Titre : Protéines de filaments intermédiaires

Protéines de filaments intermédiaires : Questions médicales fréquentes

Termes MeSH sélectionnés :

RNA, Long Noncoding
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Sources (10000 au total)

Identification of RNA silencing suppressor encoded by citrus chlorotic dwarf-associated virus.

Citrus chlorotic dwarf-associated virus (CCDaV) is an economically important citrus virus associated with leaf curling, deformation, and chlorosis found in China. Plants have evolved RNA silencing to ... Six proteins encoded by CCDaV were ectopically expressed in... V2 protein encoded by CCDaV suppressed local RNA silencing and systemic RNA silencing triggered by GFP RNA, but did not impede short-distance movement of the RNA silencing signal in... Overall, the results of this study demonstrate that CCDaV-V2 acts as an activity of silencing suppression. This is the first reported RNA-silencing suppressor encoded by...

Cas13b-mediated RNA targeted therapy alleviates genetic dilated cardiomyopathy in mice.

Recent advances in gene editing technology have opened up new avenues for in vivo gene therapy, which holds great promise as a potential treatment method for dilated cardiomyopathy (DCM). The CRISPR-C... Using PspCas13b, we were able to efficiently and specifically knockdown the mutant transcripts in the AC16 cell line carrying the heterozygous human TNNT2... These findings suggest that targeting genes through Cas13b is a promising approach for in vivo gene therapy for genetic diseases caused by aberrant gene expression. Our study provides further evidence...