Titre : Léiomyosarcome

Léiomyosarcome : Questions médicales fréquentes

Termes MeSH sélectionnés :

Tertiary Lymphoid Structures
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d'imagerie sont utilisés ?\nLe diagnostic nécessite-t-il une biopsie ?\nQuels marqueurs tumoraux sont associés ?\nPeut-on confondre le léiomyosarcome avec d'autres tumeurs ?", "url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Tertiary+Lymphoid+Structures&page=4#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Léiomyosarcome", "description": "Quels sont les symptômes courants du léiomyosarcome ?\nLe léiomyosarcome provoque-t-il une perte de poids ?\nPeut-on avoir des symptômes respiratoires ?\nLes symptômes varient-ils selon la localisation ?\nY a-t-il des symptômes spécifiques aux femmes ?", "url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Tertiary+Lymphoid+Structures&page=4#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Léiomyosarcome", "description": "Peut-on prévenir le léiomyosarcome ?\nLes facteurs environnementaux jouent-ils un rôle ?\nY a-t-il des habitudes à éviter ?\nLes antécédents familiaux influencent-ils le risque ?\nLe suivi médical régulier est-il important ?", "url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Tertiary+Lymphoid+Structures&page=4#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Léiomyosarcome", "description": "Quels traitements sont disponibles pour le léiomyosarcome ?\nLa chirurgie est-elle toujours nécessaire ?\nLa chimiothérapie est-elle efficace ?\nLa radiothérapie est-elle une option ?\nY a-t-il des traitements expérimentaux ?", "url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Tertiary+Lymphoid+Structures&page=4#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Léiomyosarcome", "description": "Quelles complications peuvent survenir ?\nLe léiomyosarcome peut-il se propager ?\nY a-t-il des risques liés aux traitements ?\nComment gérer la douleur liée au léiomyosarcome ?\nLe suivi post-traitement est-il crucial ?", "url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Tertiary+Lymphoid+Structures&page=4#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Léiomyosarcome", "description": "Quels sont les principaux facteurs de risque ?\nL'âge influence-t-il le risque de léiomyosarcome ?\nLes maladies génétiques sont-elles un facteur ?\nLe sexe joue-t-il un rôle dans le risque ?\nL'obésité est-elle un facteur de risque ?", "url": "https://questionsmedicales.fr/mesh/D007890?mesh_terms=Tertiary+Lymphoid+Structures&page=4#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostique-t-on un léiomyosarcome ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur l'imagerie médicale et la biopsie des tissus affectés." } }, { "@type": "Question", "name": "Quels examens d'imagerie sont utilisés ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les IRM et les tomodensitométries (CT) sont couramment utilisés pour visualiser la tumeur." } }, { "@type": "Question", "name": "Le diagnostic nécessite-t-il une biopsie ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une biopsie est essentielle pour confirmer la nature maligne de la tumeur." } }, { "@type": "Question", "name": "Quels marqueurs tumoraux sont associés ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de marqueurs spécifiques, mais des tests génétiques peuvent aider." } }, { "@type": "Question", "name": "Peut-on confondre le léiomyosarcome avec d'autres tumeurs ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il peut être confondu avec d'autres sarcomes ou tumeurs musculaires." } }, { "@type": "Question", "name": "Quels sont les symptômes courants du léiomyosarcome ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent des douleurs, des masses visibles et des troubles fonctionnels selon la localisation." } }, { "@type": "Question", "name": "Le léiomyosarcome provoque-t-il une perte de poids ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une perte de poids inexpliquée peut survenir en raison de la maladie avancée." } }, { "@type": "Question", "name": "Peut-on avoir des symptômes respiratoires ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, si la tumeur se développe dans les poumons, des symptômes respiratoires peuvent apparaître." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon la localisation ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes dépendent de l'emplacement de la tumeur dans le corps." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux femmes ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Les femmes peuvent éprouver des symptômes liés à des tumeurs utérines, comme des saignements." } }, { "@type": "Question", "name": "Peut-on prévenir le léiomyosarcome ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de méthode de prévention spécifique, mais un mode de vie sain peut aider." } }, { "@type": "Question", "name": "Les facteurs environnementaux jouent-ils un rôle ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certains produits chimiques peut augmenter le risque de léiomyosarcome." } }, { "@type": "Question", "name": "Y a-t-il des habitudes à éviter ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Éviter le tabagisme et l'exposition à des agents cancérigènes peut réduire le risque." } }, { "@type": "Question", "name": "Les antécédents familiaux influencent-ils le risque ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de cancers peuvent augmenter le risque de léiomyosarcome." } }, { "@type": "Question", "name": "Le suivi médical régulier est-il important ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi médical régulier peut aider à détecter précocement des anomalies." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour le léiomyosarcome ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent la chirurgie, la chimiothérapie et la radiothérapie." } }, { "@type": "Question", "name": "La chirurgie est-elle toujours nécessaire ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "La chirurgie est souvent nécessaire pour retirer la tumeur, selon sa taille et son emplacement." } }, { "@type": "Question", "name": "La chimiothérapie est-elle efficace ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La chimiothérapie peut être utilisée, mais son efficacité varie selon les cas." } }, { "@type": "Question", "name": "La radiothérapie est-elle une option ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la radiothérapie peut être utilisée pour traiter les tumeurs inopérables ou résiduelles." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Des essais cliniques peuvent proposer des traitements expérimentaux pour le léiomyosarcome." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent la métastase, la douleur chronique et des problèmes fonctionnels." } }, { "@type": "Question", "name": "Le léiomyosarcome peut-il se propager ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il peut se propager à d'autres organes, notamment les poumons et le foie." } }, { "@type": "Question", "name": "Y a-t-il des risques liés aux traitements ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent entraîner des effets secondaires comme la fatigue et des nausées." } }, { "@type": "Question", "name": "Comment gérer la douleur liée au léiomyosarcome ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "La gestion de la douleur peut inclure des médicaments, la physiothérapie et des soins palliatifs." } }, { "@type": "Question", "name": "Le suivi post-traitement est-il crucial ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi régulier est essentiel pour surveiller les récidives et gérer les complications." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent l'exposition à des radiations, des produits chimiques et des antécédents familiaux." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de léiomyosarcome ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque augmente généralement avec l'âge, touchant souvent les adultes d'âge moyen." } }, { "@type": "Question", "name": "Les maladies génétiques sont-elles un facteur ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Certaines maladies génétiques, comme le syndrome de Li-Fraumeni, augmentent le risque." } }, { "@type": "Question", "name": "Le sexe joue-t-il un rôle dans le risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les femmes sont légèrement plus susceptibles de développer un léiomyosarcome utérin." } }, { "@type": "Question", "name": "L'obésité est-elle un facteur de risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'obésité peut être associée à un risque accru de certains types de sarcomes, y compris le léiomyosarcome." } } ] } ] }

