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"description": "Comment diagnostique-t-on le syndrome de Job ?\nQuels tests sanguins sont utilisés ?\nLe syndrome de Job est-il héréditaire ?\nQuels signes cliniques indiquent ce syndrome ?\nPeut-on confondre ce syndrome avec d'autres ?",
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"name": "Comment diagnostique-t-on le syndrome de Job ?",
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"text": "Le diagnostic repose sur l'évaluation clinique, les antécédents médicaux et des tests sanguins pour mesurer les IgE."
}
},
{
"@type": "Question",
"name": "Quels tests sanguins sont utilisés ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests mesurant les niveaux d'IgE et des analyses pour détecter des infections sont effectués."
}
},
{
"@type": "Question",
"name": "Le syndrome de Job est-il héréditaire ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il est souvent héréditaire, lié à des mutations génétiques spécifiques."
}
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{
"@type": "Question",
"name": "Quels signes cliniques indiquent ce syndrome ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des infections cutanées, des pneumonies récurrentes et des éruptions cutanées sont des signes clés."
}
},
{
"@type": "Question",
"name": "Peut-on confondre ce syndrome avec d'autres ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut être confondu avec d'autres immunodéficiences, nécessitant des tests spécifiques."
}
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{
"@type": "Question",
"name": "Quels sont les symptômes principaux du syndrome de Job ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des infections récurrentes, des éruptions cutanées et des allergies."
}
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"@type": "Question",
"name": "Les éruptions cutanées sont-elles fréquentes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des éruptions cutanées, souvent prurigineuses, sont courantes chez les patients."
}
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"@type": "Question",
"name": "Y a-t-il des symptômes respiratoires associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients peuvent souffrir de pneumonies et d'autres infections respiratoires fréquentes."
}
},
{
"@type": "Question",
"name": "Le syndrome de Job cause-t-il des problèmes dentaires ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des problèmes dentaires comme des abcès peuvent survenir en raison d'infections fréquentes."
}
},
{
"@type": "Question",
"name": "Les allergies sont-elles fréquentes dans ce syndrome ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients présentent souvent des allergies, notamment aux acariens et aux pollens."
}
},
{
"@type": "Question",
"name": "Comment prévenir les infections chez les patients ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est crucial d'encourager une bonne hygiène, des vaccinations et un suivi médical régulier."
}
},
{
"@type": "Question",
"name": "Les patients doivent-ils éviter certains aliments ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'y a pas de restrictions alimentaires spécifiques, mais une alimentation équilibrée est conseillée."
}
},
{
"@type": "Question",
"name": "Les vaccinations sont-elles importantes ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccinations sont essentielles pour prévenir les infections graves chez ces patients."
}
},
{
"@type": "Question",
"name": "Comment gérer les allergies dans ce syndrome ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les allergènes connus et utiliser des antihistaminiques peut aider à gérer les allergies."
}
},
{
"@type": "Question",
"name": "Les soins dentaires sont-ils importants ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des soins dentaires réguliers sont cruciaux pour prévenir les infections buccales."
}
},
{
"@type": "Question",
"name": "Quel est le traitement principal du syndrome de Job ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des antibiotiques pour les infections et des antihistaminiques pour les allergies."
}
},
{
"@type": "Question",
"name": "Des immunothérapies sont-elles recommandées ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'immunothérapie peut être envisagée pour gérer les allergies et améliorer la réponse immunitaire."
}
},
{
"@type": "Question",
"name": "Les patients ont-ils besoin de soins réguliers ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour surveiller les infections et ajuster le traitement."
}
},
{
"@type": "Question",
"name": "Peut-on guérir le syndrome de Job ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de cure, mais les traitements peuvent aider à gérer les symptômes et les infections."
}
},
{
"@type": "Question",
"name": "Des traitements préventifs sont-ils disponibles ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements préventifs, comme les vaccins, peuvent aider à réduire les infections."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections graves, des abcès et des problèmes respiratoires chroniques."
