questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Oxidoreductases
Oxidoreductases acting on CH-NH group donors
Oxidoreductases, (N-demethylating)
Oxidoreductases, (N-demethylating) : Questions médicales fréquentes
Termes MeSH sélectionnés :
Equivalence Trials as Topic
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Oxidoreductases, (N-demethylating) : Questions médicales les plus fréquentes",
"headline": "Oxidoreductases, (N-demethylating) : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Oxidoreductases, (N-demethylating) : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-04-26",
"dateModified": "2025-04-21",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Oxidoreductases, (N-demethylating)"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Oxidoreductases acting on CH-NH group donors",
"url": "https://questionsmedicales.fr/mesh/D000587",
"about": {
"@type": "MedicalCondition",
"name": "Oxidoreductases acting on CH-NH group donors",
"code": {
"@type": "MedicalCode",
"code": "D000587",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.662"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Aminopyrine N-demethylase",
"alternateName": "Aminopyrine N-Demethylase",
"url": "https://questionsmedicales.fr/mesh/D000633",
"about": {
"@type": "MedicalCondition",
"name": "Aminopyrine N-demethylase",
"code": {
"@type": "MedicalCode",
"code": "D000633",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.662.582.276"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Dihydropteridine reductase",
"alternateName": "Dihydropteridine Reductase",
"url": "https://questionsmedicales.fr/mesh/D004093",
"about": {
"@type": "MedicalCondition",
"name": "Dihydropteridine reductase",
"code": {
"@type": "MedicalCode",
"code": "D004093",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.662.582.361"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Dimethylglycine dehydrogenase",
"alternateName": "Dimethylglycine Dehydrogenase",
"url": "https://questionsmedicales.fr/mesh/D050893",
"about": {
"@type": "MedicalCondition",
"name": "Dimethylglycine dehydrogenase",
"code": {
"@type": "MedicalCode",
"code": "D050893",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.662.582.369"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Ethylmorphine-N-demethylase",
"alternateName": "Ethylmorphine-N-Demethylase",
"url": "https://questionsmedicales.fr/mesh/D005037",
"about": {
"@type": "MedicalCondition",
"name": "Ethylmorphine-N-demethylase",
"code": {
"@type": "MedicalCode",
"code": "D005037",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.662.582.400"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Histone Demethylases",
"alternateName": "Histone Demethylases",
"url": "https://questionsmedicales.fr/mesh/D056466",
"about": {
"@type": "MedicalCondition",
"name": "Histone Demethylases",
"code": {
"@type": "MedicalCode",
"code": "D056466",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.662.582.475"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Sarcosine dehydrogenase",
"alternateName": "Sarcosine Dehydrogenase",
"url": "https://questionsmedicales.fr/mesh/D050892",
"about": {
"@type": "MedicalCondition",
"name": "Sarcosine dehydrogenase",
"code": {
"@type": "MedicalCode",
"code": "D050892",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D08.811.682.662.582.550"
}
}
}
],
"about": {
"@type": "MedicalCondition",
"name": "Oxidoreductases, (N-demethylating)",
"alternateName": "Oxidoreductases, N-Demethylating",
"code": {
"@type": "MedicalCode",
"code": "D010089",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Christopher J Schofield",
"url": "https://questionsmedicales.fr/author/Christopher%20J%20Schofield",
"affiliation": {
"@type": "Organization",
"name": "Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, UK."
}
},
{
"@type": "Person",
"name": "Rajeev Ramanan",
"url": "https://questionsmedicales.fr/author/Rajeev%20Ramanan",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, Michigan Technological University, Houghton, Michigan, 49931, USA."
}
},
{
"@type": "Person",
"name": "Sodiq O Waheed",
"url": "https://questionsmedicales.fr/author/Sodiq%20O%20Waheed",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, Michigan Technological University, Houghton, Michigan, 49931, USA."
}
},
{
"@type": "Person",
"name": "Christo Z Christov",
"url": "https://questionsmedicales.fr/author/Christo%20Z%20Christov",
"affiliation": {
"@type": "Organization",
"name": "Department of Chemistry, Michigan Technological University, Houghton, Michigan, 49931, USA."
