Titre : Désalkylation

Désalkylation : Questions médicales fréquentes

Termes MeSH sélectionnés :

Randomized Controlled Trials as Topic
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Désalkylation : Questions médicales les plus fréquentes", "headline": "Désalkylation : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Désalkylation : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-05-28", "dateModified": "2025-02-22", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Désalkylation" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Métabolisme", "url": "https://questionsmedicales.fr/mesh/D008660", "about": { "@type": "MedicalCondition", "name": "Métabolisme", "code": { "@type": "MedicalCode", "code": "D008660", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "G03" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Déméthylation", "alternateName": "Demethylation", "url": "https://questionsmedicales.fr/mesh/D000073398", "about": { "@type": "MedicalCondition", "name": "Déméthylation", "code": { "@type": "MedicalCode", "code": "D000073398", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "G03.219.500" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Déméthylation de l'ADN", "alternateName": "DNA Demethylation", "url": "https://questionsmedicales.fr/mesh/D000073399", "about": { "@type": "MedicalCondition", "name": "Déméthylation de l'ADN", "code": { "@type": "MedicalCode", "code": "D000073399", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "G03.219.500.500" } } } ] } ], "about": { "@type": "MedicalCondition", "name": "Désalkylation", "alternateName": "Dealkylation", "code": { "@type": "MedicalCode", "code": "D003640", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Michael R Baldwin", "url": "https://questionsmedicales.fr/author/Michael%20R%20Baldwin", "affiliation": { "@type": "Organization", "name": "Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600." } }, { "@type": "Person", "name": "Suzanne J Admiraal", "url": "https://questionsmedicales.fr/author/Suzanne%20J%20Admiraal", "affiliation": { "@type": "Organization", "name": "Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600." } }, { "@type": "Person", "name": "Patrick J O'Brien", "url": "https://questionsmedicales.fr/author/Patrick%20J%20O%27Brien", "affiliation": { "@type": "Organization", "name": "Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600. Electronic address: pjobrien@umich.edu." } }, { "@type": "Person", "name": "Yusuke Suzuki", "url": "https://questionsmedicales.fr/author/Yusuke%20Suzuki", "affiliation": { "@type": "Organization", "name": "Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan." } }, { "@type": "Person", "name": "Takafumi Naito", "url": "https://questionsmedicales.fr/author/Takafumi%20Naito", "affiliation": { "@type": "Organization", "name": "Department of Hospital Pharmacy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka, 431-3192, Japan. naitou@shinshu-u.ac.jp." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "PGT-A: The biology and hidden failures of randomized control trials.", "datePublished": "2022-07-25", "url": "https://questionsmedicales.fr/article/35765263", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1002/pd.6199" } }, { "@type": "ScholarlyArticle", "name": "Statistical Power of Randomized Controlled Trials in Trauma Surgery.", "datePublished": "2023-07-07", "url": "https://questionsmedicales.fr/article/37417653", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1097/XCS.0000000000000800" } }, { "@type": "ScholarlyArticle", "name": "Predictors of premature termination and completion of randomized controlled trials.", "datePublished": "2023-05-06", "url": "https://questionsmedicales.fr/article/37156372", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.cct.2023.107219" } }, { "@type": "ScholarlyArticle", "name": "Parachutes, randomized controlled trials, and all-cause mortality.", "datePublished": "2022-11-25", "url": "https://questionsmedicales.fr/article/36434291", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1007/s40656-022-00551-6" } }, { "@type": "ScholarlyArticle", "name": "Assessing transparency practices in dental randomized controlled trials.", "datePublished": "2024-08-24", "url": "https://questionsmedicales.fr/article/39182028", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s12874-024-02316-0" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Métabolisme", "item": "https://questionsmedicales.fr/mesh/D008660" }, { "@type": "ListItem", "position": 3, "name": "Désalkylation", "item": "https://questionsmedicales.fr/mesh/D003640" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Désalkylation - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Désalkylation", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-08", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Désalkylation", "description": "Comment diagnostiquer une désalkylation ?\nQuels tests sont utilisés pour la désalkylation ?\nQuels signes indiquent une désalkylation ?\nLa désalkylation est-elle détectable par imagerie ?\nQuels marqueurs sont associés à la désalkylation ?", "url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Désalkylation", "description": "Quels symptômes sont liés à la désalkylation ?\nLa désalkylation provoque-t-elle des effets neurologiques ?\nY a-t-il des symptômes cutanés associés ?\nLa désalkylation affecte-t-elle le foie ?\nQuels signes de toxicité sont observés ?", "url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Désalkylation", "description": "Comment prévenir la désalkylation ?\nLes contrôles médicaux aident-ils à prévenir la désalkylation ?\nL'éducation des patients est-elle importante ?\nLes changements de mode de vie aident-ils ?\nLes professionnels de santé jouent-ils un rôle ?", "url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Désalkylation", "description": "Quel traitement pour une désalkylation toxique ?\nLes médicaments peuvent-ils aider à la désalkylation ?\nComment gérer les symptômes de désalkylation ?\nY a-t-il des traitements préventifs ?\nLa désalkylation nécessite-t-elle une hospitalisation ?", "url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Désalkylation", "description": "Quelles complications peuvent survenir ?\nLa désalkylation peut-elle entraîner des maladies chroniques ?\nY a-t-il des risques de surdosage ?\nLes complications sont-elles réversibles ?\nComment surveiller les complications ?", "url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Désalkylation", "description": "Quels sont les facteurs de risque de désalkylation ?