Titre : Oxidoreductases, (N-demethylating)

Oxidoreductases, (N-demethylating) : Questions médicales fréquentes

Termes MeSH sélectionnés :

Observer Variation
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?\nQuels tests sont utilisés pour évaluer l'activité enzymatique ?\nQuels symptômes peuvent indiquer un dysfonctionnement enzymatique ?\nPeut-on utiliser des biomarqueurs pour le diagnostic ?\nLes tests sanguins sont-ils utiles pour le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Observer+Variation&page=4#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Oxidoreductases, (N-demethylating)", "description": "Quels symptômes sont associés à une altération de la déméthylation ?\nLes troubles neurologiques peuvent-ils être liés à ces enzymes ?\nComment les effets secondaires des médicaments sont-ils liés ?\nLes symptômes varient-ils selon les individus ?\nY a-t-il des symptômes spécifiques aux enfants ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Observer+Variation&page=4#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Oxidoreductases, (N-demethylating)", "description": "Comment prévenir les complications liées à la déméthylation ?\nY a-t-il des tests préventifs recommandés ?\nL'éducation des patients est-elle importante ?\nLes habitudes de vie peuvent-elles influencer la fonction enzymatique ?\nDes vaccinations peuvent-elles aider à prévenir des complications ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Observer+Variation&page=4#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Oxidoreductases, (N-demethylating)", "description": "Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?\nPeut-on utiliser des suppléments pour améliorer la fonction enzymatique ?\nLes modifications alimentaires peuvent-elles aider ?\nDes thérapies géniques sont-elles envisageables ?\nLes médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Observer+Variation&page=4#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Oxidoreductases, (N-demethylating)", "description": "Quelles complications peuvent survenir en cas de dysfonctionnement ?\nLes complications sont-elles réversibles ?\nComment les complications affectent-elles la qualité de vie ?\nLes complications peuvent-elles être prévenues ?\nY a-t-il des complications spécifiques aux traitements ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Observer+Variation&page=4#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Oxidoreductases, (N-demethylating)", "description": "Quels sont les facteurs de risque pour les dysfonctionnements enzymatiques ?\nL'âge joue-t-il un rôle dans le risque de dysfonctionnement ?\nLes antécédents familiaux sont-ils un facteur de risque ?\nL'exposition à des toxines peut-elle augmenter le risque ?\nLe mode de vie influence-t-il le risque de complications ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Observer+Variation&page=4#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une déficience en oxydoréductases N-déméthylantes ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests enzymatiques et des analyses génétiques peuvent être effectués." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer l'activité enzymatique ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de métabolisme des médicaments et des dosages enzymatiques sont utilisés." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un dysfonctionnement enzymatique ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes tels que des réactions médicamenteuses inattendues peuvent survenir." } }, { "@type": "Question", "name": "Peut-on utiliser des biomarqueurs pour le diagnostic ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains biomarqueurs peuvent indiquer une activité enzymatique altérée." } }, { "@type": "Question", "name": "Les tests sanguins sont-ils utiles pour le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests sanguins peuvent mesurer les niveaux de métabolites spécifiques." } }, { "@type": "Question", "name": "Quels symptômes sont associés à une altération de la déméthylation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des nausées, des vomissements et des réactions cutanées peuvent se manifester." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils être liés à ces enzymes ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles neurologiques peuvent survenir en raison d'une accumulation de toxines." } }, { "@type": "Question", "name": "Comment les effets secondaires des médicaments sont-ils liés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Une déméthylation inefficace peut entraîner des effets secondaires imprévus." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon les individus ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent varier en fonction de la génétique et de l'environnement." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux enfants ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Les enfants peuvent présenter des symptômes plus aigus, comme des troubles de l'attention." } }, { "@type": "Question", "name": "Comment prévenir les complications liées à la déméthylation ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Éviter les médicaments connus pour interférer avec la déméthylation peut aider." } }, { "@type": "Question", "name": "Y a-t-il des tests préventifs recommandés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques peuvent être recommandés pour les personnes à risque." } }, { "@type": "Question", "name": "L'éducation des patients est-elle importante ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, informer les patients sur les médicaments et leurs effets est crucial." } }, { "@type": "Question", "name": "Les habitudes de vie peuvent-elles influencer la fonction enzymatique ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des habitudes de vie saines peuvent améliorer la fonction enzymatique." } }, { "@type": "Question", "name": "Des vaccinations peuvent-elles aider à prévenir des complications ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Certaines vaccinations peuvent prévenir des infections qui compliquent les traitements." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements symptomatiques et des ajustements médicamenteux peuvent être nécessaires." } }, { "@type": "Question", "name": "Peut-on utiliser des suppléments pour améliorer la fonction enzymatique ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments comme les antioxydants peuvent aider à soutenir la fonction enzymatique." } }, { "@type": "Question", "name": "Les modifications alimentaires peuvent-elles aider ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation équilibrée peut soutenir le métabolisme et la fonction enzymatique." } }, { "@type": "Question", "name": "Des thérapies géniques sont-elles envisageables ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "La thérapie génique est une option potentielle pour corriger des déficiences enzymatiques." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ajuster les doses ou changer de médicament peut réduire les effets indésirables." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir en cas de dysfonctionnement ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme des réactions médicamenteuses graves peuvent se produire." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié." } }, { "@type": "Question", "name": "Comment les complications affectent-elles la qualité de vie ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les complications peuvent réduire la qualité de vie en provoquant des symptômes chroniques." } }, { "@type": "Question", "name": "Les complications peuvent-elles être prévenues ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une surveillance régulière et des ajustements de traitement peuvent prévenir les complications." } }, { "@type": "Question", "name": "Y a-t-il des complications spécifiques aux traitements ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains traitements peuvent entraîner des complications spécifiques, comme des allergies." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les dysfonctionnements enzymatiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque." } }, { "@type": "Question", "name": "L'âge joue-t-il un rôle dans le risque de dysfonctionnement ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque peut augmenter avec l'âge en raison de la diminution de la fonction enzymatique." } }, { "@type": "Question", "name": "Les antécédents familiaux sont-ils un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de troubles enzymatiques augmentent le risque." } }, { "@type": "Question", "name": "L'exposition à des toxines peut-elle augmenter le risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des toxines environnementales peut affecter la fonction enzymatique." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il le risque de complications ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sain peut réduire le risque de complications liées à la déméthylation." } } ] } ] }

