Titre : Érythropoïèse

Érythropoïèse : Questions médicales fréquentes

Termes MeSH sélectionnés :

DNA Copy Number Variations
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l'érythropoïèse chez les patients à risque ?", "url": "https://questionsmedicales.fr/mesh/D004920?mesh_terms=DNA+Copy+Number+Variations&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Érythropoïèse", "description": "Quels traitements sont disponibles pour l'anémie ?\nComment l'érythropoïétine est-elle utilisée en thérapie ?\nQuels médicaments peuvent affecter l'érythropoïèse ?\nQuelles sont les options pour l'érythropoïèse excessive ?\nComment traiter une carence en vitamine B12 liée à l'érythropoïèse ?", "url": "https://questionsmedicales.fr/mesh/D004920?mesh_terms=DNA+Copy+Number+Variations&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Érythropoïèse", "description": "Quelles complications peuvent survenir avec une érythropoïèse altérée ?\nComment l'érythropoïèse excessive peut-elle affecter la santé ?\nQuels risques sont associés à une érythropoïèse insuffisante ?\nComment l'érythropoïèse affecte-t-elle le système immunitaire ?\nQuelles sont les complications à long terme d'une érythropoïèse déficiente ?", "url": "https://questionsmedicales.fr/mesh/D004920?mesh_terms=DNA+Copy+Number+Variations&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Érythropoïèse", "description": "Quels facteurs augmentent le risque d'anémie ?\nComment les maladies rénales affectent-elles l'érythropoïèse ?\nQuel rôle joue l'âge dans l'érythropoïèse ?\nQuels sont les risques liés à la grossesse pour l'érythropoïèse ?\nComment le tabagisme influence-t-il l'érythropoïèse ?", "url": "https://questionsmedicales.fr/mesh/D004920?mesh_terms=DNA+Copy+Number+Variations&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une anémie par érythropoïèse insuffisante ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un bilan sanguin révèle une faible concentration de globules rouges et d'hémoglobine." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer l'érythropoïèse ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests incluent la numération globulaire complète et les niveaux d'érythropoïétine." } }, { "@type": "Question", "name": "Quels signes indiquent une érythropoïèse altérée ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des signes incluent fatigue, pâleur et essoufflement lors d'efforts physiques." } }, { "@type": "Question", "name": "Comment évaluer la moelle osseuse pour l'érythropoïèse ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Une biopsie de moelle osseuse permet d'analyser la production de globules rouges." } }, { "@type": "Question", "name": "Quel rôle joue l'érythropoïétine dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'érythropoïétine stimule la production de globules rouges, son dosage aide au diagnostic." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une érythropoïèse déficiente ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, faiblesse, palpitations et essoufflement." } }, { "@type": "Question", "name": "Comment l'anémie affecte-t-elle l'érythropoïèse ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "L'anémie peut résulter d'une érythropoïèse insuffisante, entraînant une diminution des globules rouges." } }, { "@type": "Question", "name": "Quels signes cliniques sont associés à l'érythropoïèse ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des signes comme la pâleur de la peau et des muqueuses peuvent être observés." } }, { "@type": "Question", "name": "L'érythropoïèse affecte-t-elle la circulation sanguine ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une érythropoïèse altérée peut entraîner une mauvaise oxygénation des tissus." