questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Métalloprotéines
Protéines de liaison au fer
Protéines à fer non hème
Lipoxygénases
Arachidonate lipoxygenases
Arachidonate lipoxygenases : Questions médicales fréquentes
Termes MeSH sélectionnés :
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Arachidonate lipoxygenases : Questions médicales les plus fréquentes",
"headline": "Arachidonate lipoxygenases : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Arachidonate lipoxygenases : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-01-15",
"dateModified": "2025-04-09",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Arachidonate lipoxygenases"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Lipoxygénases",
"url": "https://questionsmedicales.fr/mesh/D058945",
"about": {
"@type": "MedicalCondition",
"name": "Lipoxygénases",
"code": {
"@type": "MedicalCode",
"code": "D058945",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.556.579.374.568"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Arachidonate 5-lipoxygenase",
"alternateName": "Arachidonate 5-Lipoxygenase",
"url": "https://questionsmedicales.fr/mesh/D001094",
"about": {
"@type": "MedicalCondition",
"name": "Arachidonate 5-lipoxygenase",
"code": {
"@type": "MedicalCode",
"code": "D001094",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.556.579.374.568.500.020"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Arachidonate 12-lipoxygenase",
"alternateName": "Arachidonate 12-Lipoxygenase",
"url": "https://questionsmedicales.fr/mesh/D001092",
"about": {
"@type": "MedicalCondition",
"name": "Arachidonate 12-lipoxygenase",
"code": {
"@type": "MedicalCode",
"code": "D001092",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.556.579.374.568.500.025"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Arachidonate 15-lipoxygenase",
"alternateName": "Arachidonate 15-Lipoxygenase",
"url": "https://questionsmedicales.fr/mesh/D001093",
"about": {
"@type": "MedicalCondition",
"name": "Arachidonate 15-lipoxygenase",
"code": {
"@type": "MedicalCode",
"code": "D001093",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.556.579.374.568.500.030"
}
}
}
],
"about": {
"@type": "MedicalCondition",
"name": "Arachidonate lipoxygenases",
"alternateName": "Arachidonate Lipoxygenases",
"code": {
"@type": "MedicalCode",
"code": "D001091",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Hartmut Kuhn",
"url": "https://questionsmedicales.fr/author/Hartmut%20Kuhn",
"affiliation": {
"@type": "Organization",
"name": "Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany."
}
},
{
"@type": "Person",
"name": "Dagmar Heydeck",
"url": "https://questionsmedicales.fr/author/Dagmar%20Heydeck",
"affiliation": {
"@type": "Organization",
"name": "Department of Biochemistry, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Charitéplatz 1, 10117, Berlin, Germany."
}
},
{
"@type": "Person",
"name": "Deok-Kun Oh",
"url": "https://questionsmedicales.fr/author/Deok-Kun%20Oh",
"affiliation": {
"@type": "Organization",
"name": "Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Republic of Korea. deokkun@konkuk.ac.kr."
}
},
{
"@type": "Person",
"name": "Sabine Stehling",
"url": "https://questionsmedicales.fr/author/Sabine%20Stehling",
"affiliation": {
"@type": "Organization",
"name": "Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany."
}
},
{
"@type": "Person",
"name": "Michael Rothe",
"url": "https://questionsmedicales.fr/author/Michael%20Rothe",
"affiliation": {
"@type": "Organization",
"name": "Lipidomix GmbH, Robert-Rössle-Straße 10, 13125, Berlin, Germany."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Multi-omics profiling of PC-3 cells reveals bufadienolides-induced lipid metabolic remodeling by regulating long-chain lipids synthesis and hydrolysis.",
"datePublished": "2023-01-16",
"url": "https://questionsmedicales.fr/article/36645548",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s11306-022-01968-7"
}
},
{
"@type": "ScholarlyArticle",
"name": "Effects of Red Sorghum-Derived Deoxyanthocyanidins and Their O-β-D-Glucosides on E-Cadherin Promoter Activity in PC-3 Prostate Cancer Cells.",
"datePublished": "2024-04-21",
"url": "https://questionsmedicales.fr/article/38675711",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/molecules29081891"
}
},
{
"@type": "ScholarlyArticle",
"name": "Resveratrol suppresses serum-induced vasculogenic mimicry through impairing the EphA2/twist-VE-cadherin/AKT pathway in human prostate cancer PC-3 cells.",
"datePublished": "2022-11-22",
"url": "https://questionsmedicales.fr/article/36418859",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41598-022-24414-z"
}
},
{
"@type": "ScholarlyArticle",
"name": "The Apoptotic and Anti-Warburg Effects of Brassinin in PC-3 Cells via Reactive Oxygen Species Production and the Inhibition of the c-Myc, SIRT1, and β-Catenin Signaling Axis.",
"datePublished": "2023-09-10",
"url": "https://questionsmedicales.fr/article/37762214",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/ijms241813912"
}
},
{
"@type": "ScholarlyArticle",
"name": "Antiproliferative and Apoptotic Effects of Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and Taperebá (Spondias mombin L.) Extracts in Human Prostate Cell Line (PC-3).",