}
},
{
"@type": "Person",
"name": "Samuel E Ross",
"url": "https://questionsmedicales.fr/author/Samuel%20E%20Ross",
"affiliation": {
"@type": "Organization",
"name": "Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Conservative management versus invasive management of significant traumatic pneumothoraces in the emergency department (the CoMiTED trial): a study protocol for a randomised non-inferiority trial.",
"datePublished": "2024-06-17",
"url": "https://questionsmedicales.fr/article/38889939",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1136/bmjopen-2024-087464"
}
},
{
"@type": "ScholarlyArticle",
"name": "A randomized controlled non-inferiority trial of placebo versus macrolide antibiotics for Mycoplasma pneumoniae infection in children with community-acquired pneumonia: trial protocol for the MYTHIC Study.",
"datePublished": "2024-10-03",
"url": "https://questionsmedicales.fr/article/39363201",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13063-024-08438-6"
}
},
{
"@type": "ScholarlyArticle",
"name": "Exact-corrected confidence interval for risk difference in noninferiority binomial trials.",
"datePublished": "2022-05-23",
"url": "https://questionsmedicales.fr/article/35526217",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/biom.13688"
}
},
{
"@type": "ScholarlyArticle",
"name": "Magnesium sulphate to prevent perioperative atrial fibrillation in cardiac surgery: a randomized clinical trial : A protocol description of the PeriOperative Magnesium Infusion to Prevent Atrial fibrillation Evaluated (POMPAE) trial.",
"datePublished": "2024-08-15",
"url": "https://questionsmedicales.fr/article/39148128",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13063-024-08368-3"
}
},
{
"@type": "ScholarlyArticle",
"name": "Is casting of displaced paediatric distal forearm fractures non-inferior to reduction under general anaesthesia? Study protocol for a pragmatic, randomized, controlled non-inferiority multicentre trial (the casting trial).",
"datePublished": "2024-06-27",
"url": "https://questionsmedicales.fr/article/38937792",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13063-024-08253-z"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Enzymes et coenzymes",
"item": "https://questionsmedicales.fr/mesh/D045762"
},
{
"@type": "ListItem",
"position": 3,
"name": "Enzymes",
"item": "https://questionsmedicales.fr/mesh/D004798"
},
{
"@type": "ListItem",
"position": 4,
"name": "Oxidoreductases",
"item": "https://questionsmedicales.fr/mesh/D010088"
},
{
"@type": "ListItem",
"position": 5,
"name": "Oxidoreductases acting on CH-NH group donors",
"item": "https://questionsmedicales.fr/mesh/D000587"
},
{
"@type": "ListItem",
"position": 6,
"name": "Oxidoreductases, (N-demethylating)",
"item": "https://questionsmedicales.fr/mesh/D010089"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Oxidoreductases, (N-demethylating) - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Oxidoreductases, (N-demethylating)",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-07",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Oxidoreductases, (N-demethylating)",
"description": "Comment diagnostiquer une déficience en oxydoréductases N-déméthylantes ?\nQuels tests sont utilisés pour évaluer l'activité enzymatique ?\nQuels symptômes peuvent indiquer un dysfonctionnement enzymatique ?\nPeut-on utiliser des biomarqueurs pour le diagnostic ?\nLes tests sanguins sont-ils utiles pour le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Equivalence+Trials+as+Topic&page=2#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Oxidoreductases, (N-demethylating)",
"description": "Quels symptômes sont associés à une altération de la déméthylation ?\nLes troubles neurologiques peuvent-ils être liés à ces enzymes ?\nComment les effets secondaires des médicaments sont-ils liés ?\nLes symptômes varient-ils selon les individus ?\nY a-t-il des symptômes spécifiques aux enfants ?",
"url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Equivalence+Trials+as+Topic&page=2#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Oxidoreductases, (N-demethylating)",
"description": "Comment prévenir les complications liées à la déméthylation ?\nY a-t-il des tests préventifs recommandés ?\nL'éducation des patients est-elle importante ?\nLes habitudes de vie peuvent-elles influencer la fonction enzymatique ?\nDes vaccinations peuvent-elles aider à prévenir des complications ?",
"url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Equivalence+Trials+as+Topic&page=2#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Oxidoreductases, (N-demethylating)",
"description": "Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?\nPeut-on utiliser des suppléments pour améliorer la fonction enzymatique ?\nLes modifications alimentaires peuvent-elles aider ?\nDes thérapies géniques sont-elles envisageables ?\nLes médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?",
"url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Equivalence+Trials+as+Topic&page=2#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Oxidoreductases, (N-demethylating)",
"description": "Quelles complications peuvent survenir en cas de dysfonctionnement ?\nLes complications sont-elles réversibles ?\nComment les complications affectent-elles la qualité de vie ?\nLes complications peuvent-elles être prévenues ?\nY a-t-il des complications spécifiques aux traitements ?",
"url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Equivalence+Trials+as+Topic&page=2#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Oxidoreductases, (N-demethylating)",
"description": "Quels sont les facteurs de risque pour les dysfonctionnements enzymatiques ?\nL'âge joue-t-il un rôle dans le risque de dysfonctionnement ?\nLes antécédents familiaux sont-ils un facteur de risque ?\nL'exposition à des toxines peut-elle augmenter le risque ?\nLe mode de vie influence-t-il le risque de complications ?",
"url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Equivalence+Trials+as+Topic&page=2#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une déficience en oxydoréductases N-déméthylantes ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests enzymatiques et des analyses génétiques peuvent être effectués."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité enzymatique ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de métabolisme des médicaments et des dosages enzymatiques sont utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un dysfonctionnement enzymatique ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes tels que des réactions médicamenteuses inattendues peuvent survenir."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des biomarqueurs pour le diagnostic ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains biomarqueurs peuvent indiquer une activité enzymatique altérée."