\nL'âge influence-t-il le risque de désalkylation ?\nLes habitudes alimentaires affectent-elles le risque ?\nLe tabagisme est-il un facteur de risque ?\nLes maladies préexistantes influencent-elles le risque ?", "url": "https://questionsmedicales.fr/mesh/D003640?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une désalkylation ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur des tests biochimiques et des analyses de sang pour évaluer les métabolites." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour la désalkylation ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de toxicologie et des analyses enzymatiques sont couramment utilisés." } }, { "@type": "Question", "name": "Quels signes indiquent une désalkylation ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des signes cliniques comme des anomalies hépatiques peuvent indiquer une désalkylation." } }, { "@type": "Question", "name": "La désalkylation est-elle détectable par imagerie ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Non, la désalkylation est généralement évaluée par des tests biochimiques, pas par imagerie." } }, { "@type": "Question", "name": "Quels marqueurs sont associés à la désalkylation ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Les marqueurs comme les enzymes hépatiques peuvent être augmentés lors de la désalkylation." } }, { "@type": "Question", "name": "Quels symptômes sont liés à la désalkylation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent inclure des nausées, des vomissements et des douleurs abdominales." } }, { "@type": "Question", "name": "La désalkylation provoque-t-elle des effets neurologiques ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des effets neurologiques comme des vertiges peuvent survenir en cas de désalkylation." } }, { "@type": "Question", "name": "Y a-t-il des symptômes cutanés associés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des éruptions cutanées peuvent apparaître en raison de réactions aux métabolites de désalkylation." } }, { "@type": "Question", "name": "La désalkylation affecte-t-elle le foie ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des anomalies hépatiques et une hépatotoxicité." } }, { "@type": "Question", "name": "Quels signes de toxicité sont observés ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des signes de toxicité incluent fatigue, confusion et jaunisse dans les cas graves." } }, { "@type": "Question", "name": "Comment prévenir la désalkylation ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Éviter l'exposition à des substances chimiques et suivre les prescriptions médicales aide." } }, { "@type": "Question", "name": "Les contrôles médicaux aident-ils à prévenir la désalkylation ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des contrôles réguliers peuvent détecter des problèmes avant qu'ils ne deviennent graves." } }, { "@type": "Question", "name": "L'éducation des patients est-elle importante ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, informer les patients sur les risques des médicaments et des toxines est crucial." } }, { "@type": "Question", "name": "Les changements de mode de vie aident-ils ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Adopter un mode de vie sain peut réduire le risque de désalkylation et de complications." } }, { "@type": "Question", "name": "Les professionnels de santé jouent-ils un rôle ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les professionnels de santé doivent surveiller les interactions médicamenteuses et les risques." } }, { "@type": "Question", "name": "Quel traitement pour une désalkylation toxique ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement peut inclure des soins de soutien et des antidotes spécifiques selon le toxique." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils aider à la désalkylation ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments peuvent faciliter le métabolisme et l'élimination des toxines." } }, { "@type": "Question", "name": "Comment gérer les symptômes de désalkylation ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La gestion des symptômes inclut des antiémétiques et des analgésiques pour le confort." } }, { "@type": "Question", "name": "Y a-t-il des traitements préventifs ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Éviter les substances toxiques et surveiller les médicaments peut prévenir la désalkylation." } }, { "@type": "Question", "name": "La désalkylation nécessite-t-elle une hospitalisation ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Cela dépend de la gravité des symptômes et de l'exposition aux toxines, parfois nécessaire." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des lésions hépatiques, des troubles neurologiques et des réactions allergiques." } }, { "@type": "Question", "name": "La désalkylation peut-elle entraîner des maladies chroniques ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une désalkylation sévère peut contribuer à des maladies chroniques comme la cirrhose." } }, { "@type": "Question", "name": "Y a-t-il des risques de surdosage ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un surdosage de substances pouvant subir désalkylation peut être fatal." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement précoce, d'autres non." } }, { "@type": "Question", "name": "Comment surveiller les complications ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "La surveillance clinique et les tests de laboratoire réguliers sont essentiels pour détecter les complications." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque de désalkylation ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent l'exposition à des toxines, l'usage de certains médicaments et des antécédents hépatiques." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de désalkylation ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes âgées peuvent avoir un risque accru en raison d'une fonction hépatique diminuée." } }, { "@type": "Question", "name": "Les habitudes alimentaires affectent-elles le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation riche en toxines ou en médicaments peut augmenter le risque de désalkylation." } }, { "@type": "Question", "name": "Le tabagisme est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut augmenter le risque de désalkylation en raison de l'exposition à des substances nocives." } }, { "@type": "Question", "name": "Les maladies préexistantes influencent-elles le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme l'hépatite ou la cirrhose augmentent le risque de désalkylation." } } ] } ] }

