Activité de type insulinique non suppressible : Questions médicales fréquentes
Nom anglais: Nonsuppressible Insulin-Like Activity
Descriptor UI:D009632
Tree Number:D12.776.124.862.575
Termes MeSH sélectionnés :
Early Detection of Cancer
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Activité de type insulinique non suppressible : Questions médicales les plus fréquentes",
"headline": "Activité de type insulinique non suppressible : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Activité de type insulinique non suppressible : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-04",
"dateModified": "2025-03-31",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Activité de type insulinique non suppressible"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Protéines du sang",
"url": "https://questionsmedicales.fr/mesh/D001798",
"about": {
"@type": "MedicalCondition",
"name": "Protéines du sang",
"code": {
"@type": "MedicalCode",
"code": "D001798",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.124"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Activité de type insulinique non suppressible",
"alternateName": "Nonsuppressible Insulin-Like Activity",
"code": {
"@type": "MedicalCode",
"code": "D009632",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Jie Li",
"url": "https://questionsmedicales.fr/author/Jie%20Li",
"affiliation": {
"@type": "Organization",
"name": "Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA."
}
},
{
"@type": "Person",
"name": "Xiao-Chen Bai",
"url": "https://questionsmedicales.fr/author/Xiao-Chen%20Bai",
"affiliation": {
"@type": "Organization",
"name": "Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. Xiaochen.Bai@UTSouthwestern.edu."
}
},
{
"@type": "Person",
"name": "Eunhee Choi",
"url": "https://questionsmedicales.fr/author/Eunhee%20Choi",
"affiliation": {
"@type": "Organization",
"name": "Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA. EC3477@cumc.columbia.edu."
}
},
{
"@type": "Person",
"name": "Catherine Hall",
"url": "https://questionsmedicales.fr/author/Catherine%20Hall",
"affiliation": {
"@type": "Organization",
"name": "Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA."
}
},
{
"@type": "Person",
"name": "Jiayi Wu",
"url": "https://questionsmedicales.fr/author/Jiayi%20Wu",
"affiliation": {
"@type": "Organization",
"name": "Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Pathological and oncological outcomes of pylorus-preserving versus conventional distal gastrectomy in early gastric cancer: a systematic review and meta-analysis.",
"datePublished": "2022-09-24",
"url": "https://questionsmedicales.fr/article/36153587",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12957-022-02766-0"
}
},
{
"@type": "ScholarlyArticle",
"name": "Ornithine aminotransferase and carbamoyl phosphate synthetase 1 involved in ammonia metabolism serve as novel targets for early stages of gastric cancer.",
"datePublished": "2022-09-13",
"url": "https://questionsmedicales.fr/article/36098904",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/jcla.24692"
}
},
{
"@type": "ScholarlyArticle",
"name": "Patient characteristics and health system factors associated with adjuvant radiation therapy receipt in older women with early-stage endometrial cancer.",
"datePublished": "2022-09-08",
"url": "https://questionsmedicales.fr/article/36088216",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jgo.2022.08.020"
}
},
{
"@type": "ScholarlyArticle",
"name": "Hybrid-control arm construction using historical trial data for an early-phase, randomized controlled trial in metastatic colorectal cancer.",
"datePublished": "2022-07-15",
"url": "https://questionsmedicales.fr/article/35856081",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s43856-022-00155-y"
}
},
{
"@type": "ScholarlyArticle",
"name": "Early Mortality among Patients with Head and Neck Cancer Diagnosed in Thuringia, Germany, between 1996 and 2016-A Population-Based Study.",
"datePublished": "2022-06-24",
"url": "https://questionsmedicales.fr/article/35804871",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/cancers14133099"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides aminés, peptides et protéines",
"item": "https://questionsmedicales.fr/mesh/D000602"
},
{
"@type": "ListItem",
"position": 3,
"name": "Protéines",
"item": "https://questionsmedicales.fr/mesh/D011506"
},
{
"@type": "ListItem",
"position": 4,
"name": "Protéines du sang",
"item": "https://questionsmedicales.fr/mesh/D001798"
},
{
"@type": "ListItem",
"position": 5,
"name": "Activité de type insulinique non suppressible",
"item": "https://questionsmedicales.fr/mesh/D009632"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Activité de type insulinique non suppressible - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Activité de type insulinique non suppressible",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-08",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Activité de type insulinique non suppressible",
