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"description": "Comment diagnostiquer une indication pour l'hydroxyurée ?\nQuels tests sont nécessaires avant de commencer l'hydroxyurée ?\nL'hydroxyurée est-elle utilisée pour tous les cancers ?\nQuels signes cliniques indiquent un besoin d'hydroxyurée ?\nComment évaluer l'efficacité de l'hydroxyurée ?",
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"@type": "Question",
"name": "Comment diagnostiquer une indication pour l'hydroxyurée ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur des tests sanguins et l'évaluation des symptômes cliniques."
}
},
{
"@type": "Question",
"name": "Quels tests sont nécessaires avant de commencer l'hydroxyurée ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de la fonction hépatique et rénale sont recommandés avant le traitement."
}
},
{
"@type": "Question",
"name": "L'hydroxyurée est-elle utilisée pour tous les cancers ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle est principalement utilisée pour les leucémies et certains cancers solides."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent un besoin d'hydroxyurée ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes comme la splénomégalie ou des taux élevés de globules blancs peuvent indiquer son utilisation."
}
},
{
"@type": "Question",
"name": "Comment évaluer l'efficacité de l'hydroxyurée ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité est évaluée par des analyses sanguines régulières et l'observation des symptômes."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires courants de l'hydroxyurée ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires incluent la fatigue, des nausées et des éruptions cutanées."
}
},
{
"@type": "Question",
"name": "L'hydroxyurée provoque-t-elle des symptômes neurologiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme des maux de tête ou des vertiges peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une réaction allergique à l'hydroxyurée ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des démangeaisons, un gonflement ou des difficultés respiratoires peuvent indiquer une allergie."
}
},
{
"@type": "Question",
"name": "L'hydroxyurée peut-elle causer des problèmes gastro-intestinaux ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des nausées, vomissements ou diarrhées peuvent être des effets indésirables."
}
},
{
"@type": "Question",
"name": "Quels signes d'infection peuvent apparaître sous hydroxyurée ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une fièvre, des frissons ou des douleurs peuvent indiquer une infection due à l'immunosuppression."
}
},
{
"@type": "Question",
"name": "Comment prévenir les effets secondaires de l'hydroxyurée ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une hydratation adéquate et un suivi régulier peuvent aider à prévenir certains effets secondaires."
}
},
{
"@type": "Question",
"name": "Des précautions sont-elles nécessaires lors de la prise d'hydroxyurée ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il faut éviter les vaccins vivants et informer le médecin de toute infection."
}
},
{
"@type": "Question",
"name": "L'hydroxyurée nécessite-t-elle des tests de laboratoire réguliers ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests sanguins réguliers sont nécessaires pour surveiller la fonction sanguine."
}
},
{
"@type": "Question",
"name": "Comment minimiser le risque d'infection sous hydroxyurée ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les foules et se laver fréquemment les mains peut réduire le risque d'infection."
}
},
{
"@type": "Question",
"name": "Quelles sont les recommandations alimentaires sous hydroxyurée ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et riche en nutriments est recommandée pour soutenir la santé."
}
},
{
"@type": "Question",
"name": "Comment l'hydroxyurée est-elle administrée ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'hydroxyurée est généralement administrée par voie orale sous forme de comprimés."
}
},
{
"@type": "Question",
"name": "Quelle est la posologie standard de l'hydroxyurée ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La posologie varie, mais elle est souvent de 500 mg à 2000 mg par jour selon l'indication."
}
},
{
"@type": "Question",
"name": "L'hydroxyurée nécessite-t-elle un suivi médical régulier ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour surveiller les effets secondaires et l'efficacité."
}
},
{
"@type": "Question",
"name": "Peut-on combiner l'hydroxyurée avec d'autres traitements ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut être combinée avec d'autres thérapies anticancéreuses, mais sous supervision."
}
},
{
"@type": "Question",
"name": "Quels sont les conseils pour prendre l'hydroxyurée ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est conseillé de prendre le médicament avec un grand verre d'eau et de ne pas écraser les comprimés."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec l'hydroxyurée ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme l'anémie, la thrombocytopénie et des infections peuvent survenir."
}
},
{
"@type": "Question",
"name": "L'hydroxyurée peut-elle causer des problèmes pulmonaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des complications pulmonaires comme la fibrose pulmonaire sont possibles mais rares."
}
},
{
"@type": "Question",
"name": "Quels sont les risques de cancer associés à l'hydroxyurée ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'utilisation prolongée peut augmenter le risque de certains cancers, comme les leucémies."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées à l'hydroxyurée ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion implique un suivi médical étroit et des ajustements de posologie si nécessaire."
}
},
{
"@type": "Question",
"name": "Des complications cutanées peuvent-elles survenir ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des éruptions cutanées et des changements de pigmentation peuvent se produire."
}
},
{
"@type": "Question",
"name": "Qui est à risque d'effets secondaires de l'hydroxyurée ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées et celles avec des problèmes rénaux sont plus à risque d'effets secondaires."
}
},
{
"@type": "Question",
"name": "L'hydroxyurée est-elle contre-indiquée chez certaines personnes ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle est contre-indiquée chez les femmes enceintes et les personnes allergiques à ses composants."
}
},
{
"@type": "Question",
"name": "Quels médicaments interagissent avec l'hydroxyurée ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les immunosuppresseurs peuvent interagir et augmenter les risques."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux influencent-ils l'utilisation de l'hydroxyurée ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de maladies hématologiques peuvent influencer la décision de traitement."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour l'hydroxyurée ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir un risque accru d'effets indésirables et de complications."
