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"description": "Comment diagnostiquer une carence en biotine ?\nQuels sont les signes cliniques d'une carence ?\nLes tests génétiques sont-ils utiles ?\nQuelle est la méthode de dépistage recommandée ?\nPeut-on diagnostiquer par des symptômes seuls ?",
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"@type": "Question",
"name": "Comment diagnostiquer une carence en biotine ?",
"position": 1,
"acceptedAnswer": {
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"text": "Le diagnostic se fait par des tests sanguins mesurant les niveaux de biotine."
}
},
{
"@type": "Question",
"name": "Quels sont les signes cliniques d'une carence ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les signes incluent fatigue, dépression, éruptions cutanées et perte de cheveux."
}
},
{
"@type": "Question",
"name": "Les tests génétiques sont-ils utiles ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent identifier des troubles métaboliques liés à la biotine."
}
},
{
"@type": "Question",
"name": "Quelle est la méthode de dépistage recommandée ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un dosage de la biotine dans le sérum est la méthode standard de dépistage."
}
},
{
"@type": "Question",
"name": "Peut-on diagnostiquer par des symptômes seuls ?",
"position": 5,
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}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une carence en biotine ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, dépression, éruptions cutanées et troubles neurologiques."
}
},
{
"@type": "Question",
"name": "La perte de cheveux est-elle un symptôme ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la perte de cheveux est un symptôme courant d'une carence en biotine."
}
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{
"@type": "Question",
"name": "Y a-t-il des symptômes digestifs ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme des nausées et des douleurs abdominales peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les troubles de l'humeur sont-ils liés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la dépression et l'irritabilité peuvent être des symptômes de carence."
}
},
{
"@type": "Question",
"name": "Les éruptions cutanées sont-elles fréquentes ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des éruptions cutanées, souvent rouges et squameuses, sont fréquentes."
}
},
{
"@type": "Question",
"name": "Comment prévenir une carence en biotine ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée incluant des aliments riches en biotine aide à prévenir la carence."
}
},
{
"@type": "Question",
"name": "Les personnes à risque doivent-elles se supplémenter ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes à risque, comme les femmes enceintes, devraient envisager des suppléments."
}
},
{
"@type": "Question",
"name": "Les régimes restrictifs augmentent-ils le risque ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les régimes très restrictifs peuvent augmenter le risque de carence en biotine."
}
},
{
"@type": "Question",
"name": "Les antibiotiques affectent-ils la biotine ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains antibiotiques peuvent perturber l'absorption de la biotine."
}
},
{
"@type": "Question",
"name": "Les aliments transformés sont-ils un risque ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les aliments transformés peuvent être pauvres en biotine et augmenter le risque."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en biotine ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement consiste en des suppléments de biotine et des modifications alimentaires."
}
},
{
"@type": "Question",
"name": "Quels aliments sont riches en biotine ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les œufs, les noix, le soja et les légumes à feuilles vertes sont riches en biotine."
}
},
{
"@type": "Question",
"name": "Les suppléments sont-ils nécessaires ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, dans les cas de carence, des suppléments peuvent être nécessaires."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires aux suppléments ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires sont rares, mais peuvent inclure des troubles gastro-intestinaux."
}
},
{
"@type": "Question",
"name": "Combien de temps dure le traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut durer plusieurs semaines, selon la gravité de la carence."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles neurologiques et des problèmes cutanés graves."
}
},
{
"@type": "Question",
"name": "La carence peut-elle affecter le développement ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, chez les enfants, une carence peut affecter le développement physique et mental."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications à long terme ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence prolongée peut entraîner des problèmes de santé chroniques."
}
},
{
"@type": "Question",
"name": "Les troubles mentaux sont-ils possibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles mentaux comme la dépression peuvent être exacerbés par une carence."
}
},
{
"@type": "Question",
"name": "Les complications cutanées sont-elles fréquentes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des complications cutanées comme des infections peuvent survenir en cas de carence."
}
},
{
"@type": "Question",
"name": "Qui est à risque de carence en biotine ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes ayant une alimentation déséquilibrée ou des troubles digestifs sont à risque."
}
},
{
"@type": "Question",
"name": "Les femmes enceintes sont-elles plus à risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les femmes enceintes ont des besoins accrus en biotine et peuvent être à risque."
}
},
{
"@type": "Question",
"name": "Les personnes âgées sont-elles vulnérables ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir des carences en raison d'une absorption réduite."
}
},
{
"@type": "Question",
"name": "Les végétariens sont-ils à risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les végétariens peuvent être à risque s'ils ne consomment pas d'aliments riches en biotine."
}
},
{
"@type": "Question",
"name": "Les personnes avec des troubles métaboliques sont-elles à risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains troubles métaboliques peuvent affecter l'absorption de la biotine."
}
}
]
}
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Fine-needle aspiration cytology (FNAC) specimens are widely utilized for the diagnosis and molecular testing of various cancers. We performed a comparative proteomic analysis of three different sample...