Sources (10000 au total)

The impact of tertiary lymphoid structures on clinicopathological, genetic and gene expression characteristics in lung adenocarcinoma.

Tertiary lymphoid structures (TLS) are observed in several cancers and are associated with favorable prognosis. This study aimed to examine the clinicopathological, genetic, and gene expression profil... A total of 112 patients with pathological stage IB lung adenocarcinoma who underwent complete resection between 2011 and 2015 were enrolled in this study. We investigated whether TLS correlated with p... Among the 112 patients, 49 were TLS-positive (TLS+). TLS+ correlated with longer recurrence-free survival (RFS) than TLS-negative cases (TLS-) (hazard ratio [HR], 0.47; 95 % confidence interval [CI]: ... TLS was a favorable prognostic factor and was not associated with PD-L1 expression in patients with lung adenocarcainoma. Moreover, gene expression analysis indicated that TLS is a site for the genera...

Tertiary lymphoid structures correlate with enhancement of antitumor immunity in esophageal squamous cell carcinoma.

Tertiary lymphoid structures (TLSs) are associated with a favorable prognosis in several cancers. However, the correlation between TLSs and outcomes of esophageal squamous cell carcinoma (ESCC) and th... We pathologically evaluated the significance of TLSs in ESCC focusing on TLS maturation using 180 ESCC specimens and performed single-cell RNA sequencing (scRNA-seq) using 14 ESCC tissues to investiga... TLS+ cases had better recurrence-free-survival (RFS) (p < 0.0001) and overall survival (OS) (p = 0.0016) compared with TLS- cases. Additionally, mature TLS+ cases had better RFS and OS compared with i... These data suggest the prognostic and functional significance of TLSs in ESCC and provides new insights into TLSs on the TIME....

Density of tertiary lymphoid structures predicts clinical outcome in breast cancer brain metastasis.

