Titre : Oxidoreductases, (N-demethylating)

Oxidoreductases, (N-demethylating) : Questions médicales fréquentes

Termes MeSH sélectionnés :

Randomized Controlled Trials as Topic
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?\nQuels tests sont utilisés pour évaluer l'activité enzymatique ?\nQuels symptômes peuvent indiquer un dysfonctionnement enzymatique ?\nPeut-on utiliser des biomarqueurs pour le diagnostic ?\nLes tests sanguins sont-ils utiles pour le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Oxidoreductases, (N-demethylating)", "description": "Quels symptômes sont associés à une altération de la déméthylation ?\nLes troubles neurologiques peuvent-ils être liés à ces enzymes ?\nComment les effets secondaires des médicaments sont-ils liés ?\nLes symptômes varient-ils selon les individus ?\nY a-t-il des symptômes spécifiques aux enfants ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Oxidoreductases, (N-demethylating)", "description": "Comment prévenir les complications liées à la déméthylation ?\nY a-t-il des tests préventifs recommandés ?\nL'éducation des patients est-elle importante ?\nLes habitudes de vie peuvent-elles influencer la fonction enzymatique ?\nDes vaccinations peuvent-elles aider à prévenir des complications ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Oxidoreductases, (N-demethylating)", "description": "Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?\nPeut-on utiliser des suppléments pour améliorer la fonction enzymatique ?\nLes modifications alimentaires peuvent-elles aider ?\nDes thérapies géniques sont-elles envisageables ?\nLes médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?", "url": 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familiaux sont-ils un facteur de risque ?\nL'exposition à des toxines peut-elle augmenter le risque ?\nLe mode de vie influence-t-il le risque de complications ?", "url": "https://questionsmedicales.fr/mesh/D010089?mesh_terms=Randomized+Controlled+Trials+as+Topic&page=1000#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une déficience en oxydoréductases N-déméthylantes ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests enzymatiques et des analyses génétiques peuvent être effectués." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer l'activité enzymatique ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests de métabolisme des médicaments et des dosages enzymatiques sont utilisés." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un dysfonctionnement enzymatique ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes tels que des réactions médicamenteuses inattendues peuvent survenir." } }, { "@type": "Question", "name": "Peut-on utiliser des biomarqueurs pour le diagnostic ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains biomarqueurs peuvent indiquer une activité enzymatique altérée." } }, { "@type": "Question", "name": "Les tests sanguins sont-ils utiles pour le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests sanguins peuvent mesurer les niveaux de métabolites spécifiques." } }, { "@type": "Question", "name": "Quels symptômes sont associés à une altération de la déméthylation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des nausées, des vomissements et des réactions cutanées peuvent se manifester." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils être liés à ces enzymes ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles neurologiques peuvent survenir en raison d'une accumulation de toxines." } }, { "@type": "Question", "name": "Comment les effets secondaires des médicaments sont-ils liés ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Une déméthylation inefficace peut entraîner des effets secondaires imprévus." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon les individus ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent varier en fonction de la génétique et de l'environnement." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux enfants ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Les enfants peuvent présenter des symptômes plus aigus, comme des troubles de l'attention." } }, { "@type": "Question", "name": "Comment prévenir les complications liées à la déméthylation ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Éviter les médicaments connus pour interférer avec la déméthylation peut aider." } }, { "@type": "Question", "name": "Y a-t-il des tests préventifs recommandés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques peuvent être recommandés pour les personnes à risque." } }, { "@type": "Question", "name": "L'éducation des patients est-elle importante ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, informer les patients sur les médicaments et leurs effets est crucial." } }, { "@type": "Question", "name": "Les habitudes de vie peuvent-elles influencer la fonction enzymatique ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des habitudes de vie saines peuvent améliorer la fonction enzymatique." } }, { "@type": "Question", "name": "Des vaccinations peuvent-elles aider à prévenir des complications ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Certaines vaccinations peuvent prévenir des infections qui compliquent les traitements." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des traitements symptomatiques et des ajustements médicamenteux peuvent être nécessaires." } }, { "@type": "Question", "name": "Peut-on utiliser des suppléments pour améliorer la fonction enzymatique ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments comme les antioxydants peuvent aider à soutenir la fonction enzymatique." } }, { "@type": "Question", "name": "Les modifications alimentaires peuvent-elles aider ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation équilibrée peut soutenir le métabolisme et la fonction enzymatique." } }, { "@type": "Question", "name": "Des thérapies géniques sont-elles envisageables ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "La thérapie génique est une option potentielle pour corriger des déficiences enzymatiques." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ajuster les doses ou changer de médicament peut réduire les effets indésirables." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir en cas de dysfonctionnement ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme des réactions médicamenteuses graves peuvent se produire." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié." } }, { "@type": "Question", "name": "Comment les complications affectent-elles la qualité de vie ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les complications peuvent réduire la qualité de vie en provoquant des symptômes chroniques." } }, { "@type": "Question", "name": "Les complications peuvent-elles être prévenues ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une surveillance régulière et des ajustements de traitement peuvent prévenir les complications." } }, { "@type": "Question", "name": "Y a-t-il des complications spécifiques aux traitements ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains traitements peuvent entraîner des complications spécifiques, comme des allergies." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les dysfonctionnements enzymatiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque." } }, { "@type": "Question", "name": "L'âge joue-t-il un rôle dans le risque de dysfonctionnement ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque peut augmenter avec l'âge en raison de la diminution de la fonction enzymatique." } }, { "@type": "Question", "name": "Les antécédents familiaux sont-ils un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de troubles enzymatiques augmentent le risque." } }, { "@type": "Question", "name": "L'exposition à des toxines peut-elle augmenter le risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des toxines environnementales peut affecter la fonction enzymatique." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il le risque de complications ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sain peut réduire le risque de complications liées à la déméthylation." } } ] } ] }

Sources (10000 au total)

A randomized controlled trial of an oral probiotic to reduce antepartum group B Streptococcus colonization and gastrointestinal symptoms.

