Comment diagnostiquer une déficience en NADH oxydoréductases ?

Des tests enzymatiques et des analyses génétiques peuvent être utilisés pour diagnostiquer.

Quels tests sanguins sont utiles pour évaluer NADPH ?

Les dosages de NADPH et d'autres coenzymes dans le sang peuvent être effectués.

Quels symptômes indiquent un problème avec ces enzymes ?

Fatigue, faiblesse musculaire et troubles métaboliques peuvent indiquer un problème.

Les tests d'activité enzymatique sont-ils fiables ?

Oui, ils sont souvent utilisés pour évaluer la fonction des NADH et NADPH oxydoréductases.

Peut-on détecter des anomalies génétiques liées à ces enzymes ?

Oui, des tests génétiques peuvent identifier des mutations affectant ces enzymes.

Quels sont les symptômes d'une carence en NADH ?

Les symptômes incluent fatigue, troubles cognitifs et faiblesse musculaire.

Comment se manifeste une déficience en NADPH ?

Elle peut se manifester par des infections fréquentes et des troubles métaboliques.

Y a-t-il des symptômes neurologiques associés ?

Oui, des troubles neurologiques peuvent survenir en cas de dysfonctionnement enzymatique.

Les symptômes varient-ils selon l'âge ?

Oui, les symptômes peuvent varier en fonction de l'âge et de l'état de santé général.

Des symptômes digestifs peuvent-ils apparaître ?

Oui, des troubles digestifs peuvent être liés à des anomalies dans le métabolisme énergétique.

Comment prévenir les déficiences en NADH ?

Une alimentation équilibrée riche en nutriments essentiels peut aider à prévenir ces déficiences.

Y a-t-il des habitudes de vie à adopter ?

Oui, un mode de vie sain incluant exercice et gestion du stress est recommandé.

Les bilans de santé réguliers sont-ils utiles ?

Oui, des bilans réguliers peuvent aider à détecter précocement des anomalies enzymatiques.

Les vaccinations peuvent-elles jouer un rôle ?

Certaines vaccinations peuvent prévenir des infections qui aggravent les déficiences.

L'éducation nutritionnelle est-elle importante ?

Oui, comprendre l'importance des nutriments peut aider à prévenir les carences.

Quels traitements existent pour les déficiences enzymatiques ?

Les traitements peuvent inclure des suppléments enzymatiques et des modifications diététiques.

La thérapie génique est-elle une option ?

Oui, la thérapie génique est explorée pour traiter certaines déficiences enzymatiques.

Les médicaments peuvent-ils aider à réguler ces enzymes ?

Certains médicaments peuvent aider à moduler l'activité des NADH et NADPH oxydoréductases.

Y a-t-il des traitements naturels recommandés ?

Des antioxydants et des nutriments peuvent soutenir la fonction enzymatique.

Les transfusions sanguines sont-elles nécessaires ?

Dans certains cas graves, des transfusions peuvent être nécessaires pour corriger des déficiences.

Quelles complications peuvent survenir avec une déficience en NADH ?

Des complications incluent des troubles métaboliques graves et des problèmes neurologiques.

Les infections sont-elles une complication fréquente ?

Oui, les personnes avec des déficiences enzymatiques sont plus susceptibles aux infections.

Y a-t-il des risques de maladies chroniques ?

Oui, des déficiences peuvent augmenter le risque de maladies chroniques comme le diabète.

Les complications cardiovasculaires sont-elles possibles ?

Oui, des troubles métaboliques peuvent entraîner des complications cardiovasculaires.

Des complications hématologiques peuvent-elles survenir ?

Oui, des anomalies dans le métabolisme peuvent entraîner des complications hématologiques.

Quels facteurs de risque sont associés aux déficiences enzymatiques ?

Les facteurs incluent des antécédents familiaux, des maladies métaboliques et une mauvaise nutrition.

L'âge est-il un facteur de risque ?

Oui, certaines déficiences peuvent être plus fréquentes chez les personnes âgées.

Le mode de vie influence-t-il le risque ?

Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.

Les maladies génétiques sont-elles un facteur ?

Oui, certaines maladies génétiques prédisposent aux déficiences en NADH et NADPH.

Le stress oxydatif joue-t-il un rôle ?

Oui, le stress oxydatif peut aggraver les déficiences enzymatiques et leurs effets.