"description": "Comment diagnostiquer l'activité insulinique non suppressible ?\nQuels tests sont utilisés pour évaluer cette condition ?\nQuels signes cliniques indiquent cette activité ?\nL'imagerie est-elle utile pour le diagnostic ?\nPeut-on utiliser des biomarqueurs pour le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D009632?mesh_terms=Early+Detection+of+Cancer&page=1000#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Activité de type insulinique non suppressible",
"description": "Quels sont les symptômes courants de cette condition ?\nL'hypoglycémie est-elle un symptôme possible ?\nY a-t-il des symptômes liés à la prise de poids ?\nLes troubles de la vision sont-ils possibles ?\nDes symptômes cutanés peuvent-ils apparaître ?",
"url": "https://questionsmedicales.fr/mesh/D009632?mesh_terms=Early+Detection+of+Cancer&page=1000#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Activité de type insulinique non suppressible",
"description": "Comment prévenir l'activité insulinique non suppressible ?\nL'alimentation joue-t-elle un rôle préventif ?\nLe dépistage précoce est-il important ?\nLe stress influence-t-il cette condition ?\nLes habitudes de sommeil affectent-elles la prévention ?",
"url": "https://questionsmedicales.fr/mesh/D009632?mesh_terms=Early+Detection+of+Cancer&page=1000#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Activité de type insulinique non suppressible",
"description": "Quels traitements sont disponibles pour cette condition ?\nL'insuline est-elle utilisée dans le traitement ?\nLes changements alimentaires sont-ils recommandés ?\nLa thérapie physique peut-elle aider ?\nDes traitements alternatifs existent-ils ?",
"url": "https://questionsmedicales.fr/mesh/D009632?mesh_terms=Early+Detection+of+Cancer&page=1000#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Activité de type insulinique non suppressible",
"description": "Quelles complications peuvent survenir ?\nL'insulinorésistance peut-elle entraîner des complications ?\nDes problèmes rénaux peuvent-ils se développer ?\nLes troubles neurologiques sont-ils possibles ?\nY a-t-il un risque accru de maladies cardiaques ?",
"url": "https://questionsmedicales.fr/mesh/D009632?mesh_terms=Early+Detection+of+Cancer&page=1000#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Activité de type insulinique non suppressible",
"description": "Quels sont les principaux facteurs de risque ?\nL'âge influence-t-il le risque ?\nLe tabagisme est-il un facteur de risque ?\nLes antécédents médicaux jouent-ils un rôle ?\nLe stress chronique est-il un facteur de risque ?",
"url": "https://questionsmedicales.fr/mesh/D009632?mesh_terms=Early+Detection+of+Cancer&page=1000#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer l'activité insulinique non suppressible ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins mesurant les niveaux d'insuline et de glucose sont effectués."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer cette condition ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le test de tolérance au glucose et les dosages d'insuline sont courants."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent cette activité ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme l'hyperglycémie persistante peuvent être observés."
}
},
{
"@type": "Question",
"name": "L'imagerie est-elle utile pour le diagnostic ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'imagerie n'est généralement pas utilisée pour cette condition spécifique."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des biomarqueurs pour le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des biomarqueurs comme le peptide C peuvent aider à évaluer l'insulinémie."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes courants de cette condition ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, soif excessive et besoin fréquent d'uriner."
}
},
{
"@type": "Question",
"name": "L'hypoglycémie est-elle un symptôme possible ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des épisodes d'hypoglycémie peuvent survenir malgré une insulinémie élevée."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes liés à la prise de poids ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une prise de poids inexpliquée peut être un symptôme associé."
}
},
{
"@type": "Question",
"name": "Les troubles de la vision sont-ils possibles ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles visuels peuvent survenir en raison de l'hyperglycémie prolongée."
}
},
{
"@type": "Question",
"name": "Des symptômes cutanés peuvent-ils apparaître ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections cutanées fréquentes peuvent être un signe d'insulinorésistance."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'activité insulinique non suppressible ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un poids santé et adopter un mode de vie actif sont essentiels."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle préventif ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut réduire le risque de résistance à l'insuline."
