questionsmedicales.fr
Composés polycycliques
Hydrocarbures aromatiques polycycliques
Phénanthrènes
Morphinanes
Nalbuphine
Nalbuphine : Questions médicales fréquentes
Diagnostic
5
Douleur
Évaluation de la douleur
Tests de laboratoire
Fonction hépatique
Antécédents médicaux
Addiction
Douleur aiguë
État général
Efficacité du traitement
Effets secondaires
Symptômes
5
Douleur
Activités de la vie quotidienne
Effets secondaires
Nausées
Sevrage
Traitement opioïde
Réaction allergique
Confusion
Prévention
5
Surveillance médicale
Effets secondaires
Antécédents médicaux
Allergies
Prévention de la douleur
Traitement de la douleur
Conseils aux patients
Alcool
Dépendance
Prescription médicale
Traitements
5
Administration de médicaments
Voie intraveineuse
Posologie
Médicaments opioïdes
Interactions médicamenteuses
Analgésiques
Thérapies alternatives
Anti-inflammatoires
Ajustement de la dose
Réponse au traitement
Complications
5
Complications
Réactions allergiques
Réaction allergique
Antihistaminiques
Complications respiratoires
Cyanose
Problèmes cardiaques
Surveillance médicale
Prévention des complications
Ajustement de la posologie
Facteurs de risque
5
Facteurs de risque
Âge avancé
Antécédents d'addiction
Dépendance
Maladies respiratoires
Complications respiratoires
Utilisation d'opioïdes
Dépression respiratoire
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"name": "Comment diagnostiquer une douleur nécessitant la nalbuphine ?",
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"text": "Évaluer l'intensité de la douleur et son impact sur la qualité de vie."
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{
"@type": "Question",
"name": "Quels tests sont nécessaires avant d'administrer la nalbuphine ?",
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"@type": "Question",
"name": "La nalbuphine est-elle appropriée pour tous les patients ?",
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"@type": "Question",
"name": "Quels signes indiquent un besoin urgent de nalbuphine ?",
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"@type": "Question",
"name": "Comment évaluer l'efficacité de la nalbuphine ?",
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"acceptedAnswer": {
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"text": "Surveiller la réduction de la douleur et les effets secondaires."
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"@type": "Question",
"name": "Quels symptômes indiquent une douleur modérée à sévère ?",
"position": 6,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Quels effets secondaires peuvent survenir avec la nalbuphine ?",
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"text": "Nausées, somnolence, constipation et vertiges sont possibles."
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"@type": "Question",
"name": "La nalbuphine peut-elle provoquer des symptômes de sevrage ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un sevrage peut survenir si le traitement est arrêté brusquement."
}
},
{
"@type": "Question",
"name": "Quels symptômes nécessitent une attention médicale urgente ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Respiration lente, confusion sévère ou réactions allergiques."
}
},
{
"@type": "Question",
"name": "Comment reconnaître une overdose de nalbuphine ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Somnolence extrême, difficulté à respirer et perte de conscience."
}
},
{
"@type": "Question",
"name": "Comment prévenir les effets secondaires de la nalbuphine ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller les signes vitaux et ajuster la posologie si nécessaire."
}
},
{
"@type": "Question",
"name": "Quelles précautions prendre avant de commencer la nalbuphine ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Informer le médecin des allergies, des médicaments en cours et des antécédents médicaux."
}
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{
"@type": "Question",
"name": "La nalbuphine peut-elle être utilisée en prévention de la douleur ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est généralement utilisée pour traiter la douleur, pas pour la prévention."
}
},
{
"@type": "Question",
"name": "Quels conseils donner aux patients sous nalbuphine ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'alcool, ne pas conduire et signaler tout effet indésirable."
}
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{
"@type": "Question",
"name": "Comment prévenir la dépendance à la nalbuphine ?",
"position": 15,
"acceptedAnswer": {
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"text": "Utiliser la nalbuphine uniquement selon les prescriptions médicales et surveiller l'usage."
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{
"@type": "Question",
"name": "Comment la nalbuphine est-elle administrée ?",
"position": 16,
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{
"@type": "Question",
"name": "Quelle est la posologie standard de la nalbuphine ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
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"@type": "Question",
"name": "Peut-on combiner la nalbuphine avec d'autres analgésiques ?",
"position": 18,
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"@type": "Question",
"name": "Quels sont les traitements alternatifs à la nalbuphine ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "D'autres opioïdes, anti-inflammatoires ou thérapies non médicamenteuses peuvent être envisagés."
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{
"@type": "Question",
"name": "Comment ajuster la dose de nalbuphine ?",
"position": 20,
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"@type": "Answer",
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{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la nalbuphine ?",
"position": 21,
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"@type": "Answer",
"text": "Complications respiratoires, hypotension et réactions allergiques graves."
}
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{
"@type": "Question",
"name": "Comment gérer une réaction allergique à la nalbuphine ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cesser l'administration et administrer des antihistaminiques ou des corticostéroïdes."