Probiotics have been suggested as a strategy to reduce antenatal group B Streptococcus colonization. Although probiotics are known to improve gastrointestinal symptoms, this has not been studied durin... This study aimed to evaluate the efficacy of a probiotic to reduce: (1) standard-of-care antenatal group B Streptococcus colonization and colony counts and (2) gastrointestinal symptoms of pregnancy.... In a double-blind fashion, 109 healthy adult pregnant people were randomized to Florajen3 probiotic or placebo capsules once daily from 28 weeks' gestation until labor onset. Baseline vaginal and rect... A total of 83 participants completed the study to 36 weeks' gestation with no adverse events. Standard-of-care group B Streptococcus colonization was 20.4% in the control group and 15.4% in probiotic ... The findings of this study provided insufficient evidence for the clinical application of the Florajen3 probiotic intervention to reduce standard-of-care vaginal-rectal group B Streptococcus colonizat...

Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial.

Considering the presence of sexual dysfunction in patients with polycystic ovary syndrome, our aim was to provide scientific evidence studying effect of oral probiotic on sexual function in patients w... This study was a double blind randomized clinical trial. Eligible women were allocated to Lactofem plus letrozole (n = 20) or letrozole (n = 20). Folic acid was prescribed to all participants in two g... There is statistically significant increase in chemical pregnancy rate (10% vs. 0%; p = 0.05) and clinical pregnancy (10% vs. 0%; p = 0.05) in Probiotic plus letrozole group compared to letrozole grou... The results of the current study suggests that eight weeks of administration of probiotic may improve chemical and clinical pregnancy rate, sexual function and body satisfaction in women with PCOS....

The Efficacy of Integrated Rehabilitation for Post-Stroke Anxiety: Study Protocol for a Prospective, Multicenter, Randomized Controlled Trial.

Post-stroke anxiety (PSA) remains a challenging medical problem. Integrated rehabilitation involves a combination of traditional Chinese medicine (TCM) and Western conventional rehabilitation techniqu... The study is a prospective, multicenter, randomized, controlled trial involving 188 PSA patients from four clinical centers in China. Eligible participants will be randomly divided into the integrated... Results of this trial will ascertain the efficacy and safety of integrated rehabilitation on PSA, thereby providing evidence regarding integrated rehabilitation strategies for treating PSA. It will al... ClinicalTrials.gov NCT05147077....

Ultrasound-guided paravertebral blockade reduced perioperative opioids requirement in pancreatic resection: A randomized controlled trial.

Perioperative opioid use for pain control has been found to be associated with side effects and adverse prognosis. In this study, we hypothesized that paravertebral block could reduce the consumption ... We conducted a prospective, randomized trial. Patients with resectable pancreatic cancer were randomly assigned to one of the two groups: those who received bilateral paravertebral block combined with... A total of 153 patients were enrolled in the study and 119 cases were analyzed. Compared to the control group, patients in PTB patients had significantly lower perioperative (30.81 vs. 56.17 µg), and ... Bilateral paravertebral block combined with general anesthesia reduced the perioperative consumption of opioids by 45%.... ChiCTR1800020291 (available on http://www.chictr.org.cn/)....

Pericapsular nerve group (PENG) block for hip arthroscopy: a randomized, double-blinded, placebo-controlled trial.

Arthroscopic hip surgery is associated with significant postoperative pain. Femoral nerve blocks have been shown to improve postoperative analgesia at the expense of quadriceps weakness. The pericapsu... Subjects presenting for arthroscopic hip surgery were randomized in a 1:1 ratio to either an ultrasound-guided unilateral, single-injection PENG block (PENG group) with 20 mL of 0.5% ropivacaine or a ... Sixty-eight subjects, 34 from the PENG group and 34 from the Sham group, completed the study per protocol. Analysis of the primary outcome demonstrated a mean difference in pain scores of -0.79 (95% C... This study demonstrates that a preoperative PENG block does not improve analgesia following arthroscopic hip surgery.... NCT04508504....

A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis.

Efruxifermin has shown clinical efficacy in patients with non-alcoholic steatohepatitis (NASH) and F1-F3 fibrosis. The primary objective of the BALANCED Cohort C was to assess the safety and tolerabil... Patients with NASH and stage 4 fibrosis (n = 30) were randomized 2:1 to receive efruxifermin 50 mg (n = 20) or placebo (n = 10) once-weekly for 16 weeks. The primary endpoint was safety and tolerabili... Efruxifermin was safe and well-tolerated; most adverse events (AEs) were grade 1 (n = 7, 23.3%) or grade 2 (n = 19, 63.3%). The most frequent AEs were gastrointestinal, including transient, mild to mo... Efruxifermin appeared safe and well-tolerated with encouraging improvements in markers of liver injury, fibrosis, and glucose and lipid metabolism following 16 weeks of treatment, warranting confirmat... Cirrhosis resulting from non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease, represents a major unmet medical need. Currently there are no approved drugs f... NCT03976401....