NADH, NADPH oxidoreductases - Informations médicales vérifiées

Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly.

Nov 2022

DOI: 10.1055/a-1913-7900 PMID: 36075228

To investigate the clinical characteristics and associated factors of colonic polyps in patients with acromegaly.... Clinical characteristics and colonoscopy findings of 86 acromegaly patients who received treatment were retrospectively reviewed, and colonoscopy findings and the correlation with growth hormone (GH)-... The prevalence of colonic polyps in acromegaly patients was 40.7% and increased significantly with advanced age, especially in those ≥50 years. Multiple polyps (62.8%) and colonic polyps in the left c... The acromegalic patients are a population with a high prevalence of colonic polyps. GHPA volumes and IGF-1×ULN levels may be predictors of colonic polyp occurrence....

Humans Middle Aged Colonic Polyps Acromegaly Insulin-Like Growth Factor I +3 autres

Combined Endoscopic Robotic Surgery for Complex Colon Polyps.

01 08 2023

DOI: 10.1097/DCR.0000000000002689 PMID: 36876961

Combined endoscopic robotic surgery is a surgical technique that modifies traditional endoscopic laparoscopic surgery with robotic assistance to aid in the removal of complex colonic polyps. This tech... This study aimed to evaluate the safety and outcomes of combined endoscopic robotic surgery.... A retrospective review of a prospective database.... East Jefferson General Hospital, Metairie, Louisiana.... Ninety-three consecutive patients who underwent combined endoscopic robotic surgery from March 2018 to October 2021 were included in the study.... Operative time, intraoperative complication, 30-day postoperative complication, hospital length of stay, and follow-up pathology report results were the main outcome measures.... Combined endoscopic robotic surgery was completed in 88 of 93 participants (95%). Among the 88 participants who completed combined endoscopic robotic surgery, the average age was 66 years (SD = 10), B... Limitations for our study include a lack of randomization and follow-up rate to assess for recurrence. The low compliance rate may be due to procedure cancelations/difficulty scheduling because of cha... Compared to literature-reported statistics for its laparoscopic counterpart, combined endoscopic robotic surgery was associated with decreased operation times and resection site polyp recurrence. See ... ANTECEDENTES:La cirugía robótica endoscópica combinada es una técnica quirúrgica que modifica la cirugía laparoscópica endoscópica tradicional con asistencia robótica para ayudar en la extracción de p...

Aged Humans Colon Colonic Polyps COVID-19 +3 autres

A Case of Sporadic Multiple Colonic Polyps in a Young Woman.

17 01 2023

DOI: 10.3390/curroncol30020100 PMID: 36826061

Sporadic colorectal cancer arises from an adenoma. As mutations in the adenomatous polyposis coli (APC) tumor suppressor gene have been frequently detected in colorectal adenomas, the APC gene is cons...

Female Humans Adult Colonic Polyps Adenomatous Polyposis Coli +4 autres

Prevention of delayed bleeding after resection of large colonic polyps.

Mar 2024

DOI: 10.1016/j.bpg.2024.101907 PMID: 38749583

A significant problem encountered in the resection of large, complex colonic polyps is delayed bleeding. This can occur up to two weeks after the procedure and is a significant source of comorbidity. ...

Humans Colonic Polyps Postoperative Hemorrhage Colonoscopy Endoscopic Mucosal Resection +4 autres

Liver Cirrhosis Increases the Risk of Developing Advanced Colon Polyps.

03 2023

DOI: 10.1007/s10620-022-07561-1 PMID: 35670896

To analyze our experience with adenoma detection rates in patients with liver cirrhosis in a community setting.... Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer death in men and women in the USA. The majority of CRCs arise from premalignant polyps (adenomas), which are typical... A total of 351 colonoscopies were performed (2006 to 2019) in patients with liver cirrhosis. Mean age was 62.3 ± 9.4 years, there were 158 females and 193 males. Adenomas were found in 159 procedures ... Adenoma detection rates in patients with cirrhosis (49%) undergoing elective colonoscopy were higher than rates reported in the literature for LT candidates (22-42%) undergoing standardized screenings...

Male Humans Female Middle Aged Aged +6 autres

A novel polyp retrieval bag reduces the polyp fragmentation rate in colon polypectomy: a single-blind randomized controlled study.