}
},
{
"@type": "Question",
"name": "Quels sont les signes d'une complication respiratoire ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Respiration lente, difficulté à respirer ou cyanose des lèvres et des ongles."
}
},
{
"@type": "Question",
"name": "La nalbuphine peut-elle causer des problèmes cardiaques ?",
"position": 24,
"acceptedAnswer": {
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"text": "Des effets sur la fréquence cardiaque peuvent survenir, nécessitant une surveillance."
}
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{
"@type": "Question",
"name": "Comment prévenir les complications liées à la nalbuphine ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller attentivement le patient et ajuster la posologie en fonction des besoins."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'effets secondaires ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Âge avancé, problèmes hépatiques ou rénaux, et utilisation concomitante d'autres médicaments."
}
},
{
"@type": "Question",
"name": "Les antécédents d'addiction sont-ils un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les antécédents d'addiction augmentent le risque de dépendance à la nalbuphine."
}
},
{
"@type": "Question",
"name": "Comment le poids corporel influence-t-il la posologie ?",
"position": 28,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Les maladies respiratoires sont-elles un facteur de risque ?",
"position": 29,
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"name": "L'utilisation d'autres opioïdes est-elle un facteur de risque ?",
"position": 30,
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"text": "Oui, cela peut augmenter le risque d'effets secondaires et de dépression respiratoire."
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 19/06/2026
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230061, PR China. Electronic address: luyao@ahmu.edu.cn.
Publications dans "Nalbuphine" :
3 publications dans cette catégorie
Affiliations :
Trevi Therapeutics, New Haven, CT.
Publications dans "Nalbuphine" :
3 publications dans cette catégorie
Affiliations :
Ärztliche Leitung Rettungsdienst, Landkreis Osnabrück, Am Schölerberg 1, 49082, Osnabrück, Deutschland.
Klinik für Anästhesiologie, Klinikum Osnabrück, Am Finkenhügel 1, 49076, Osnabrück, Deutschland.
Publications dans "Nalbuphine" :
3 publications dans cette catégorie
Affiliations :
Biostatistik und Medizinische Biometrie, Medizinische Fakultät OWL, Universität Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Deutschland.
Publications dans "Nalbuphine" :
3 publications dans cette catégorie
Affiliations :
Ärztliche Leitung Rettungsdienst, Kreis Gütersloh, Herzebrocker Straße 140, 33324, Gütersloh, Deutschland.
Publications dans "Nalbuphine" :
3 publications dans cette catégorie
Affiliations :
Ärztliche Leitung Rettungsdienst, Kreis Gütersloh, Herzebrocker Straße 140, 33324, Gütersloh, Deutschland.
Publications dans "Nalbuphine" :
3 publications dans cette catégorie
Affiliations :
Universitätsklinik für Anästhesiologie, Intensivmedizin und Notfallmedizin, Johannes Wesling Klinikum Minden, Ruhr Universität Bochum, Hans-Nolte-Straße 1, 32429, Minden, Deutschland. gerrit.jansen@muehlenkreiskliniken.de.
Medizinische Fakultät OWL, Universität Bielefeld, Universitätsstraße 25, 33615, Bielefeld, Deutschland. gerrit.jansen@muehlenkreiskliniken.de.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesia, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesia, Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Κappa Pharmaceuticals LLC, Alachua, FL 32615, USA.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Serodopa Therapeutics Inc., Gainesville, FL 32601, USA.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Κappa Pharmaceuticals LLC, Alachua, FL 32615, USA.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230061, PR China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, The Affiliated Huai an Hospital of Xuzhou Medical University, Huai'an, China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of General Surgery, The Affiliated Huai an Hospital of Xuzhou Medical University, Huai'an, China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, The Affiliated Huai an Hospital of Xuzhou Medical University, Huai'an, China.
Publications dans "Nalbuphine" :
2 publications dans cette catégorie
Affiliations :
Hospital Pharmacy, University Children's Hospital Zurich, Zurich, Switzerland miriam.pfiffner@kispi.uzh.ch.
Publications dans "Nalbuphine" :
Despite the development of various analgesic concepts, prehospital oligoanalgesia remains very common. The present work examines prehospital analgesia by paramedics using morphine vs. nalbuphine + par...
Patients with out-of-hospital-analgesia performed by paramedics from the emergency medical services of the districts of Fulda (morphine) and Gütersloh (nalbuphine + paracetamol) were evaluated with re...
A total of 1,808 patients who received out-of-hospital-analgesia were evaluated (nalbuphine + paracetamol: 1,635 (90.4%), NRS-initial: 8.0 ± 1.4, NRS-at-handover: 3.7 ± 2.0; morphine: 173(9.6%), NRS-i...
Compared to morphine, prehospital analgesia with nalbuphine + paracetamol yields favourable effects in terms of analgesic effectiveness and a lower rate of complications and should therefore be consid...
To investigate the effects of nalbuphine on emergency agitation (EA), which affects up to 80% of the children following otolaryngology procedures, in children undergoing cochlear implantation....
