questionsmedicales.fr
Maladies du système immunitaire
Hypersensibilité
Hypersensibilité retardée
Hypersensibilité retardée : Questions médicales fréquentes
Termes MeSH sélectionnés :
Hypersensitivity, Immediate
Diagnostic
5
Hypersensibilité retardée
Tests cutanés
Tests de patch
Lymphocytes T
Éruption cutanée
Réaction allergique
Analyse sanguine
Inflammation
Antécédents médicaux
Allergènes
Symptômes
5
Éruption cutanée
Démangeaisons
Réaction retardée
Allergène
Symptômes systémiques
Fatigue
Réaction cutanée
Vésicules
Variabilité des symptômes
Réaction individuelle
Prévention
5
Tests d'allergie
Prévention des réactions
Changements de mode de vie
Allergènes alimentaires
Antihistaminiques
Prévention
Gestion des allergies
Médicaments d'urgence
Traitements
5
Corticostéroïdes
Évitement des allergènes
Antihistaminiques
Démangeaisons
Corticostéroïdes
Inflammation
Traitements topiques
Pommades corticostéroïdes
Traitement pédiatrique
Hypersensibilité
Complications
5
Infections cutanées
Complications
Maladies chroniques
Réactions répétées
Anaphylaxie
Réactions sévères
Qualité de vie
Démangeaisons
Hospitalisation
Traitement intensif
Facteurs de risque
5
Facteurs de risque
Antécédents d'allergies
Professions à risque
Produits chimiques
Antécédents familiaux
Allergies
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"text": "Le diagnostic repose sur l'historique médical et des tests cutanés spécifiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests de patch et les tests de stimulation lymphocytaire sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une hypersensibilité retardée ?",
"position": 3,
"acceptedAnswer": {
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"text": "Des éruptions cutanées, démangeaisons et rougeurs apparaissent après exposition à l'allergène."
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"@type": "Question",
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"@type": "Question",
"name": "Quel rôle joue l'historique médical dans le diagnostic ?",
"position": 5,
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"text": "L'historique médical aide à identifier les allergènes potentiels et les antécédents d'exposition."
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"@type": "Question",
"name": "Quels sont les symptômes courants ?",
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"@type": "Question",
"name": "Les symptômes apparaissent-ils immédiatement ?",
"position": 7,
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"@type": "Question",
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"name": "Comment se manifeste une réaction cutanée ?",
"position": 9,
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"@type": "Question",
"name": "Les symptômes varient-ils d'une personne à l'autre ?",
"position": 10,
"acceptedAnswer": {
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"text": "Oui, l'intensité et la nature des symptômes peuvent varier selon les individus."
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"@type": "Question",
"name": "Comment prévenir l'hypersensibilité retardée ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'exposition aux allergènes connus est la meilleure méthode de prévention."
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"@type": "Question",
"name": "Les tests d'allergie aident-ils à la prévention ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, les tests d'allergie peuvent identifier les allergènes à éviter pour prévenir les réactions."
}
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"@type": "Question",
"name": "Les changements de mode de vie sont-ils nécessaires ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des changements de mode de vie, comme éviter certains aliments ou produits, peuvent être nécessaires."
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"@type": "Question",
"name": "Les médicaments préventifs sont-ils disponibles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antihistaminiques peuvent être pris en prévention avant une exposition connue."
}
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"@type": "Question",
"name": "Comment gérer les expositions accidentelles ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Avoir un plan d'action et des médicaments d'urgence peut aider à gérer les expositions accidentelles."
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"@type": "Question",
"name": "Quel est le traitement principal de l'hypersensibilité retardée ?",
"position": 16,
"acceptedAnswer": {
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"text": "Le traitement principal consiste en l'évitement de l'allergène et l'utilisation de corticostéroïdes."
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"@type": "Question",
"name": "Les antihistaminiques sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
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"text": "Les antihistaminiques peuvent soulager les démangeaisons, mais ne traitent pas la cause."
}
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"@type": "Question",
"name": "Comment les corticostéroïdes aident-ils ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les corticostéroïdes réduisent l'inflammation et soulagent les symptômes cutanés."
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"@type": "Question",
"name": "Y a-t-il des traitements topiques recommandés ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des crèmes ou pommades corticostéroïdes peuvent être appliquées sur les zones affectées."
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"@type": "Question",
"name": "Les traitements sont-ils différents pour les enfants ?",
"position": 20,
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"text": "Oui, les traitements peuvent être adaptés en fonction de l'âge et de la gravité des symptômes."
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"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des infections cutanées peuvent survenir si les lésions sont grattées."
}
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"@type": "Question",
"name": "L'hypersensibilité retardée peut-elle entraîner des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des réactions répétées peuvent contribuer à des maladies cutanées chroniques."
