questionsmedicales.fr
Système digestif
Tube digestif
Tube digestif inférieur
Gros intestin
Caecum
Appendice vermiforme
Appendice vermiforme : Questions médicales fréquentes
Termes MeSH sélectionnés :
Gene Expression Regulation
Diagnostic
5
Appendicite
Échographie
Tomodensitométrie
Numération formule sanguine
Globules blancs
Appendicite
Douleur abdominale
Nausées
Fièvre
Imagerie
Diagnostic
Appendicite
Palpation
Douleur abdominale
Appendicite
Symptômes
5
Douleur abdominale
Nausées
Perte d'appétit
Douleur abdominale
Appendicite
Symptômes
Enfants
Douleur abdominale
Vomissements
Urgence
Fièvre
Douleur abdominale
Âge
Symptômes
Appendicite
Prévention
5
Prévention
Alimentation
Fibres
Antécédents familiaux
Risque
Appendicite
Hygiène
Infections
Prévention
Jeunes
Risque
Appendicite
Maladies digestives
Risque
Appendicite
Traitements
5
Appendicectomie
Chirurgie
Traitement
Antibiotiques
Traitement
Appendicite
Chirurgie
Infections
Complications
Hospitalisation
Appendicectomie
Récupération
Soins post-opératoires
Infection
Chirurgie
Complications
5
Complications
Abcès
Péritonite
Péritonite
Douleur abdominale
Fièvre
Abcès
Infection
Appendicite
Obstruction intestinale
Douleur abdominale
Vomissements
Complications
Appendicite
Traitement
Facteurs de risque
5
Facteurs de risque
Jeunes adultes
Maladies digestives
Alimentation
Fibres
Risque
Infections intestinales
Risque
Appendicite
Maladies inflammatoires
Risque
Appendicite
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Appendice vermiforme : Questions médicales les plus fréquentes",
"headline": "Appendice vermiforme : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Appendice vermiforme : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-04-11",
"dateModified": "2025-04-06",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Appendice vermiforme"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Caecum",
"url": "https://questionsmedicales.fr/mesh/D002432",
"about": {
"@type": "MedicalCondition",
"name": "Caecum",
"code": {
"@type": "MedicalCode",
"code": "D002432",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A03.556.249.249.209"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Appendice vermiforme",
"alternateName": "Appendix",
"code": {
"@type": "MedicalCode",
"code": "D001065",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Mahendra Pratap Singh",
"url": "https://questionsmedicales.fr/author/Mahendra%20Pratap%20Singh",
"affiliation": {
"@type": "Organization",
"name": "Department of General Surgery, All India Institute of Medical Sciences, Bhopal, India."
}
},
{
"@type": "Person",
"name": "Franziska Köhler",
"url": "https://questionsmedicales.fr/author/Franziska%20K%C3%B6hler",
"affiliation": {
"@type": "Organization",
"name": "Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital of Würzburg, Germany; Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Germany; Institute of Pathology, University of Würzburg, Germany; Medical Clinic and Polyclinic II, University Hospital of Würzburg, Germany; Department of Biochemistry and Molecular Biology, University of Würzburg, Germany."
