Tree Number:B01.050.150.900.649.313.750.377.750.600.500
Termes MeSH sélectionnés :
Uveal Neoplasms
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"description": "Comment identifier un lion dans la nature ?\nQuels tests pour évaluer la santé d'un lion ?\nQuels signes indiquent une maladie chez un lion ?\nComment diagnostiquer une infection chez un lion ?\nQuels sont les indicateurs de stress chez un lion ?",
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"name": "Comment identifier un lion dans la nature ?",
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"text": "Un lion se distingue par sa crinière, son rugissement et son comportement social en groupe."
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"name": "Comment reconnaître une douleur chez un lion ?",
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"@type": "Question",
"name": "Quels signes indiquent une infection parasitaire ?",
"position": 8,
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"text": "Perte de poids, diarrhée et pelage terne peuvent indiquer une infection parasitaire."
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"name": "Quels symptômes d'une maladie respiratoire chez un lion ?",
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"text": "Toux, respiration rapide et écoulement nasal sont des symptômes de maladie respiratoire."
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"@type": "Question",
"name": "Comment un lion montre-t-il des signes de dépression ?",
"position": 10,
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"text": "Un lion déprimé peut devenir apathique, éviter les interactions sociales et perdre de l'appétit."
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"name": "Comment prévenir les maladies chez les lions ?",
"position": 11,
"acceptedAnswer": {
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"text": "Des vaccinations régulières et une bonne hygiène sont essentielles pour prévenir les maladies."
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"name": "Quelles mesures pour éviter les blessures chez les lions ?",
"position": 12,
"acceptedAnswer": {
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"text": "Un habitat sécurisé et des interactions contrôlées peuvent réduire le risque de blessures."
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"@type": "Question",
"name": "Comment éviter le stress chez les lions en captivité ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Offrir un espace suffisant et des activités stimulantes aide à prévenir le stress."
}
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"@type": "Question",
"name": "Quelles pratiques alimentaires pour la santé des lions ?",
"position": 14,
"acceptedAnswer": {
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"text": "Une alimentation équilibrée et adaptée à leur espèce est cruciale pour leur santé."
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"@type": "Question",
"name": "Comment protéger les lions dans leur habitat naturel ?",
"position": 15,
"acceptedAnswer": {
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"text": "La conservation des habitats et la lutte contre le braconnage sont essentielles."
}
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{
"@type": "Question",
"name": "Quels traitements pour une infection chez un lion ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les infections peuvent être traitées avec des antibiotiques et des soins de soutien."
}
},
{
"@type": "Question",
"name": "Comment traiter une blessure chez un lion ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les blessures nécessitent un nettoyage, des sutures et parfois des antibiotiques pour prévenir l'infection."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont utilisés pour les lions ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des analgésiques, des anti-inflammatoires et des antibiotiques sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Comment gérer le stress chez un lion ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des environnements enrichis et des interactions sociales peuvent aider à réduire le stress."
}
},
{
"@type": "Question",
"name": "Quels soins préventifs pour les lions en captivité ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des vaccinations, des examens réguliers et une alimentation équilibrée sont essentiels."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir après une chirurgie chez un lion ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent l'infection, les saignements et les réactions anesthésiques."
}
},
{
"@type": "Question",
"name": "Quels risques de maladies chroniques chez les lions ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les lions peuvent développer des maladies chroniques comme l'arthrite ou des maladies cardiaques."
}
},
{
"@type": "Question",
"name": "Comment les maladies infectieuses affectent-elles les lions ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les maladies infectieuses peuvent entraîner des épidémies et affecter la population de lions."
}
},
{
"@type": "Question",
"name": "Quelles complications liées à l'âge chez les lions ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les lions âgés peuvent souffrir de problèmes articulaires, de perte de dents et de maladies organiques."
}
},
{
"@type": "Question",
"name": "Quels effets du stress chronique sur les lions ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut entraîner des problèmes de santé mentale et physique chez les lions."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de maladies chez les lions ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, le stress et une mauvaise nutrition augmentent le risque de maladies."
}
},
{
"@type": "Question",
"name": "Comment le braconnage affecte-t-il les lions ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le braconnage réduit les populations de lions et augmente le risque d'extinction."
