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Enzymes et coenzymes
Enzymes
Oxidoreductases
Oxidoreductases acting on CH-NH group donors
Oxidoreductases, (N-demethylating)
Oxidoreductases, (N-demethylating) : Questions médicales fréquentes
Termes MeSH sélectionnés :
Randomized Controlled Trials as Topic
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"@type": "Question",
"name": "Comment diagnostiquer une déficience en oxydoréductases N-déméthylantes ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests enzymatiques et des analyses génétiques peuvent être effectués."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'activité enzymatique ?",
"position": 2,
"acceptedAnswer": {
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"text": "Des tests de métabolisme des médicaments et des dosages enzymatiques sont utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un dysfonctionnement enzymatique ?",
"position": 3,
"acceptedAnswer": {
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"@type": "Question",
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"position": 4,
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"@type": "Question",
"name": "Les tests sanguins sont-ils utiles pour le diagnostic ?",
"position": 5,
"acceptedAnswer": {
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}
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{
"@type": "Question",
"name": "Quels symptômes sont associés à une altération de la déméthylation ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des nausées, des vomissements et des réactions cutanées peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques peuvent-ils être liés à ces enzymes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles neurologiques peuvent survenir en raison d'une accumulation de toxines."
}
},
{
"@type": "Question",
"name": "Comment les effets secondaires des médicaments sont-ils liés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une déméthylation inefficace peut entraîner des effets secondaires imprévus."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon les individus ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier en fonction de la génétique et de l'environnement."
}
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{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques aux enfants ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les enfants peuvent présenter des symptômes plus aigus, comme des troubles de l'attention."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications liées à la déméthylation ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les médicaments connus pour interférer avec la déméthylation peut aider."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests préventifs recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être recommandés pour les personnes à risque."
}
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{
"@type": "Question",
"name": "L'éducation des patients est-elle importante ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer les patients sur les médicaments et leurs effets est crucial."
}
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{
"@type": "Question",
"name": "Les habitudes de vie peuvent-elles influencer la fonction enzymatique ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes de vie saines peuvent améliorer la fonction enzymatique."
}
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{
"@type": "Question",
"name": "Des vaccinations peuvent-elles aider à prévenir des complications ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent prévenir des infections qui compliquent les traitements."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements symptomatiques et des ajustements médicamenteux peuvent être nécessaires."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des suppléments pour améliorer la fonction enzymatique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments comme les antioxydants peuvent aider à soutenir la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Les modifications alimentaires peuvent-elles aider ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut soutenir le métabolisme et la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Des thérapies géniques sont-elles envisageables ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est une option potentielle pour corriger des déficiences enzymatiques."
}
},
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"@type": "Question",
"name": "Les médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ajuster les doses ou changer de médicament peut réduire les effets indésirables."
}
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"@type": "Question",
"name": "Quelles complications peuvent survenir en cas de dysfonctionnement ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des réactions médicamenteuses graves peuvent se produire."
}
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"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent réduire la qualité de vie en provoquant des symptômes chroniques."
}
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{
"@type": "Question",
"name": "Les complications peuvent-elles être prévenues ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance régulière et des ajustements de traitement peuvent prévenir les complications."
}
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{
"@type": "Question",
"name": "Y a-t-il des complications spécifiques aux traitements ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains traitements peuvent entraîner des complications spécifiques, comme des allergies."
}
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"@type": "Question",
"name": "Quels sont les facteurs de risque pour les dysfonctionnements enzymatiques ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque."
}
},
{
"@type": "Question",
"name": "L'âge joue-t-il un rôle dans le risque de dysfonctionnement ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque peut augmenter avec l'âge en raison de la diminution de la fonction enzymatique."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux sont-ils un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de troubles enzymatiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines peut-elle augmenter le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines environnementales peut affecter la fonction enzymatique."
}
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{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque de complications ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sain peut réduire le risque de complications liées à la déméthylation."
}
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A concerningly large proportion of recently published RCTs in trauma surgery do not report a priori sample size calculations, do not meet enrollment targets, and are not adequately powered to detect e...
Randomized clinical trials (RCTs) have a key role in progressing biomedical research and guiding clinical decision making, but premature termination remains high (up to 30%), raising concerns regardin...
In 2003 and 2018 researchers discussed the perils of blind reliance on randomized controlled trials that have been substituted for medical experience and clinical acumen. Although these past articles ...
To evaluate transparency practices in randomized controlled trials (RCTs) in dentistry....
This meta-research study included RCTs in dentistry regardless of topic, methods, or level of detail reported. Only studies in English were considered. We searched PubMed for RCTs in dentistry publish...
A total of 844 RCTs were included. Only 12.86% of studies reported any information about data and code sharing. Protocol registration was reported for 50.36% of RCTs. Conflict of interest (83.41%) and...
Considering the importance of RCTs for evidence-based dentistry, it is crucial that everyone who participates in the scientific production and dissemination process actively and consistently promotes ...
The P value is a widely used measure of statistical importance but has many drawbacks and limitations, one being that it does not reflect the robustness of the results of a clinical trial. The Fragili...
We conducted a comprehensive systematic search of high-impact anesthesia, surgical, and medical journals from the last 25 years for trials comparing an intervention between two groups with a statistic...
The median [interquartile range] FI was 3 [1-7] and correlated positively with the number of participants (r...
The FI of published trials in pediatric anesthesiology is similarly low as in other medical specialties. Larger trials with more events and P values ≤ 0.01 were associated with a higher FI....
Central serous chorioretinopathy (CSCR), a common chorioretinal disease, presents with a myriad of manifestations. Acute CSCR presents with localized neurosensory detachment whereas chronic CSCR may s...
Sample size and statistical power are often limited in pediatric cardiology studies due to the relative infrequency of specific congenital malformations of the heart and specific circulatory physiolog...
Madole & Harden argue that just as the results of randomized controlled trials (RCTs) represent gains in causal knowledge and are useful, despite their limitations, so too are the findings of human be...
Randomized controlled trials (RCT) represent evidence at the lowest potential risk for bias. Clinicians in all specialties depend upon RCTs to guide patient care. Issues such as statistical discordanc...
PubMed was searched using "randomized controlled trial." Studies were selected using a random number generator. Studies were included if the primary outcome could be reproduced using the data and stat...
Overall, 572 RCTs were selected involving six specialties. Of these, 45% were positive (p<0.05) studies. Eleven (2%) published results that differed from the reproduction analysis and crossed the p=0....
Less than 5% of published RCTs reported a discordant p-value that crossed the "p=0.05" threshold. Although the occurrence is uncommon, the existence of even one RCT publishing nonreproducible results ...