24 Jul 2024

DOI: 10.1007/s00384-024-04694-9 PMID: 39048748

The fragmentation of polyps affects complete resection confirmation. The primary aim of this study was to assess the feasibility of a novel polyp retrieval bag for reducing the fragmentation rate of c... Patients with a 5-15 mm colon polyp were recruited and randomized into two groups at a 1:1 ratio. After polyp resection, polyps obtained from patients in the treatment group were extracted via a novel... From January to July 2022, 225 patients were assessed for eligibility. The study participants included 204 patients, and seven patients whose samples were not retrieved were excluded. Polyp fragmentat... This study demonstrated that the polyp retrieval bag was safe and feasible for reducing the fragmentation rate of retrieved polyps.... The study was registered at ClinicalTrials.gov (NCT05189912, 1/12/2021)....

Humans Colonic Polyps Male Female Middle Aged +4 autres

Distinct colon mucosa microbiomes associated with tubular adenomas and serrated polyps.

29 08 2022

DOI: 10.1038/s41522-022-00328-6 PMID: 36038569

Colorectal cancer is the second most deadly and third most common cancer in the world. Its development is heterogenous, with multiple mechanisms of carcinogenesis. Two distinct mechanisms include the ...

Adenoma Carcinogenesis Carcinoma Colonic Polyps Colorectal Neoplasms +2 autres

The Surface Morphology of Large Nonpedunculated Colonic Polyps Predicts Synchronous Large Lesions.

08 2023

DOI: 10.1016/j.cgh.2023.01.034 PMID: 36787836

Large (≥20 mm) nonpedunculated colorectal polyps (LNPCPs) may have synchronous LNPCPs in up to 18% of cases. The nature of this relationship has not been investigated. We aimed to examine the relation... Consecutive patients referred for resection of LNPCPs over 130 months until March 2022 were enrolled. Serrated lesions and mixed granularity LNPCPs were excluded from analysis. Patients with multiple ... There were 3149 of 3381 patients (93.1%) who had a single LNPCP. In 232 (6.9%) a synchronous lesion was detected. Solitary lesions had a median size of 35 mm with a predominant Paris 0-IIa morphology ... We found that 6.9% of LNPCPs have synchronous disease, with NG-LNPCPs demonstrating a greater than 4-fold increased risk. With post-colonoscopy interval cancers exceeding 5%, endoscopists must be cogn... gov, NCT01368289; NCT02000141; NCT02198729....

Humans Adenoma Colon Colonic Polyps Colonoscopy +1 autres

Bleeding Risk With Cold Snare Polypectomy of ≤10 mm Pedunculated Colon Polyps.

01 03 2023

DOI: 10.1097/MCG.0000000000001699 PMID: 35470299

Pedunculated polyps (PPs) in the colon are usually resected with hot snare polypectomy to prevent immediate postpolypectomy bleeding (IPPB). This study aimed to evaluate the safety of CSP of <10 mm PP... Patients undergoing colonoscopy from February 18, 2019, to April 24, 2020, and were found to have at least 1 ≤10 mm PP resected with CSP were included prospectively in a continuous quality improvement... We found 239 eligible polyps in 182 patients. The mean (SD) age was 58.8 (8.3) years, and 61% were males. IPPB occurred in 72 of 239 polyps, corresponding to a per-polyp bleeding percentage of 30.1% a... CSP can be used for resection of ≤10 mm PPs. It is associated with a lower risk of immediate bleeding than the common perception among gastroenterologists....

Male Humans Middle Aged Female Colonic Polyps +4 autres

A stacking-based artificial intelligence framework for an effective detection and localization of colon polyps.

21 10 2022

DOI: 10.1038/s41598-022-21574-w PMID: 36271114

Polyp detection through colonoscopy is a widely used method to prevent colorectal cancer. The automation of this process aided by artificial intelligence allows faster and improved detection of polyps...

Humans Artificial Intelligence Colonic Polyps Colonoscopy Algorithms +2 autres

NADH, NADPH oxidoreductases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Cytochrome reductases

NADH tetrazolium reductase

NADP transhydrogenases

NADPH dehydrogenase

Quinone reductases

NADPH-ferrihemoprotéine reductase

NADP transhydrogenase, AB-specific

NADPH dehydrogenase (quinone)

Auteurs principaux

Sources (7591 au total)