}
},
{
"@type": "Question",
"name": "Les tests sanguins sont-ils utiles pour le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests sanguins peuvent mesurer les niveaux de métabolites spécifiques."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à une altération de la déméthylation ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des nausées, des vomissements et des réactions cutanées peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques peuvent-ils être liés à ces enzymes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles neurologiques peuvent survenir en raison d'une accumulation de toxines."
}
},
{
"@type": "Question",
"name": "Comment les effets secondaires des médicaments sont-ils liés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une déméthylation inefficace peut entraîner des effets secondaires imprévus."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon les individus ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier en fonction de la génétique et de l'environnement."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques aux enfants ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les enfants peuvent présenter des symptômes plus aigus, comme des troubles de l'attention."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications liées à la déméthylation ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les médicaments connus pour interférer avec la déméthylation peut aider."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests préventifs recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être recommandés pour les personnes à risque."
}
},
{
"@type": "Question",
"name": "L'éducation des patients est-elle importante ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer les patients sur les médicaments et leurs effets est crucial."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie peuvent-elles influencer la fonction enzymatique ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes de vie saines peuvent améliorer la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Des vaccinations peuvent-elles aider à prévenir des complications ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent prévenir des infections qui compliquent les traitements."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements symptomatiques et des ajustements médicamenteux peuvent être nécessaires."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des suppléments pour améliorer la fonction enzymatique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments comme les antioxydants peuvent aider à soutenir la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Les modifications alimentaires peuvent-elles aider ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut soutenir le métabolisme et la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Des thérapies géniques sont-elles envisageables ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est une option potentielle pour corriger des déficiences enzymatiques."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ajuster les doses ou changer de médicament peut réduire les effets indésirables."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir en cas de dysfonctionnement ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des réactions médicamenteuses graves peuvent se produire."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent réduire la qualité de vie en provoquant des symptômes chroniques."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être prévenues ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance régulière et des ajustements de traitement peuvent prévenir les complications."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications spécifiques aux traitements ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains traitements peuvent entraîner des complications spécifiques, comme des allergies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les dysfonctionnements enzymatiques ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque."
}
},
{
"@type": "Question",
"name": "L'âge joue-t-il un rôle dans le risque de dysfonctionnement ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque peut augmenter avec l'âge en raison de la diminution de la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de troubles enzymatiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines peut-elle augmenter le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines environnementales peut affecter la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque de complications ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sain peut réduire le risque de complications liées à la déméthylation."
}
}
]
}
]
}
Traumatic pneumothoraces are present in one of five victims of severe trauma. Current guidelines advise chest drain insertion for most traumatic pneumothoraces, although very small pneumothoraces can ...
The CoMiTED (Conservative Management in Traumatic Pneumothoraces in the Emergency Department) trial is a multicentre, pragmatic parallel group, individually randomised controlled non-inferiority trial...
This trial received approval from the Wales Research Ethics Committee 4 (reference: 22/WA/0118) and the Health Research Authority. Results will be submitted for publication in a peer-reviewed journal....
ISRCTN35574247....
Mycoplasma pneumoniae is a major cause of community-acquired pneumonia (CAP) in school-aged children. Macrolides are the first-line treatment for this infection. However, it is unclear whether macroli...
The MYTHIC Study is a randomized, double-blind, placebo-controlled, multicenter, non-inferiority trial in 13 Swiss pediatric centers. Previously healthy ambulatory and hospitalized children aged 3-17 ...
This trial will produce efficacy data for macrolide treatment in children with M. pneumoniae CAP that might help to reduce the prescription of antibiotics and therefore contribute to the global effort...
ClinicalTrials.gov, NCT06325293. Registered on 24 April 2024....
