{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Desmosomes : Questions médicales les plus fréquentes",
"headline": "Desmosomes : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Desmosomes : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-02-01",
"dateModified": "2025-04-26",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Desmosomes"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Jonctions intercellulaires",
"url": "https://questionsmedicales.fr/mesh/D007365",
"about": {
"@type": "MedicalCondition",
"name": "Jonctions intercellulaires",
"code": {
"@type": "MedicalCode",
"code": "D007365",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A11.284.149.165.420"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Desmosomes",
"alternateName": "Desmosomes",
"code": {
"@type": "MedicalCode",
"code": "D003896",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Kathleen J Green",
"url": "https://questionsmedicales.fr/author/Kathleen%20J%20Green",
"affiliation": {
"@type": "Organization",
"name": "Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA."
}
},
{
"@type": "Person",
"name": "Jens Waschke",
"url": "https://questionsmedicales.fr/author/Jens%20Waschke",
"affiliation": {
"@type": "Organization",
"name": "Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany."
}
},
{
"@type": "Person",
"name": "Andrew P Kowalczyk",
"url": "https://questionsmedicales.fr/author/Andrew%20P%20Kowalczyk",
"affiliation": {
"@type": "Organization",
"name": "Department of Dermatology, Penn State College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA."
}
},
{
"@type": "Person",
"name": "Franziska Vielmuth",
"url": "https://questionsmedicales.fr/author/Franziska%20Vielmuth",
"affiliation": {
"@type": "Organization",
"name": "Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich, Germany."
}
},
{
"@type": "Person",
"name": "Camilla Schinner",
"url": "https://questionsmedicales.fr/author/Camilla%20Schinner",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedicine, University of Basel, Basel, Switzerland."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity.",
"datePublished": "2024-01-28",
"url": "https://questionsmedicales.fr/article/38281933",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12933-023-02099-6"
}
},
{
"@type": "ScholarlyArticle",
"name": "Secondary Carnitine Deficiency in Neonates and Infants Requiring Surgery for Intestinal Obstructions-An Underestimated and Undermanaged Problem.",
"datePublished": "2024-01-24",
"url": "https://questionsmedicales.fr/article/38397259",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/children11020147"
}
},
{
"@type": "ScholarlyArticle",
"name": "5,10-methenyltetrahydrofolate synthetase deficiency: An extreme rare defect of folate metabolism in two Dutch siblings.",
"datePublished": "2024-01-14",
"url": "https://questionsmedicales.fr/article/38444578",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/jmd2.12409"
}
},
{
"@type": "ScholarlyArticle",
"name": "Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women with Repeated Implantation Failure.",
"datePublished": "2024-01-09",
"url": "https://questionsmedicales.fr/article/38195194",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1210/endocr/bqae002"
}
},
{
"@type": "ScholarlyArticle",
"name": "Long-Term Outcomes with Macroplastique in Women with Stress Urinary Incontinence Secondary to Intrinsic Sphincter Deficiency.",
"datePublished": "2024-01-08",
"url": "https://questionsmedicales.fr/article/38199277",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.urology.2023.12.019"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Cellules",
"item": "https://questionsmedicales.fr/mesh/D002477"
},
{
"@type": "ListItem",
"position": 3,
"name": "Structures cellulaires",
"item": "https://questionsmedicales.fr/mesh/D022082"
},
{
"@type": "ListItem",
"position": 4,
"name": "Membrane cellulaire",
"item": "https://questionsmedicales.fr/mesh/D002462"
},
{
"@type": "ListItem",
"position": 5,
"name": "Structures de la membrane cellulaire",
"item": "https://questionsmedicales.fr/mesh/D021961"
},
{
"@type": "ListItem",
"position": 6,
"name": "Jonctions intercellulaires",
"item": "https://questionsmedicales.fr/mesh/D007365"
},
{
"@type": "ListItem",
"position": 7,
"name": "Desmosomes",
"item": "https://questionsmedicales.fr/mesh/D003896"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Desmosomes - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Desmosomes",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-05",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Desmosomes",
"description": "Comment diagnostiquer une dysfonction des desmosomes ?\nQuels tests sont utilisés pour évaluer les desmosomes ?\nQuels signes cliniques indiquent un problème des desmosomes ?\nPeut-on détecter des anomalies génétiques liées aux desmosomes ?\nQuel rôle joue l'histologie dans le diagnostic des desmosomes ?",
"url": "https://questionsmedicales.fr/mesh/D003896?mesh_terms=Iron+Deficiencies&page=1000#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Desmosomes",
"description": "Quels symptômes sont associés à une défaillance des desmosomes ?\nComment les desmosomes affectent-ils la peau ?\nLes troubles des desmosomes causent-ils des douleurs ?\nQuels signes indiquent une maladie liée aux desmosomes ?\nLes symptômes des desmosomes varient-ils selon l'âge ?",
"url": "https://questionsmedicales.fr/mesh/D003896?mesh_terms=Iron+Deficiencies&page=1000#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Desmosomes",
"description": "Comment prévenir les maladies liées aux desmosomes ?\nLes facteurs environnementaux influencent-ils les desmosomes ?\nL'éducation des patients est-elle importante pour la prévention ?\nLes vaccinations peuvent-elles aider à prévenir des maladies cutanées ?\nComment un mode de vie sain influence-t-il les desmosomes ?",