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer une surproduction de globules rouges ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme des maux de tête, des vertiges et une hypertension peuvent survenir." } }, { "@type": "Question", "name": "Comment prévenir l'anémie liée à l'érythropoïèse ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée riche en fer et en vitamines est essentielle pour prévenir l'anémie." } }, { "@type": "Question", "name": "Quels conseils nutritionnels pour soutenir l'érythropoïèse ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Consommer des aliments riches en fer, vitamine B12 et acide folique favorise l'érythropoïèse." } }, { "@type": "Question", "name": "Comment éviter les carences nutritionnelles ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation variée et des contrôles réguliers des niveaux de nutriments aident à prévenir les carences." } }, { "@type": "Question", "name": "Quels sont les risques d'une érythropoïèse excessive ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "L'érythropoïèse excessive peut entraîner des complications comme des thromboses et des AVC." } }, { "@type": "Question", "name": "Comment surveiller l'érythropoïèse chez les patients à risque ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Des bilans sanguins réguliers permettent de surveiller l'érythropoïèse chez les patients à risque." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour l'anémie ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent des suppléments de fer, des transfusions sanguines et des érythropoïétines." } }, { "@type": "Question", "name": "Comment l'érythropoïétine est-elle utilisée en thérapie ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "L'érythropoïétine est administrée pour stimuler la production de globules rouges chez les patients anémiques." } }, { "@type": "Question", "name": "Quels médicaments peuvent affecter l'érythropoïèse ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Certains médicaments comme les anti-inflammatoires peuvent inhiber l'érythropoïèse." } }, { "@type": "Question", "name": "Quelles sont les options pour l'érythropoïèse excessive ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements comme la phlébotomie peuvent être utilisés pour réduire le nombre de globules rouges." } }, { "@type": "Question", "name": "Comment traiter une carence en vitamine B12 liée à l'érythropoïèse ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments de vitamine B12 sont prescrits pour corriger la carence et améliorer l'érythropoïèse." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec une érythropoïèse altérée ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent l'anémie, la fatigue chronique et des problèmes cardiaques." } }, { "@type": "Question", "name": "Comment l'érythropoïèse excessive peut-elle affecter la santé ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut entraîner des complications comme des caillots sanguins et des problèmes cardiovasculaires." } }, { "@type": "Question", "name": "Quels risques sont associés à une érythropoïèse insuffisante ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les risques incluent une hypoxie tissulaire, des troubles cognitifs et une diminution de la qualité de vie." } }, { "@type": "Question", "name": "Comment l'érythropoïèse affecte-t-elle le système immunitaire ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Une érythropoïèse altérée peut affaiblir le système immunitaire, augmentant le risque d'infections." } }, { "@type": "Question", "name": "Quelles sont les complications à long terme d'une érythropoïèse déficiente ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Les complications à long terme incluent des maladies cardiaques et des troubles métaboliques." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque d'anémie ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent une mauvaise alimentation, des maladies chroniques et des pertes sanguines." } }, { "@type": "Question", "name": "Comment les maladies rénales affectent-elles l'érythropoïèse ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Les maladies rénales peuvent réduire la production d'érythropoïétine, entraînant une érythropoïèse insuffisante." } }, { "@type": "Question", "name": "Quel rôle joue l'âge dans l'érythropoïèse ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Avec l'âge, la production de globules rouges peut diminuer, augmentant le risque d'anémie." } }, { "@type": "Question", "name": "Quels sont les risques liés à la grossesse pour l'érythropoïèse ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "La grossesse peut entraîner une anémie due à une demande accrue en fer et en nutriments." } }, { "@type": "Question", "name": "Comment le tabagisme influence-t-il l'érythropoïèse ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Le tabagisme peut augmenter le nombre de globules rouges, mais aussi causer des complications respiratoires." } } ] } ] }