Patients with breast cancer brain metastases (BCBM) experience a rapid decline in their quality of life. Recently, tertiary lymphoid structures (TLSs), analogs of secondary lymphoid organs, have attra... Clinicopathological data were collected from 98 patients (2015-2021). TLSs were evaluated, and a TLS scoring system was constructed. Differences in progression-free survival (PFS) and overall survival... TLSs were identified in 47 patients with BCBM. High TLSs density indicated favorable survival (OS, p=0.003; PFS, p<0.001). TLS was positively associated with OS (p=0.0172) and PFS (p=0.0161) in the hu... Our results highlight the impact of TLSs abundance on the OS and PFS of patients with BCBM. Additionally, we described the immune composition of TLSs and proposed novel nomograms to predict the progno...

Prognostic value of tertiary lymphoid structures in hepatocellular carcinoma: a meta-analysis and systematic review.

Multiple investigations and scholarly articles have presented compelling evidence indicating that tertiary lymphoid structures (TLS) play a pivotal role in inhibiting and controlling the advancement o... We conducted a thorough search across four databases, namely Web of Science, PubMed, Embase, and the Cochrane Library, to identify pertinent studies. The search utilized the keywords "tertiary lymphoi... Six studies were incorporated into the analysis. Among them, four studies, encompassing 6 datasets and involving 1490 patients, and three studies, comprising 5 datasets and involving 656 patients, res... The presence of intratumoral TLSs is correlated with better RFS and reduced early recurrence in HCC patients. Further investigation is warranted to elucidate the roles of peritumoral TLSs in the progn... https://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier CRD42023466793....

Tertiary Lymphoid Structures Are Related to Inflammatory Progression and Bone Loss in Human Apical Periodontitis.

Bone loss is strongly associated with the immunologic milieu in apical periodontitis (AP). Tertiary lymphoid structures (TLSs) are organized lymphoid cell aggregates that form in nonlymphoid tissues u... Tissues from human apical lesions (n = 61) and healthy oral mucosa (n = 5) were collected. Immunohistochemistry and multiplex immunofluorescence were used to detect the formation of TLSs. Correlation ... Periapical granulomas (n = 24) and cysts (n = 37) were identified by histologic evaluation. TLSs, composed of B-cell and T-cell clusters, developed in periapical granulomas and radicular cysts. The CX... The formation of TLSs in periapical granulomas and cysts was closely associated with persistent immune responses and bone loss in apical lesions. TLSs provide an updated insight into the complicated i...

Clinical implications and molecular features of tertiary lymphoid structures in stage I lung adenocarcinoma.

We investigated the clinical implications and molecular features of TLS in stage I lung adenocarcinoma (LUAD).... We retrospectively reviewed the clinicopathological characteristics of 540 patients with p-stage I LUAD. Logistic regression analysis was applied to determining the relationships between clinicopathol... The presence of TLS was associated with a higher pT stage, low- and middle-grade patterns, and the absence of tumor spreading through air spaces (STAS) and subsolid nodules. Multivariate Cox regressio... The presence of TLS was an independent favorable factor for patients with stage I LUAD. The presence TLS was featured by special immune profiles which might aid oncologists in determining personalized...

Peritumor tertiary lymphoid structures are associated with infiltrating neutrophils and inferior prognosis in hepatocellular carcinoma.

The positive prediction of prognosis and immunotherapy within tertiary lymphoid structure (TLS) in cancerous tissue has been well demonstrated, including liver cancer. However, the relationship betwee... This study included cancerous and paracancerous tissue from 170 patients after surgical resection of HCC. TLS was examined and identified by pathological H&E examination, and the impact on prognosis w... In peritumoral tissue, the TLS- group had better overall survival (OS) and disease-free survival (DFS) outcomes compared with the TLS+ group. On the contrary, the intratumor TLS+ group showed better D... TLS might have a dual prognostic role in different regions of HCC. The abundance of peritumoral TLS is an independent influence of DFS. The inconsistent correlation between neutrophils and correspondi...

Tertiary lymphoid structures in breast ductal carcinoma in situ correlate with adverse pathological parameters.

To investigate tertiary lymphoid structures (TLSs) in ductal carcinoma in situ (DCIS) of the breast and their correlation with pathological features, immune cell markers and clinical outcomes.... Morphological identification of TLSs in 198 DCIS cases incorporated B and T cell zones with high endothelial venules. TLS positivity was defined as ≥ 1 TLSs in lesional areas, while TLS area percentag... TLSs in DCIS were associated with unfavourable prognostic features, TILs and immune cell markers in our study. TLSs...