Sources (10000 au total)

PGT-A: The biology and hidden failures of randomized control trials.

Preimplantation Genetic Testing - Aneuploidy (PGT-A) for embryo selection has undergone significant advancements in the last 2 decades and yet many studies still fail to demonstrate any clinical benef... All suitable blastocysts were biopsied and analyzed for chromosome copy number. Outcomes (positive beta hCG, implantation, ongoing pregnancy, and live birth rates) for Eu-S were compared to Mo-S using... Compared to Eu-S embryos, Mo-S embryos resulted in significant reduction of outcomes for positive beta hCG (p = 0.0005), implantation (p = 0.0008), ongoing pregnancy (p = 0.0046), livebirth (p = 0.011... Embryo chromosome status is central to improved embryo transfer outcomes and sole reliance on current morphology-based selection practices, without Eu-S, will always compromise outcomes. Often overloo...

Statistical Power of Randomized Controlled Trials in Trauma Surgery.

Our purpose was to conduct a bibliometric study investigating the prevalence of underpowered randomized controlled trials (RCTs) in trauma surgery.... A medical librarian conducted a search of RCTs in trauma published from 2000 to 2021. Data extracted included study type, sample size calculation, and power analyses. Post hoc calculations were perfor... In total 187 RCTs from multiple continents and 60 journals were examined. A total of 133 (71%) were found to have "positive" findings consistent with their hypothesis. When evaluating their methods, 5... A concerningly large proportion of recently published RCTs in trauma surgery do not report a priori sample size calculations, do not meet enrollment targets, and are not adequately powered to detect e...

Assessing transparency practices in dental randomized controlled trials.

To evaluate transparency practices in randomized controlled trials (RCTs) in dentistry.... This meta-research study included RCTs in dentistry regardless of topic, methods, or level of detail reported. Only studies in English were considered. We searched PubMed for RCTs in dentistry publish... A total of 844 RCTs were included. Only 12.86% of studies reported any information about data and code sharing. Protocol registration was reported for 50.36% of RCTs. Conflict of interest (83.41%) and... Considering the importance of RCTs for evidence-based dentistry, it is crucial that everyone who participates in the scientific production and dissemination process actively and consistently promotes ...

The Fragility Index of randomized controlled trials in pediatric anesthesiology.

The P value is a widely used measure of statistical importance but has many drawbacks and limitations, one being that it does not reflect the robustness of the results of a clinical trial. The Fragili... We conducted a comprehensive systematic search of high-impact anesthesia, surgical, and medical journals from the last 25 years for trials comparing an intervention between two groups with a statistic... The median [interquartile range] FI was 3 [1-7] and correlated positively with the number of participants (r... The FI of published trials in pediatric anesthesiology is similarly low as in other medical specialties. Larger trials with more events and P values ≤ 0.01 were associated with a higher FI....

Reproducing Statistics Performed in Published Randomized Controlled Trials.

Randomized controlled trials (RCT) represent evidence at the lowest potential risk for bias. Clinicians in all specialties depend upon RCTs to guide patient care. Issues such as statistical discordanc... PubMed was searched using "randomized controlled trial." Studies were selected using a random number generator. Studies were included if the primary outcome could be reproduced using the data and stat... Overall, 572 RCTs were selected involving six specialties. Of these, 45% were positive (p<0.05) studies. Eleven (2%) published results that differed from the reproduction analysis and crossed the p=0.... Less than 5% of published RCTs reported a discordant p-value that crossed the "p=0.05" threshold. Although the occurrence is uncommon, the existence of even one RCT publishing nonreproducible results ...