Titre : Substances humiques

Substances humiques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Gain of Function Mutation
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carence en substances humiques ?\nQuels tests sont utilisés pour mesurer les substances humiques ?\nLes substances humiques peuvent-elles être mesurées dans le sang ?\nQuels indicateurs de santé des sols sont liés aux substances humiques ?\nComment évaluer l'impact des substances humiques sur la santé des plantes ?", "url": "https://questionsmedicales.fr/mesh/D006812?mesh_terms=Gain+of+Function+Mutation&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Substances humiques", "description": "Quels symptômes indiquent un manque de substances humiques dans le sol ?\nLes substances humiques affectent-elles la qualité de l'eau ?\nComment les substances humiques influencent-elles la santé des sols ?\nQuels effets les substances humiques ont-elles sur les cultures ?\nLes substances humiques peuvent-elles causer des symptômes chez l'homme ?", "url": 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utilisées en agriculture ?\nComment les substances humiques aident-elles à traiter les sols pollués ?\nLes substances humiques sont-elles utilisées en médecine ?", "url": "https://questionsmedicales.fr/mesh/D006812?mesh_terms=Gain+of+Function+Mutation&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Substances humiques", "description": "Quelles complications peuvent survenir avec une carence en substances humiques ?\nLes substances humiques peuvent-elles interagir avec des polluants ?\nComment une mauvaise gestion des substances humiques affecte-t-elle l'environnement ?\nLes substances humiques peuvent-elles causer des problèmes de santé ?\nQuels effets les substances humiques ont-elles sur les écosystèmes aquatiques ?", "url": "https://questionsmedicales.fr/mesh/D006812?mesh_terms=Gain+of+Function+Mutation&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Substances humiques", "description": "Quels facteurs augmentent la dégradation des substances humiques ?\nComment le changement climatique affecte-t-il les substances humiques ?\nQuels types de sols sont plus susceptibles de perdre des substances humiques ?\nL'utilisation de pesticides influence-t-elle les substances humiques ?\nQuels impacts des pratiques agricoles intensives sur les substances humiques ?", "url": "https://questionsmedicales.fr/mesh/D006812?mesh_terms=Gain+of+Function+Mutation&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une carence en substances humiques ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur l'analyse des sols et des échantillons d'eau pour évaluer leur teneur en humiques." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour mesurer les substances humiques ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests chimiques et spectroscopiques, comme la spectroscopie UV-Vis, sont couramment utilisés." } }, { "@type": "Question", "name": "Les substances humiques peuvent-elles être mesurées dans le sang ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Non, elles sont principalement présentes dans le sol et l'eau, pas dans le sang humain." } }, { "@type": "Question", "name": "Quels indicateurs de santé des sols sont liés aux substances humiques ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "La biodiversité microbienne et la capacité de rétention d'eau sont des indicateurs clés." } }, { "@type": "Question", "name": "Comment évaluer l'impact des substances humiques sur la santé des plantes ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "On évalue la croissance des plantes et leur résistance aux maladies en fonction de leur teneur en humiques." } }, { "@type": "Question", "name": "Quels symptômes indiquent un manque de substances humiques dans le sol ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes incluent une croissance réduite des plantes et une mauvaise rétention d'eau." } }, { "@type": "Question", "name": "Les substances humiques affectent-elles la qualité de l'eau ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles améliorent la qualité de l'eau en réduisant la toxicité et en favorisant la filtration." } }, { "@type": "Question", "name": "Comment les substances humiques influencent-elles la santé des sols ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Elles améliorent la structure du sol, augmentent la fertilité et favorisent la biodiversité." } }, { "@type": "Question", "name": "Quels effets les substances humiques ont-elles sur les cultures ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Elles augmentent le rendement des cultures et améliorent leur résistance aux stress environnementaux." } }, { "@type": "Question", "name": "Les substances humiques peuvent-elles causer des symptômes chez l'homme ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Non, elles ne sont pas toxiques pour l'homme et n'entraînent pas de symptômes directs." } }, { "@type": "Question", "name": "Comment prévenir la dégradation des substances humiques