High-throughput proteomic analysis was conducted on matched FNAC, CNB, and surgical resection tissue samples obtained from breast cancer patients. The protein identification, including currently estab...
Compared to tissue samples, FNAC testing revealed a comparable number of proteins (7,179 in FNAC; 7,196 in CNB; 7,190 in resection samples). Around 85% of proteins were mutually identified in all samp...
FNAC is suitable for high-throughput proteomic analysis, in addition to an emerging source that could be used to identify and quantify novel cancer biomarkers....
This study aimed to determine the difference in prostate volume (PV) derived from transrectal ultrasound (TRUS) and multiparametric magnetic resonance imaging (mpMRI), and to further investigate the r...
Patients who underwent an initial prostate biopsy within 3 mo after mpMRI between January 2016 and December 2021 were analyzed retrospectively. The sensitivity, specificity, positive predictive value ...
The median prostate-specific antigen level of 875 patients was 9.79 (interquartile range [IQR]: 7.09-13.50) ng/ml. The median mpMRI-PV and TRUS-PV were 41.92 (IQR: 29.29-60.73) and 41.04 (IQR: 29.24-5...
TRUS-PV and MRI-PV exhibited a strong linear correlation and reached sufficient agreement. The efficiency of TRUS-PSAD and mpMRI-PSAD for PCa detection was comparable. TRUS could be used for PV estima...
In this work, prostate volume (PV) derived from transrectal ultrasound (TRUS) exhibited a strong linear correlation with the PV derived from multiparametric magnetic resonance imaging (mpMRI). The eff...
This study aimed to assess the diagnostic value of human epididymal protein 4 (HE4), a potential novel biomarker for lung cancer, and its combined detection with five other conventional biomarkers in ...
In this retrospective study, 115 lung cancer patients, 50 patients with benign pulmonary disease, and 50 healthy controls were included. Serum HE4, progastrin-releasing peptide (ProGRP), squamous cell...
All six biomarkers showed significantly elevated levels in the lung cancer group compared to both benign pulmonary disease and control groups (...
HE4 and its combined detection held substantial clinical significance in the diagnosis of lung cancer and its histologic subtyping, especially for lung adenocarcinoma and lung squamous cell carcinoma....
Tumor budding refers to a cluster of one to four tumor cells located at the tumor-invasive front. While tumor budding is a prognostic factor for colorectal cancer, counting and grading tumor budding a...
To compare the diagnostic performance of 40 keV and 70 keV virtual monoenergetic images (VMIs) generated from dual-energy CT in the detection of pancreatic cancer....
This retrospective study included patients who underwent pancreatic protocol dual-energy CT from January 2019 to August 2022. Four radiologists (1-11 years of experience), who were blinded to the fina...
Overall, 137 patients (median age, 71 years; interquartile range, 63-78 years; 77 men) were included. Among them, 62 patients (45%) had pathologically proven pancreatic cancer. The 40 keV VMIs had hig...
The 40 keV VMIs showed better diagnostic performance in diagnosing pancreatic cancer than the 70 keV VMIs, along with higher reader confidence....
Surface-enhanced Raman scattering (SERS) technology have unique advantages of rapid, simple, and highly sensitive in the detection of serum, it can be used for the detection of liver cancer. However, ...
Serum samples were collected from 60 patients with liver cancer (27 patients with stage T1 and T2 liver cancer, 33 patients with stage T3 and T4 liver cancer) and 40 healthy volunteers. Herein, immuno...
The experimental results show that the serum LAPs SERS detection combined with multivariate statistical algorithms can be used for effectively distinguishing liver cancer patients from healthy volunte...
This study investigated the potential ability of the fluorescent probe Ly-CHO to detect formaldehyde (FA) in living cells and tumor-bearing mice. Ly-CHO exhibited great selectivity, excellent sensitiv...
A 62-year-old woman with follicular thyroid cancer who had received total thyroidectomy and multiple rounds of radioactive iodine therapy underwent both 18F-FDG and 18F-FAPI PET/CT. 18F-FAPI PET faile...
Prostate cancer is one of the most common malignancies affecting elderly men worldwide and the fifth leading cause of cancer death in men. Prostate cancer includes many histological variants with the ...
Cerebrospinal fluid (CSF) has revealed the unique genetic characteristics of leptomeningeal metastasis (LM) from non-small cell lung cancer (NSCLC). However, the research in this area is still very li...
Patients with LM from NSCLC (n = 80) were retrospectively analyzed. Circulating tumor DNA (ctDNA) in CSF was tested by next-generation sequencing (NGS), with paired extracranial tissue or plasma sampl...
An overwhelming 93.8% of patients carried druggable mutations in NSCLC LM, with EGFR (78.8%) being the most prevalent. Notably, 4 patients who tested negative for driver genes in extracranial samples ...
CSF-based ctDNA analysis is crucial for detecting and characterizing genetic alterations in NSCLC LM. The distinct genetic profiles in CSF and extracranial tissues emphasize the need for personalized ...