"url": "https://questionsmedicales.fr/mesh/D003896?mesh_terms=Iron+Deficiencies&page=1000#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Desmosomes",
"description": "Quels traitements sont disponibles pour les troubles des desmosomes ?\nLa thérapie génique peut-elle aider les troubles des desmosomes ?\nComment les soins de la peau aident-ils les patients ?\nLes traitements varient-ils selon le type de maladie des desmosomes ?\nDes traitements topiques sont-ils efficaces pour les troubles des desmosomes ?",
"url": "https://questionsmedicales.fr/mesh/D003896?mesh_terms=Iron+Deficiencies&page=1000#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Desmosomes",
"description": "Quelles complications peuvent survenir avec des troubles des desmosomes ?\nLes troubles des desmosomes peuvent-ils entraîner des cancers ?\nComment les complications affectent-elles la qualité de vie ?\nLes complications sont-elles réversibles ?\nLes complications des desmosomes nécessitent-elles une intervention chirurgicale ?",
"url": "https://questionsmedicales.fr/mesh/D003896?mesh_terms=Iron+Deficiencies&page=1000#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Desmosomes",
"description": "Quels sont les facteurs de risque pour les troubles des desmosomes ?\nL'âge influence-t-il le risque de troubles des desmosomes ?\nLes facteurs génétiques jouent-ils un rôle dans les troubles des desmosomes ?\nL'exposition à des produits chimiques augmente-t-elle le risque ?\nLe stress peut-il affecter la santé des desmosomes ?",
"url": "https://questionsmedicales.fr/mesh/D003896?mesh_terms=Iron+Deficiencies&page=1000#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une dysfonction des desmosomes ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic peut inclure des biopsies et des tests immunohistochimiques pour évaluer l'adhérence cellulaire."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les desmosomes ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent l'immunofluorescence et l'électromicroscopie pour visualiser les desmosomes."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent un problème des desmosomes ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes incluent des lésions cutanées, des bulles et des troubles de l'adhérence cellulaire."
}
},
{
"@type": "Question",
"name": "Peut-on détecter des anomalies génétiques liées aux desmosomes ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests génétiques peuvent identifier des mutations affectant les protéines des desmosomes."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'histologie dans le diagnostic des desmosomes ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'histologie permet d'observer la structure des desmosomes et d'identifier des anomalies."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à une défaillance des desmosomes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des éruptions cutanées, des cloques et des douleurs cutanées."
}
},
{
"@type": "Question",
"name": "Comment les desmosomes affectent-ils la peau ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une défaillance des desmosomes peut entraîner une perte d'intégrité de la peau et des lésions."
}
},
{
"@type": "Question",
"name": "Les troubles des desmosomes causent-ils des douleurs ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des douleurs peuvent survenir en raison de l'inflammation et des lésions cutanées."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une maladie liée aux desmosomes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes incluent des bulles, des fissures cutanées et des infections secondaires."
}
},
{
"@type": "Question",
"name": "Les symptômes des desmosomes varient-ils selon l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier selon l'âge et la gravité de la maladie associée."
}
},
{
"@type": "Question",
"name": "Comment prévenir les maladies liées aux desmosomes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention inclut une bonne hygiène cutanée et l'évitement des irritants."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils les desmosomes ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs comme l'exposition au soleil et les produits chimiques peuvent affecter les desmosomes."
}
},
{
"@type": "Question",
"name": "L'éducation des patients est-elle importante pour la prévention ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer les patients sur les soins de la peau et les signes d'alerte est crucial."
}
},
{
"@type": "Question",
"name": "Les vaccinations peuvent-elles aider à prévenir des maladies cutanées ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent réduire le risque d'infections cutanées associées aux desmosomes."
}
},
{
"@type": "Question",
"name": "Comment un mode de vie sain influence-t-il les desmosomes ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant une alimentation équilibrée, peut renforcer la santé de la peau."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les troubles des desmosomes ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des corticostéroïdes, des immunosuppresseurs et des soins de la peau."
}
},
{
"@type": "Question",
"name": "La thérapie génique peut-elle aider les troubles des desmosomes ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique est explorée pour corriger les mutations affectant les desmosomes."
}
},
{
"@type": "Question",
"name": "Comment les soins de la peau aident-ils les patients ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les soins de la peau aident à maintenir l'hydratation et à prévenir les infections cutanées."
