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"description": "Quelles complications peuvent résulter d'une biodisponibilité élevée ?\nUne biodisponibilité faible peut-elle causer des complications ?\nComment les complications sont-elles liées à la biodisponibilité ?\nLes complications peuvent-elles être évitées par une bonne biodisponibilité ?\nQuels sont les risques de surdosage liés à la biodisponibilité ?",
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"description": "Quels facteurs augmentent le risque d'une biodisponibilité faible ?\nLe tabagisme affecte-t-il la biodisponibilité ?\nLes maladies chroniques influencent-elles la biodisponibilité ?\nL'âge influence-t-il la biodisponibilité ?\nLes habitudes alimentaires affectent-elles la biodisponibilité ?",
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"@type": "Question",
"name": "Comment évaluer la biodisponibilité d'un médicament ?",
"position": 1,
"acceptedAnswer": {
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"text": "On utilise des études pharmacocinétiques pour mesurer la concentration dans le sang."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour mesurer la biodisponibilité ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins et des études de bioéquivalence sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "La biodisponibilité est-elle la même pour tous les médicaments ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle varie selon la voie d'administration et la formulation du médicament."
}
},
{
"@type": "Question",
"name": "Quels facteurs influencent la biodisponibilité ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'alimentation, le pH gastrique et la présence d'autres médicaments peuvent l'affecter."
}
},
{
"@type": "Question",
"name": "Comment la biodisponibilité est-elle mesurée ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est mesurée par le rapport entre la concentration plasmatique et la dose administrée."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une faible biodisponibilité ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes d'inefficacité du traitement, comme la persistance de la maladie."
}
},
{
"@type": "Question",
"name": "Peut-on ressentir des effets secondaires d'une biodisponibilité élevée ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une biodisponibilité élevée peut entraîner des effets secondaires plus marqués."
}
},
{
"@type": "Question",
"name": "Comment la biodisponibilité affecte-t-elle les symptômes ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une biodisponibilité insuffisante peut retarder la réponse thérapeutique et aggraver les symptômes."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon la voie d'administration ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier selon que le médicament est pris par voie orale ou intraveineuse."
}
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{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer une surdose liée à la biodisponibilité ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes tels que nausées, vertiges ou confusion peuvent indiquer une surdose."
}
},
{
"@type": "Question",
"name": "Comment prévenir une biodisponibilité faible ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "En respectant les recommandations d'administration et en évitant les interactions médicamenteuses."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle la biodisponibilité ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains aliments peuvent augmenter ou diminuer la biodisponibilité des médicaments."
}
},
{
"@type": "Question",
"name": "Quelles habitudes de vie favorisent une bonne biodisponibilité ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une hydratation adéquate et une alimentation équilibrée peuvent favoriser une bonne biodisponibilité."
}
},
{
"@type": "Question",
"name": "Les médicaments doivent-ils être pris à jeun ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cela dépend du médicament; certains nécessitent d'être pris à jeun pour une meilleure biodisponibilité."
}
},
{
"@type": "Question",
"name": "Comment éviter les interactions médicamenteuses ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "En consultant un professionnel de santé avant de prendre plusieurs médicaments simultanément."
}
},
{
"@type": "Question",
"name": "Comment améliorer la biodisponibilité d'un médicament ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "On peut utiliser des formulations spécifiques ou des co-administrations pour l'optimiser."
}
},
{
"@type": "Question",
"name": "Quels traitements augmentent la biodisponibilité ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements sous forme injectable ont généralement une biodisponibilité plus élevée."
}
},
{
"@type": "Question",
"name": "Les médicaments à libération prolongée affectent-ils la biodisponibilité ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent améliorer la biodisponibilité en libérant le principe actif sur une période prolongée."
}
},
{
"@type": "Question",
"name": "Comment la biodisponibilité influence-t-elle le choix du traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle guide le choix de la voie d'administration et la posologie pour maximiser l'efficacité."
}
},
{
"@type": "Question",
"name": "Les suppléments nutritionnels affectent-ils la biodisponibilité ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains suppléments peuvent interagir et modifier la biodisponibilité des médicaments."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent résulter d'une biodisponibilité élevée ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une biodisponibilité élevée peut entraîner des effets indésirables graves ou une toxicité."
}
},
{
"@type": "Question",
"name": "Une biodisponibilité faible peut-elle causer des complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner un échec thérapeutique et des complications liées à la maladie."
}
},
{
"@type": "Question",
"name": "Comment les complications sont-elles liées à la biodisponibilité ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications surviennent souvent lorsque la concentration du médicament est insuffisante ou excessive."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être évitées par une bonne biodisponibilité ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une biodisponibilité adéquate peut réduire le risque de complications liées au traitement."
}
},
{
"@type": "Question",
"name": "Quels sont les risques de surdosage liés à la biodisponibilité ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un surdosage peut survenir si la biodisponibilité est trop élevée, entraînant des effets toxiques."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'une biodisponibilité faible ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge, les maladies gastro-intestinales et les interactions médicamenteuses peuvent l'augmenter."
