Titre : Hémolysines

Hémolysines : Questions médicales fréquentes

Termes MeSH sélectionnés :

DNA Copy Number Variations
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Hémolysines : Questions médicales les plus fréquentes", "headline": "Hémolysines : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Hémolysines : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-07-22", "dateModified": "2025-04-18", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Hémolysines" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Perforines", "url": "https://questionsmedicales.fr/mesh/D052899", "about": { "@type": "MedicalCondition", "name": "Perforines", "code": { "@type": "MedicalCode", "code": "D052899", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.543.695" } } }, "about": { "@type": "MedicalCondition", "name": "Hémolysines", "alternateName": "Hemolysin Proteins", "code": { "@type": "MedicalCode", "code": "D006460", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Vanesa Herlax", "url": "https://questionsmedicales.fr/author/Vanesa%20Herlax", "affiliation": { "@type": "Organization", "name": "Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), CCT- La Plata, CONICET. Facultad de Ciencias Médicas. Universidad Nacional de La Plata, Argentina. Electronic address: vherlax@med.unlp.edu.ar." } }, { "@type": "Person", "name": "Li Li", "url": "https://questionsmedicales.fr/author/Li%20Li", "affiliation": { "@type": "Organization", "name": "Sichuan Animal Disease Prevention and Control Center, Chengdu 610041, China." } }, { "@type": "Person", "name": "Lucía Cané", "url": "https://questionsmedicales.fr/author/Luc%C3%ADa%20Can%C3%A9", "affiliation": { "@type": "Organization", "name": "Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), CCT- La Plata, CONICET. Facultad de Ciencias Médicas. Universidad Nacional de La Plata, Argentina." } }, { "@type": "Person", "name": "Pablo J Schwarzbaum", "url": "https://questionsmedicales.fr/author/Pablo%20J%20Schwarzbaum", "affiliation": { "@type": "Organization", "name": "Instituto de Química y Fisico-Química Biológicas (IQUIFIB) \"Prof. Alejandro C. Paladini\", Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina." } }, { "@type": "Person", "name": "Lin Wei", "url": "https://questionsmedicales.fr/author/Lin%20Wei", "affiliation": { "@type": "Organization", "name": "Changchun University of Chinese Medicine, Changchun, 130117, China." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Mapping recurrent mosaic copy number variation in human neurons.", "datePublished": "2024-05-17", "url": "https://questionsmedicales.fr/article/38760338", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1038/s41467-024-48392-0" } }, { "@type": "ScholarlyArticle", "name": "A pan-cancer landscape of pathogenic somatic copy number variations.", "datePublished": "2023-10-18", "url": "https://questionsmedicales.fr/article/37858853", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.jbi.2023.104529" } }, { "@type": "ScholarlyArticle", "name": "Copy number variations in SPAST and ATL1 are rare among Brazilians.", "datePublished": "2023-01-15", "url": "https://questionsmedicales.fr/article/36537231", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1111/cge.14280" } }, { "@type": "ScholarlyArticle", "name": "Copy number variation alters local and global mutational tolerance.", "datePublished": "2023-08-31", "url": "https://questionsmedicales.fr/article/37652668", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1101/gr.277625.122" } }, { "@type": "ScholarlyArticle", "name": "Contribution of copy number variations to the risk of severe eating disorders.", "datePublished": "2022-06-20", "url": "https://questionsmedicales.fr/article/35611833", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1111/pcn.13430" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Acides aminés, peptides et protéines", "item": "https://questionsmedicales.fr/mesh/D000602" }, { "@type": "ListItem", "position": 3, "name": "Protéines", "item": "https://questionsmedicales.fr/mesh/D011506" }, { "@type": "ListItem", "position": 4, "name": "Protéines membranaires", "item": "https://questionsmedicales.fr/mesh/D008565" }, { "@type": "ListItem", "position": 5, "name": "Perforines", "item": "https://questionsmedicales.fr/mesh/D052899" }, { "@type": "ListItem", "position": 6, "name": "Hémolysines", "item": "https://questionsmedicales.fr/mesh/D006460" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Hémolysines - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Hémolysines", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-09", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Hémolysines", "description": "Comment diagnostiquer une infection par hémolysines ?