"datePublished": "2024-04-01",
"url": "https://questionsmedicales.fr/article/38679995",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.31557/APJCP.2024.25.4.1339"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides aminés, peptides et protéines",
"item": "https://questionsmedicales.fr/mesh/D000602"
},
{
"@type": "ListItem",
"position": 3,
"name": "Protéines",
"item": "https://questionsmedicales.fr/mesh/D011506"
},
{
"@type": "ListItem",
"position": 4,
"name": "Métalloprotéines",
"item": "https://questionsmedicales.fr/mesh/D008667"
},
{
"@type": "ListItem",
"position": 5,
"name": "Protéines de liaison au fer",
"item": "https://questionsmedicales.fr/mesh/D033862"
},
{
"@type": "ListItem",
"position": 6,
"name": "Protéines à fer non hème",
"item": "https://questionsmedicales.fr/mesh/D019159"
},
{
"@type": "ListItem",
"position": 7,
"name": "Lipoxygénases",
"item": "https://questionsmedicales.fr/mesh/D058945"
},
{
"@type": "ListItem",
"position": 8,
"name": "Arachidonate lipoxygenases",
"item": "https://questionsmedicales.fr/mesh/D001091"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Arachidonate lipoxygenases - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Arachidonate lipoxygenases",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-11",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Arachidonate lipoxygenases",
"description": "Comment diagnostiquer une dysfonction des lipoxygénases ?\nQuels tests sont utilisés pour évaluer l'activité des lipoxygénases ?\nLes tests génétiques sont-ils utiles pour les lipoxygénases ?\nQuels symptômes peuvent indiquer un problème avec les lipoxygénases ?\nPeut-on mesurer les niveaux de lipoxygénases dans le sang ?",
"url": "https://questionsmedicales.fr/mesh/D001091?mesh_terms=PC-3+Cells&page=2#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Arachidonate lipoxygenases",
"description": "Quels symptômes sont liés à une surproduction de leucotriènes ?\nLes douleurs articulaires peuvent-elles être liées aux lipoxygénases ?\nComment les lipoxygénases affectent-elles la peau ?\nLes allergies peuvent-elles être influencées par les lipoxygénases ?\nQuels signes indiquent une inflammation due aux lipoxygénases ?",
"url": "https://questionsmedicales.fr/mesh/D001091?mesh_terms=PC-3+Cells&page=2#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Arachidonate lipoxygenases",
"description": "Comment prévenir les troubles liés aux lipoxygénases ?\nL'exercice physique influence-t-il les lipoxygénases ?\nLe stress a-t-il un impact sur les lipoxygénases ?\nLes habitudes de vie peuvent-elles influencer les lipoxygénases ?\nLes compléments alimentaires sont-ils bénéfiques pour les lipoxygénases ?",
"url": "https://questionsmedicales.fr/mesh/D001091?mesh_terms=PC-3+Cells&page=2#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Arachidonate lipoxygenases",
"description": "Quels médicaments ciblent les lipoxygénases ?\nLes corticostéroïdes affectent-ils l'activité des lipoxygénases ?\nComment les acides gras oméga-3 influencent-ils les lipoxygénases ?\nLes traitements naturels peuvent-ils aider avec les lipoxygénases ?\nLa thérapie génique est-elle une option pour les troubles des lipoxygénases ?",
"url": "https://questionsmedicales.fr/mesh/D001091?mesh_terms=PC-3+Cells&page=2#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Arachidonate lipoxygenases",
"description": "Quelles complications peuvent survenir avec une dysfonction des lipoxygénases ?\nLes maladies cardiovasculaires sont-elles liées aux lipoxygénases ?\nLes troubles respiratoires peuvent-ils être aggravés par les lipoxygénases ?\nLes troubles métaboliques sont-ils associés aux lipoxygénases ?\nLes cancers peuvent-ils être influencés par les lipoxygénases ?",
"url": "https://questionsmedicales.fr/mesh/D001091?mesh_terms=PC-3+Cells&page=2#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Arachidonate lipoxygenases",
"description": "Quels facteurs de risque sont associés aux troubles des lipoxygénases ?\nL'hérédité joue-t-elle un rôle dans les troubles des lipoxygénases ?\nL'exposition à des polluants affecte-t-elle les lipoxygénases ?\nLe vieillissement influence-t-il l'activité des lipoxygénases ?\nLe stress oxydatif est-il un facteur de risque pour les lipoxygénases ?",
"url": "https://questionsmedicales.fr/mesh/D001091?mesh_terms=PC-3+Cells&page=2#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des lipoxygénases ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur des tests biochimiques et l'analyse des métabolites lipidiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité des lipoxygénases ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests enzymatiques et des dosages de leucotriènes dans le sang sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Les tests génétiques sont-ils utiles pour les lipoxygénases ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests génétiques peuvent identifier des mutations affectant l'activité des lipoxygénases."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec les lipoxygénases ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes d'inflammation chronique, comme l'asthme ou l'arthrite, peuvent survenir."
