Titre : Temps partiel de thromboplastine

Temps partiel de thromboplastine : Questions médicales fréquentes

Termes MeSH sélectionnés :

Prostatic Neoplasms
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"position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Un échantillon de sang est prélevé et mélangé avec des réactifs pour mesurer le temps de coagulation." } }, { "@type": "Question", "name": "Quels résultats indiquent un TPT prolongé ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Un TPT prolongé peut indiquer des troubles hémorragiques ou une carence en facteurs de coagulation." } }, { "@type": "Question", "name": "Le TPT est-il lié à d'autres tests ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il est souvent associé à l'INR et au temps de prothrombine pour une évaluation complète." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème de coagulation ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des saignements excessifs, des ecchymoses fréquentes ou des saignements spontanés." } }, { "@type": "Question", "name": "Comment reconnaître une hémorragie interne ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Par des douleurs abdominales, des vomissements de sang ou des selles noires." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les jeunes enfants et les personnes âgées peuvent présenter des symptômes différents." } }, { "@type": "Question", "name": "Les saignements de nez sont-ils un signe de problème de coagulation ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des saignements de nez fréquents peuvent indiquer un trouble de la coagulation." } }, { "@type": "Question", "name": "Les femmes enceintes doivent-elles surveiller leur TPT ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des modifications de la coagulation peuvent survenir pendant la grossesse." } }, { "@type": "Question", "name": "Comment prévenir les troubles de la coagulation ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Maintenir un mode de vie sain, éviter les blessures et suivre les conseils médicaux." } }, { "@type": "Question", "name": "Les vaccinations influencent-elles la coagulation ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Certaines vaccinations peuvent affecter la coagulation, il est important de consulter un médecin." } }, { "@type": "Question", "name": "Le suivi médical est-il essentiel ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un suivi régulier est crucial pour les personnes à risque de troubles de la coagulation." } }, { "@type": "Question", "name": "Les exercices physiques aident-ils à la coagulation ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une activité physique régulière peut améliorer la circulation sanguine et la coagulation." } }, { "@type": "Question", "name": "Faut-il éviter certains médicaments ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments peuvent interférer avec la coagulation, consultez un médecin." } }, { "@type": "Question", "name": "Comment traiter un TPT prolongé ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement dépend de la cause sous-jacente, pouvant inclure des transfusions ou des médicaments." } }, { "@type": "Question", "name": "Les anticoagulants affectent-ils le TPT ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les anticoagulants comme l'héparine peuvent prolonger le TPT." } }, { "@type": "Question", "name": "Des suppléments peuvent-ils aider ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments de vitamine K peuvent être nécessaires en cas de carence." } }, { "@type": "Question", "name": "Le traitement est-il différent pour les enfants ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les dosages et les médicaments peuvent varier selon l'âge et le poids." } }, { "@type": "Question", "name": "Les changements alimentaires influencent-ils le TPT ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation riche en vitamine K peut améliorer la coagulation." } }, { "@type": "Question", "name": "Quelles sont les complications d'un TPT prolongé ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des saignements graves, des hématomes ou des thromboses." } }, { "@type": "Question", "name": "Un TPT anormal peut-il entraîner des AVC ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles de la coagulation peuvent augmenter le risque d'accidents vasculaires cérébraux." } }, { "@type": "Question", "name": "Les complications varient-elles selon l'âge ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications peuvent être plus graves chez les personnes âgées ou les enfants." } }, { "@type": "Question", "name": "Comment gérer les complications liées au TPT ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Une gestion rapide et appropriée des saignements et des traitements médicaux est essentielle." } }, { "@type": "Question", "name": "Les complications peuvent-elles être évitées ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être évitées par un suivi médical régulier et des traitements appropriés." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque de troubles de la coagulation ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux, certaines maladies et l'utilisation de médicaments anticoagulants." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il la coagulation ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut affecter la coagulation et augmenter le risque de thrombose." } }, { "@type": "Question", "name": "L'obésité est-elle un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'obésité augmente le risque de troubles de la coagulation et de complications associées." } }, { "@type": "Question", "name": "Les maladies chroniques influencent-elles le TPT ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme le diabète ou les maladies cardiaques peuvent affecter le TPT." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque de troubles de la coagulation augmente avec l'âge." } } ] } ] }

Sources (10000 au total)

Prostate and metastasis-directed focal therapy in prostate cancer: hype or hope?

The paradigm of focal therapy's role in metastatic patients is being challenged by evolving attitudes and emerging data. At the current time, specifically regarding prostate cancer, does the evidence ... We searched the literature via PubMed, MEDLINE, and Embase for studies from 2014 to the present addressing focal therapy with non-palliative intent in metastatic prostate cancer patients, emphasizing ... Current evidence is strongest, and in our opinion practice-changing, for prostate-directed RT in de novo metastatic patients with low metastatic burden. Metastasis-directed therapy with SBRT is consis...

