questionsmedicales.fr
Facteurs biologiques
Pigments biologiques
Porphyrines
Métalloporphyrines
Hème
Hémine
Hémine : Questions médicales fréquentes
Termes MeSH sélectionnés :
Extensively Drug-Resistant Tuberculosis
Diagnostic
5
Électrophorèse
Hémoglobine
Analyse d'urine
Hémoglobine
Métabolisme du fer
Globules rouges
Symptômes
5
Douleur abdominale
Nausées
Éruption cutanée
Photosensibilité
Douleur articulaire
Inflammation
Fatigue
Faiblesse musculaire
Prévention
5
Suppléments de fer
Carence en fer
Bilan sanguin
Surveillance
Traitements
5
Suppléments de fer
Nutrition
Administration intraveineuse
Hémoglobine
Médecine alternative
Plantes médicinales
Complications
5
Maladies hépatiques
Troubles neurologiques
Système immunitaire
Infections
Intoxication
Dommages organiques
Facteurs de risque
5
Carence en fer
Troubles digestifs
Végétarisme
Carence en fer
Personnes âgées
Carence en fer
Maladies chroniques
Insuffisance rénale
Stress
Métabolisme du fer
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Hémine : Questions médicales les plus fréquentes",
"headline": "Hémine : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Hémine : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-09",
"dateModified": "2025-04-05",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Hémine"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Hème",
"url": "https://questionsmedicales.fr/mesh/D006418",
"about": {
"@type": "MedicalCondition",
"name": "Hème",
"code": {
"@type": "MedicalCode",
"code": "D006418",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D23.767.727.640.587"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Hémine",
"alternateName": "Hemin",
"code": {
"@type": "MedicalCode",
"code": "D006427",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Simone Dell'Acqua",
"url": "https://questionsmedicales.fr/author/Simone%20Dell%27Acqua",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy."
}
},
{
"@type": "Person",
"name": "Enrico Monzani",
"url": "https://questionsmedicales.fr/author/Enrico%20Monzani",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy."
}
},
{
"@type": "Person",
"name": "David Monchaud",
"url": "https://questionsmedicales.fr/author/David%20Monchaud",
"affiliation": {
"@type": "Organization",
"name": "Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB), CNRS UMR6302, UBFC Dijon 21000, France."
}
},
{
"@type": "Person",
"name": "Amir M Alsharabasy",
"url": "https://questionsmedicales.fr/author/Amir%20M%20Alsharabasy",
"affiliation": {
"@type": "Organization",
"name": "CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Ireland."
}
},
{
"@type": "Person",
"name": "Pau Farràs",
"url": "https://questionsmedicales.fr/author/Pau%20Farr%C3%A0s",
"affiliation": {
"@type": "Organization",
"name": "CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Ireland; School of Biological and Chemical Sciences, Ryan Institute, National University of Ireland Galway, Ireland."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Epidemiology of extensively drug-resistant tuberculosis among patients with multidrug-resistant tuberculosis: A systematic review and meta-analysis.",
"datePublished": "2023-04-16",
"url": "https://questionsmedicales.fr/article/37072053",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.ijid.2023.04.392"
}
},
{
"@type": "ScholarlyArticle",
"name": "Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis.",
"datePublished": "2022-08-30",
"url": "https://questionsmedicales.fr/article/36042200",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41467-022-32455-1"
}
},
{
"@type": "ScholarlyArticle",
"name": "Spatial heterogeneity of extensively drug resistant-tuberculosis in Western Cape Province, South Africa.",
"datePublished": "2022-06-27",
"url": "https://questionsmedicales.fr/article/35760977",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41598-022-14581-4"
}
},
{
"@type": "ScholarlyArticle",
"name": "In vitro activity of tetracycline analogs against multidrug-resistant and extensive drug resistance clinical isolates of Mycobacterium tuberculosis.",
"datePublished": "2023-03-11",
"url": "https://questionsmedicales.fr/article/36963294",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.tube.2023.102336"
}
},
{
"@type": "ScholarlyArticle",
"name": "Clinical application of whole-genome sequencing in the management of extensively drug-resistant tuberculosis: a case report.",
"datePublished": "2024-08-22",
"url": "https://questionsmedicales.fr/article/39175078",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12941-024-00737-9"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Facteurs biologiques",
"item": "https://questionsmedicales.fr/mesh/D001685"
},
{
"@type": "ListItem",
"position": 3,
"name": "Pigments biologiques",
"item": "https://questionsmedicales.fr/mesh/D010860"
},
{
"@type": "ListItem",
"position": 4,
"name": "Porphyrines",
"item": "https://questionsmedicales.fr/mesh/D011166"
},
{
"@type": "ListItem",
"position": 5,
"name": "Métalloporphyrines",
"item": "https://questionsmedicales.fr/mesh/D008665"
},
{
"@type": "ListItem",
"position": 6,
"name": "Hème",
"item": "https://questionsmedicales.fr/mesh/D006418"
},
{
"@type": "ListItem",
"position": 7,
"name": "Hémine",