dans le sol ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Pratiquer une agriculture durable et éviter l'érosion du sol aide à préserver les humiques." } }, { "@type": "Question", "name": "Quelles pratiques agricoles favorisent les substances humiques ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "La rotation des cultures et l'utilisation de cultures de couverture favorisent leur accumulation." } }, { "@type": "Question", "name": "Comment la gestion de l'eau influence-t-elle les substances humiques ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Une gestion adéquate de l'eau prévient le lessivage des humiques et maintient leur concentration." } }, { "@type": "Question", "name": "Les substances humiques peuvent-elles être protégées par des pratiques de conservation ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les pratiques de conservation comme le paillage aident à maintenir leur niveau dans le sol." } }, { "@type": "Question", "name": "Quel rôle joue la biodiversité dans la préservation des substances humiques ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Une biodiversité riche favorise la décomposition et la formation de substances humiques dans le sol." } }, { "@type": "Question", "name": "Comment améliorer la teneur en substances humiques du sol ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "L'ajout de compost, de fumier ou d'amendements organiques enrichit le sol en humiques." } }, { "@type": "Question", "name": "Quels produits contiennent des substances humiques ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des extraits de tourbe, de lignite et des produits à base de compost en contiennent." } }, { "@type": "Question", "name": "Les substances humiques peuvent-elles être utilisées en agriculture ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles sont utilisées comme amendements pour améliorer la fertilité et la structure du sol." } }, { "@type": "Question", "name": "Comment les substances humiques aident-elles à traiter les sols pollués ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Elles peuvent immobiliser les contaminants et améliorer la dégradation des polluants." } }, { "@type": "Question", "name": "Les substances humiques sont-elles utilisées en médecine ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Elles sont explorées pour leurs propriétés antioxydantes et anti-inflammatoires, mais pas encore validées." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec une carence en substances humiques ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Une carence peut entraîner une baisse de la fertilité du sol et des rendements agricoles." } }, { "@type": "Question", "name": "Les substances humiques peuvent-elles interagir avec des polluants ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent se lier à des polluants, réduisant leur biodisponibilité et leur toxicité." } }, { "@type": "Question", "name": "Comment une mauvaise gestion des substances humiques affecte-t-elle l'environnement ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut entraîner une dégradation des sols, une perte de biodiversité et une pollution de l'eau." } }, { "@type": "Question", "name": "Les substances humiques peuvent-elles causer des problèmes de santé ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Non, elles ne sont pas considérées comme nocives pour la santé humaine lorsqu'elles sont utilisées correctement." } }, { "@type": "Question", "name": "Quels effets les substances humiques ont-elles sur les écosystèmes aquatiques ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Elles peuvent améliorer la qualité de l'eau et soutenir la vie aquatique en réduisant la toxicité." } }, { "@type": "Question", "name": "Quels facteurs augmentent la dégradation des substances humiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'érosion, la surexploitation des sols et l'utilisation excessive de produits chimiques sont des facteurs clés." } }, { "@type": "Question", "name": "Comment le changement climatique affecte-t-il les substances humiques ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Le changement climatique peut modifier la décomposition de la matière organique, affectant les humiques." } }, { "@type": "Question", "name": "Quels types de sols sont plus susceptibles de perdre des substances humiques ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Les sols sableux et ceux soumis à une forte érosion sont plus susceptibles de perdre des humiques." } }, { "@type": "Question", "name": "L'utilisation de pesticides influence-t-elle les substances humiques ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'utilisation excessive de pesticides peut nuire à la biodiversité et réduire les humiques." } }, { "@type": "Question", "name": "Quels impacts des pratiques agricoles intensives sur les substances humiques ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Elles entraînent une dégradation du sol et une diminution des substances humiques, affectant la fertilité." } } ] } ] }