\nQuels tests sont utilisés pour détecter les hémolysines ?\nLes hémolysines sont-elles visibles sur une analyse sanguine ?\nQuels signes indiquent une hémolyse dans le sang ?\nPeut-on détecter les hémolysines par PCR ?", "url": "https://questionsmedicales.fr/mesh/D006460?mesh_terms=DNA+Copy+Number+Variations&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Hémolysines", "description": "Quels sont les symptômes d'une infection hémolytique ?\nComment l'hémolyse affecte-t-elle le corps ?\nY a-t-il des symptômes spécifiques aux hémolysines ?\nLes hémolysines provoquent-elles des réactions allergiques ?\nQuels signes cliniques sont associés à l'hémolyse ?", "url": "https://questionsmedicales.fr/mesh/D006460?mesh_terms=DNA+Copy+Number+Variations&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Hémolysines", "description": "Comment prévenir les infections par hémolysines ?\nLes personnes à risque doivent-elles prendre des précautions ?\nLes hémolysines peuvent-elles être évitées par l'alimentation ?\nLes mesures d'hygiène sont-elles suffisantes ?\nLes voyages à l'étranger augmentent-ils le risque d'hémolyse ?", "url": "https://questionsmedicales.fr/mesh/D006460?mesh_terms=DNA+Copy+Number+Variations&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Hémolysines", "description": "Quel traitement est recommandé pour une infection hémolytique ?\nComment traiter l'anémie causée par hémolyse ?\nLes corticostéroïdes sont-ils efficaces contre l'hémolyse ?\nY a-t-il des traitements préventifs pour les hémolysines ?\nQuand faut-il envisager une splénectomie ?", "url": "https://questionsmedicales.fr/mesh/D006460?mesh_terms=DNA+Copy+Number+Variations&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Hémolysines", "description": "Quelles complications peuvent survenir avec l'hémolyse ?\nL'hémolyse peut-elle entraîner des problèmes rénaux ?\nY a-t-il un risque de choc hypovolémique ?\nLes complications neurologiques sont-elles possibles ?\nComment gérer les complications liées à l'hémolyse ?", "url": "https://questionsmedicales.fr/mesh/D006460?mesh_terms=DNA+Copy+Number+Variations&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Hémolysines", "description": "Quels sont les facteurs de risque d'hémolyse ?\nLes personnes âgées sont-elles plus à risque ?\nLes maladies génétiques augmentent-elles le risque d'hémolyse ?\nLe stress peut-il influencer l'hémolyse ?\nLes transfusions sanguines augmentent-elles le risque d'hémolyse ?", "url": "https://questionsmedicales.fr/mesh/D006460?mesh_terms=DNA+Copy+Number+Variations&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une infection par hémolysines ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un diagnostic peut être établi par des tests sanguins et cultures bactériennes." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour détecter les hémolysines ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests d'hémolyse sur milieux de culture et les tests sérologiques sont courants." } }, { "@type": "Question", "name": "Les hémolysines sont-elles visibles sur une analyse sanguine ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Elles ne sont pas directement visibles, mais peuvent être détectées par des tests spécifiques." } }, { "@type": "Question", "name": "Quels signes indiquent une hémolyse dans le sang ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Une augmentation de la bilirubine et une diminution des globules rouges peuvent indiquer une hémolyse." } }, { "@type": "Question", "name": "Peut-on détecter les hémolysines par PCR ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la PCR peut être utilisée pour détecter les gènes codant pour les hémolysines." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une infection hémolytique ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fièvre, fatigue, et signes d'anémie comme pâleur." } }, { "@type": "Question", "name": "Comment l'hémolyse affecte-t-elle le corps ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "L'hémolyse peut entraîner une anémie, une jaunisse et des douleurs abdominales." