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Phénomènes physiologiques de l'appareil locomoteur et du système nerveux
Phénomènes physiologiques du système nerveux
Transmission synaptique
Transmission synaptique : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"@type": "Question",
"name": "Comment diagnostiquer un dysfonctionnement synaptique ?",
"position": 1,
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"text": "Des tests électrophysiologiques et des imageries cérébrales peuvent être utilisés."
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{
"@type": "Question",
"name": "Quels examens sont utilisés pour évaluer la transmission synaptique ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IRM fonctionnelle et l'électroencéphalogramme (EEG) sont couramment utilisés."
}
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{
"@type": "Question",
"name": "Quels symptômes indiquent un problème de transmission synaptique ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles de la mémoire, des convulsions ou des changements de comportement peuvent survenir."
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"@type": "Question",
"name": "Peut-on mesurer la transmission synaptique directement ?",
"position": 4,
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"text": "Oui, des techniques comme la microscopie à fluorescence permettent d'observer la transmission."
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"name": "Quels marqueurs biologiques sont associés à la transmission synaptique ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des protéines comme la synaptophysine peuvent servir de marqueurs pour la synapse."
}
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{
"@type": "Question",
"name": "Quels symptômes sont liés à une transmission synaptique altérée ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes incluent des troubles cognitifs, des spasmes musculaires et des douleurs."
}
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{
"@type": "Question",
"name": "Comment la dépression affecte-t-elle la transmission synaptique ?",
"position": 7,
"acceptedAnswer": {
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"text": "La dépression peut réduire la plasticité synaptique, affectant la communication neuronale."
}
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{
"@type": "Question",
"name": "Les troubles de l'humeur sont-ils liés à la transmission synaptique ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres dans les neurotransmetteurs peuvent provoquer des troubles de l'humeur."
}
},
{
"@type": "Question",
"name": "Quels signes neurologiques peuvent indiquer un problème synaptique ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes incluent des tremblements, des troubles de la coordination et des réflexes anormaux."
}
},
{
"@type": "Question",
"name": "La fatigue chronique est-elle liée à la transmission synaptique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies dans la transmission synaptique peuvent contribuer à la fatigue chronique."
}
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{
"@type": "Question",
"name": "Comment prévenir les troubles de la transmission synaptique ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, est essentiel."
}
},
{
"@type": "Question",
"name": "Le stress affecte-t-il la transmission synaptique ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut altérer la transmission synaptique et la plasticité."
}
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{
"@type": "Question",
"name": "L'exercice physique influence-t-il la transmission synaptique ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier favorise la santé neuronale et la transmission synaptique."
}
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{
"@type": "Question",
"name": "Les habitudes de sommeil affectent-elles la transmission synaptique ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un sommeil de qualité est crucial pour la régénération synaptique et cognitive."
}
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{
"@type": "Question",
"name": "La méditation peut-elle améliorer la transmission synaptique ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la méditation peut augmenter la plasticité synaptique et réduire le stress."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour améliorer la transmission synaptique ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les antidépresseurs et les nootropiques peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "La thérapie cognitive peut-elle aider la transmission synaptique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut améliorer la plasticité synaptique et la fonction cognitive."
}
},
{
"@type": "Question",
"name": "Les suppléments alimentaires influencent-ils la transmission synaptique ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains suppléments comme les oméga-3 peuvent favoriser la santé synaptique."
}
},
{
"@type": "Question",
"name": "Comment la stimulation cérébrale affecte-t-elle la transmission synaptique ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La stimulation cérébrale peut renforcer les connexions synaptiques et améliorer la fonction."
}
},
{
"@type": "Question",
"name": "Les thérapies comportementales aident-elles la transmission synaptique ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent améliorer les interactions neuronales et la plasticité synaptique."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent résulter d'une transmission synaptique altérée ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des troubles neurologiques, des troubles de l'humeur et des crises."
}
},
{
"@type": "Question",
"name": "Les maladies neurodégénératives affectent-elles la transmission synaptique ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme Alzheimer altèrent gravement la transmission synaptique."
}
},
{
"@type": "Question",
"name": "Comment les troubles de l'apprentissage sont-ils liés à la transmission synaptique ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la transmission synaptique peuvent entraîner des difficultés d'apprentissage."
}
},
{
"@type": "Question",
"name": "Les troubles psychotiques sont-ils liés à la transmission synaptique ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres dans les neurotransmetteurs peuvent contribuer aux troubles psychotiques."
}
},
{
"@type": "Question",
"name": "La schizophrénie affecte-t-elle la transmission synaptique ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la schizophrénie est associée à des dysfonctionnements dans la transmission synaptique."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque influencent la transmission synaptique ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme l'âge, le stress et la génétique peuvent influencer la transmission."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans la transmission synaptique ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en nutriments favorise une transmission synaptique saine."
}
},
{
"@type": "Question",
"name": "Le tabagisme affecte-t-il la transmission synaptique ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut altérer la fonction synaptique et augmenter le risque de troubles."
}
},
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"@type": "Question",
"name": "Les maladies chroniques influencent-elles la transmission synaptique ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le diabète peuvent affecter la transmission synaptique."
