{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Léiomyosarcome : Questions médicales les plus fréquentes",
"headline": "Léiomyosarcome : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Léiomyosarcome : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-06-08",
"dateModified": "2025-03-05",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Léiomyosarcome"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Sarcomes",
"url": "https://questionsmedicales.fr/mesh/D012509",
"about": {
"@type": "MedicalCondition",
"name": "Sarcomes",
"code": {
"@type": "MedicalCode",
"code": "D012509",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "C04.557.450.795"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Léiomyosarcome",
"alternateName": "Leiomyosarcoma",
"code": {
"@type": "MedicalCode",
"code": "D007890",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Emily Z Keung",
"url": "https://questionsmedicales.fr/author/Emily%20Z%20Keung",
"affiliation": {
"@type": "Organization",
"name": "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA."
}
},
{
"@type": "Person",
"name": "Anupama Bahadur",
"url": "https://questionsmedicales.fr/author/Anupama%20Bahadur",
"affiliation": {
"@type": "Organization",
"name": "Obstetrics and Gynecology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND."
}
},
{
"@type": "Person",
"name": "Rajlaxmi Mundhra",
"url": "https://questionsmedicales.fr/author/Rajlaxmi%20Mundhra",
"affiliation": {
"@type": "Organization",
"name": "Obstetrics and Gynecology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND."
}
},
{
"@type": "Person",
"name": "Anoosha K Ravi",
"url": "https://questionsmedicales.fr/author/Anoosha%20K%20Ravi",
"affiliation": {
"@type": "Organization",
"name": "Obstetrics and Gynecology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND."
}
},
{
"@type": "Person",
"name": "Poonam Gill",
"url": "https://questionsmedicales.fr/author/Poonam%20Gill",
"affiliation": {
"@type": "Organization",
"name": "Obstetrics and Gynecology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "MKRN3 circulating levels in Prader-Willi syndrome: a pilot study.",
"datePublished": "2022-07-19",
"url": "https://questionsmedicales.fr/article/35854182",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s40618-022-01860-0"
}
},
{
"@type": "ScholarlyArticle",
"name": "Three pediatric cases of symptomatic hyponatremia in Prader-Willi syndrome.",
"datePublished": "2022-07-12",
"url": "https://questionsmedicales.fr/article/35822720",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1515/jpem-2022-0127"
}
},
{
"@type": "ScholarlyArticle",
"name": "Recommendations for the diagnosis and management of childhood Prader-Willi syndrome in China.",
"datePublished": "2022-06-13",
"url": "https://questionsmedicales.fr/article/35698200",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13023-022-02302-z"
}
},
{
"@type": "ScholarlyArticle",
"name": "Effectiveness of the Kaufman Brief Intelligence Test in people with Prader-Willi syndrome.",
"datePublished": "2023-09-21",
"url": "https://questionsmedicales.fr/article/37732721",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/jir.13090"
}
},
{
"@type": "ScholarlyArticle",
"name": "Liraglutide therapy in an adolescent with Prader‑Willi syndrome and concomitant diabetes mellitus.",
"datePublished": "2023-03-14",
"url": "https://questionsmedicales.fr/article/36916545",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.5603/EP.a2023.0011"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Tumeurs",
"item": "https://questionsmedicales.fr/mesh/D009369"
},
{
"@type": "ListItem",
"position": 3,
"name": "Tumeurs par type histologique",
"item": "https://questionsmedicales.fr/mesh/D009370"
},
{
"@type": "ListItem",
"position": 4,
"name": "Tumeurs du tissu conjonctif et des tissus mous",
"item": "https://questionsmedicales.fr/mesh/D018204"
},
{
"@type": "ListItem",
"position": 5,
"name": "Sarcomes",
"item": "https://questionsmedicales.fr/mesh/D012509"
},
{
"@type": "ListItem",
"position": 6,
"name": "Léiomyosarcome",
"item": "https://questionsmedicales.fr/mesh/D007890"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Léiomyosarcome - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Léiomyosarcome",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-19",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Léiomyosarcome",
"description": "Comment diagnostique-t-on un léiomyosarcome ?\nQuels examens d'imagerie sont utilisés ?\nLe diagnostic nécessite-t-il une biopsie ?\nQuels marqueurs tumoraux sont associés ?\nPeut-on confondre le léiomyosarcome avec d'autres tumeurs ?",
"url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Prader-Willi+Syndrome&page=3#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Léiomyosarcome",
"description": "Quels sont les symptômes courants du léiomyosarcome ?\nLe léiomyosarcome provoque-t-il une perte de poids ?\nPeut-on avoir des symptômes respiratoires ?\nLes symptômes varient-ils selon la localisation ?\nY a-t-il des symptômes spécifiques aux femmes ?",
"url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Prader-Willi+Syndrome&page=3#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Léiomyosarcome",
"description": "Peut-on prévenir le léiomyosarcome ?\nLes facteurs environnementaux jouent-ils un rôle ?\nY a-t-il des habitudes à éviter ?\nLes antécédents familiaux influencent-ils le risque ?\nLe suivi médical régulier est-il important ?",
"url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Prader-Willi+Syndrome&page=3#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Léiomyosarcome",
"description": "Quels traitements sont disponibles pour le léiomyosarcome ?\nLa chirurgie est-elle toujours nécessaire ?\nLa chimiothérapie est-elle efficace ?\nLa radiothérapie est-elle une option ?\nY a-t-il des traitements expérimentaux ?",