}
},
{
"@type": "Question",
"name": "Le syndrome de Job augmente-t-il le risque de cancer ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il existe un risque accru de certains cancers, notamment les lymphomes, chez ces patients."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles être mortelles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections graves peuvent être mortelles si elles ne sont pas traitées rapidement."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications dermatologiques ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections cutanées récurrentes et des abcès peuvent survenir fréquemment."
}
},
{
"@type": "Question",
"name": "Les complications respiratoires sont-elles fréquentes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients souffrent souvent de pneumonies et d'autres infections respiratoires."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque du syndrome de Job ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, des mutations génétiques et des infections fréquentes."
}
},
{
"@type": "Question",
"name": "Les enfants sont-ils plus à risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le syndrome de Job se manifeste souvent dans l'enfance, avec des infections récurrentes."
}
},
{
"@type": "Question",
"name": "Les personnes immunodéprimées sont-elles plus à risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes immunodéprimées peuvent avoir un risque accru de développer ce syndrome."
}
},
{
"@type": "Question",
"name": "Les allergies augmentent-elles le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les antécédents d'allergies peuvent être un facteur de risque pour le syndrome de Job."
}
},
{
"@type": "Question",
"name": "Les infections fréquentes sont-elles un indicateur ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections fréquentes peuvent indiquer un risque accru de syndrome de Job."
}
}
]
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Topics associated with the chemical sciences form a significant part of the curriculum in science at the primary school level in the U.K. In this methodology paper, we demonstrate how a wide range of ...
Approximately 1-2% of mothers may experience severe mental illness (SMI) requiring admission to an inpatient Mother and Baby Unit (MBU). MBUs aim to provide mental health assessment and treatment and ...
A multi-site, parallel-group, single-blind pilot randomized controlled trial (registration: ISRCTN12765736) comparing BTP+TAU to TAU in participants, recruited from two MBUs in England. The Baby Tripl...
Thirty-seven of the 67 eligible participants consented; 34 were randomized (16 to BTP+TAU and 18 to TAU), of whom 20 were retained at post-intervention data collection and 21 at six-month follow-up. T...
This is the first trial of a parenting intervention in a MBU setting. BTP is feasible and acceptable to mothers with SMI, with a promising signal for treatment efficacy. Although minor modifications m...
BACKGROUND Schwannomas are benign tumors and their appearance in the pelvic region is rare and poses a major diagnostic problem. They can be sporadic or associated with genetical syndromes. They have ...
Perinatal depression (depression during pregnancy or the first year postpartum) affects 10%-25% of perinatal individuals, with a higher risk among youths aged <25 years. The Mothers and Babies Course ...
We developed a digital adaptation of MB (Interactive Maternal Group for Information and Emotional Support [IMAGINE]) and evaluated it in a pre-post mixed methods pilot among young perinatal people in ...
IMAGINE was a structured digital group of up to 7 participants, with scheduled MB content and open discussion for 12 weeks, facilitated by a social worker. Scheduled content included asynchronous SMS ...
Among 68 individuals who contacted this study, 22 were screened, 13 were eligible, and 10 enrolled, for an uptake of 76.9%. Furthermore, 4 (40%) participants were pregnant at enrollment. Participants ...
This pilot study provides promising evidence of the acceptability and utility of IMAGINE among perinatal youths. Our study's small sample size did not detect changes in clinical outcomes; our findings...
Collecting women's views and suggestions for improving quality of maternal-newborn care (QMNC) is a crucial aspect of maternity care evaluation often overlooked in Italy and globally. Childbearing wom...
Data were collected from an open-ended question included in a validated online questionnaire administered to mothers who gave birth in an Italian hospital between November 2020 to March 2022. The resp...
The thematic analysis identified five main themes from the 2017 responses: 1) Support for mothers during the postnatal period; 2) Better use of resources; 3) Improvement of the maternity environment; ...
This is the first qualitative study in Italy focusing on women's suggestions for improving QMNC during the COVID-19 pandemic. Its findings can be used to inform what aspects of QMNC need improvement i...