}
},
{
"@type": "Question",
"name": "Les traitements varient-ils selon le type de maladie des desmosomes ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements sont adaptés en fonction du type et de la gravité de la maladie."
}
},
{
"@type": "Question",
"name": "Des traitements topiques sont-ils efficaces pour les troubles des desmosomes ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des traitements topiques peuvent réduire l'inflammation et améliorer l'état de la peau."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des troubles des desmosomes ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections cutanées, des cicatrices et des déformations."
}
},
{
"@type": "Question",
"name": "Les troubles des desmosomes peuvent-ils entraîner des cancers ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies liées aux desmosomes peuvent augmenter le risque de cancers cutanés."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent entraîner des douleurs chroniques et des impacts psychologiques."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être traitées, mais d'autres peuvent être permanentes."
}
},
{
"@type": "Question",
"name": "Les complications des desmosomes nécessitent-elles une intervention chirurgicale ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas, une intervention chirurgicale peut être nécessaire pour traiter des lésions graves."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les troubles des desmosomes ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, des maladies auto-immunes et des irritants cutanés."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de troubles des desmosomes ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains troubles sont plus fréquents chez les personnes âgées en raison de la dégradation tissulaire."
}
},
{
"@type": "Question",
"name": "Les facteurs génétiques jouent-ils un rôle dans les troubles des desmosomes ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations génétiques peuvent prédisposer les individus à des troubles des desmosomes."
}
},
{
"@type": "Question",
"name": "L'exposition à des produits chimiques augmente-t-elle le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains produits chimiques peut endommager les desmosomes et augmenter le risque."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter la santé des desmosomes ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut influencer la santé cutanée et la fonction des desmosomes."
}
}
]
}
]
}
Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins, including lipoproteins, from the circulation. In humans, loss-of...
ASGR1 deficient mice (ASGR1...
ASGR1...
ASGR1 deficiency impacts energetic homeostasis during obesity leading to improved plasma lipid levels but increased VAT lipid accumulation and liver damage....
This study aims to elucidate the relationship between intestinal obstruction and carnitine deficiency in neonates and infants. We retrospectively reviewed medical records of 330 neonates and infants, ...
Two siblings, presenting with a neurometabolic phenotype, were identified with 5, 10-methenyltetrahydrofolate synthetase (MTHFS) deficiency. Whole genome sequencing in both patients demonstrated an ho...
Repeated implantation failure (RIF) leads to a waste of high-quality embryos and remains a challenge in assisted reproductive technology. During early human placentation, the invasion of trophoblast c...
Mid-luteal phase endometrial samples were biopsied from RIF and routine control IVF patients followed by qPCR and immunoblotting analyses. Human trophoblast organoids, primary human trophoblast cells,...
We found that BMP2 were aberrantly low in mid-luteal phase endometrial tissues from RIF patients. Recombinant human BMP2 treatment upregulated integrin β3 (ITGB3) in a SMAD2/3-SMAD4 signaling-dependen...
Our results demonstrate endometrial BMP2 deficiency in RIF patients. ITGB3 mediates both basal and BMP2-promoted human trophoblast invasion and is essential for early placentation. These findings broa...
To evaluate the long-term outcomes of polydimethylsiloxane (Macroplastique® (MPQ) in women with stress urinary incontinence (SUI) secondary to intrinsic sphincter deficiency (ISD) using validated ques...
Following IRB approval, charts of non-neurogenic women with SUI secondary to ISD who underwent MPQ injection were reviewed from a prospectively maintained database. ISD was defined as positive stress ...
From April 2011-December 2016, 106 patients (median age 67) met study criteria. Median follow-up time was 7.4 years. Median MPQ injected was 5 ml. Overall success was 43%, with 54% successful after on...
MPQ demonstrated long-term favorable outcomes in a subset of women with SUI secondary to ISD....
Endosseous implants have revolutionized the field of Implants and Prosthodontics. Implant placement is a viable option in the treatment of partial and full edentulism. However, placement of implants i...
Patients suspected of Alpha 1-Antitrypsin (A1AT) abnormality based on low serum concentration are routinely confirmed through polymerase chain reaction (PCR) testing of peripheral blood. Genotyping fo...
Eighteen (12.68%) of 142 patients with end-stage liver disease showed PASD/A1AT positive globules. FFPE of the explants was tested through qPCR to detect S and Z alleles. A second age- and sex-matched...
qPCR assay was successful with all the samples meeting QC parameters. All patients included in the study elucidated Z allele variants; 2 homozygous (11.1%) and 16 heterozygous (88.9%). The control gro...
Screening for A1AT deficiency using serum levels is not sufficiently sensitive to detect deficiency, especially in carriers. If A1AT testing was not performed preoperatively and the risk is high based...
In response to injury, vascular smooth muscle cells (VSMCs) of the arterial wall dedifferentiate into a proliferative and migratory phenotype, leading to intimal hyperplasia. The ERK1/2 pathway partic...