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"@type": "Question",
"name": "Y a-t-il un risque d'anaphylaxie ?",
"position": 23,
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"@type": "Answer",
"text": "L'anaphylaxie est rare dans l'hypersensibilité retardée, mais des réactions sévères peuvent survenir."
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"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 24,
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"@type": "Answer",
"text": "Les complications peuvent entraîner des douleurs, des démangeaisons et une gêne sociale."
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"@type": "Question",
"name": "Les complications nécessitent-elles une hospitalisation ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas graves, une hospitalisation peut être nécessaire pour un traitement intensif."
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"@type": "Question",
"name": "Quels sont les facteurs de risque principaux ?",
"position": 26,
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"text": "Les antécédents d'allergies, l'exposition répétée et la génétique sont des facteurs de risque."
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"@type": "Question",
"name": "L'âge influence-t-il le risque d'hypersensibilité ?",
"position": 27,
"acceptedAnswer": {
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"text": "Oui, les jeunes enfants et les personnes âgées peuvent être plus à risque."
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"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut exacerber les symptômes et augmenter la sensibilité aux allergènes."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un historique familial d'allergies peut augmenter le risque d'hypersensibilité retardée."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 30/03/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Elizabeth.j.phillips@vumc.org.
Publications dans "Hypersensibilité retardée" :
3 publications dans cette catégorie
Affiliations :
Cancer Vaccine & Immune Cell Therapy Core Lab, Department of Medical Research, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan; Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 112 Taiwan. Electronic address: sihung@cgmh.org.tw.
Publications dans "Hypersensibilité retardée" :
3 publications dans cette catégorie
Affiliations :
Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia.
Clinical Immunology and Allergy, McGill University Health Center, Montréal, Canada.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Cancer Vaccine & Immune Cell Therapy Core Lab, Department of Medical Research, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, No. 123, Xiafei Road, Haicang District, Xiamen, China.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Cancer Vaccine & Immune Cell Therapy Core Lab, Department of Medical Research, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, No. 123, Xiafei Road, Haicang District, Xiamen, China; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung Branch, No. 222, Maijin Rd., Anle Dist., Keelung 204, Taiwan; College of Medicine, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan 333, Taiwan. Electronic address: chung1@cgmh.org.tw.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
IRCCS Oasi Maria S.S., Troina, Italy.
Fondazione Mediterranea G.B. Morgagni, Italy.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
département de Dermatologie et Allergologie, Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP.Sorbonne Université, Hôpital Tenon, Paris F75020, France. Electronic address: annick.barbaud@aphp.fr.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain.
Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Faculty of Health Sciences, Universidad Europea de Valencia, 46010 Valencia, Spain.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Faculty of Health Sciences, Universidad Europea de Valencia, 46010 Valencia, Spain.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain.
Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Pharmacy Unit, University General Hospital Consortium, 46014 Valencia, Spain.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain.
Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain.
Research and Teaching Unit, University General Hospital Consortium, 46014 Valencia, Spain.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Department of Infectious Diseases, Austin Health, Center for Antibiotic Allergy and Research, Heidelberg, VIC, Australia.
Department of Oncology, Sir Peter MacCallum Cancer Center, The University of Melbourne, Parkville, VIC, Australia.
Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, VIC, Australia.
The National Center for Infections in Cancer, Peter MacCallum Cancer Center, Melbourne, VIC, Australia.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Department of Allergy, Zhongnan Hospital of Wuhan University, Wuhan, China.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Department of Immunology, Jagiellonian University Medical College, 18 Czysta St., 31-121 Krakow, Poland.
Department of Immunology, Hospital de la Princesa, Health Research Institute of Princesa Hospital (ISS-IP), Autonomous University of Madrid, 28006 Madrid, Spain.
Section of Rheumatology, Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 208011, USA.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Department of Immunology, Jagiellonian University Medical College, 18 Czysta St., 31-121 Krakow, Poland.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Section of Rheumatology, Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 208011, USA.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Department of Immunology, Jagiellonian University Medical College, 18 Czysta St., 31-121 Krakow, Poland.
Section of Rheumatology, Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 208011, USA.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Werner Siemens Imaging Center, Department of Preclinical Imaging and RadiopharmacyEberhard Karls University, 72076 Tübingen, Germany.
Publications dans "Hypersensibilité retardée" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Eberhard Karls University, 72076 Tübingen, Germany.
Publications dans "Hypersensibilité retardée" :
Paclitaxel is one of the first-line treatments for breast, ovarian, and lung cancers. However, its use is limited by the high frequency of hypersensitivity reactions. In this retrospective chart revie...