}
},
{
"@type": "Question",
"name": "Le tabagisme affecte-t-il la biodisponibilité ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut modifier le métabolisme des médicaments, affectant leur biodisponibilité."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques influencent-elles la biodisponibilité ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le diabète ou l'insuffisance hépatique peuvent altérer la biodisponibilité."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il la biodisponibilité ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir une biodisponibilité modifiée en raison de changements physiologiques."
}
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{
"@type": "Question",
"name": "Les habitudes alimentaires affectent-elles la biodisponibilité ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en graisses ou en fibres peut influencer la biodisponibilité des médicaments."
}
}
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Developmental language disorder (DLD) is a lifelong condition that when impacting educational performance is identified and serviced through U.S. schools as outlined in the Individuals with Disabiliti...
We analyzed publicly available data released by the U.S. Department of Education from six school years between 2010 and 2020. We examined the use of S/LI and SLD categories across students of differen...
We present a trend in which younger students tend to be identified with the S/LI category, whereas older students tend to be identified with the SLD category. This trend is evident in all 6 years of d...
We discuss these findings in the context of research on language disorders to explain this trend. We highlight the potential damaging effects of using inconsistent terminology, including affecting the...
The Health of the Nation Outcome Scales for People with Learning Disabilities (HoNOS-LD) is one of the most used outcome measures in learning disability services in the United Kingdom. There is relati...
A data set of HoNOS-LD scales from 571 people with learning disabilities was randomly split into two halves. Exploratory Mokken analysis was applied to the first dataset, and confirmatory scale factor...
Two-factor and three-factor solutions were explored in the Mokken analysis, with the three-factor option having somewhat better characteristics. One-factor, three-factor and seven-factor solutions wer...
The HoNOS-LD is best conceptualised as consisting of three scales, accounting for 14 items that can be labelled as 'Cognitive and Physical Functioning', 'Behaviour and Mood Disturbances' and 'Function...
The COVID-19 pandemic has had disproportionate impact on vulnerable populations including those with learning disabilities. Assessing the incidence and risk of death in such settings can improve the p...
Surveillance records for COVID-19 infections in England from 02 February 2020 to 31 March 2022 were extracted. Data on property type, variant wave, vaccination, hospitalisation and death were derived ...
A total of 3501 individuals were identified as diagnosed with SARS-CoV-2 whilst living in 632 care home properties for learning disabilities and/or autism. Of the 3686 episodes of infection, 80.4% wer...
Care home residents with learning disabilities and/or autism have a greater risk of death from COVID-19. Optimising guidance to meet their needs is of great importance....
Studies have shown that young maternal age at childbirth can increase the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, but a study of the U.S. population has not been reported...
This study evaluated the association between young and advanced maternal age at childbirth and offspring risk of ADHD and LD in the U.S. population. Using data from 8,098 participants included in the ...
Among all participants, the offspring of subjects with a maternal age at childbirth of 18-24 years had an increased risk of ADHD (OR = 1.34, 95% CI: 1.01, 1.79) and LD (OR = 1.36, 95% CI: 1.06, 1.79) ...
These results provide epidemiological evidence showing that young and advanced maternal age at childbirth are associated with ADHD and LD risk....
The Health of the Nation Outcomes Scales for people with Learning Disabilities (HoNOS-LD) is an 18-item measure which provides a structured and standardized approach to rating various clinical and psy...
To revise and improve the HoNOS-LD's utility in contemporary intellectual disability (ID) services whilst retaining its original objectives and five-point severity ratings....
ID clinicians were invited to complete an online survey, rating each item on the existing measure for being fit for purpose, identifying issues and suggesting improvements based on their experience of...
A total of 75 individuals replied. Respondents had used HoNOS-LD for an average of 8.0 years (...
The changes outlined in this paper are based on the advisory group's expert consensus. These changes are intended to improve reliability and validity but now need empirical testing as well as review b...
Substantial progress has been made in defining children with nonverbal learning disability (NLD), but longitudinal studies are still lacking. To start filling this gap, we examined changes in general ...
Women with learning disabilities are less likely to breastfeed than other women. They may find it hard to understand or learn feeding techniques or know that they have infant feeding choices. This pop...
The use of restrictive practices has significant adverse effects on the individual, care providers and organisations. This review will describe how, why, for whom, and in what circumstances approaches...
Evidence from the literature will be synthesised using a realist review approach - an interpretative, theory-driven approach to understand how complex healthcare approaches work in reducing the use of...
Findings will be used to provide recommendations for practice and policymaking....
In accordance with the guidelines, this realist review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 4th December 2019 (CRD42019158432)....
This study used data from a national birth cohort study to investigate the duration of internet use at the age of 12 years among children diagnosed with attention-deficit/hyperactivity disorder (ADHD)...
The 5.5- and 12-year-old Taiwan Birth Cohort Study dataset was used (N = 17,694)....
More boys were diagnosed with LDs, IDs, ADHD and ASD; however, girls were at increased likelihood of PIU. ID and ASD diagnoses were not associated with increasing PIU likelihood. However, children who...
Dissociative absorption was found to be a mediating factor between childhood diagnosis and PIU and can be used as a screening indicator in prevention programs to reduce the duration and severity of PI...
Limited evidence exists concerning how a diagnosis of attention-deficit hyperactivity disorder and/or learning disabilities (ADHD/LD) modifies recovery and behavior following sport-related concussion ...