A novel confidence interval estimator is proposed for the risk difference in noninferiority binomial trials. The proposed confidence interval, which is dependent on the prespecified noninferiority mar...
Postoperative atrial fibrillation (POAF) is a common and potentially serious complication post cardiac surgery. Hypomagnesaemia is common after cardiac surgery and recent evidence indicates that suppl...
The (POMPAE) trial is a phase 2, single-center, double-blinded randomized superiority clinical study. It aims to assess the impact of perioperative continuous intravenous magnesium administration on t...
The primary outcome measure is the incidence of de novo POAF within the first 7 days following surgery, with censoring at hospital discharge. This trial may generate crucial evidence for the preventio...
The POMPAE trial was registered at ClinicalTrials.gov under the following identifier NTC05669417, https://clinicaltrials.gov/ct2/show/NCT05669417 . Registered on December 30, 2022....
Version 3.3, dated 13-01-2023....
Treatment of displaced distal forearm fractures in children has traditionally been closed reduction and pin fixation, although they might heal and remodel without surgery with no functional impairment...
A multicentre non-inferiority randomized controlled trial. Children aged 4-10 years with a displaced distal forearm fracture will be offered inclusion, if the on-duty orthopaedic surgeon finds indicat...
The results of this trial may change our understanding of the healing potential of paediatric distal forearm fractures. If non-inferiority of non-surgical treatment is shown, the results may contribut...
www....
gov (ID: NCT05736068). Date of registry: 17 February 2023....
Cryopreservation at -80°C in dimethylsulphoxide extends platelet shelf-life from 7 days to 2 years. Only limited comparative trial data supports the safety and effectiveness of cryopreserved platelets...
CLIP-II and CLIPNZ-II are harmonised, blinded, multicentre, randomised, controlled clinical non-inferiority trials comparing bleeding, transfusion, safety and cost outcomes associated with cryopreserv...
CLIP-II was approved by the Austin Health Human Research Ethics Committee (HREC/54406/Austin-2019) and by the Australian Red Cross Lifeblood Ethics Committee (2019#23). CLIPNZ-II was approved by the N...
NCT03991481 and ACTRN12621000271808....
The recent guidelines from the European and American Hernia Societies recommend a continuous small-bite suturing technique with slowly absorbable sutures for fascial closure of midline abdominal wall ...
We propose a single-institute, prospective, randomized, blinded-endpoint trial to assess the superiority of the combination of continuous suturing of the fascia without peritoneal closure and continuo...
This trial will provide initial evidence on the ideal combination of fascial and skin closure for midline abdominal wall incision to reduce the incidence of overall postoperative wound complications a...
UMIN-CTR UMIN000048442. Registered on 1 August 2022. https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000055205....
A recent meta-analysis concluded that outpatient appendectomy appears feasible and safe, but there is a lack of high-quality evidence and a randomized trial is needed. The aim of this trial is to demo...
SAMBA is a prospective, randomized, controlled, multicenter non-inferiority trial. We will include 1400 patients admitted to 15 French hospitals between January 2023 and June 2025. Inclusion criteria ...
The SAMBA trial tests the hypothesis that outpatient surgery (i.e., without an overnight hospital stay) of uncomplicated acute appendicitis is a feasible and reliable procedure in establishments with ...
ClinicalTrials.gov NCT05691348. Registered on 20 January 2023....
The reporting of randomised controlled non-inferiority (NI) drug trials is poor with less than 50% of published trials reporting a justification of the NI margin. This is despite the introduction of t...
We will conduct a systematic review of published randomised controlled trials in abdominal surgery that use an NI design. Key eligibility criteria will be: surgical intervention in at least one trial ...
The review will describe and appraise the design and reporting of surgical NI trials including shortcomings thereof and allow a comparison with pharmaceutical trials. These findings will inform resear...
Ethical approval is not required and any changes to the protocol will be communicated via the registration platform. The final manuscript will be submitted to a journal for publication and the finding...
Despite several incremental improvements in the management of tuberculous meningitis (TBM), the mortality rates remain high. In spite of national and international guidelines, variation in the choice,...
An open label, parallel arms, randomized controlled superiority trial will be conducted among 372 participants across 6 sites in India. Eligible participants will be randomly allocated in 1:1:1 ratio ...
Clinical Trial Registry India CTRI/2023/05/053314. Registered on 31 May 2023 ( https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=ODYzMzg=&Enc=&userName=CTRI/2023/05/053314 )....
gov NCT05917340. Registered on 6 August 2023 ( https://classic....
gov/ct2/show/NCT05917340 )....
Version 1.3 dated 12 July 2023....