}
},
{
"@type": "Question",
"name": "Peut-on mesurer les niveaux de lipoxygénases dans le sang ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des analyses sanguines peuvent mesurer les niveaux d'enzymes et de métabolites."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à une surproduction de leucotriènes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surproduction peut entraîner des symptômes respiratoires, comme la dyspnée et la toux."
}
},
{
"@type": "Question",
"name": "Les douleurs articulaires peuvent-elles être liées aux lipoxygénases ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activité anormale des lipoxygénases peut contribuer à l'inflammation articulaire."
}
},
{
"@type": "Question",
"name": "Comment les lipoxygénases affectent-elles la peau ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent jouer un rôle dans des affections cutanées inflammatoires comme l'eczéma."
}
},
{
"@type": "Question",
"name": "Les allergies peuvent-elles être influencées par les lipoxygénases ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les lipoxygénases sont impliquées dans la réponse allergique et l'inflammation."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une inflammation due aux lipoxygénases ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Rougeur, chaleur, gonflement et douleur sont des signes d'inflammation active."
}
},
{
"@type": "Question",
"name": "Comment prévenir les troubles liés aux lipoxygénases ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et riche en oméga-3 peut aider à prévenir l'inflammation."
}
},
{
"@type": "Question",
"name": "L'exercice physique influence-t-il les lipoxygénases ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut réduire l'inflammation et moduler l'activité des lipoxygénases."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur les lipoxygénases ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut augmenter l'inflammation et affecter l'activité des lipoxygénases."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie peuvent-elles influencer les lipoxygénases ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes de vie saines, comme éviter le tabac, peuvent réduire les risques."
}
},
{
"@type": "Question",
"name": "Les compléments alimentaires sont-ils bénéfiques pour les lipoxygénases ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des compléments d'oméga-3 peuvent aider à réguler l'activité des lipoxygénases."
}
},
{
"@type": "Question",
"name": "Quels médicaments ciblent les lipoxygénases ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques des lipoxygénases, comme les anti-inflammatoires, sont utilisés."
}
},
{
"@type": "Question",
"name": "Les corticostéroïdes affectent-ils l'activité des lipoxygénases ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les corticostéroïdes peuvent réduire l'expression des lipoxygénases et l'inflammation."
}
},
{
"@type": "Question",
"name": "Comment les acides gras oméga-3 influencent-ils les lipoxygénases ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les oméga-3 peuvent moduler l'activité des lipoxygénases et réduire l'inflammation."
}
},
{
"@type": "Question",
"name": "Les traitements naturels peuvent-ils aider avec les lipoxygénases ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines plantes médicinales ont des propriétés anti-inflammatoires et peuvent aider."
}
},
{
"@type": "Question",
"name": "La thérapie génique est-elle une option pour les troubles des lipoxygénases ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est en recherche pour corriger des mutations affectant les lipoxygénases."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une dysfonction des lipoxygénases ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des maladies inflammatoires chroniques comme l'asthme et l'arthrite."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles liées aux lipoxygénases ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une activité anormale des lipoxygénases peut contribuer à l'inflammation cardiovasculaire."
}
},
{
"@type": "Question",
"name": "Les troubles respiratoires peuvent-ils être aggravés par les lipoxygénases ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surproduction de leucotriènes peut aggraver des troubles respiratoires comme l'asthme."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils associés aux lipoxygénases ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres dans l'activité des lipoxygénases peuvent être liés à des troubles métaboliques."
}
},
{
"@type": "Question",
"name": "Les cancers peuvent-ils être influencés par les lipoxygénases ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent que les lipoxygénases peuvent jouer un rôle dans la progression tumorale."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés aux troubles des lipoxygénases ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme l'obésité, le tabagisme et une alimentation riche en graisses saturées augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'hérédité joue-t-elle un rôle dans les troubles des lipoxygénases ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies inflammatoires peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "L'exposition à des polluants affecte-t-elle les lipoxygénases ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des polluants environnementaux peut altérer l'activité des lipoxygénases."