}
},
{
"@type": "Person",
"name": "Niels Matthes",
"url": "https://questionsmedicales.fr/author/Niels%20Matthes",
"affiliation": {
"@type": "Organization",
"name": ""
}
},
{
"@type": "Person",
"name": "Mathias Rosenfeldt",
"url": "https://questionsmedicales.fr/author/Mathias%20Rosenfeldt",
"affiliation": {
"@type": "Organization",
"name": ""
}
},
{
"@type": "Person",
"name": "Volker Kunzmann",
"url": "https://questionsmedicales.fr/author/Volker%20Kunzmann",
"affiliation": {
"@type": "Organization",
"name": ""
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Regulation of myogenic gene expression.",
"datePublished": "2022-08-01",
"url": "https://questionsmedicales.fr/article/35926660",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.yexcr.2022.113299"
}
},
{
"@type": "ScholarlyArticle",
"name": "Repetitive DNA regulates gene expression.",
"datePublished": "2023-09-21",
"url": "https://questionsmedicales.fr/article/37733865",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1126/science.adk2055"
}
},
{
"@type": "ScholarlyArticle",
"name": "Regulation of Gene Expression in Cancer-An Overview.",
"datePublished": "2022-12-15",
"url": "https://questionsmedicales.fr/article/36552821",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/cells11244058"
}
},
{
"@type": "ScholarlyArticle",
"name": "Factors and Methods for the Detection of Gene Expression Regulation.",
"datePublished": "2023-02-06",
"url": "https://questionsmedicales.fr/article/36830673",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/biom13020304"
}
},
{
"@type": "ScholarlyArticle",
"name": "Viral miRNA regulation of host gene expression.",
"datePublished": "2022-11-30",
"url": "https://questionsmedicales.fr/article/36463091",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.semcdb.2022.11.007"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Système digestif",
"item": "https://questionsmedicales.fr/mesh/D004064"
},
{
"@type": "ListItem",
"position": 3,
"name": "Tube digestif",
"item": "https://questionsmedicales.fr/mesh/D041981"
},
{
"@type": "ListItem",
"position": 4,
"name": "Tube digestif inférieur",
"item": "https://questionsmedicales.fr/mesh/D041741"
},
{
"@type": "ListItem",
"position": 5,
"name": "Gros intestin",
"item": "https://questionsmedicales.fr/mesh/D007420"
},
{
"@type": "ListItem",
"position": 6,
"name": "Caecum",
"item": "https://questionsmedicales.fr/mesh/D002432"
},
{
"@type": "ListItem",
"position": 7,
"name": "Appendice vermiforme",
"item": "https://questionsmedicales.fr/mesh/D001065"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Appendice vermiforme - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Appendice vermiforme",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-06",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Appendice vermiforme",
"description": "Comment diagnostiquer une appendicite ?\nQuels tests sanguins sont utiles ?\nQuels symptômes indiquent une appendicite ?\nL'imagerie est-elle toujours nécessaire ?\nPeut-on diagnostiquer par palpation ?",
"url": "https://questionsmedicales.fr/mesh/D001065?mesh_terms=Gene+Expression+Regulation#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Appendice vermiforme",
"description": "Quels sont les premiers symptômes de l'appendicite ?\nLa douleur se déplace-t-elle ?\nY a-t-il des symptômes chez les enfants ?\nQuels signes indiquent une urgence ?\nLes symptômes varient-ils selon l'âge ?",
"url": "https://questionsmedicales.fr/mesh/D001065?mesh_terms=Gene+Expression+Regulation#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Appendice vermiforme",
"description": "Peut-on prévenir l'appendicite ?\nLes antécédents familiaux jouent-ils un rôle ?\nL'hygiène a-t-elle un impact ?\nLes jeunes sont-ils plus à risque ?\nLes maladies digestives influencent-elles le risque ?",
"url": "https://questionsmedicales.fr/mesh/D001065?mesh_terms=Gene+Expression+Regulation#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Appendice vermiforme",
"description": "Quel est le traitement standard de l'appendicite ?\nPeut-on traiter l'appendicite sans chirurgie ?\nQuels sont les risques de la chirurgie ?\nQuelle est la durée de l'hospitalisation ?\nY a-t-il des soins post-opératoires spécifiques ?",
"url": "https://questionsmedicales.fr/mesh/D001065?mesh_terms=Gene+Expression+Regulation#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Appendice vermiforme",
"description": "Quelles sont les complications possibles de l'appendicite ?\nComment se manifeste une péritonite ?\nUn abcès peut-il se former après une appendicite ?\nQuels sont les signes d'une obstruction intestinale ?\nLes complications sont-elles fréquentes ?",
"url": "https://questionsmedicales.fr/mesh/D001065?mesh_terms=Gene+Expression+Regulation#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Appendice vermiforme",
"description": "Quels sont les principaux facteurs de risque ?\nL'alimentation influence-t-elle le risque ?\nLes infections intestinales sont-elles un facteur ?\nLe sexe joue-t-il un rôle dans le risque ?\nLes maladies inflammatoires augmentent-elles le risque ?",
"url": "https://questionsmedicales.fr/mesh/D001065?mesh_terms=Gene+Expression+Regulation#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une appendicite ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'examen clinique, l'échographie et la tomodensitométrie."
}
},
{
"@type": "Question",
"name": "Quels tests sanguins sont utiles ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une numération formule sanguine peut montrer une élévation des globules blancs."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une appendicite ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur abdominale, nausées, vomissements et fièvre sont des symptômes clés."