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux hémolysines ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des douleurs lombaires et des urines foncées peuvent survenir en cas d'hémolyse." } }, { "@type": "Question", "name": "Les hémolysines provoquent-elles des réactions allergiques ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Elles peuvent provoquer des réactions immunitaires, mais pas des allergies classiques." } }, { "@type": "Question", "name": "Quels signes cliniques sont associés à l'hémolyse ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Les signes incluent tachycardie, hypotension et signes de choc dans les cas graves." } }, { "@type": "Question", "name": "Comment prévenir les infections par hémolysines ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Maintenir une bonne hygiène et se faire vacciner contre les bactéries responsables." } }, { "@type": "Question", "name": "Les personnes à risque doivent-elles prendre des précautions ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes immunodéprimées doivent éviter les contacts avec des sources d'infection." } }, { "@type": "Question", "name": "Les hémolysines peuvent-elles être évitées par l'alimentation ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée renforce le système immunitaire, mais ne prévient pas directement." } }, { "@type": "Question", "name": "Les mesures d'hygiène sont-elles suffisantes ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Elles sont essentielles, mais doivent être combinées avec la vaccination pour une protection optimale." } }, { "@type": "Question", "name": "Les voyages à l'étranger augmentent-ils le risque d'hémolyse ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains pays présentent un risque accru d'infections hémolytiques, surtout sans vaccination." } }, { "@type": "Question", "name": "Quel traitement est recommandé pour une infection hémolytique ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les antibiotiques sont souvent prescrits pour traiter les infections causées par hémolysines." } }, { "@type": "Question", "name": "Comment traiter l'anémie causée par hémolyse ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des transfusions sanguines et des suppléments de fer peuvent être nécessaires." } }, { "@type": "Question", "name": "Les corticostéroïdes sont-ils efficaces contre l'hémolyse ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent réduire l'inflammation et la destruction des globules rouges." } }, { "@type": "Question", "name": "Y a-t-il des traitements préventifs pour les hémolysines ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "La vaccination contre certaines bactéries peut aider à prévenir les infections hémolytiques." } }, { "@type": "Question", "name": "Quand faut-il envisager une splénectomie ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Une splénectomie peut être envisagée en cas d'hémolyse auto-immune sévère et réfractaire." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec l'hémolyse ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent l'anémie sévère, la jaunisse et des défaillances organiques." } }, { "@type": "Question", "name": "L'hémolyse peut-elle entraîner des problèmes rénaux ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'hémolyse peut provoquer une insuffisance rénale aiguë en raison de la libération de toxines." } }, { "@type": "Question", "name": "Y a-t-il un risque de choc hypovolémique ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une hémolyse massive peut entraîner un choc hypovolémique en raison de la perte de sang." } }, { "@type": "Question", "name": "Les complications neurologiques sont-elles possibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Des complications neurologiques peuvent survenir, notamment en cas d'anémie sévère prolongée." } }, { "@type": "Question", "name": "Comment gérer les complications liées à l'hémolyse ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "La gestion nécessite un traitement rapide des infections et un suivi médical régulier." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque d'hémolyse ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des maladies auto-immunes, des infections et des antécédents transfusionnels." } }, { "@type": "Question", "name": "Les personnes âgées sont-elles plus à risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes âgées ont un risque accru d'hémolyse en raison de la fragilité de leur système immunitaire." } }, { "@type": "Question", "name": "Les maladies génétiques augmentent-elles le risque d'hémolyse ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Certaines maladies génétiques, comme la sphérocytose, augmentent le risque d'hémolyse." } }, { "@type": "Question", "name": "Le stress peut-il influencer l'hémolyse ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Le stress peut affaiblir le système immunitaire, augmentant ainsi le risque d'infections hémolytiques." } }, { "@type": "Question", "name": "Les transfusions sanguines augmentent-elles le risque d'hémolyse ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des transfusions incompatibles peuvent provoquer une hémolyse aiguë." } } ] } ] }