Sources (10000 au total)

Anastomotic perfusion assessment with indocyanine green in robot-assisted low-anterior resection, a multicenter study of interobserver variation.

Securing sufficient blood perfusion to the anastomotic area after low-anterior resection is a crucial factor in preventing anastomotic leakage (AL). Intra-operative indocyanine green fluorescent imagi... A multicenter study, including patients undergoing robot-assisted low anterior resection with stapled anastomosis. ICG-FI was evaluated visually by the surgeon intra-operatively. Postoperatively, reco... Fifty-five patients were included, and five developed clinical AL. Bland-Altman plots (BA plots) demonstrated wide inter-observer variation for visually assessed fluorescence on all parameters (TTV, T... The surgeon's visual assessment of the ICG-FI demonstrated wide inter-observer variation, there were no differences between patients with and without AL. However, quantitative pixel analysis showed a ... ClinicalTrials.gov Identifier: NCT04766060....

The 2018 Classification of Periodontal Diseases: An Observational Study on Inter-examiner Agreement among Undergraduate Students.

The objective of the present observational study was to assess the inter-examiner agreement for the diagnosis of periodontitis using the 2018 CPD among fourth and fifth year undergraduate students. It... All participants received training on the 2018 CPD scheme through a mandatory periodontics course conducted by a periodontist. Documentation for seven deidentified periodontitis patients, comprising m... The percentage of undergraduate students in the fourth and fifth year that correctly identified the stage of periodontitis according to the 2018 CPD ranged between 28% and 72% and 18.5% and 77.8%, res... Fourth- and fifth-year undergraduate students demonstrated high inter-examiner agreement using the 2018 CPD....

An independent inter- and intra-observer agreement assessment of the AOSpine upper cervical injury classification system.

The complex anatomy of the upper cervical spine resulted in numerous separate classification systems of upper cervical spine trauma. The AOSpine upper cervical classification system (UCCS) was recentl... To perform an independent evaluation of the AOSpine UCCS.... Agreement study.... Eighty-four patients with upper cervical spine injuries.... Inter-observer agreement; intra-observer agreement.... Complete imaging studies of 84 patients with upper cervical spine injuries, including all morphological types of injuries defined by the AOSpine UCCS were selected and classified by six evaluators (fr... The interobserver agreement was almost perfect when considering the fracture site (I, II or III), with κ=0.82 (0.78-0.83), but the agreement according to the site and type level was moderate, κ=0.57 (... We observed only a moderate inter-observer agreement using this classification. We believe our results can be explained because this classification attempted to organize many different injury types in...

MRI tagging of colonic chyme mixing in healthy subjects: Inter-observer variability and reliability of the measurement with time.