Immediate hypersensitivity reactions (IHRs) to antineoplastic agents occur frequently, and every oncologist will encounter these reactions in their clinical practice at some point. The clinical signat...
Corticosteroids, which are anti-inflammatory and immunosuppressive agents used for the treatment of various diseases including allergic disorders, can induce immediate and delayed hypersensitivity rea...
In this review, we summarise the prevalence, pathogenetic mechanism, clinical manifestations, risk factors, diagnostic and therapeutic approach for corticosteroid-induced hypersensitivity reactions....
An integrative review of the literature was conducted using PubMed searches (mainly large cohort-based studies) regarding the different aspects of corticosteroid hypersensitivity....
Hypersensitivity reactions to corticosteroids can be immediate or delayed and can follow all modes of corticosteroid administration. Prick and intradermal skin tests are useful diagnostic tools for im...
Physicians of all medical disciplines should be aware that corticosteroids can cause (paradoxically) immediate or delayed allergic hypersensitivity reactions. The diagnosis of such allergic reactions ...
Ibuprofen is the most common culprit drug causing nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity in children. We aimed to evaluate the frequency, clinical characteristics, and risk facto...
We evaluated 50 (35 M, 15 F) children with a median age of 7 years, who were referred to our clinic with suspected immediate ibuprofen hypersensitivity. Patients were subjected to a diagnostic work up...
Ibuprofen allergy was confirmed in 34% (n: 17) of children; 9 patients were diagnosed by DPTs and 8 patients diagnosed based on their histories. Angioedema was the most common clinical manifestation (...
DPTs should be performed to confirm or exclude ibuprofen allergy in children and to find safe alternative drugs. Male gender and older age are risk factors for ibuprofen allergy. NSAID-induced hyperse...
Gadolinium based contrast agents (GBCAs) are safe compounds globally used in magnetic resonance imaging (MRI). However, in last years it has been detected an increase of immediate hypersensitivity rea...
Polyethylene glycol (PEG) allergy has been recently observed after COVID-19 mRNA vaccination. We present a case of a patient with a history of two hospitalisations for unexplained recurrence of immedi...
With the implementation of mass vaccination campaigns against COVID-19, the safety of vaccine needs to be evaluated....
We aimed to assess the incidence and risk factors for immediate hypersensitivity reactions (IHSR) and immunization stress-related responses (ISRR) with the Moderna COVID-19 vaccine....
This nested case-control study included recipients who received the Moderna vaccine at a mass vaccination center, Japan. Recipients with IHSR and ISRR were designated as cases 1 and 2, respectively. C...
Of the 614,151 vaccine recipients who received 1,201,688 vaccine doses, 306 recipients (cases 1) and 2478 recipients (cases 2) showed 318 events of IHSR and 2558 events of ISRR, respectively. The inci...
In the mass vaccination settings, the Moderna vaccine can be used safely owing to the low incidence rates of IHSR and anaphylaxis. However, providers should be aware of the occurrence of ISRR. Althoug...
Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contraindication to the BNT162b2 mRNA COVID-19 vaccine, which contains 50 ug of...
Iodinated contrast media produce non-immediate hypersensitivity reactions (NIHR). The goal of this prospective study was to determine the utility of skin tests and the subsequent tolerance to negative...
Prick and intradermal tests with iomeprol, iopamidol, iopromide, and iobitridol were performed in all patients. IV challenge with the causative contrast (iomeprol in 90%) was made if skin tests were n...
Skin tests were positive in 47.6% (20/42) of patients with NIHR induced by iomeprol. Of the 66 challenge tests performed with negative skin-tested iodinated contrasts, tolerance was confirmed in 35 (5...
Sensitivity of the skin tests was less than 50% NIHRs due to iomeprol, while the negative predictive value of skin tests in patients who tolerated challenges with alternative contrasts (mainly iopamid...
Iodinated contrast media (ICM) are a common cause of drug-induced immediate hypersensitivity reaction (IHR). Repeated use of ICM is often necessary; therefore, a standardized protocol to prevent recur...
We aimed to propose an intradermal skin test (IDT)-guided strategy for previous reactors to prevent recurrence of IHR....
We conducted a prospective multicenter study from May 2018 to December 2020 and recruited patients who had experienced IHR to ICM. Once enrolled, the participants underwent IDT with a causative ICM. T...
A total of 496 participants were enrolled, and 299 were reexposed to ICM. Among 269 participants who followed the protocol, 228 (84.8%) completed computed tomography examinations without adverse react...
Our IDT-guided strategy not only reduced recurrence of IHR to ICM but also mitigated the severity in recurred cases. This provides evidence for recommending an IDT to diagnose ICM allergy and find saf...