Sources (10000 au total)

A pan-cancer landscape of pathogenic somatic copy number variations.

Copy number variations (CNVs) play crucial roles in physiological and pathological processes, including cancer. However, the functional implications of somatic CNVs in tumor progression and evolution ... Starting from 7352 copy number profiles across 33 different cancer types, we infer the pathogenicity of each CNV and perform both intra- and inter-tumor analyses to predict the functional impact of di... Our analysis uncovered large heterogeneity among different tumors suggesting in many cases distinct genetic drivers of tumorigenesis. Recurrent genomic alterations frequently coincide with dysfunction... This study contributes to elucidate the functional impact of pathogenic CNVs in tumor progression and sheds light on their potential as prognostic markers in specific cancer types....

Contribution of copy number variations to the risk of severe eating disorders.

Eating disorders (EDs) are complex, multifactorial psychiatric conditions. Previous studies identified pathogenic copy number variations associated with NDDs (NDD-CNVs) in ED patients. However, no sta... Using array comparative genomic hybridization (aCGH), we conducted a high-resolution CNV analysis of 71 severe female ED patients and 1045 female controls. According to the American College of Medical... Of the samples analyzed with aCGH, 70 severe ED patients (98.6%) and 1036 controls (99.1%) passed our quality control filtering. We obtained 189 and 2539 rare CNVs from patients and controls, respecti... Our study provides the first preliminary evidence that NDD-CNVs may confer risk for severe EDs. The pathophysiology may involve synaptic dysfunction....

Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma.

Circulating cell-free DNA (cfDNA) is a noninvasive substitute to liver biopsy for hepatocellular carcinoma (HCC) molecular profiling. This study aimed to use cfDNA to investigate copy number variation... Real-Time Polymerase Chain Reaction was used to determine the CNV and cfDNA integrity index in 100 HCC patients.... CNV gain in BCL9 and RPS6KB1 genes was detected in 14% and 24% of patients, respectively. Gain in CNV of BCL9 associated with risk of HCC in alcohol drinkers and hepatitis C seropositivity. In patient... cfDNA was used to detect BCL9 and RPS6KB1 CNVs, which influence prognosis and can be used as independent predictors of HCC patient survival....

Multiallelic Copy Number Variation in ORM1 is Associated with Plasma Cell-Free DNA Levels as an Intermediate Phenotype for Venous Thromboembolism.

Venous thromboembolism (VTE) is a common disease with high heritability. However, only a small portion of the genetic variance of VTE can be explained by known genetic risk factors. Neutrophil extrace...

Mitochondrial DNA copy number and risk of papillary thyroid carcinoma.

Mitochondrial DNA (mtDNA) copy number is associated with tumor activity and carcinogenesis. This study was undertaken to investigate mtDNA copy number in papillary thyroid cancer (PTC) tissues and to ... DNA was extracted from 105 PTC tissues and 67 control thyroid tissues, and mtDNA copy number mtDNA oxidative damage were determined using qPCR techniques.... Overall, the relative mtDNA copy number was significantly higher in PTC patients (p < 0.001). The risk of developing PTC increased significantly across the tertiles of mtDNA copy number (p trend < 0.0... Our results indicated that the augmentation of mtDNA content plays a significant role during the initiation of thyroid cancer, and it might represent a potential biomarker for predicting the risk of P...

Copy number variations (CNVs) and karyotyping analysis in males with azoospermia and oligospermia.

Considering the essential roles that genetic factors play in azoospermia and oligospermia, this study aims to identify abnormal chromosomes using karyotyping and CNVs and elucidate the associated gene... A total of 1157 azoospermia and oligospermia patients were recruited, of whom, 769 and 674 underwent next-generation sequencing (NGS) to identify CNVs and routine G-band karyotyping, respectively.... First, 286 patients were co-analyzed using CNV sequencing (CNV-seq) and karyotyping. Of the 725 and 432 patients with azoospermia and oligospermia, 33.8% and 48.9% had abnormal karyotypes and CNVs, re... Sex chromosome and autosomal CNV loci, such as Xp22.31 and 2p24.3, as well as the associated genes, such as VCX and NACAP9, could be candidate spermatogenesis genes. The high-frequency abnormal karyot...

dbCNV: deleteriousness-based model to predict pathogenicity of copy number variations.

Copy number variation (CNV) is a type of structural variation, which is a gain or loss event with abnormal changes in copy number. Methods to predict the pathogenicity of CNVs are required to realize ... From single nucleotide polymorphism (SNP), gene and region dimensions, we collected 79 informative features that quantitatively describe the characteristics of CNV, such as CNV length, the number of p... The performance of the dbCNV suggest that functional deleteriousness-based model of CNV is a promising approach to support the classification prediction and to further understand the pathogenic mechan...