As in many low-income countries, the treatment gap for developmental disorders in Pakistan is nearly 100%. The World Health Organization (WHO) has developed the mental Health Gap Intervention guide (m...
The implementation evaluation was conducted as a part of the mhGAP-IG implementation in the pilot sub-district of Gujar Khan. Family volunteers used a technology-assisted approach to deliver the paren...
We trained 36 volunteers in delivering the program using technology. All volunteers were female with a mean age of 39 (± 4.38) years. The volunteers delivered the program to 270 caregivers in group se...
Technology can be used to train non-specialist family volunteers in delivering evidence-based intervention at scale with fidelity in low-resource settings of Pakistan. However, cultural and gender nor...
The interplay among neuropathological mechanisms underlying Alzheimer's disease (AD), as neuroinflammation and amyloid-beta (Aβ), as well their impact on neuronal function remains elusive. A major gap...
Chronic ankle instability (CAI) is a major condition in athletes. It is known that both ankle joint proprioception and joint motion control are important for the improvement of CAI, but the relationsh...
The participants were 27 females (age 20.3±0.9 years, healthy group: 15, CAI group: 12). The star excursion balance test (SEBT) was used for the dynamic balance task, and the ankle joint angles were m...
There was no significant difference in the error in AJRT between the groups, but the joint angle in SEBT was significantly lower in the CAI group than in the healthy group for ankle dorsiflexion only....
CAI individuals showed no difference in ankle-joint proprioception compared to healthy individuals, but their ankle-joint-dorsiflexion angle in the dynamic balance task was smaller. Ankle-joint propri...
The present diary study was conducted for the purpose of bridging and integrating empirical research on the antecedents and consequences of work-related ruminative processes in the evening. Based on t...
The need to define core competencies for clinical research professionals has been widely recognized. And after the Joint Task Force have proposed Core Competency Framework in 2014 (Sonstein et al. in ...
We surveyed Ukrainian-based clinical research practitioners on their self-assessment in the competency domains proposed by Sonstein et al. (JAMA 28(3):17-23, 2014), tested their GCP knowledge, assesse...
We identified competence issues in four competence domains: Medicines Development and Regulation, Data Management and Informatics, Scientific Concepts and Research Design, and Study and Site Managemen...
The identified knowledge gaps provide evidence for the need to broaden the range of educational tools for Ukrainian-based clinical research professionals; we suggest launching long-term academic progr...
This study aimed to investigate how different strategies of task constraint manipulation impact physical and tactical demands in small-sided and conditioned games (SSCG). Ten recreational U-17 soccer ...
In the Cancer Core Europe Consortium (CCE), standardized biomarkers are required for therapy monitoring oncologic multicenter clinical trials. Multiparametric functional MRI and particularly diffusion...
Phantom and volunteer measurements (single-shot T2w and DW-EPI) were performed at the seven CCE sites using the MR hardware produced by three different vendors. Repeated measurements were performed at...
For DWI/ADC phantom measurements using a central post-processing algorithm, the maximum deviation could be decreased to 2%. However, there is no significant difference compared to a decentralized ADC ...
Harmonization of MR acquisition and post-processing parameters results in acceptable standard deviations for MR/DW imaging. MRI could be the tool in oncologic multicenter trials to overcome the limita...
• Harmonizing acquisition parameters and post-processing homogenization, standardized protocols result in acceptable standard deviations for multicenter MR-DWI studies. • Total measurement variation d...
Ballistic injuries during the Great March of Return (GMR) protests in Gaza have resulted in young, civilian amputees. This article defines this unique population, their injuries and clinical variables...
A multidisciplinary team (MDT) assessed 103 lower limb amputees (104 stumps). Individualized prescriptions of care were formulated and applied for both stump and prosthesis management. The cohort's he...
The population is predominantly young, male, suffering unilateral amputation with an equal ratio of above knee (AKA) to below knee (BKA) amputations. 18% were amputated immediately and 82% with delay....
Youth, proximal injury, high numbers of AKA, psychosocial issues and the need for stump and prosthetic support define this group of amputees. Unifying expertise within a National MDT will promote cont...
Implementation science (IS) has received increased attention as it provides a means to bridge the know-do gap to implement evidence-based interventions in real-world settings. Against this backdrop, p...
Alzheimer's disease has become increasingly prevalent among the older population, leading to significant social and economic burdens. Transcranial photobiomodulation (tPBM) has shown promise as a cogn...
This study aimed to compare the effects of different dosages in a single tPBM session on cognitive efficiency in healthy older adults....
In this randomized controlled trial, 88 healthy older participants were assigned to either a single dose (irradiance = 30 mW/cm2, fluence = 10.8 J/cm2; n = 44) or a double dose (irradiance = 30 mW/cm2...
The single dose group exhibited significantly greater cognitive efficiency enhancement, indicated by a more pronounced reduction in oxygenated hemoglobin during a challenging task level (span level 9)...
These findings suggest that higher tPBM dosages may not necessarily result in superior cognitive improvement in older adults....