"url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Prader-Willi+Syndrome&page=3#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Léiomyosarcome",
"description": "Quelles complications peuvent survenir ?\nLe léiomyosarcome peut-il se propager ?\nY a-t-il des risques liés aux traitements ?\nComment gérer la douleur liée au léiomyosarcome ?\nLe suivi post-traitement est-il crucial ?",
"url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Prader-Willi+Syndrome&page=3#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Léiomyosarcome",
"description": "Quels sont les principaux facteurs de risque ?\nL'âge influence-t-il le risque de léiomyosarcome ?\nLes maladies génétiques sont-elles un facteur ?\nLe sexe joue-t-il un rôle dans le risque ?\nL'obésité est-elle un facteur de risque ?",
"url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Prader-Willi+Syndrome&page=3#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostique-t-on un léiomyosarcome ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'imagerie médicale et la biopsie des tissus affectés."
}
},
{
"@type": "Question",
"name": "Quels examens d'imagerie sont utilisés ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les IRM et les tomodensitométries (CT) sont couramment utilisés pour visualiser la tumeur."
}
},
{
"@type": "Question",
"name": "Le diagnostic nécessite-t-il une biopsie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une biopsie est essentielle pour confirmer la nature maligne de la tumeur."
}
},
{
"@type": "Question",
"name": "Quels marqueurs tumoraux sont associés ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de marqueurs spécifiques, mais des tests génétiques peuvent aider."
}
},
{
"@type": "Question",
"name": "Peut-on confondre le léiomyosarcome avec d'autres tumeurs ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut être confondu avec d'autres sarcomes ou tumeurs musculaires."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes courants du léiomyosarcome ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des douleurs, des masses visibles et des troubles fonctionnels selon la localisation."
}
},
{
"@type": "Question",
"name": "Le léiomyosarcome provoque-t-il une perte de poids ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une perte de poids inexpliquée peut survenir en raison de la maladie avancée."
}
},
{
"@type": "Question",
"name": "Peut-on avoir des symptômes respiratoires ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, si la tumeur se développe dans les poumons, des symptômes respiratoires peuvent apparaître."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon la localisation ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes dépendent de l'emplacement de la tumeur dans le corps."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques aux femmes ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les femmes peuvent éprouver des symptômes liés à des tumeurs utérines, comme des saignements."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir le léiomyosarcome ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention spécifique, mais un mode de vie sain peut aider."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux jouent-ils un rôle ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains produits chimiques peut augmenter le risque de léiomyosarcome."
}
},
{
"@type": "Question",
"name": "Y a-t-il des habitudes à éviter ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter le tabagisme et l'exposition à des agents cancérigènes peut réduire le risque."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le risque ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers peuvent augmenter le risque de léiomyosarcome."
}
},
{
"@type": "Question",
"name": "Le suivi médical régulier est-il important ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi médical régulier peut aider à détecter précocement des anomalies."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour le léiomyosarcome ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la chirurgie, la chimiothérapie et la radiothérapie."
}
},
{
"@type": "Question",
"name": "La chirurgie est-elle toujours nécessaire ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chirurgie est souvent nécessaire pour retirer la tumeur, selon sa taille et son emplacement."
}
},
{
"@type": "Question",
"name": "La chimiothérapie est-elle efficace ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chimiothérapie peut être utilisée, mais son efficacité varie selon les cas."
}
},
{
"@type": "Question",
"name": "La radiothérapie est-elle une option ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la radiothérapie peut être utilisée pour traiter les tumeurs inopérables ou résiduelles."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des essais cliniques peuvent proposer des traitements expérimentaux pour le léiomyosarcome."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent la métastase, la douleur chronique et des problèmes fonctionnels."
}
},
{
"@type": "Question",
"name": "Le léiomyosarcome peut-il se propager ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut se propager à d'autres organes, notamment les poumons et le foie."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques liés aux traitements ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent entraîner des effets secondaires comme la fatigue et des nausées."
}
},
{
"@type": "Question",
"name": "Comment gérer la douleur liée au léiomyosarcome ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion de la douleur peut inclure des médicaments, la physiothérapie et des soins palliatifs."