Development and evaluation of the MiCheck® Prostate test for clinically significant prostate cancer.

There is a clinical need to identify patients with an elevated PSA who would benefit from prostate biopsy due to the presence of clinically significant prostate cancer (CSCaP). We have previously repo... To further develop and adapt the MiCheck® Prostate test so it can be performed using a standard clinical chemistry analyzer and characterize its performance using the MiCheck-01 clinical trial sample ... About 358 patient samples from the MiCheck-01 US clinical trial were used for the development of the MiCheck® Prostate test. These consisted of 46 controls, 137 non-CaP, 62 non-CSCaP, and 113 CSCaP.... Serum analyte concentrations for cellular growth factors were determined using custom-made Luminex-based R&D Systems multi-analyte kits. Analytes that can also be measured using standard chemistry ana... Logistic regression modeling with Monte Carlo cross-validation was used to identify Human Epidydimal Protein 4 (HE4) as an analyte able to significantly improve the algorithm specificity at 95% sensit... The MiCheck® logistic regression model was developed and consisted of PSA, %free PSA, DRE, and HE4. The model differentiated clinically significant cancer from no cancer or not-clinically significant ... The MiCheck® Prostate test identifies clinically significant prostate cancer with high sensitivity and negative predictive value (NPV). It can be performed in a clinical laboratory using a Roche Cobas...

New strategy for the identification of prostate cancer: The combination of Proclarix and the prostate health index.

Prostate health index (PHI) and, more recently, Proclarix have been proposed as serum biomarkers for prostate cancer (PCa). In this study, we aimed to evaluate Proclarix and PHI for predicting clinica... Proclarix and PHI were measured using samples of 344 men from two different centers. All patients underwent prostate biopsy, and among those, 188 men with PCa on biopsy had an additional radical prost... The cohort median age and PSA were 65 (interquartile range [IQR]: 60-71) and 5.6 (IQR: 4.3-7.2) ng/ml, respectively. CsPCa was diagnosed in 161 (47%) men based on the RP specimen. ROC analysis showed ... Results of this study show that both Proclarix and PHI accurately detect the presence of csPCa. The model combining Proclarix and PHI revealed the synergistic effect and improved the diagnostic perfor...

Detection of clinically significant prostate cancer by transperineal multiparametric magnetic resonance imaging-ultrasound fusion targeted prostate biopsy in smaller prostates.

Transperineal (TP) multiparametric magnetic resonance imaging (mpMRI)-targeted biopsy (TBx) has been shown to detect more clinically significant (cs) prostate cancer (PCa) than standard template biops... We identified all men who with suspicious lesions on mpMRI and underwent TP TBx (3-core) and concomitant SBx (20-core) in our single hospital from September 2019 to February 2021. Clinical, MRI and bi... Three hundred and one (n = 301) men were included. The median prostate volume by MRI was 45 ml. The patients were divided by prostate volume into three groups: ≤30ml group (19.9%), >30 to ≤45 ml group... Our data suggest that performing TBx with limited additional cores may potentially achieve the same csPCa detection rate as the combined SBx and TBx in smaller prostates....

Are elevated mitochondrial DNA fragments in prostatic inflammation a potential biomarker for prostate cancer?

We sought to determine whether two soluble forms with different size of mtDNA are linked to prostatic inflammation, and whether they discriminate prostate cancer (PCa) from inflammatory prostatic cond... Histopathologically diagnosed prostatitis, PCa and benign prostatic hyperplasia patients (n = 93) were enrolled in this study and they were categorized as with and without prostate inflammation. Quant... The urine mtDNA-79 and mtDNA-230 were significantly increased in patients with prostate inflammation compared with those in without inflammation. Here, 79-bp fragment of apoptotic origin was significa... Our results demonstrate that shorter cf-mtDNA fragment size in particular, increase in the presence of prostate inflammation in post-prostatic massage urine but both fragments could never improve seru...

The rapid assessment for prostate imaging and diagnosis (RAPID) prostate cancer diagnostic pathway.

To report outcomes within the Rapid Assessment for Prostate Imaging and Diagnosis (RAPID) diagnostic pathway, introduced to reduce patient and healthcare burdens and standardize delivery of pre-biopsy... A total of 2130 patients from three centres who completed the RAPID pathway (3 April 2017 to 31 March 2020) were consecutively entered as a prospective registry. These patients were also compared to a... The median patient age and PSA level were 66 years and 6.6 ng/mL, respectively. Biopsy could be omitted in 43% of patients (920/2130). A further 7.9% of patients (168/2130) declined a recommendation f... The RAPID prostate cancer diagnostic pathway allows 43% of men to avoid a biopsy while preserving good detection of clinically significant cancers and low detection of insignificant cancers, although ...