}
},
{
"@type": "Question",
"name": "L'imagerie est-elle toujours nécessaire ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Pas toujours, mais elle aide à confirmer le diagnostic en cas de doute."
}
},
{
"@type": "Question",
"name": "Peut-on diagnostiquer par palpation ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la douleur à la palpation dans le quadrant inférieur droit est un indicateur."
}
},
{
"@type": "Question",
"name": "Quels sont les premiers symptômes de l'appendicite ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les premiers symptômes incluent douleur abdominale, perte d'appétit et nausées."
}
},
{
"@type": "Question",
"name": "La douleur se déplace-t-elle ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle commence souvent autour du nombril puis se déplace vers le bas à droite."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes chez les enfants ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les enfants peuvent présenter des douleurs abdominales et des vomissements."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une urgence ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre élevée, douleur intense et vomissements fréquents nécessitent une attention immédiate."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent être moins typiques chez les personnes âgées."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir l'appendicite ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention garantie, mais une alimentation riche en fibres peut aider."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux d'appendicite peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "L'hygiène a-t-elle un impact ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une bonne hygiène peut réduire le risque d'infections, mais n'empêche pas l'appendicite."
}
},
{
"@type": "Question",
"name": "Les jeunes sont-ils plus à risque ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'appendicite est plus fréquente chez les adolescents et les jeunes adultes."
}
},
{
"@type": "Question",
"name": "Les maladies digestives influencent-elles le risque ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies digestives peuvent augmenter le risque d'appendicite."
}
},
{
"@type": "Question",
"name": "Quel est le traitement standard de l'appendicite ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'appendicectomie, l'ablation chirurgicale de l'appendice, est le traitement standard."
}
},
{
"@type": "Question",
"name": "Peut-on traiter l'appendicite sans chirurgie ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas, des antibiotiques peuvent être utilisés, mais la chirurgie est souvent nécessaire."
}
},
{
"@type": "Question",
"name": "Quels sont les risques de la chirurgie ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les risques incluent infections, saignements et complications anesthésiques."
}
},
{
"@type": "Question",
"name": "Quelle est la durée de l'hospitalisation ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'hospitalisation dure généralement de 1 à 3 jours après une appendicectomie."
}
},
{
"@type": "Question",
"name": "Y a-t-il des soins post-opératoires spécifiques ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il est important de surveiller les signes d'infection et de suivre les recommandations médicales."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles de l'appendicite ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent l'abcès, la péritonite et l'obstruction intestinale."
}
},
{
"@type": "Question",
"name": "Comment se manifeste une péritonite ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "La péritonite se manifeste par une douleur abdominale intense, de la fièvre et des vomissements."
}
},
{
"@type": "Question",
"name": "Un abcès peut-il se former après une appendicite ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un abcès peut se former si l'infection n'est pas correctement traitée."
}
},
{
"@type": "Question",
"name": "Quels sont les signes d'une obstruction intestinale ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les signes incluent des douleurs abdominales, des vomissements et l'absence de selles."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles fréquentes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications surviennent dans environ 5 à 10 % des cas d'appendicite traitée."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les jeunes adultes, les antécédents familiaux et certaines maladies digestives augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation pauvre en fibres peut augmenter le risque d'appendicite."
}
},
{
"@type": "Question",
"name": "Les infections intestinales sont-elles un facteur ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections intestinales peuvent augmenter le risque d'appendicite."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les hommes ont un risque légèrement plus élevé d'appendicite que les femmes."
}
},
{
"@type": "Question",
"name": "Les maladies inflammatoires augmentent-elles le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme la maladie de Crohn peuvent augmenter le risque d'appendicite."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 06/04/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Department of General Surgery, All India Institute of Medical Sciences, Bhopal, India.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital of Würzburg, Germany; Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg, Germany; Institute of Pathology, University of Würzburg, Germany; Medical Clinic and Polyclinic II, University Hospital of Würzburg, Germany; Department of Biochemistry and Molecular Biology, University of Würzburg, Germany.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Colorectal Surgery, Nepean Hospital, Sydney, New South Wales, Australia.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Colorectal Surgery, Nepean Hospital, Sydney, New South Wales, Australia.