"item": "https://questionsmedicales.fr/mesh/D006427"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Hémine - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Hémine",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-18",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Hémine",
"description": "Comment diagnostiquer une carence en hémine ?\nQuels tests sont utilisés pour évaluer l'hémine ?\nQuels symptômes indiquent un problème d'hémine ?\nPeut-on détecter l'hémine dans les urines ?\nQuel rôle joue l'hémine dans le diagnostic des maladies ?",
"url": "https://questionsmedicales.fr/mesh/D006427?mesh_terms=Extensively+Drug-Resistant+Tuberculosis#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Hémine",
"description": "Quels sont les symptômes d'une surproduction d'hémine ?\nComment l'hémine affecte-t-elle la peau ?\nQuels signes indiquent une intoxication par l'hémine ?\nL'hémine peut-elle causer des douleurs articulaires ?\nQuels symptômes sont liés à une carence en hémine ?",
"url": "https://questionsmedicales.fr/mesh/D006427?mesh_terms=Extensively+Drug-Resistant+Tuberculosis#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Hémine",
"description": "Comment prévenir une carence en hémine ?\nLes suppléments de fer sont-ils nécessaires ?\nQuels aliments sont riches en hémine ?\nComment surveiller les niveaux d'hémine ?\nLes femmes enceintes doivent-elles surveiller leur hémine ?",
"url": "https://questionsmedicales.fr/mesh/D006427?mesh_terms=Extensively+Drug-Resistant+Tuberculosis#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Hémine",
"description": "Comment traiter une carence en hémine ?\nQuels médicaments sont utilisés pour l'excès d'hémine ?\nL'hémine peut-elle être administrée par voie intraveineuse ?\nQuels changements alimentaires sont recommandés ?\nY a-t-il des traitements alternatifs pour l'hémine ?",
"url": "https://questionsmedicales.fr/mesh/D006427?mesh_terms=Extensively+Drug-Resistant+Tuberculosis#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Hémine",
"description": "Quelles complications peuvent survenir avec une carence en hémine ?\nL'excès d'hémine peut-il causer des maladies ?\nComment l'hémine affecte-t-elle le système immunitaire ?\nQuelles sont les conséquences d'une intoxication par l'hémine ?\nL'hémine peut-elle affecter la grossesse ?",
"url": "https://questionsmedicales.fr/mesh/D006427?mesh_terms=Extensively+Drug-Resistant+Tuberculosis#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Hémine",
"description": "Quels sont les facteurs de risque de carence en hémine ?\nLes végétariens sont-ils à risque d'une carence en hémine ?\nLes personnes âgées sont-elles plus à risque ?\nLes maladies chroniques augmentent-elles le risque ?\nLe stress peut-il affecter les niveaux d'hémine ?",
"url": "https://questionsmedicales.fr/mesh/D006427?mesh_terms=Extensively+Drug-Resistant+Tuberculosis#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une carence en hémine ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic se fait par des tests sanguins mesurant les niveaux d'hémoglobine et de fer."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'hémine ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent l'électrophorèse des protéines et des dosages spécifiques d'hémine."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent un problème d'hémine ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme fatigue, pâleur et essoufflement peuvent indiquer un problème."
}
},
{
"@type": "Question",
"name": "Peut-on détecter l'hémine dans les urines ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests urinaires peuvent détecter des dérivés de l'hémine en cas de troubles."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'hémine dans le diagnostic des maladies ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'hémine est essentielle pour évaluer les troubles du métabolisme du fer et des globules rouges."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une surproduction d'hémine ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des douleurs abdominales, des nausées et des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Comment l'hémine affecte-t-elle la peau ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une accumulation d'hémine peut provoquer des éruptions cutanées et une photosensibilité."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une intoxication par l'hémine ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes d'intoxication incluent confusion, vertiges et troubles de la vision."
}
},
{
"@type": "Question",
"name": "L'hémine peut-elle causer des douleurs articulaires ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une accumulation d'hémine peut entraîner des douleurs articulaires et des inflammations."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à une carence en hémine ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, faiblesse musculaire et troubles cognitifs."
}
},
{
"@type": "Question",
"name": "Comment prévenir une carence en hémine ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et riche en fer aide à prévenir les carences en hémine."
}
},
{
"@type": "Question",
"name": "Les suppléments de fer sont-ils nécessaires ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les suppléments de fer peuvent être nécessaires pour les personnes à risque de carence."
