questionsmedicales.fr
Maladies du système immunitaire
Hypersensibilité
Hypersensibilité retardée
Hypersensibilité retardée : Questions médicales fréquentes
Termes MeSH sélectionnés :
Randomized Controlled Trials as Topic
Diagnostic
5
Hypersensibilité retardée
Tests cutanés
Tests de patch
Lymphocytes T
Éruption cutanée
Réaction allergique
Analyse sanguine
Inflammation
Antécédents médicaux
Allergènes
Symptômes
5
Éruption cutanée
Démangeaisons
Réaction retardée
Allergène
Symptômes systémiques
Fatigue
Réaction cutanée
Vésicules
Variabilité des symptômes
Réaction individuelle
Prévention
5
Tests d'allergie
Prévention des réactions
Changements de mode de vie
Allergènes alimentaires
Antihistaminiques
Prévention
Gestion des allergies
Médicaments d'urgence
Traitements
5
Corticostéroïdes
Évitement des allergènes
Antihistaminiques
Démangeaisons
Corticostéroïdes
Inflammation
Traitements topiques
Pommades corticostéroïdes
Traitement pédiatrique
Hypersensibilité
Complications
5
Infections cutanées
Complications
Maladies chroniques
Réactions répétées
Anaphylaxie
Réactions sévères
Qualité de vie
Démangeaisons
Hospitalisation
Traitement intensif
Facteurs de risque
5
Facteurs de risque
Antécédents d'allergies
Professions à risque
Produits chimiques
Antécédents familiaux
Allergies
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},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour le diagnostic ?",
"position": 2,
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"@type": "Question",
"name": "Quels signes indiquent une hypersensibilité retardée ?",
"position": 3,
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"@type": "Question",
"name": "Quel rôle joue l'historique médical dans le diagnostic ?",
"position": 5,
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"name": "Quels sont les symptômes courants ?",
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"@type": "Question",
"name": "Les symptômes apparaissent-ils immédiatement ?",
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"text": "Non, ils apparaissent généralement 24 à 72 heures après l'exposition à l'allergène."
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"@type": "Question",
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"name": "Comment se manifeste une réaction cutanée ?",
"position": 9,
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"name": "Les symptômes varient-ils d'une personne à l'autre ?",
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"text": "Oui, l'intensité et la nature des symptômes peuvent varier selon les individus."
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"@type": "Question",
"name": "Comment prévenir l'hypersensibilité retardée ?",
"position": 11,
"acceptedAnswer": {
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"text": "Éviter l'exposition aux allergènes connus est la meilleure méthode de prévention."
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"@type": "Question",
"name": "Les tests d'allergie aident-ils à la prévention ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, les tests d'allergie peuvent identifier les allergènes à éviter pour prévenir les réactions."
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"@type": "Question",
"name": "Les changements de mode de vie sont-ils nécessaires ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des changements de mode de vie, comme éviter certains aliments ou produits, peuvent être nécessaires."
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"@type": "Question",
"name": "Les médicaments préventifs sont-ils disponibles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antihistaminiques peuvent être pris en prévention avant une exposition connue."
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"name": "Comment gérer les expositions accidentelles ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Avoir un plan d'action et des médicaments d'urgence peut aider à gérer les expositions accidentelles."
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"@type": "Question",
"name": "Quel est le traitement principal de l'hypersensibilité retardée ?",
"position": 16,
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"text": "Le traitement principal consiste en l'évitement de l'allergène et l'utilisation de corticostéroïdes."
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"@type": "Question",
"name": "Les antihistaminiques sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
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"text": "Les antihistaminiques peuvent soulager les démangeaisons, mais ne traitent pas la cause."
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"@type": "Question",
"name": "Comment les corticostéroïdes aident-ils ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les corticostéroïdes réduisent l'inflammation et soulagent les symptômes cutanés."
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"@type": "Question",
"name": "Y a-t-il des traitements topiques recommandés ?",
"position": 19,
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"text": "Des crèmes ou pommades corticostéroïdes peuvent être appliquées sur les zones affectées."
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"@type": "Question",
"name": "Les traitements sont-ils différents pour les enfants ?",
"position": 20,
"acceptedAnswer": {
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"text": "Oui, les traitements peuvent être adaptés en fonction de l'âge et de la gravité des symptômes."
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"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des infections cutanées peuvent survenir si les lésions sont grattées."
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"@type": "Question",
"name": "L'hypersensibilité retardée peut-elle entraîner des maladies chroniques ?",
"position": 22,
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"text": "Oui, des réactions répétées peuvent contribuer à des maladies cutanées chroniques."
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"@type": "Question",
"name": "Y a-t-il un risque d'anaphylaxie ?",
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"text": "L'anaphylaxie est rare dans l'hypersensibilité retardée, mais des réactions sévères peuvent survenir."
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"position": 24,
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"name": "Les complications nécessitent-elles une hospitalisation ?",
"position": 25,
"acceptedAnswer": {
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"text": "Dans certains cas graves, une hospitalisation peut être nécessaire pour un traitement intensif."
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"position": 26,
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"name": "Les professions exposées sont-elles à risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines professions, comme celles en contact avec des produits chimiques, présentent un risque accru."
