'autres maladies ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent être confondus avec d'autres maladies pulmonaires ou hépatiques." } }, { "@type": "Question", "name": "Peut-on prévenir le déficit en alpha-1-antitrypsine ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention est limitée, mais le dépistage précoce peut aider à gérer la maladie." } }, { "@type": "Question", "name": "Quelles habitudes de vie peuvent aider ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Éviter le tabac et l'alcool, et maintenir un poids santé peuvent réduire les risques." } }, { "@type": "Question", "name": "Le vaccin contre la grippe est-il recommandé ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la vaccination contre la grippe est recommandée pour prévenir les infections respiratoires." } }, { "@type": "Question", "name": "Des conseils nutritionnels sont-ils utiles ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée peut soutenir la santé du foie et des poumons." } }, { "@type": "Question", "name": "Le suivi médical régulier est-il important ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des consultations régulières permettent de surveiller l'évolution de la maladie." } }, { "@type": "Question", "name": "Quel est le traitement principal pour le déficit ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement principal est la thérapie de remplacement d'alpha-1-antitrypsine par perfusion." } }, { "@type": "Question", "name": "Des médicaments sont-ils prescrits pour les symptômes ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des bronchodilatateurs et des corticostéroïdes peuvent être prescrits pour soulager les symptômes." } }, { "@type": "Question", "name": "La chirurgie est-elle une option de traitement ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Dans les cas graves, une transplantation hépatique peut être envisagée." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux disponibles ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des essais cliniques explorent de nouvelles thérapies, mais leur efficacité varie." } }, { "@type": "Question", "name": "Comment la physiothérapie aide-t-elle ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "La physiothérapie respiratoire peut améliorer la fonction pulmonaire et la qualité de vie." } }, { "@type": "Question", "name": "Quelles sont les complications pulmonaires possibles ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent emphysème, infections pulmonaires et insuffisance respiratoire." } }, { "@type": "Question", "name": "Le déficit peut-il causer des maladies hépatiques ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il peut entraîner des maladies hépatiques comme la cirrhose et le cancer du foie." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes atteintes de déficit ont un risque accru de cancer du foie." } }, { "@type": "Question", "name": "Comment le déficit affecte-t-il la qualité de vie ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Il peut réduire la qualité de vie en limitant l'activité physique et en causant des douleurs." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque génétiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux de déficit en alpha-1-antitrypsine augmentent le risque." } }, { "@type": "Question", "name": "Le tabagisme est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme aggrave les symptômes et augmente le risque de complications pulmonaires." } }, { "@type": "Question", "name": "L'exposition à des polluants est-elle préoccupante ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des polluants environnementaux peut aggraver les symptômes respiratoires." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de complications ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque de complications augmente avec l'âge, surtout sans traitement." } }, { "@type": "Question", "name": "Les infections respiratoires fréquentes sont-elles un facteur ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des infections respiratoires fréquentes peuvent aggraver l'état des patients atteints." } } ] } ] }

Sources (10000 au total)

Description of antidepressant withdrawal symptoms in clinical practice guidelines on depression: A systematic review.

Antidepressant withdrawal symptoms may mimic symptoms of depression relapse and can be challenging for patients when tapering or discontinuing antidepressants. We aimed to assess how withdrawal sympto... Systematic review of major clinical practice guidelines on depression from the United Kingdom, the United States, Canada, Australia, Singapore, Ireland, and New Zealand. We searched PubMed, 14 guideli... We included 21 guidelines, 15 (71 %) of which stated that withdrawal or discontinuation symptoms can occur. None of the guidelines provided an exhaustive list of potential withdrawal symptoms; ten (48... We included clinical practice guidelines from English-speaking countries only; our findings may not be generalizable to non-English-speaking countries.... Clinical practice guidelines provide scarce and inadequate information on antidepressant withdrawal symptoms and limited guidance for distinguishing withdrawal symptoms from symptoms of relapse....

Recent clinical practice guidelines for the management of low back pain: a global comparison.

Low back pain (LBP) is a significant health problem worldwide, with a lifetime prevalence of 84% in the general adult population. To rationalise the management of LBP, clinical practice guidelines (CP... MEDLINE, EMBASE, CINAHL, PEDro, and major guideline databases were searched from 2017 to 2022 to identify CPGs. CPGs focusing on information regarding the management and/or treatment of non-specific L... Our analysis identified a total of 22 CPGs that met the inclusion criteria, and were of middle and high methodological quality as assessed by the AGREE II tool. The guidelines exhibited heterogeneity ... Current CPGs provide recommendations for almost all major aspects of the management of LBP, but there is marked heterogeneity between them. Some recommendations lack clarity and overlap with other tre...