}
},
{
"@type": "Question",
"name": "Le dépistage précoce est-il important ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le dépistage régulier peut aider à identifier les problèmes tôt."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il cette condition ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut aggraver la résistance à l'insuline et les symptômes."
}
},
{
"@type": "Question",
"name": "Les habitudes de sommeil affectent-elles la prévention ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un sommeil de qualité est crucial pour la régulation de l'insuline."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour cette condition ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments antidiabétiques et des modifications du mode de vie."
}
},
{
"@type": "Question",
"name": "L'insuline est-elle utilisée dans le traitement ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'insuline peut être administrée pour contrôler les niveaux de glucose."
}
},
{
"@type": "Question",
"name": "Les changements alimentaires sont-ils recommandés ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un régime équilibré et pauvre en glucides est souvent conseillé."
}
},
{
"@type": "Question",
"name": "La thérapie physique peut-elle aider ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la sensibilité à l'insuline."
}
},
{
"@type": "Question",
"name": "Des traitements alternatifs existent-ils ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines approches comme la médecine complémentaire peuvent être explorées."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme le diabète de type 2 et des maladies cardiovasculaires peuvent se développer."
}
},
{
"@type": "Question",
"name": "L'insulinorésistance peut-elle entraîner des complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'insulinorésistance est liée à des complications métaboliques graves."
}
},
{
"@type": "Question",
"name": "Des problèmes rénaux peuvent-ils se développer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies rénales chroniques peuvent être une complication de cette condition."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques sont-ils possibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des neuropathies peuvent survenir en raison de l'hyperglycémie prolongée."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de maladies cardiaques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de maladies cardiaques est significativement augmenté."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'obésité, le manque d'exercice et des antécédents familiaux sont des facteurs clés."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente avec l'âge, surtout après 45 ans."
}
},
{
"@type": "Question",
"name": "Le tabagisme est-il un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme est associé à une augmentation de la résistance à l'insuline."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux jouent-ils un rôle ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de diabète gestationnel augmentent le risque futur."
}
},
{
"@type": "Question",
"name": "Le stress chronique est-il un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut contribuer à l'insulinorésistance."
}
}
]
}
]
}
Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery for the treatment of early gastric cancer (EGC) in the middle third of the stomach. According to the literature reports, PPG decre...
The protocol was registered in PROSPERO under number CRD42022304677. Databases including PubMed, Embase, Web of Science, and the Cochrane Register of Controlled Trials were searched before February 21...
A total of 4500 patients from 16 studies were included. Compared with the CDG group, the PPG group had fewer lymph nodes harvested (WMD= -3.09; 95% CI -4.75 to -1.43; P < 0.001). Differences in the nu...
The meta-analysis of existing evidence demonstrated that the survival outcomes of PPG may be comparable to those of CDG. However, fewer lymph nodes at stations in No. 5, No. 6, No. 9, and No. 11p were...
The sensitivity and specificity of current biomarkers for gastric cancer were insufficient. The aim of the present study was to screen novel biomarkers and determine the diagnostic values of ornithine...
With stable isotope tags, we labelled an initial discovery group of four paired gastric cancer tissue samples and identified with LC-ESI-MS/MS. A validation group of 159 gastric cancer samples and 30 ...
Four hundred and thirty one proteins were found differentially expressed in gastric cancer tissues. Of these proteins, OAT and CPS1 were found over-expressed in gastric cancer patients, with sensitivi...
The present findings indicated a tight correlation between the co-expression of OAT and CPS1 and the histological grade, local invasion, and TNM stages of gastric cancer. Therefore, OAT and CPS1 might...
Among women with early-stage endometrial cancer (EC), age, stage, grade, and histology are used to determine fitness for adjuvant radiation therapy (RT) administration. We examined non-cancer factors ...
Using data from the Surveillance Epidemiology and End Results cancer registry program linked with Medicare claims, we identified 25,654 women (aged ≥66 years) diagnosed with first primary stage I-II E...
Adjuvant RT was less commonly administered to Asian American and Pacific Islander patients than non-Hispanic White patients (Prevalence ratio [PR], 0.84; 95% confidence interval [CI], 0.73 to 0.97). C...