}
}
]
}
]
}
The Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i) trial is being conducted to establish whether 'screening and intervention', consisting of usual school practice...
iCATS-i2i is a definitive, superiority, pragmatic, school-based cluster randomised controlled trial (with internal pilot), with two parallel groups. Schools are randomised 1:1 to receive either screen...
ClinicalTrials.gov ISRCTN76119074. Registered on 4 January 2022....
Although mental health challenges disproportionately affect people in humanitarian contexts, most refugee youth do not receive the mental health support needed. Uganda is the largest refugee-hosting n...
The aim of this study is to evaluate the feasibility and effectiveness of two youth-tailored mental health interventions (VR alone and VR combined with GMP+) in comparison with the standard of care in...
A three-arm cluster randomized controlled trial will be implemented across five informal settlements grouped into three sites, based on proximity, and randomized in a 1:1:1 design. Approximately 330 a...
The study will be conducted in accordance with CONSORT (Consolidated Standards of Reporting Trials) guidelines. The study has received ethical approval from the University of Toronto (#40965; May 12, ...
This study will contribute to the knowledge of youth-tailored mental health intervention strategies for urban refugee and displaced youth living in informal settlements in LMIC contexts. Findings will...
ClinicalTrials.gov NCT05187689; https://clinicaltrials.gov/ct2/show/NCT05187689....
DERR1-10.2196/42342....
The self-medication hypothesis (SMH) suggests that individuals consume alcohol to alleviate stressful emotions. Still, the underlying mechanisms between stress and heavy episodic drinking remain to be...
We examined the indirect influences of parenting styles (e.g., permissive, authoritarian, and authoritative) on heavy episodic drinking and alcohol-related problems through the mediating mechanisms of...
Higher levels of authoritative parenting (mother and father) were indirectly linked to fewer alcohol-related problems and less heavy episodic drinking through less stress and IC. Maternal permissivene...
Maternal permissiveness contributes to the use of alcohol to alleviate stress. Thus, reducing stress may reduce problematic heavy drinking and alcohol problems among emerging adults with high IC who m...
Anal human papillomavirus (HPV) disproportionately affects men who have sex with men (MSM), particularly those who are older and those living with HIV. After experiencing difficulty recruiting older M...
We conducted focus groups with 30 men who have sex with men (MSM), both HIV-negative and MSM living with HIV, ages 50-75....
We identified multiple themes that were barriers to participation including: (1) lack of knowledge about human papillomavirus and anal cancer; (2) research focused on anal cancer or discomfort with to...
Researchers seeking to enroll older men who have sex with men should be aware of these barriers and facilitators to participation in order to maximize recruitment....
Common mental health problems (particularly depression and anxiety) are common among adolescents during the perinatal period. Previous research has identified the distinctive needs of this group and c...
Excessive alcohol use can bring about adverse health and work-related consequences in civilian and military populations. Screening for excessive drinking can help identify individuals at risk for alco...
Cross-sectional pre/post-deployment survey data were used....
Comprised Army locations in Canada and UK, and selected US Army units....
Included soldiers in each of the above-mentioned settings....
Soldiers' AUDIT scores for hazardous and harmful alcohol use or high levels of alcohol problems served as a benchmark against which optimal sex-specific AUDIT-C cut-points were assessed....
Across the three-nation samples, AUDIT-C cut-points of ≥6/7 for men and ≥5/6 for women performed well in detecting hazardous and harmful alcohol use and provided comparable prevalence estimates to AUD...
This multi-national study provides valuable information regarding appropriate AUDIT-C cut-points for detecting hazardous and harmful alcohol use, and high levels of alcohol problems among soldiers. Su...
Gain insight into the effects of the COVID-19 pandemic on the prevalence, incidence, and risk factors of mental health problems among the Dutch general population and different age groups in November-...
We extracted data from the Longitudinal Internet studies for the Social Sciences (LISS) panel that is based on a probability sample of the Dutch population of 16 years and older by Statistics Netherla...
Among the total study sample, no significant increase in the prevalence of anxiety and depression symptoms, sleep problems, fatigue, impaired functioning due to health problems, use of medicines for s...
The prevalence, incidence, and risk factors of the examined mental health problems examined nine months after the COVID-19 outbreak appear to be very stable across the end of 2018, 2019, and 2020 amon...
Perioperative oral management contributes to the prevention of dental/systemic complications. However, a professional dental checkup before surgery is generally not performed and relies on the patient...
We performed an oral cavity check in all patients before scheduled surgery for primary esophageal and lung cancer. A total of 183 patients were enrolled (M, 112; F, 71; 24-88 years, median, 69 years),...
Overall sensitivity and specificity for detecting oral health problems were 0.263 and 0.898, respectively. There were no significant differences by sex or disease (primary esophageal or lung cancer)....
This simple question has low sensitivity but high specificity for detecting oral health problems. Although challenging to detect surgical patients with oral health problems by simply asking questions,...
Alcohol-related problems disproportionally affect people experiencing homelessness. As the first wave of the COVID-2019 pandemic spread in 2020, a number of emergency shelters were opened in Lisbon. I...
A total of 69 people using shelters self-reported alcohol-related problems. Among them, 36.2% of the people accepted a pharmacological intervention, and 23.2% selected an addiction appointment. The ta...
This study suggests that non-abstinence-focused interventions can be useful and well-tolerated in treating addiction in this population....
Kidney selling is a global phenomenon engraved by poverty and governance in low-income countries with the higher-income countries functioning as recipients and the lower-income countries as donors. Ov...