}
},
{
"@type": "Question",
"name": "Le stress peut-il aggraver l'hypersensibilité ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut exacerber les symptômes et augmenter la sensibilité aux allergènes."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un historique familial d'allergies peut augmenter le risque d'hypersensibilité retardée."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
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Diquafosol enhances fluid transfer and mucin secretion on ocular surface, which has been suggested as an effective treatment for dry eye disease (DED). The aim of the systematic review and meta-analys...
Relevant randomized controlled trials were obtained via search of electronic including PubMed, Embase, Cochrane Library, and Web of Science. A random-effects model was used to pool the results after i...
A total of nine RCTs involving 1295 patients with DED were included in the meta-analysis. Compared to treatment with 0.1% HA, topical treatment with 3% diquafosol significantly improved the Ocular Sur...
Topical treatment with 3% diquafosol may be more effective than 0.1% HA for patients with DED. However, the long-term efficacy and tolerability of diquafosol still need to be determined....
Narrowband ultraviolet B (NB-UVB) phototherapy is commonly prescribed for patients with moderate-to-severe atopic eczema (AE). The efficacy of NB-UVB, however, has not yet properly been established, a...
A pragmatic, multicenter, PROBE trial will be performed with 1:1 randomization of 316 adult patients with moderate-to-severe AE who have inadequate disease control with topical therapy and who are eli...
The UPDATE trial aims to provide high-quality evidence regarding the (cost-)effectiveness and safety of NB-UVB phototherapy in moderate-to-severe AE patients. Challenges that are addressed in the prot...
ClinicalTrials.gov NCT05704205. Registered on December 8, 2022....
Topical drugs are often used as first-line treatment for dermatological conditions. A within-person design may then be well adapted: it consists of randomizing lesions/body sites rather than patients,...
The aim of this review was to provide a methodological overview of within-person randomized trials (WP-RCTs) in dermatology....
We searched for eligible trials published between 2017 and 2021 in MEDLINE, Embase, and Central in dermatology journals and the 6 highest-impact-factor general medical journals. Two authors selected p...
From 1,034 articles identified, we included 54 WP-RCTs, mainly for acne vulgaris, psoriasis, actinic keratosis, and atopic dermatitis. In most of the trials, patients had only 2 lesions/body sites. In...
Our systematic review highlights that despite the publication of the CONSORT checklist extension for WP-RCTs in 2017, this design is rarely used, and when it is, there are methodological and reporting...
We aim to evaluate the clinical efficacy and safety of using laser and light combined with topical minoxidil for alopecia areata. We searched PubMed, Embase, Web of Science, the Cochrane Library, Chin...
Vulvar lichen sclerosus (LS) is a chronic debilitating inflammatory skin disease. Today, the gold standard is a life-long topical steroid treatment. Alternative options are highly desired. We present ...
We recruited 66 patients, 44 in the laser arm and 22 in the steroid arm. Patients with a physician-administered clinical LS score ≥ 4 were included. Participants received either four laser treatments ...
The findings of this trial have the potential to offer a novel treatment option for LS. The standardized Nd:YAG/Er:YAG laser settings and the treatment regime are presented in this paper....
NCT03926299....
Alopecia areata (AA) is a common autoimmune skin disease. Our study aimed to systematically evaluate the efficacy and safety of compound glycyrrhizin (CG) combined with topical minoxidil therapy in tr...
We searched the PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases. Randomized controlled trials (RCTs) on CG combined with topical minoxidil therapy compared with topi...
11 RCTs and 1189 patients were included. Compared with topical minoxidil therapy alone, CG combined with topical minoxidil therapy was more effective at improving the clinical efficacy (RR = 1.36, 95%...
The current evidence indicates that CG combined with topical minoxidil therapy is effective and safe for AA. However, owing to the suboptimal quality of the included studies, more high-quality and lar...
The purpose was to identify and summarize the existing evidence on the efficacy and safety of the topical application of olive oil for preventing pressure ulcers (PUs). We included only randomized con...
To investigate the clinical efficacy and safety of topical difamilast in mild-to-moderate atopic dermatitis (AD)....
Only randomized controlled trials (RCTs) that compared topical difamilast with vehicle treatment for patients with AD were included. PubMed, Web of Science, Ovid Medline, Cochrane Library, ClinicalTri...
Five studies enrolling a total of 1009 patients with mild-to-moderate AD were identified. Compared with the topical vehicle, topical difamilast was associated with a significantly higher success rate ...
This meta-analysis suggests that topical difamilast is an effective and safe treatment for mild-to-moderate AD....
Melasma is a chronic relapsing skin condition. Laser therapy is a new advancement in treatment. Whether the topical application of tranexamic acid (TXA) increases the efficacy of laser therapy in mela...
Randomized controlled trials are used to estimate the causal effect of a treatment on a health outcome of interest in a patient population. Often the specified treatment in a randomized controlled tri...
We use causal reasoning to explain why randomized controlled trials of biomarker targets can arrive at conflicting or misleading conclusions. We describe four key threats to the validity of trials of ...
We illustrate these findings using evidence from 15 randomized controlled trials of blood pressure targets for management of hypertension. Randomized trials of blood pressure targets exhibit substanti...
Researchers should critically assess meta-analyses of trials of targets for variation in the types, distributions, and off-target effects of therapies studied. Trial investigators should release detai...
