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Systèmes sanguin et immunitaire
Système immunitaire
Leucocytes
Granulocytes
Granulocytes : Questions médicales fréquentes
Termes MeSH sélectionnés :
REM Sleep Behavior Disorder
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"name": "Comment diagnostiquer une granulocytopénie ?",
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"text": "Un hémogramme révèle une diminution des granulocytes dans le sang."
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"@type": "Question",
"name": "Quels tests pour évaluer les granulocytes ?",
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"@type": "Question",
"name": "Quels signes indiquent une infection liée aux granulocytes ?",
"position": 3,
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"text": "Fièvre, fatigue et inflammation peuvent signaler une infection."
}
},
{
"@type": "Question",
"name": "Comment évaluer la fonction des granulocytes ?",
"position": 4,
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"text": "Des tests de phagocytose et de dégranulation peuvent être réalisés."
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"@type": "Question",
"name": "Quel rôle joue la biopsie dans le diagnostic ?",
"position": 5,
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"name": "Quels symptômes d'une carence en granulocytes ?",
"position": 6,
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"name": "Comment se manifeste une réaction allergique ?",
"position": 7,
"acceptedAnswer": {
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"name": "Quels symptômes d'une inflammation ?",
"position": 8,
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"text": "Rougeur, chaleur, gonflement et douleur sont des signes d'inflammation."
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"name": "Quels signes d'une infection bactérienne ?",
"position": 9,
"acceptedAnswer": {
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"name": "Quels symptômes d'une leucémie ?",
"position": 10,
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"text": "Fatigue, ecchymoses et infections fréquentes peuvent être présents."
}
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{
"@type": "Question",
"name": "Comment prévenir les infections chez les patients à faible granulocytes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir une bonne hygiène et éviter les foules sont essentiels."
}
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{
"@type": "Question",
"name": "Quels vaccins sont recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccins contre la grippe et le pneumocoque sont souvent conseillés."
}
},
{
"@type": "Question",
"name": "Comment éviter les complications liées aux granulocytes ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller les signes d'infection et consulter rapidement un médecin."
}
},
{
"@type": "Question",
"name": "Quel rôle de l'alimentation dans la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée renforce le système immunitaire."
}
},
{
"@type": "Question",
"name": "Comment gérer le stress pour la santé des granulocytes ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques de relaxation peuvent aider à réduire le stress."
}
},
{
"@type": "Question",
"name": "Comment traiter une granulocytopénie ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des transfusions de granulocytes ou des médicaments stimulants peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels médicaments stimulent les granulocytes ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le filgrastim et le pegfilgrastim sont des agents couramment utilisés."
}
},
{
"@type": "Question",
"name": "Comment traiter une infection liée aux granulocytes ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antibiotiques sont prescrits pour traiter les infections bactériennes."
}
},
{
"@type": "Question",
"name": "Quel rôle des corticostéroïdes dans le traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent réduire l'inflammation et moduler la réponse immunitaire."
}
},
{
"@type": "Question",
"name": "Quand envisager une greffe de moelle osseuse ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "En cas de maladies graves affectant la production de granulocytes."
}
},
{
"@type": "Question",
"name": "Quelles complications d'une granulocytopénie sévère ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections graves, septicémie et complications hémorragiques peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels risques d'une leucémie myéloïde ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Risque accru d'infections et de saignements en raison de la production anormale."
}
},
{
"@type": "Question",
"name": "Comment les granulocytes affectent-ils la cicatrisation ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une diminution des granulocytes peut retarder la cicatrisation des plaies."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications des traitements immunosuppresseurs ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections opportunistes et cancers peuvent survenir avec ces traitements."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires des médicaments sur les granulocytes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains médicaments peuvent entraîner une diminution des granulocytes."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'infections ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une immunodépression, le diabète et l'âge avancé augmentent le risque."
}
},
{
"@type": "Question",
"name": "Quel rôle des maladies auto-immunes ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent entraîner une destruction accrue des granulocytes."
}
},
{
"@type": "Question",
"name": "Comment le tabagisme affecte-t-il les granulocytes ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme peut altérer la fonction des granulocytes et augmenter l'inflammation."
}
},
{
"@type": "Question",
"name": "Quels risques liés à l'exposition aux produits chimiques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains produits chimiques peuvent endommager la moelle osseuse et réduire les granulocytes."
}
},
{
"@type": "Question",
"name": "Quel impact de la génétique sur les granulocytes ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des prédispositions génétiques peuvent influencer la production et la fonction des granulocytes."
}
}
]
}
]
}
Isolated REM Sleep Behavior Disorder (iRBD) is considered a prodrome of Parkinson's disease (PD). We investigate whether the potentially disease-modifying compound acetyl-DL-leucine (ADLL; 5 g/d) has ...