}
},
{
"@type": "Question",
"name": "Quels aliments sont riches en hémine ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les viandes rouges, le poisson et les légumineuses sont riches en hémine et en fer."
}
},
{
"@type": "Question",
"name": "Comment surveiller les niveaux d'hémine ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des bilans sanguins réguliers peuvent aider à surveiller les niveaux d'hémine et de fer."
}
},
{
"@type": "Question",
"name": "Les femmes enceintes doivent-elles surveiller leur hémine ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les femmes enceintes doivent surveiller leurs niveaux d'hémine pour éviter les carences."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en hémine ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des suppléments de fer et des modifications alimentaires pour augmenter l'hémine."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont utilisés pour l'excès d'hémine ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des agents chélateurs peuvent être prescrits pour réduire l'excès d'hémine dans le corps."
}
},
{
"@type": "Question",
"name": "L'hémine peut-elle être administrée par voie intraveineuse ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'hémine peut être administrée par voie intraveineuse dans certains cas cliniques."
}
},
{
"@type": "Question",
"name": "Quels changements alimentaires sont recommandés ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en fer, comme les viandes rouges et les légumes à feuilles, est recommandée."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements alternatifs pour l'hémine ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements alternatifs incluent des thérapies à base de plantes, mais leur efficacité varie."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une carence en hémine ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent l'anémie, la fatigue chronique et des troubles cognitifs."
}
},
{
"@type": "Question",
"name": "L'excès d'hémine peut-il causer des maladies ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un excès d'hémine peut entraîner des maladies hépatiques et des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Comment l'hémine affecte-t-elle le système immunitaire ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux anormaux d'hémine peuvent affaiblir le système immunitaire et augmenter les infections."
}
},
{
"@type": "Question",
"name": "Quelles sont les conséquences d'une intoxication par l'hémine ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les conséquences incluent des dommages organiques, des troubles neurologiques et des décès potentiels."
}
},
{
"@type": "Question",
"name": "L'hémine peut-elle affecter la grossesse ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux anormaux d'hémine peuvent entraîner des complications pendant la grossesse."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de carence en hémine ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent une alimentation pauvre en fer, des troubles digestifs et des menstruations abondantes."
}
},
{
"@type": "Question",
"name": "Les végétariens sont-ils à risque d'une carence en hémine ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les végétariens peuvent être à risque en raison d'une consommation réduite de fer héminique."
}
},
{
"@type": "Question",
"name": "Les personnes âgées sont-elles plus à risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir un risque accru de carence en hémine en raison de l'absorption réduite."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques augmentent-elles le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies chroniques comme l'insuffisance rénale peuvent augmenter le risque de carence."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter les niveaux d'hémine ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut influencer les niveaux d'hémine et le métabolisme du fer."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 05/04/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Publications dans "Hémine" :
4 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Publications dans "Hémine" :
3 publications dans cette catégorie
Affiliations :
Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB), CNRS UMR6302, UBFC Dijon 21000, France.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Ireland.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Ireland; School of Biological and Chemical Sciences, Ryan Institute, National University of Ireland Galway, Ireland.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Ireland. Electronic address: Abhay.pandit@nuigalway.ie.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Department of Materials, Laboratory for Multifunctional Materials, ETH Zürich Vladimir-Prelog-Weg 5 8093 Zürich Switzerland peter.walde@mat.ethz.ch.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Department of Materials, Laboratory for Multifunctional Materials, ETH Zürich Vladimir-Prelog-Weg 5 8093 Zürich Switzerland peter.walde@mat.ethz.ch.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
2 publications dans cette catégorie
Affiliations :
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Chengdu, Sichuan, People's Republic of China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, People's Republic of China.
Publications dans "Hémine" :
To estimate the pooled proportion of extensively drug-resistant tuberculosis (XDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) in patients with multidrug-resistant TB (MDR-TB)....
We systematically searched articles from electronic databases: MEDLINE (PubMed), ScienceDirect, and Google Scholar. We also searched gray literature from the different literature sources main outcome ...
A total of 64 studies that reported on 12,711 patients with MDR-TB from 22 countries were retrieved. The pooled proportion of pre-XDR-TB was 26% (95% confidence interval [CI]: 22-31%), whereas XDR-TB ...
The burden of pre-XDR-TB and XDR-TB in MDR-TB were considerable. The high burdens of pre-XDR-TB and XDR-TB in patients treated for MDR-TB suggests the need to strengthen TB programs and drug resistanc...
Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the largest single contributor to human mortality due to antimicrobial resistance. A few major clades of the Mycobact...
Tuberculosis (TB) remains a leading infectious disease killer globally. Treatment outcomes are especially poor among people with extensively drug-resistant (XDR) TB, until recently defined as rifampic...