}
},
{
"@type": "Question",
"name": "Le suivi post-traitement est-il crucial ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour surveiller les récidives et gérer les complications."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'exposition à des radiations, des produits chimiques et des antécédents familiaux."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de léiomyosarcome ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente généralement avec l'âge, touchant souvent les adultes d'âge moyen."
}
},
{
"@type": "Question",
"name": "Les maladies génétiques sont-elles un facteur ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies génétiques, comme le syndrome de Li-Fraumeni, augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les femmes sont légèrement plus susceptibles de développer un léiomyosarcome utérin."
}
},
{
"@type": "Question",
"name": "L'obésité est-elle un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'obésité peut être associée à un risque accru de certains types de sarcomes, y compris le léiomyosarcome."
}
}
]
}
]
}
Hypogonadism in Prader-Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or to primary gonadal defect. MKRN3, a maternal imprinted gene located on 15q11.2-q13 region, encodes ma...
This study aimed to evaluate MKRN3 levels in patients with PWS and to analyze its correlation with sexual hormone levels, insulin resistance and Body Mass Index (BMI)....
We performed an observational cross-sectional study and enrolled 80 patients with genetically confirmed diagnosis of PWS with median age of 9.6 years....
MKRN3 levels were measurable in 49 PWS patients with a geometric mean of 34.9 ± 22 pg/ml (median: 28.4). Unmeasurable levels of MKRN3 were found in 31 patients. No statistically significant difference...
The typical genetic defect of PWS should lead to unmeasurable levels of the MKRN3 protein due to the inactivation of the paternal allele. Measurable circulating MKRN3 could suggest the possible involv...
A recent large retrospective cohort study of cases of hyponatremia in Prader-Willi syndrome (PWS), conducted at nine reference centers, showed that severe hyponatremia was rare in PWS (0.5%); furtherm...
The cases involved two girls and one boy, and only one patient showed uniparental disomy. All patients had hyponatremia during infancy and presented with clinical symptoms, such as convulsions. All th...
We report three pediatric cases of symptomatic hyponatremia of unknown cause in PWS. In patients with PWS, especially those with neurological symptoms such as convulsions, it is necessary to take hypo...
Prader-Willi syndrome (PWS) is a complex and multisystem neurobehavioral disease, which is caused by the lack of expression of paternally inherited imprinted genes on chromosome15q11.2-q13.1. The clin...
Evaluating intelligence using conventional tools is very complex in patients with Prader-Willi Syndrome (PWS), as it is time consuming and requires levels of care that are difficult to sustain for thi...
This study included individuals with a genetically confirmed diagnosis of PWS, with regular attendance at transdisciplinary treatment in an institution dedicated to the care of rare diseases in Argent...
Correlation was obtained between the scales in paediatric and adult populations. Within the paediatric population, no significant differences were identified between the WISC-IV scale (Wechsler for pa...
We observed the feasibility and potential usefulness of a brief intelligence test (K-BIT) in patients with PWS with an acceptable agreement with conventional tools....
Prader-Willi syndrome (PWS) is a complex disorder caused by impaired paternally expressed genes on chromosome 15q11-q13. Variable findings have been reported about the phenotypic differences among PWS...
A total of 110 PWS patients were diagnosed from 8,572 pediatric patients included from July 2013 to December 2021 by MLPA and MS-MLPA assays. Atypical deletions were defined by genomic CNV-sequencing....
Genetically, the 110 patients with PWS included 29 type I deletion, 56 type II deletion, 6 atypical deletion, 11 heterodisomy UPD, and 8 isodisomy UPD. The UPD group had significantly higher maternal ...
We explored the physical, psychological and behavioral phenotype-genotype associations as well as the GH treatment effect on PWS from a large cohort of Chinese pediatric patients. Our data might promo...
Prader-Willi syndrome (PWS), which is a complex epigenetic disorder caused by the deficiency of paternally expressed genes in chromosome 15q11-q13, is associated with several psychiatric dimensions, i...
Prader-Willi syndrome (PWS) is a complex genetic disorder with three PWS molecular genetic classes and presents as severe hypotonia, failure to thrive, hypogonadism/hypogenitalism and developmental de...
To facilitate the development of new therapies for Prader-Willi syndrome (PWS), we sought to develop a reliable and valid assessment of anxiousness and distress, common characteristics that have a sig...
The PWS Anxiousness and Distress Behaviors Questionnaire (PADQ) was developed with extensive input from clinical experts, as well as caregivers of individuals with PWS, who participated in iterative s...
Qualitative interview participants consistently endorsed the content of the PADQ and were confident they could accurately respond to each item based on their observations of their child's behavior. An...
The current body of evidence supports the conclusion that the PADQ measures observable behaviors that are meaningful to patients and their families and provides a valid and reliable method to assess b...
The CpG island flanking the promoter region of SNRPN on chromosome 15q11.2 contains CpG sites that are completely methylated in the maternally derived allele and unmethylated in the paternally derived...