A prospective double-blinded randomized controlled clinical trial was conducted between November 2020 and October 2022. Eligible children, aged 6 months to 3 years old, were randomly assigned to eithe...
A total of 104 children were enrolled, with 26 children in each group. Nalbuphine significantly reduced the EA occurrence from 73.1% in the saline group to 38.5%, 30.8%, and 26.9% in the 0.1 mg/kg, 0....
Young children undergoing cochlear implantation surgery were at a high risk of EA and postoperative pain, while 0.2 mg/kg nalbuphine might be an ideal candidate for EA and pain prevention when used un...
ChiCTR2000040407....
Administration of adjuvant drugs epidurally in combination with local anesthetics offers new dimensions in the management of postoperative pain. This study aimed to compare the addition of either nalb...
This prospective randomized double-blind study included 69 patients scheduled for lower limb orthopedic surgeries. Anesthesia was started with 15 mg hyperbaric bupivacaine 0.5% intrathecally, and then...
The onset of epidural analgesia was 17.83 ± 2.53 versus 13.39 ± 1.27 versus 12.17 ± 1.27 min in groups C, N and D, respectively (p value < 0.001). The mean duration of analgesia was 241.3 ± 14.24 vers...
The addition of either nalbuphine or dexmedetomidine to epidural bupivacaine was effective for postoperative analgesia in terms of onset, duration, and patient satisfaction with the superiority of dex...
Approval from the research ethics committee of the Faculty of Medicine, Zagazig University was obtained with the reference number (ZU-IRB#:7045-15-8-2021) and it was registered under clinicaltrials.go...
Severe postoperative pain requiring opioid treatment has been reported in 20% to 40% of hemorrhoidectomy patients. Compared with morphine, nalbuphine offers better hemodynamic stability, a lower risk ...
A randomized, double-blind, placebo-controlled, multiple-dose, parallel-design trial was conducted to evaluate the safety and efficacy of PHN131 in patients undergoing hemorrhoidectomy. Eligible patie...
Visual Analog Scale results in patients receiving PHN131 were significantly lower than placebo group scores through 48 hours postoperatively (149.2±75.52 vs. 179.6±65.97; P =0.0301). According to Brie...
Our findings demonstrate that PHN131 is effective and well-tolerated in the treatment of moderate-to-severe post hemorrhoidectomy pain and may provide another option for patients to control their pain...
Erector spinae plane block (ESPB) is an easy and safe method for postoperative analgesia. However its effect lasts only for several hours. This trial was to investigate the effectiveness of different ...
Patients scheduled for PCNL were randomized into three groups and received ultrasound-guided ESPB at T...
The median [interquartile range, IQR] time to first opioid demand was significantly longer in group RNH (8.70 [6.90,14.85] h) than that of group R and group RNL (2.90 [2.00,6.30] h and 5.80 [2.95,7.00...
Adding 20mg nalbuphine to ropivacaine in ESPB could significantly improve the effect of analgesia and prolong the duration of nerve blocks for PCNL....
Postoperative pain and postanesthesia shivering are the two common problems in patients undergoing surgery under spinal anesthesia (SA). The present study aimed to compare the preemptive prescription ...
Present study was a prospective, randomized double-blind study, conducted on patients of either gender, with American Society of Anesthesiologists physical status class I or II, aged 21-60 years, post...
The incidence of postoperative shivering was 22 % and 36 % in groups N and K respectively and the difference was statistically significant. The first request for analgesia (minutes) was later in group...
Preemptive nalbuphine had less incidence of postoperative shivering, delayed first request for analgesia, and less total analgesic consumption than ketorolac in patients undergoing surgery under SA....
Developing an effective antidote for fentanyl-induced overdose to achieve timely reversal is an unmet public health need. Previously, we found that naloxone derivative NX90 with mild κ-opioid agonisti...
BACKGROUND: Treatment of acute pain is an essential element of pre-hospital care for injured and critically ill patients. Clinical studies indicate the need for improvement in the prehospital analgesi...
The aim of this study is to assess the current situation in out of hospital pain management in Germany regarding the substances, indications, dosage and the delegation of the use of analgesics to emer...
A standardized survey of the medical directors of the emergency services (MDES) in Germany was carried out using an online questionnaire. The anonymous results were evaluated using the statistical sof...
Seventy-seven MDES responsible for 989 rescue stations and 397 EMS- physician bases in 15 federal states took part in this survey. Morphine (98.7%), Fentanyl (85.7%), Piritramide (61%), Sufentanil (18...
Effective analgesics are available for EMS staff in Germany, the approach to improvement lies in the area of application. For this purpose, the adaptations of the legal framework as well as the creati...
The purpose of this study was to evaluate the pharmacokinetics (PK) of intravenously (IV) and subcutaneously (SC) administered nalbuphine in domestic goats. Nalbuphine hydrochloride was administered a...
Nalbuphine, a semi-synthetic opioid, has gained attention for its analgesic properties, but its specific impact on hemodynamics in ear, nose, and throat (ENT) surgeries remains a subject of exploratio...