Multidrug-resistant tuberculosis (MDR-TB) has become a big threaten to global health. The current strategy for treatment of MDR-TB and extensive drug resistant tuberculosis (XDR-TB) is with low effica...
The activity of 8 tetracycline-class antibiotics against mycobacterium tuberculosis (M.tb) were determined by Minimum Inhibitory Concentration (MIC) in vitro. A transposon M.smeg libraries was generat...
We found that three of eight drugs efficiently inhibited mycobacteria growth under the peak plasma concentration in the human body. Further tests showed these three tetracycline analogs (demeclocyclin...
Our findings show that tetracycline analogs such as doxycycline, has bactericidal activity against not only drug sensitive M.tb, but also clinical MDR and XDR strains, provided proof of concept to rep...
Whole-genome sequencing (WGS)-based prediction of drug resistance in Mycobacterium tuberculosis has the potential to guide clinical decisions in the design of optimal treatment regimens....
We utilized WGS to investigate drug resistance mutations in a 32-year-old Tanzanian male admitted to Kibong'oto Infectious Diseases Hospital with a history of interrupted multidrug-resistant tuberculo...
Drug susceptibility testing of serial M. tuberculosis isolates using Mycobacterium Growth Incubator Tubes culture and WGS revealed resistance to first-line anti-TB drugs, bedaquiline, and fluoroquinol...
We propose the incorporation of WGS in the diagnostic framework for the optimal management of patients with drug-resistant and extensively drug-resistant tuberculosis....
The treatment success rate of conventional anti-tuberculosis (TB) regimens for extensively drug-resistant TB (XDR-TB) is low, resulting in high morbidity and healthcare cost especially in the high TB ...
A 2-year decision-analytic model was designed to evaluate the clinical and economic outcomes of a hypothetical cohort of adult XDR-TB patients with (1) BDQ-based regimen and (2) injectable-based conve...
In the base-case analysis, the BDQ group reduced 4.4152 DALYs with an incremental cost of USD1,606 when compared to the conventional group. The incremental cost per DALY averted (ICER) by the BDQ grou...
The BDQ-based therapy appeared to be cost-effective and showed a high probability to be accepted as the preferred cost-effective option for active XDR-TB treatment....
This study investigated the prevalence and significant clinical outcomes of pre-extensively drug-resistant plus additional drug-resistant tuberculosis (pre-XDR-plus) in Henan Provincial Chest Hospital...
We analysed and summarized the drug sensitivity test (DST) results of clinical Mycobacterium tuberculosis (MTB) strains in TB patients seeking care in the Tuberculosis Clinical Medical Research Centre...
Of the 3689 Mycobacterium tuberculosis strains, 639 (17.32%), 353 (9.56%), and 109 (2.95%), multidrug-resistant tuberculosis (MDR-TB), pre-extensively drug-resistant tuberculosis (pre-XDR), and pre-XD...
Our data suggest that the population of pre-XDR-plus had significantly decreased over the past five years in the Henan Provincial Chest Hospital. The COVID-19 and flood disaster affect TB patients' se...
Historically, extensively drug-resistant tuberculosis has been notoriously difficult to treat with devasting outcomes. As we are coming to the end of an era where the 2006 extensively drug-resistant t...
We conducted a systematic review of PubMed/MEDLINE, Scopus, Web of Science, and Embase from January 1, 2005, through April 3, 2023. Included studies reported WHO treatment outcomes, or adaptions hereo...
Among 5056 studies reviewed, we identified 94 studies from 26 countries, involving 10,223 extensively drug-resistant tuberculosis patients. The pooled proportion of successful treatment outcomes was 4...
Globally, the success rate of extensively drug-resistant tuberculosis treatment is 44.2%, far below the WHO's target rate of 75%. These results may serve as a reference for future studies assessing ex...
We describe a patient with concurrent ocular and pulmonary tuberculosis (TB) in whom the diagnosis of extensively drug-resistant TB was made through phenotypic drug-sensitivity testing of an ocular fl...
Anti-tuberculosis (antiTB) drugs are characterized by an important inter-interindividual pharmacokinetic variability poorly predictable from individual patients' characteristics. Therapeutic drug moni...
Plasma protein precipitation was used for all analytes except cycloserine, which was analyzed separately after derivatization with benzoyl chloride. AntiTB quadritherapy drugs (Pool1) were separated b...
The method covers the clinically relevant plasma levels and was extensively validated based on FDA recommendations, with intra- and inter-assay precision (CV) < 15% over the validated ranges. Applicat...
Such convenient extraction methods and the use of stable isotope-labelled drugs as internal standards provide an accurate and precise quantification of plasma concentrations of all major clinically-us...