}
},
{
"@type": "Question",
"name": "Quels impacts de la perte d'habitat sur les lions ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "La perte d'habitat entraîne une diminution des ressources alimentaires et des conflits avec les humains."
}
},
{
"@type": "Question",
"name": "Comment le changement climatique affecte-t-il les lions ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le changement climatique modifie les écosystèmes, affectant la disponibilité de proies et d'eau."
}
},
{
"@type": "Question",
"name": "Quels risques liés à la captivité pour les lions ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les lions en captivité peuvent souffrir de stress, de maladies et de comportements anormaux."
}
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Background: Specific subvariants of uveal melanoma (UM) are associated with increased rates of metastasis compared to other subvariants. BRCA1 (BReast CAncer gene 1)-associated protein-1 (BAP1) is enc...
Despite improvements in the treatment of primary uveal melanoma (UM), patients with metastatic disease continue to exhibit poor survival....
A retrospective review of metastatic UM patients at Yale (initial cohort) and Memorial Sloan Kettering (validation cohort) was conducted. Cox proportional hazards regression was used to determine base...
A total of 89 patients with metastatic UM were identified; 71 and 18, in the initial and validation cohorts, respectively. In the initial cohort, median follow-up was 19.8 months (range, 2-127 months)...
Development of extrahepatic-only metastases, ECOG of 0, immune checkpoint therapy, and female sex were each associated with more than 2-fold reductions in risk of death....
Metastatic uveal melanoma patients face limited treatment options and poor survival rates. Results from this retrospective analysis indicate that immune checkpoint inhibitors, such as anti-CTLA-4 and ...
Ophthalmic treatments are successful in managing uveal melanomas achieving good local control. However, a large number still metastasise, primarily to the liver, resulting in mortality. There is no co...
The PReferentially expressed Antigen in MElanoma (PRAME) protein has been shown to be an independent biomarker for increased risk of metastasis in Class 1 uveal melanomas (UM). Intrinsically disordere...
A bioinformatics study to characterize PRAME's propensity for the intrinsic disorder. We first used the AlphaFold tool to qualitatively assess the protein structure of PRAME. Then we used the Composit...
Our structural analysis showed that PRAME contains intrinsically disordered protein regions (IDPRs), which are structureless and flexible. We found that PRAME is significantly enriched with serine (p-...
Our study revealed that PRAME has IDPRs that are possibly linked to its functionality in the context of Class 1 UM. The regions of functionality (i.e., DOT regions, PTM sites, droplet-promoting region...
To investigate post-enucleation outcomes and assess the effect of extrascleral extension (ESE) on these outcomes for patients with uveal melanoma (UM) managed at a tertiary referral centre in Scotland...
Retrospective review of all cases of UM managed by the Scottish Ocular Oncology Service for which enucleation was undertaken between 13/03/2008 and 31/12/2020. Primary outcomes were length of survival...
Of 172 enucleated UMs, 32 (18.6%) had ESE. Over a median follow-up period of 33.7 months (range = 1.1-163.7 months), 91 (52.9%) patients died. The median length of all-cause survival of 54.1 months (r...
ESE was present in one-sixth of our cohort and was associated with a significantly shorter length of survival, particularly in the presence of ESE > 5 mm or high-risk characteristics warranting adjuva...
Tumor biopsy can identify prognostic biomarkers for metastatic uveal melanoma (UM), however aqueous humor (AH) liquid biopsy may serve as an adjunct. This study investigated whether the AH of UM eyes ...
Uveal and conjunctival melanomas are relatively rare tumors; nonetheless, they pose a significant risk of mortality for a large number of affected individuals. The pathogenesis of melanoma at differen...
The metastatic risk of uveal melanoma (UM) is defined by a limited number of molecular lesions, somatic mutations (SF3B1 and BAP1), and copy number alterations (CNA): monosomy of chromosome 3 (M3), ch...
Alternative splicing is an important mechanism that enhances protein functional diversity. To date, our understanding of alternative splicing variants has been based on mRNA transcript data, but due t...
Uveal melanomas are rare tumors arising from melanocytes that reside in the eye. Despite surgical or radiation treatment, approximately 50% of patients with uveal melanoma will progress to metastatic ...
Here, we demonstrate integrated, longitudinal cfDNA sequencing using multi-omic approaches is more effective than unimodal analysis. This approach supports the use of frequent blood testing using comp...