Sources (10000 au total)

A pan-cancer landscape of pathogenic somatic copy number variations.

Copy number variations (CNVs) play crucial roles in physiological and pathological processes, including cancer. However, the functional implications of somatic CNVs in tumor progression and evolution ... Starting from 7352 copy number profiles across 33 different cancer types, we infer the pathogenicity of each CNV and perform both intra- and inter-tumor analyses to predict the functional impact of di... Our analysis uncovered large heterogeneity among different tumors suggesting in many cases distinct genetic drivers of tumorigenesis. Recurrent genomic alterations frequently coincide with dysfunction... This study contributes to elucidate the functional impact of pathogenic CNVs in tumor progression and sheds light on their potential as prognostic markers in specific cancer types....

Contribution of copy number variations to the risk of severe eating disorders.

Eating disorders (EDs) are complex, multifactorial psychiatric conditions. Previous studies identified pathogenic copy number variations associated with NDDs (NDD-CNVs) in ED patients. However, no sta... Using array comparative genomic hybridization (aCGH), we conducted a high-resolution CNV analysis of 71 severe female ED patients and 1045 female controls. According to the American College of Medical... Of the samples analyzed with aCGH, 70 severe ED patients (98.6%) and 1036 controls (99.1%) passed our quality control filtering. We obtained 189 and 2539 rare CNVs from patients and controls, respecti... Our study provides the first preliminary evidence that NDD-CNVs may confer risk for severe EDs. The pathophysiology may involve synaptic dysfunction....

Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma.

Circulating cell-free DNA (cfDNA) is a noninvasive substitute to liver biopsy for hepatocellular carcinoma (HCC) molecular profiling. This study aimed to use cfDNA to investigate copy number variation... Real-Time Polymerase Chain Reaction was used to determine the CNV and cfDNA integrity index in 100 HCC patients.... CNV gain in BCL9 and RPS6KB1 genes was detected in 14% and 24% of patients, respectively. Gain in CNV of BCL9 associated with risk of HCC in alcohol drinkers and hepatitis C seropositivity. In patient... cfDNA was used to detect BCL9 and RPS6KB1 CNVs, which influence prognosis and can be used as independent predictors of HCC patient survival....

Multiallelic Copy Number Variation in ORM1 is Associated with Plasma Cell-Free DNA Levels as an Intermediate Phenotype for Venous Thromboembolism.

Venous thromboembolism (VTE) is a common disease with high heritability. However, only a small portion of the genetic variance of VTE can be explained by known genetic risk factors. Neutrophil extrace...

Mitochondrial DNA copy number and risk of papillary thyroid carcinoma.

Mitochondrial DNA (mtDNA) copy number is associated with tumor activity and carcinogenesis. This study was undertaken to investigate mtDNA copy number in papillary thyroid cancer (PTC) tissues and to ... DNA was extracted from 105 PTC tissues and 67 control thyroid tissues, and mtDNA copy number mtDNA oxidative damage were determined using qPCR techniques.... Overall, the relative mtDNA copy number was significantly higher in PTC patients (p < 0.001). The risk of developing PTC increased significantly across the tertiles of mtDNA copy number (p trend < 0.0... Our results indicated that the augmentation of mtDNA content plays a significant role during the initiation of thyroid cancer, and it might represent a potential biomarker for predicting the risk of P...

Copy number variations (CNVs) and karyotyping analysis in males with azoospermia and oligospermia.

Considering the essential roles that genetic factors play in azoospermia and oligospermia, this study aims to identify abnormal chromosomes using karyotyping and CNVs and elucidate the associated gene... A total of 1157 azoospermia and oligospermia patients were recruited, of whom, 769 and 674 underwent next-generation sequencing (NGS) to identify CNVs and routine G-band karyotyping, respectively.... First, 286 patients were co-analyzed using CNV sequencing (CNV-seq) and karyotyping. Of the 725 and 432 patients with azoospermia and oligospermia, 33.8% and 48.9% had abnormal karyotypes and CNVs, re... Sex chromosome and autosomal CNV loci, such as Xp22.31 and 2p24.3, as well as the associated genes, such as VCX and NACAP9, could be candidate spermatogenesis genes. The high-frequency abnormal karyot...

dbCNV: deleteriousness-based model to predict pathogenicity of copy number variations.

Copy number variation (CNV) is a type of structural variation, which is a gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity of CNVs are required to realize ... From single nucleotide polymorphism (SNP), gene and region dimensions, we collected 79 informative features that quantitatively describe the characteristics of CNV, such as CNV length, the number of p... The performance of the dbCNV suggest that functional deleteriousness-based model of CNV is a promising approach to support the classification prediction and to further understand the pathogenic mechan...