Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
From the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
From the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
From the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
From the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
From the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
From the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
From the China National Clinical Research Center for Neurological Diseases (Y.-Y.X.), Beijing Tiantan Hospital, Capital Medical University; Centre for Clinical Brain Sciences (F.M.C., M.D.C.V.H., C.A.-R., U.C., D.J.G., S.W., M.S.S., M.T., A.C.C.J., F.D., J.M.W.), UK Dementia Research Institute, University of Edinburgh, United Kingdom; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu; Department of Neurology & Institute of Neurology (J.Z.), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine; and Division of Neurology (X.L.), Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, China.
Perls Prussian blue stain (PPB) for hemosiderin, a marker of vascular injury is often employed as an adjunct in the diagnosis of vasculitic neuropathies. However, inflammation/vascular injury is also ...
We evaluated 208 peripheral nerve biopsies for hemosiderin deposits by PPB stain in vasculitis (78) and compared with inflammatory/immune neuropathies [leprous neuritis-32, chronic inflammatory demyel...
Hemosiderin deposits were most frequent in vasculitis (48.72%) [59.2% in systemic; 43.1% in nonsystemic vasculitides] and enhanced the sensitivity of diagnosis in "probable" vasculitis (34.48%) that l...
These findings suggest that PPB stain for detection of hemosiderin is a useful adjunct in diagnosis of vasculitic neuropathy with high specificity but low sensitivity....
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematopoietic stem cell disease with features of hemolytic anemia, thrombosis, and bone marrow failure. Due to intravascular hemolysis and hemoglobi...
A 25-year old woman presenting gross hematuria after coronavirus disease 2019 infection was admitted to our medical center. She had mild nausea and headache. She was diagnosed with iron deficiency ane...
Renal biopsy was done to determine the cause of renal failure and the result was acute tubular necrosis with deposition of golden pigments, hemosiderin. With pathologic result and laboratory finding o...
With AKI and oliguria, the patient started to take hemodialysis....
After taking 5 sessions of hemodialysis, the patient's renal function was recovered from AKI. With diagnosis of PNH, the patient is now being treated with complement C5 inhibitor....
This challenging case tells us that we should consider the first manifestation of PNH as a cause of severe AKI requiring hemodialysis in a patient with anemia and evidence of hemolysis....
A quarter of ischemic strokes are of lacunar clinical subtype and have an underlying recent small subcortical infarct (RSSI), but their long-term outcomes remain poorly characterized. Hemosiderin depo...
Participants with RSSIs were identified from a prospective longitudinal study and evaluated on 3T MRI including susceptibility-weighted imaging (SWI) from stroke diagnosis to 12 months. We categorized...
HDs were observed in 43 (55.0%) of 108 participants within 3 months and 83 (76.9%) of 108 within 12 months after stroke onset. The mean time to first detection of HDs was 87 (interquartile range 53-16...
HDs occur commonly in RSSIs and may be associated with infarct volume and SVD score. Hemosiderin "rim" is common in RSSIs, urging caution to avoid mistaking ischemic RSSI for primary hemorrhage in sub...
To describe, and to evaluate the clinical and radiological characteristics of pediatric cavernous malformations (CMs) and the surgical approaches and their outcomes in a single center....
We retrospectively reviewed pediatric patients with CMs that were treated in our center between 2010 and 2020. Radiological, clinical, and demographic features, as well as treatment details were evalu...
Of 23 patients, 12 were male, and 11 were female. Two patients with multiple CMs had a family history. The most common symptoms were headaches (9/23, 39.1%) and seizures (9/23, 39.1%). Twenty patients...
Since pediatric CMs are more aggressive than adult CMs, they should not be underestimated. Microsurgical total resection should be the first treatment choice where possible. We concluded that early su...
Spinal epidural cavernous hemangiomas (SECHs) are rare, and merely a few have previously been described in case reports. The present study aims to explore the magnetic resonance imaging (MRI) features...
The present retrospective study included 11 patients (three male and eight female patients, mean age ± standard deviation: 47.55±17.39 years old) with histopathologically confirmed SECH between Januar...
The cervical, thoracic and thoracolumbar segments were involved in 2, 7 and 2 patients, respectively. All lesions grew along the long axis of the spine. The tumors were shuttle-shaped in six patients,...
SECH presents as a long spindle-shaped mass, and the "'pen cap sign" is common at the lesion edges. SECH also exhibits a hairline or grid sign on T2WI. Furthermore, some lesions present with hemorrhag...
The deceased was a 44-year-old male who was treated for a suspected Ebstein's anomaly observed using transthoracic echocardiogram. He was found dead in his bed at home. Autopsy revealed that the septa...
Cerebral microbleeds (CMBs) detected on magnetic resonance imaging are common in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The...
The objective of this study was to describe the CT and MRI features of sclerosing angiomatoid nodular transformation (SANT) of the spleen with pathologic correlation....
Ten patients with surgically resected and pathologically confirmed SANTs were included. Clinical history was reviewed, and gross pathologic, histologic, and immunohistochemical findings were recorded....
Patients included seven men and three women, with a mean age of 42.9±16.7 years. Pathologic features of SANTs involved multiple angiomatous nodules in a radiating pattern with a central stellate fibro...
Characteristics of SANTs on CT/MRI reflected the underlying pathology. Hypointensity on DWI and T2WI, and change of signal on T1 chemicalshift imaging were found to be due to hemosiderin deposition an...
Superficial siderosis is a rare disease resulting from the deposited hemosiderin owing to repeated subarachnoid hemorrhage. It has been reported that hemosiderin deposits on the brain surface and brai...
Tenosynovial Giant Cell Tumor (TGCT) is a group of typically benign lesions arising from the synovium of joints, bursae and tendon sheaths. Depending on their growth pattern and clinical course, they ...