}
},
{
"@type": "Question",
"name": "Le vieillissement influence-t-il l'activité des lipoxygénases ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut modifier l'activité des lipoxygénases et augmenter l'inflammation."
}
},
{
"@type": "Question",
"name": "Le stress oxydatif est-il un facteur de risque pour les lipoxygénases ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress oxydatif peut exacerber l'inflammation et affecter l'activité des lipoxygénases."
}
}
]
}
]
}
Lipid metabolism participates in various biological processes such as proliferation, apoptosis, migration, invasion, and maintenance of membrane homeostasis of prostate tumor cells. Bufadienolides, th...
Our study explored the regulatory effects of bufadienolides on lipid metabolism in human prostate carcinoma cells (PC-3)....
Untargeted lipidomics and transcriptomics were combined to study the effect of different bufadienolides interventions on lipid and gene changes of PC-3 cells. The key genes related to lipid metabolism...
Lipidomic analysis showed that the active bufadienolides significantly downregulated the content of long-chain lipids of PC-3 cells. Based on transcriptomic and qPCR analyses, many genes related to li...
All these findings support that bufadienolides might induce lipid metabolic remodeling by regulating long-chain lipids synthesis and phospholipid hydrolysis to achieve an anti-prostate cancer effect, ...
Although much less common than anthocyanins, 3-Deoxyanthocyanidins (3-DAs) and their glucosides can be found in cereals such as red sorghum. It is speculated that their bioavailability is higher than ...
Vasculogenic mimicry (VM) is closely related to cancer progression and metastasis, contributing to poor prognosis in patients with cancer. Resveratrol (RES) is well known to possess anti-cancer activi...
Though Brassinin is known to have antiangiogenic, anti-inflammatory, and antitumor effects in colon, prostate, breast, lung, and liver cancers, the underlying antitumor mechanism of Brassinin is not f...
The present study aimed to evaluate the antiproliferative and apoptotic effects of extracts obtained from the murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and taperebá (Spondias...
Four extract was produced from the pulps: murici aqueous extract (MA), taperebá aqueous extract (TA), murici ethanolic extract (ME) and taperebá ethanolic extract (TE). In the present study, the analy...
The results showed that murici and taperebá extracts proved to be inhibitors of cell growth, modulation of cell cycle promoters and capable of enhancing the death in prostate carcinoma cells PC-3; sug...
These results open a series of perspectives on the use of these bioactive extracts in the prevention and treatment of prostate cancer....
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive phospholipids that act as mitogens in various cancers. Both LPA and S1P activate G-protein coupled receptors (GPCRs). We exa...
For many years, it has been speculated that elevated testosterone levels may be critically involved in the genesis and proliferation of prostate cancer....
The effect of testosterone on the metabolic activity of hormone-independent [PC-3] and hormone-dependent [LNCAP] cancer cells was investigated in vitro. Additionally, the impact of testosterone nanoem...
Despite the dependency of the normal prostate and of most prostatic cancers upon androgens, the obtained results indicate that, contrary to prevailing opinion, the supplementation of testosterone with...
We conclude that the growth of hormone-independent and hormone-dependent prostate cancer cells was reduced by the exposure of a nanoemulsion of bioidentical testostosterone in vitro. To the best of ou...
In this study, a new series of...
The rising incidence of prostate cancer in the U.S. necessitates innovative therapeutic approaches to this disease. Though extensive research has studied Selenium as an anticarcinogen against prostate...
The PC-3 cell line was chosen as a model for its representation of advanced-stage malignancy. Three Se compounds-sodium selenite, methylseleninic acid, and nano-selenium-were selected for their promis...
Absolute IC...
The specific form of Selenium plays a pivotal role in determining its physiological effects and therapeutic potential against prostate cancer. All three selenium compounds showed variable antineoplast...
Prostate cancer (PC) prevention is effectively achieved through its inhibition. Oridonin (ORD), an active diterpenoid isolated from Rabdosia rubescens, has been shown to have an inhibitory effect on P...
The present work investigated the actions and probable mechanisms of ORD on cellular proliferation, apoptosis, PC, and the wingless-type MMTV integration site family member 2 (Wnt)/β-catenin signaling...
In this study, cell viability was analyzed with MTT assay method, apoptotic morphology determined using DAPI dye method, while protein (CD1333, OCT-4, Nanog, SOX-2 & Aldh1A1) and mRNA expressions were...
We demonstrated a concentration-dependent ORD inhibition of PC-3 cell proliferation and inhibition of induction apoptosis. Furthermore, ORD decreased PC-3 Wnt-2, phosphorylated glycogen synthase kinas...
Oridonin inhibited proliferation and induced apoptosis in PC-3 cells, with the findings suggesting that it acted via the Wnt/β-catenin pathway to exert its effects. This study demonstrates that ORD ma...