Findings suggest that various non-cancer factors affect the delivery of adjuvant RT to older women with early-stage EC in real-world oncology practice. Advancing our understanding of factors associate...
Treatment for metastatic colorectal cancer patients beyond the second line remains challenging, highlighting the need for early phase trials of combination therapies for patients who had disease progr...
MORPHEUS-CRC is an umbrella, multicenter, open-label, phase Ib/II, randomized, controlled trial (NCT03555149), with active experimental arms ongoing. Patients enrolled were assigned to a control arm (...
The experimental arm showed no efficacy signal, yet a well-tolerated safety profile in the MORPHEUS-CRC trial. Treatment effects estimated in hybrid control design were comparable to those in the MORP...
Hybrid control provides comparable treatment-effect estimates with generally improved precision, and thus can be of value to inform early-phase clinical development in metastatic colorectal cancer....
Population-based studies on early mortality in head and neck cancer (HNC) are sparse. This retrospective population-based study investigated early mortality of HNC and the influence of patients' tumor...
Early biochemical recurrence (eBCR) indicated a high risk for potential recurrence and metastasis in prostate cancer. The N6-methyladenosine (m6A) methylation modification played an important role in ...
Pearson correlation analysis was first conducted to explore m6A lncRNAs and univariate Cox regression analysis was further performed to identify m6A lncRNAs of prognostic roles for predicting eBCR in ...
Five hundred and thirty-eighth m6A lncRNAs were searched out through Pearson correlation analysis and 25 out of 538 m6A lncRNAs were identified to pose prediction roles for eBCR in prostate cancers. A...
The m6A lncRNA signature in this study could be utilized to efficiently predict eBCR occurrence, various clinical characteristic and immune microenvironment for prostate cancer....
To investigate whether breast edema characteristics at preoperative T2-weighted imaging (T2WI) could help evaluate axillary lymph node (ALN) burden in patients with early-stage breast cancer....
This retrospective study included women with clinical T1 and T2 stage breast cancer and preoperative MRI examination in two independent cohorts from May 2014 to December 2020. Low (< 3 LNs+) and high ...
A total of 1092 patients were included in this study. BES was identified as the independent predictor of pALN burden in primary (n = 677) and validation (n = 415) cohorts. The analysis using MRI-ALN s...
In individuals with early-stage breast cancer, preoperative MRI characteristics of breast edema could be a promising predictor for pALN burden, which may aid in treatment planning....
• In this retrospective study of 1092 patients with early-stage breast cancer from two cohorts, the MRI characteristic of breast edema has independent and additive predictive value for assessing axill...
To evaluate the value of combined detection of serum CA125, CA199, and HE4 in the diagnosis of ovarian cancer....
Relevant articles retrieved from PubMed, Elsevier Science, Springer, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases were screened strictly according to inclusion and exclus...
The results of meta-analysis showed that there was a statistical difference in diagnostic specificity analysis of CA125 (OR = 1.91, 95% CI (1.58, 2.32),...
In the clinical assisted diagnosis of ovarian cancer, combined detection of CA125, CA199, and HE4 has the stronger discriminant ability and higher accuracy than single detection of CA125, which can im...
Embryo quality is an important determinant of successful implantation and a resultant live birth. Current clinical approaches for evaluating embryo quality rely on subjective morphology assessments or...
Increase in body mass index (BMI) in early childhood (1-6 years) was found to be a contributing factor for impaired final height in boys with Cystic Fibrosis (CF). Early adrenarche (before age 9 years...
Boys with CF, aged 8-9 years, visiting the CF expertize center Utrecht were included. Since 2018, anthropomorphic, pubertal and endocrine data were collected. Early adrenarche in boys was defined as a...
Thirteen boys (mean age 8.55 ± 0.27 years) were enrolled. The median (IQR) DHEAS-level was 1.3 µmol/L (0.71-2.40). Eight boys (61.5%) had an early rise in DHEAS-levels ≥ 1 µmol/L. Mean increase in BMI...
In this small cohort, 61.5% of boys with CF between 8 and 9 years had an early rise of DHEAS, which was correlated to ΔBMI...