}
},
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"@type": "Question",
"name": "Le manque d'activité physique est-il un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'inactivité physique peut nuire à la santé synaptique et cognitive."
}
}
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Dysregulated complement system is linked to pathophysiology of major depressive disorder (MDD). Childhood trauma has been associated with an increased incidence of adult depression via a putative mech...
The participants were 49 medication-free MDD patients and 45 healthy controls. All participants were asked to finish the Childhood Trauma Questionnaire, followed by blood sampling for measurement of p...
Peripheral plasma concentration of C3 and C3a in medication-free MDD group was significantly higher than that in the healthy controls; whereas the concentration of plasma C1q and CRP in depressed pati...
Our data suggest that complement C3 and C3a may be implicated in the pathophysiology of MDD, although traumatic childhood experiences were not associated with the circulating levels of complement C3, ...
C3 glomerulopathy (C3G) is a complement-mediated disease. Although genetic studies are not required for diagnosis, they are valuable for treatment planning and prognosis prediction. The aim of this st...
Sixty pediatric C3G patients were included, divided into two groups based on complement-related gene mutations. Demographic and clinical-pathological findings, treatment modalities, and outcome data w...
Out of the 60 patients, 17 had mutations. The most common mutation was in the CFH gene (47%). The mean age at diagnosis was higher in the group with mutation (12.9 ± 3.6 vs. 11.2 ± 4.1 years, p = 0.03...
This study is the largest pediatric C3G study examining the relationship between genotype and phenotype. We showed that the mutation group often presented with asymptomatic urinary abnormalities, was ...
Mn (Manganese, Mn) is an essential trace element involved in various biological processes such as the regulation of immune, nervous and digestive system functions. However, excessive Mn exposure can l...
Evidence from a Phase IIa trial showed that a complement C3-targeted drug reduced gingival inflammation in patients with gingivitis. Using drug-target Mendelian randomization (MR), we investigated whe...
We used multiple 'cis' instruments from the vicinity of the encoding loci of C3. Instrument selection was restricted to the drug target encoding loci (chromosome 19; 6,677,715-6,730,573 (GRCh37/hg19))...
MR analysis revealed that the inhibition of C3 reduces the odds of periodontitis (OR 0.91 per 1 standard deviation reduction in C3; 95% confidence interval 0.87-0.96, p value = .0003)....
Findings from our MR analysis suggest a potential protective effect of C3 blockade against periodontitis....
Microglia, a resident immune cell of the central nervous system (CNS), play a pivotal role in facilitating neurovascular development through mechanisms that are not fully understood. Previous reports ...
Biomarkers are needed to predict prognosis and disease activity in patients with Guillain-Barré syndrome (GBS). The complement system is a key player in the pathogenesis of GBS. This study aimed to as...
We reviewed the medical records of 76 GBS patients with C3 and C4 measurements during hospitalization between 2010 and 2021. Clinical outcomes were correlated with baseline serum C3, C4, and seven add...
Higher C3, but not C4, was associated with poorer outcomes: lower Medical Research Council sum scores (MRCSS), higher GBS disability score (GBSDS), longer hospitalization, and more frequent treatment-...
This study highlights the use of serum C3 as a novel mechanistic biomarker in GBS. Larger prospective studies are needed to validate our findings....
IgG and complement 3 (C3) are generally found to be deposited along the glomerular basement membrane (GBM) in human anti-GBM disease. The pathogenic role of complement activation in kidney damage of a...
Ninety-four anti-GBM disease patients between January 2004 and December 2020 at the National Clinical Research Center of Kidney Diseases Jinling Hospital were retrospectively analyzed, and were divide...
A total of 94 patients (aged 43.6 ± 16.2; male patients, 46%) with anti-GBM disease were enrolled. There were 26 patients with low C3 levels and 68 patients with normal C3 levels. Compared with the no...
The kidney outcomes of anti-GBM disease in the low C3 group were poorer than those in the normal C3 group. The influence of C3 on the kidney outcomes of patients with anti-GBM disease may be of clinic...
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis affecting multiple organ systems, including the kidney. The activation of the complement system con...
The activation of the complement system contributes essentially to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. We here aimed to directly compare levels...
Serum levels of complement components C3 and C4 were directly compared in association with clinical and outcome data in a retrospective cohort of ANCA-associated renal vasculitis....
As compared to poor outcome prediction by low levels of complement C3 (p = 0.0093), low levels of complement C4 did not associate with early requirement of kidney replacement therapy (KRT) or death (p...
While low levels of complement C3 were superior in predicting poor outcome in ANCA-associated renal vasculitis, a minor fraction with poor outcome had isolated C4 lowering not captured by serum C3 mea...
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially life-threatening systemic small-vessel vasculitis that is characterized by pauci-immune glomerulonephritis, depi...
A cohort of 53 biopsy-proven cases of ANCA-associated renal vasculitis were retrospectively enrolled in a single-center observational study. Univariate and multivariate regression analysis was perform...
Lower platelet counts correlated with markers of kidney injury including eGFR loss (...
Based on our observation that an association between platelets and complement system activation is only observed in the MPO-ANCA subgroup, this could implicate that platelets and complement C3 link in...