Sources (10000 au total)

Clinical azole cross-resistance in Candida parapsilosis is related to a novel MRR1 gain-of-function mutation.

Hereby, we describe the molecular mechanisms underlying the acquisition of azole resistance by a Candida parapsilosis isolate following fluconazole treatment due to candiduria.... A set of three consecutive C. parapsilosis isolates were recovered from the urine samples of a patient with candiduria. Whole-genome sequencing and antifungal susceptibility assays were performed. The... The initial isolate CPS-A was susceptible to all three azoles tested (fluconazole, voriconazole and posaconazole); isolate CPS-B, collected after the second cycle of treatment, exhibited a susceptible... Our results describe clinical azole cross-resistance acquisition in C. parapsilosis due to a G1810A (G604R) gain-of-function mutation, resulting in MRR1 hyperactivation and consequently, MDR1 efflux p...

Immunophenotyping and Therapeutic Insights from Chronic Mucocutaneous Candidiasis Cases with STAT1 Gain-of-Function Mutations.

Heterozygous STAT1 Gain-of-Function (GOF) mutations are the most common cause of chronic mucocutaneous candidiasis (CMC) among Inborn Errors of Immunity. Clinically, these mutations manifest as a broa... We analyzed clinical presentations, cellular phenotypes, and functional impacts in five Taiwanese patients with STAT1 GOF.... We identified two novel GOF mutations in 5 patients from 2 Taiwanese families, presenting with symptoms of CMC, late-onset rosacea, and autoimmunity. The enhanced phosphorylation and delayed dephospho... Our study provides the first comprehensive clinical and molecular characteristics in STAT1 GOF patient in Taiwan and highlights the dysregulated T and B cells subsets which may hinge the autoimmunity ...

Chinese Pedigree of Chronic Mucocutaneous Candidiasis Due to STAT1 Gain-of-Function Mutation: A Case Study and Literature Review.

To further elucidate the clinical, immunological and genetic features of chronic mucocutaneous candidiasis (CMC) due to STAT1 GOF mutation in the Chinese population.... Clinical data for a proband were collected, and pedigree analyses were performed. Whole-exome sequencing and targeted Sanger sequencing were conducted to explore genetic factors of a Chinese pedigree ... An autosomal dominant CMC pedigree was identified, and both the proband and his father had mucocutaneous Candida infections without involvement of other systems. A rare mutation (c.T1175C) in STAT1 wa... STAT1 GOF mutation at c.T1175C (p.M392T) may lead to mucocutaneous Candida infections and an increase in serum IFN-α. T385M in the DNA-binding domain is the most common STAT1 GOF mutation found in the...

TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma.

Although the molecular features of pancreatic ductal adenocarcinoma (PDAC) have been well described, the impact of detailed gene mutation subtypes on disease progression remained unclear. This study a... We included 639 patients treated with PDAC in Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine between Jan 2019 and Jun 2021. The genomic alterations of PDAC were analyzed... TP53 missense mutation was significantly associated with poor differentiation in KRAS... TP53 missense mutation was associated with poor tumor differentiation, and revealed gain-of-function properties in small-sized KRAS transformed PDAC. Nonetheless, it was not associated with insensitiv...

Gain-of-function p.F28S variant in

We investigated an early adolescent female with intellectual disability, drug-responsive epilepsy and white matter abnormalities. Through exome sequencing, we identified the novel de novo variant (NM_... In vitro analyses revealed that the p.F28S variant was spontaneously activated by substantially increased intrinsic GTP/GDP-exchange activity and bound to downstream effectors tested, such as PAK1 and... Our results indicate that RAC3 is critical for brain development and the p.F28S variant causes morphological and functional defects in cortical neurons, likely due to the hyperactivation of PAK1....

Distal Arthrogryposis type 5 in an Italian family due to an autosomal dominant gain-of-function mutation of the PIEZO2 gene.

Arthrogryposis multiplex congenita (AMC) is a group of clinically and etiologically heterogeneous conditions, characterized by prenatal onset contractures affecting two or more joints. Its incidence i... Hereby, we report on a four-generation Italian family with DA5. Our first proband was a newborn with prenatal suspicion of AMC. At birth, clinical findings were compatible with a DA diagnosis. Family ... Our patients contribute to the current DA5 genomic database, and to a better characterization of the disease. Clinicians may have suspicion of a DA diagnosis based on suggestive (also prenatal) clinic...

EZH2 W113C is a gain-of-function mutation in B-cell lymphoma enabling both PRC2 methyltransferase activation and tazemetostat resistance.

Polycomb repressive complex 2 (PRC2) suppresses gene transcription by methylating lysine 27 of histone H3 (H3K27) and plays critical roles in embryonic development. Among the core PRC2 subunits, EZH2 ...