In early-stage Parkinson's disease (PD), rapid eye movement (REM) sleep behavior disorder (RBD) predicts poor cognitive and motor outcome. However, the baseline significance and disease evolution asso...
The objective is to determine whether iRWA was a mild form of RBD and progressed similarly over time....
Participants with early PD (<4 years from medical diagnosis) were included from 2014 to 2021 in a longitudinal study. They underwent interviews and examinations in the motor, cognitive, autonomous, ps...
Among 159 PD participants, 25% had RBD, 25% had iRWA, and 50% had normal REM sleep. At baseline, the non-motor symptoms were less prevalent and the LC/LsC signal intensity was more intense in particip...
We demonstrated that iRWA is frequent in early PD, but is not a milder form of RBD. Both groups have distinct baseline characteristics and clinical trajectories. They should be distinguished in clinic...
Patients with synucleinopathies frequently display language abnormalities. However, whether patients with isolated rapid eye movement sleep behavior disorder (iRBD) have prodromal language impairment ...
We examined whether the linguistic abnormalities in iRBD can serve as potential biomarkers for conversion to synucleinopathy, including the possible effect of mild cognitive impairment (MCI), speaking...
We enrolled 139 Czech native participants, including 40 iRBD without MCI and 14 iRBD with MCI, compared with 40 PD without MCI, 15 PD with MCI, and 30 healthy control subjects. Spontaneous discourse a...
Compared with control subjects, patients with iRBD showed poorer content density, reflecting the reduction of content words and modifiers. Both PD and iRBD subgroups with MCI manifested less occurrenc...
Linguistic features might provide a reliable automated method for detecting cognitive decline caused by prodromal neurodegeneration in subjects with iRBD, providing critical outcomes for future therap...
Isolated Rapid Eye Movement (REM) sleep Behavior Disorder (iRBD) requires quantitative tools to detect incipient Parkinson's disease (PD)....
A motor battery was designed and compared with the Movement Disorder Society-Unified Parkinson's Disease Rating Scale part III (MDS-UPDRS-III) in people with iRBD and controls. This included two keybo...
We included 33 iRBD patients and 29 controls. The iRBD group performed both keyboard-based tapping tests more slowly (P < 0.001, P = 0.020) and less rhythmically (P < 0.001, P = 0.006) than controls. ...
Speed, rhythm, and dual task motor deterioration might be accurate indicators of incipient PD in iRBD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of Internatio...
Rapid eye movement (REM) sleep behavior disorder (RBD) is the result of the loss of physiological inhibition of muscle tone during REM sleep, characterized by dream-enacting behavior and widely recogn...
Introduction: Fatigue is one of the most common and disabling symptoms of Parkinson’s Disease (PD). The occurrence and clinical features of fatigue in patients with prodromal PD remain largely elusive...
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is an important non-motor complication of Parkinson's disease. At the same time, iRBD is considered to be the prodromal stage of α-synuclei...
Dream-enactment behavior that emerges during episodes of rapid eye movement (REM) sleep without muscle atonia is a parasomnia known as REM sleep behavior disorder (RBD). RBD constitutes a prodromal ma...
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is one of the most specific prodromal symptoms of synucleinopathies, including Parkinson's disease (PD) and multiple system atrophy. The Ja...
This cross-sectional study was conducted in 108 patients with iRBD, selected from the J-PPMI study. We divided the patients into four groups based on the MIBG and DaT results. We also recorded the pat...
Ninety-five of the enrolled patients (88%) met the diagnostic criteria for prodromal PD based on the probability score. Only five patients had normal MIBG and DaT. We identified 29 cases with decrease...
Both DaT and MIBG are important biomarkers for confirming synucleinopathies and/or staging disease progression. Although 95% of iRBD patients were consistent with the body-first subtype concept, alpha...
Non-REM sleep symptoms remain poorly understood in alpha-synucleinopathies....
The aims of the study were to compare sleep stability and transitions, arousals, and sleep cycle structure between isolated rapid eye movement (REM) sleep behavior disorder (iRBD), Parkinson's disease...
Sleep transition and stability measures were assessed in one-night video-polysomnography records. Transition measures were the number of shifts between Wake and REM, Wake and NREM, and REM and NREM. S...
We assessed 54 PD, 24 DLB, and 21 iRBD patients (54 RBD+, 22 RBD-). There were no significant differences regarding sleep stability measures. Arousal indices in N1 and N2 stages were significantly hig...
There were no significant differences in stability/transition measures. Arousals and disturbance in sleep cycling were higher in PD, but the difference was no longer significant after adjusting for me...
Different alpha-synucleinopathies have a similar degree of non-REM sleep instability, but medication could worsen symptoms in PD....