Magnetic resonance imaging (MRI) tagging techniques have been applied to the GI tract to assess bowel contractions and content mixing. We aimed to evaluate the dependence of a tagging measurement (for... Two independent datasets of healthy adults were used for the retrospective inter-observer variability (Study 1: 13 datasets and Study 2: 31 datasets), and ten participants were scanned for the prospec... Scatter plots and Bland-Altman plots showed a large range of data with low variation and small limits of agreements (<5% CoV). The intraclass correlation coefficient of inter-rater reliability was exc... MRI tagging technique can provide an assessment of colonic chyme mixing. The inter-observer study data showed high inter-rater agreement. The temporal variation study showed some individual variations...

Convolutional neural network-based model observer for signal known statistically task in breast tomosynthesis images.

Since human observer studies are resource-intensive, mathematical model observers are frequently used to assess task-based image quality. The most common implementation of these model observers assume... Considering the limitations of the tasks for which signal information is exactly known, we proposed a convolutional neural network (CNN)-based model observer for signal known statistically (SKS) and b... A wide parameter search was conducted from six different acquisition angles (i.e., 10°, 20°, 30°, 40°, 50°, and 60°) within the same dose level (i.e., 2.3 mGy) under two separate acquisition schemes: ... The CNN-based model observer achieved a higher detection performance compared to that of the HO for all tasks. Moreover, the improvement in its detection performance was greater for SKS tasks compared... In this work, we proposed a CNN-based model observer for SKS and BKS detection tasks in breast tomosynthesis images. Throughout the study, we demonstrated that the detection performance of the propose...

Accuracy and Inter-observer Agreement Among Endoscopists for Visual Identification of Colorectal Polyps Using Endoscopy Images.

It is essential to accurately distinguish small benign hyperplastic colon polyps (HP) from sessile serrated lesions (SSL) or adenomatous polyps (TA) based on endoscopic appearances. Our objective was ... High-quality endoscopic images of 30 small HPs, SSLs, and TAs were used randomly to create two-timed PowerPoint slide sets-one with and another one without information on polyp size and location. Seve... When polyp size and location were provided, overall accuracy was 67.1% for TAs, 50.0% for SSLs, and 41.4% for HPs; the corresponding accuracies were 60%, 44.3%, and 34.3% when polyp size and location ... The ability to distinguish between small TAs, SSLs, and HPs on their endoscopic appearance is poor regardless of the endoscopists' knowledge of polyp size and location....

Assessing engagement in rehabilitation: development, validity, reliability, and responsiveness to change of the Rehabilitation Observation Measure of Engagement (ROME).

We describe the development of an observational video coding tool, the Rehabilitation Observation Measure of Engagement (ROME), to quantify engagement in rehabilitative settings at the person (interna... Forty-nine children with unilateral spastic cerebral palsy (29 males; Age:... For construct validity, results showed a positive correlation for person-level engagement (... These findings provide evidence that the ROME is a reliable tool to objectively examine the construct of engagement within rehabilitation and is valid for quantifying person-level engagement. It provi...

Inter-observer variability in male pelvic-floor MRI measurements that might predict post-prostatectomy incontinence.

Current studies are focusing on the relationship between anatomical variables in preoperative prostate MRI and the development of post-prostatectomy incontinence (PPI). Nevertheless, there is little e... Pelvic floor measurements with 3T-MRI were performed by two radiologists and two urologists independently and blindly. Interobserver agreement was determined using the intraclass correlation coefficie... The concordance was good-acceptable for most measurements, except for the levator ani and puborectalis muscle thickness (some ICC values < 0.20/p value > 0.05). The anatomical parameters with the high... MUL, IPP, prostate volume, aLUMP, OIT, urethral width and prostatic length show acceptable inter-observer concordance and they would be reliable as possible predictors of PPI. Levator ani and puborect...

Observer Variability as a Determinant of Measurement Error of Ultrasonographic Measurements of the Optic Nerve Sheath Diameter: A Systematic Review.

Ultrasonographic measurements of the diameter of the sheath of the optic nerve can be used to assess intracranial pressure indirectly. These measurements come with measurement error.... Our aim was to estimate observer's measurement error as a determinant of ultrasonographic measurement variability of the optic nerve sheath diameter.... A systematic search of the literature was conducted in Embase, Medline, Web of Science, the Cochrane Central Register of Trials, and the first 200 articles of Google Scholar up to April 19, 2021. Incl... The standard error of measurement of the intra- and interobserver variability had a range of 0.10-0.41 mm and 0.14-0.42 mm, respectively. Minimal detectable difference of a single observer was 0.28-1.... The standard errors of measurement and minimal detectable differences of ultrasonographic measurements of the optic nerve sheath diameter found in this review with healthy participants indicate cautio...