Sydney School of Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Colorectal Surgery, Nepean Hospital, Sydney, New South Wales, Australia.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Colorectal Surgery, Nepean Hospital, Sydney, New South Wales, Australia.
Department of Obstetrics and Gynaecology, Nepean Hospital, Sydney, New South Wales, Australia.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Colorectal Surgery, Nepean Hospital, Sydney, New South Wales, Australia.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Akai House Clinic, Accra, Ghana.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Surgery, University of Ghana Medical School, College of Health Sciences, University of Ghana.
Department of Surgery, Korle Bu Teaching Hospital.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Surgery, University of Ghana Medical School, College of Health Sciences, University of Ghana.
Department of Surgery, Korle Bu Teaching Hospital.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Radiology, Korle Bu Teaching Hospital.
Department of Radiology, University of Ghana Medical School, College of Health Sciences, University of Ghana.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Radiology, Korle Bu Teaching Hospital.
Department of Radiology, University of Ghana Medical School, College of Health Sciences, University of Ghana.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Surgery, University of Ghana Medical School, College of Health Sciences, University of Ghana.
Department of Surgery, Korle Bu Teaching Hospital.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Pathology, Korle Bu Teaching Hospital.
Publications dans "Appendice vermiforme" :
1 publication dans cette catégorie
Affiliations :
Department of Surgery, College of Medicine, University of Duhok, Kurdistan Region, Iraq.
Publications dans "Appendice vermiforme" :
Skeletal muscle development and regeneration is governed by the combined action of Myf5, MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These transcription factors are expr...
Short tandem repeats affect gene expression by binding regulatory proteins....
Regulation of gene expression takes a central place in normal cells to maintain tissue homeostasis but also in cancer cells to respond to intra- and extra-cellular stimuli, such as therapeutic drugs [...
Gene-expression regulation involves multiple processes and a range of regulatory factors. In this review, we describe the key factors that regulate gene expression, including transcription factors (TF...
Viruses have evolved a multitude of mechanisms to combat barriers to productive infection in the host cell. Virally-encoded miRNAs are one such means to regulate host gene expression in ways that bene...
Cellular functions are regulated by signal transduction pathway networks consisting of protein-modifying enzymes that control the activity of many downstream proteins. Protein kinases and phosphatases...
Variation in DNA methylation (DNAm) in adipose tissue is associated with the pathogenesis of obesity and insulin resistance. The activity of enzymes involved in altering DNAm levels is dependent on se...
To understand the role of metabolites as mechanistic regulators of epigenetic marks, we tested the association between selected plasma metabolites and DNAm levels in the adipose tissue of African Amer...
In the AAGMEx cohort (N = 256), plasma levels of metabolites were measured by untargeted liquid chromatography-mass spectrometry; adipose tissue DNAm and transcript levels were measured by reduced rep...
Among the 21 one-carbon metabolism pathway metabolites evaluated, six were associated with gluco-metabolic traits (P...
Our study suggests that a subset of metabolites modulates the methylation levels of CpG sites in specific loci and, in turn, regulates the expression of transcripts involved in obesity and insulin res...
Coronary artery disease (CAD) is the leading cause of death worldwide. Recent meta-analyses of genome-wide association studies have identified over 175 loci associated with CAD. The majority of these ...
We measured gene expression in SMCs isolated from the ascending aortas of 151 heart transplant donors of various genetic ancestries in quiescent or proliferative conditions and calculated the associat...
We identified 4910 expression and 4412 splicing quantitative trait loci (sQTLs) representing regions of the genome associated with transcript abundance and splicing. A total of 3660 expression quantit...
Collectively, our results provide evidence for the molecular mechanisms of genetic susceptibility to CAD in distinct SMC phenotypes....
Cell type- and differentiation-specific gene expression is precisely controlled by genomic non-coding regulatory elements (NCREs), which include promoters, enhancers, silencers and insulators. It is e...
Although gene-expression (GE) and protein levels are typically strongly genetically regulated, their correlation is known to be low. Here we investigate this phenomenon by focusing on the genetic back...
We performed locus-wide association studies of 92 protein levels measured in whole blood for 2,014 samples of European ancestry and found that 66 are genetically regulated. Three female- and one male-...
While total GE and protein levels are only weakly correlated, we found high correlations between their genetically regulated components across multiple tissues. Of note, strong negative causal effects...