Diagnosis of gestational diabetes mellitus (GDM) in a pregnancy has a significant impact on health service resources and represents a substantial financial and time impost on women....
To describe a cost-minimisation analysis conducted following the demonstration of clinically equivalent care of women using a novel, digital model for GDM management, compared with conventional care....
A pre-implementation model of care was compared with the post-implementation model of care which included systematic development and delivery of education videos, use of the Commonwealth Scientific an...
Health service costs showed a modest saving of AU$17 441.78 (US$12 158.92) in the intervention group over a 12-month period. Cost savings for the woman were estimated at $566.56 (US$394.96) per patien...
Re-imagining GDM patient care by introducing a novel, digital-based GDM model of care has substantial positive cost implications for patients....
Retinal vein occlusion (RVO) is the second most common retinal vascular disorder. Despite promising advances with anti-VEGF therapy, select patients are unresponsive to therapy. A precision medicine-b...
The IMAGINE study is a post-hoc assessment of aqueous humour cytokines with correlation to higher level analysis of imaging studies. OCT scans underwent machine learning enhanced segmentation of the i...
Twenty-six eyes were included. The OCT-based response schema identified 21 Responders (81%) and 5 Non-Responders (19%). VEGF levels directly correlated with intraretinal fluid volume and angiogenin wa...
Cytokine expression was linked to specific OCT features and treatment response in RVO. Identification of an imaging phenotype that could serve as a surrogate for underlying active disease pathways cou...
Restrictions during the COVID-19 pandemic compromised maternal and newborn care....
Countries in the German speaking area share several clinical care guidelines but differed significantly in the strictness of COVID-19 protective measures....
To investigate the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic in the German-speaking area and explore associations between the reorganisational changes due to COVID-19 an...
As part of the IMAgiNE EURO study (ClinicalTrials.gov: NCT04847336), we conducted an online survey on the QMNC in the German-speaking area, including women who gave birth in Germany, Switzerland, and ...
Out of a total of 70,721 women accessing the online questionnaire, 1,875 were included (Germany: n = 1,053, Switzerland: n = 494, Austria: n = 328). Significant differences across countries were found...
Midwives and other health professional should pay particular attention to the provision of respectful, high-quality care....
To effectively improve QMNC, further research is essential to monitor the quality of care and develop targeted interventions beyond the COVID-19 pandemic addressing inherent challenges in the organisa...
To investigate whether a 2-year MRI treat-to-target strategy targeting the absence of osteitis combined with clinical remission, compared with a conventional treat-to-target strategy targeting clinica...
IMAGINE-more was an observational extension study of the original 2-year IMAGINE-RA randomised trial (NCT01656278). Clinical examinations and radiographs (hands and feet) were obtained yearly. Prespec...
In total 131 patients, 86 women (67%), mean age 61.2, disease duration 9.5 years, median baseline DAS28-CRP 1.9 (IQR 1.6-2.2) and vdHSS 16.0 (IQR 7.0-36.0) were included in the study; 59 (59%) patient...
A 2-year combined MRI and clinical treat-to-target strategy, compared with a conventional clinical treat-to-target strategy alone, had no effect on the long-term probability of achieving DAS28-CRP rem...
Health workers' (HWs') perspectives on the quality of maternal and newborn care (QMNC) are not routinely collected. In this cross-sectional study, we aimed to document HWs' perspectives on QMNC around...
HWs involved in maternal/neonatal care for at least one year between March 2020 and March 2023 answered an online validated WHO standards-based questionnaire collecting 40 quality measures for improvi...
Data from 4143 respondents were analysed. For 39 out of 40 quality measures, at least 20% of HWs reported a 'need for improvement', with large variations across countries. Effective training on health...
HWs from 12 European countries reported significant gaps in QMNC, lacking association with COVID-19 pandemic trends. Routine monitoring of QMNC and tailored actions are needed to improve health servic...
ClinicalTrials.gov NCT04847336....