2023 clinical practice guidelines on autism spectrum disorder in children and adolescents in Singapore.

Autism is a neurodevelopmental condition that is increasing in prevalence worldwide. There has been an exponential increase in autism-related research since 2010, when the first Singapore Clinical Pra... A multidisciplinary workgroup that comprised representatives from various sectors worked on this CPG. Clinical questions were organised into 10 different sections, each with its own subgroup of member... Recommendation and good practice statements pertaining to care of children and adolescents on the autism spectrum across 10 different sections were developed. Evidence matrices complement these recomm... It is intended for these guidelines to promote effective management and healthcare services for children and adolescents on the autism spectrum, by reinforcing good and evidence-based clinical practic...

Heterogeneous methodology in the development of patient versions of clinical practice guidelines: a scoping review.

We aimed to gain an overview of the methods and approaches used to develop, disseminate, and implement patient versions of clinical practice guidelines (PVGs).... We searched PubMed and MEDLINE through Ovid for articles reporting on the development, dissemination, or implementation of PVGs until March 2022. We searched the homepages of guideline organizations, ... Of 3,941 publications screened, 27 were included in the study. The identified method reports focused on patient involvement and peer-review processes. The other included publications highlighted the r... The terminology used for PVGs varies widely. The extent to which the methods were described was heterogeneous. Organizations developing PVGs should make their methods publicly available and use unifor...

Adherence to clinical practice guidelines for using electroconvulsive therapy in elderly depressive patients.

Electroconvulsive therapy (ECT) is one of the most effective treatments in mood disorders, mainly in major depressive episode (MDE) in the context of either unipolar (MDD) or bipolar disorder (BD). Ho... In this multicenter, retrospective study including patients aged 65 years or over with MDEs in MDD or BD who have been treated with ECT for MDEs, data on the duration of MDEs and the number of lines o... We identified 335 patients. The mean duration of MDEs before ECT was about 9 months. It was significantly shorter in BD than in MDD- about 7 and 10 months, respectively. The co-occurrence of chronic m... Even if ECT seems to be a key treatment in the elderly population due to its efficacity and safety for MDEs, the delay before this treatment is still too long....

Supporting family carers in general practice: a scoping review of clinical guidelines and recommendations.

Increasing numbers of family carers are providing informal care in community settings. This creates a number of challenges because family carers are at risk of poor physical and psychological health o... A scoping review was undertaken to examine clinical guidelines and recommendations for GPs to support them in their role with family carers. This involved a multidisciplinary team, in line with Arksey... The searches yielded a total of 4,651 English language papers, 35 of which met the criteria for inclusion after removing duplicates, screening titles and abstracts, and performing full-text readings. ... Our review addresses a significant gap in the literature by providing an important synthesis of current available evidence on clinical guidelines for GPs in supporting family carers, including strateg...

A critical appraisal of clinical practice guidelines on pharmacological treatments for spinal cord injury.

Spinal cord injury brings devastating consequences and huge economic burden. Different authoritative organizations have developed different guidelines for pharmacological treatments of spinal cord inj... To systematically review and appraise guidelines regarding their recommendations for pharmacological treatments for spinal cord injury.... Systematic review.... We searched Medline, Embase, Cochrane, and Web of Science from January 2000 to January 2022 as well as guideline-specific databases (eg, Congress of Neurological Surgeons) and Google Scholar. We inclu... Eight guidelines developed from 2008 to 2020 were included, but all of them scored lowest in the domain of applicability among all six domains. Twelve pharmacological agents (eg, methylprednisolone) w... There were inconsistencies among recommendations for methylprednisolone and GM-1. Evidence-based recommendations tended to recommend against, whereas consensus-based recommendations tended to recommen...

Financial conflicts of interest among authors of clinical practice guideline for headache disorders in Japan.

Financial relationships between clinical guideline authors and pharmaceutical companies introduce conflicts of interest (COI), potentially biasing guideline recommendations. Thus, proper management of... This is a retrospective analysis of 2016-2020 personal payments data disclosed by all pharmaceutical companies affiliated with the Japan Pharmaceutical Manufacturers Association. We examined amounts a... Among 57 CPGHD authors, 56 (98.3%) received personal payments totaling $2.7 million from pharmaceutical companies between 2016 and 2020. Median five-year payments were $89,955 for CPGHD authors, while... More than 98% of CPGHD authors received much higher personal payments from pharmaceutical companies than those to board-certified neurologists during the guideline development period in Japan....