Mahnaz Fatahzadeh, DMD, MDS, FRCP (Edin), Rutgers School of Dental Medicine, Newark, United States, 110 Bergen Street Newark, United States fatahza@sdm.rutgers.edu.
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. Electronic address: nutt@wehi.edu.au.
Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, Arizona 85724, USA; email: ripperger@arizona.edu, deeptab@arizona.edu.
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya (UPC-BarcelonaTECH), Escola d'Enginyeria Barcelona Est (EEBE), Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, Spain.
Research Center in Biomedical Engineering (CREB), UPC, Barcelona, Spain.
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya (UPC-BarcelonaTECH), Escola d'Enginyeria Barcelona Est (EEBE), Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, Spain.
Research Center in Biomedical Engineering (CREB), UPC, Barcelona, Spain.
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering (CEM), Universitat Politècnica de Catalunya (UPC-BarcelonaTECH), Escola d'Enginyeria Barcelona Est (EEBE), Barcelona, Spain. cristina.canal@upc.edu.
Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, Spain. cristina.canal@upc.edu.
Research Center in Biomedical Engineering (CREB), UPC, Barcelona, Spain. cristina.canal@upc.edu.
Department of Mechanical and Aerospace Engineering , The George Washington University , 800 22nd Street NW , Washington , D.C. 20052 , United States of America.
Department of Mechanical and Aerospace Engineering , The George Washington University , 800 22nd Street NW , Washington , D.C. 20052 , United States of America.
Department of Mechanical and Aerospace Engineering , The George Washington University , 800 22nd Street NW , Washington , D.C. 20052 , United States of America.
Department of Mechanical and Aerospace Engineering , The George Washington University , 800 22nd Street NW , Washington , D.C. 20052 , United States of America.
Department of Mechanical and Aerospace Engineering , The George Washington University , 800 22nd Street NW , Washington , D.C. 20052 , United States of America.
1Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, 877 Bangeojin Sunhwan-doro, Dong-gu, Ulsan, 44033 Republic of Korea.
1Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, 877 Bangeojin Sunhwan-doro, Dong-gu, Ulsan, 44033 Republic of Korea.
Common variable immunodeficiency enteropathy (CVID-E) is a noninfectious complication of CVID caused by chronic inflammation of the gastrointestinal (GI) tract. Based on literature, a paucity or lack ...
Reduced plasma cell counts are commonly found over the entire GI tract, except for in the oesophagus. Immunoglobulin A+ (IgA+) plasma cells appear to be the most commonly reduced plasma cell class in ...
We propose two optimized methodologies of quantification using a cut-of value of <10 plasma cells per HPF at 40× magnification, or a proportion of ≥1-5% of total mononuclear cells, recorded over ≥3 se...
Systemic light chain amyloidosis (AL) is a clonal plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains (LC) as insoluble fibrils in organs. The lack of suitabl...
Multiparameter flow cytometry (FC) immunophenotyping is a key tool for detailed identification and characterization of human blood leucocytes, including B-lymphocytes and plasma cells (PC). However, c...
Here, we designed, constructed and validated an automated database-guided gating and identification (AGI) approach for fast and standardized in-depth dissection of B-lymphocyte and PC populations in h...
For this purpose, 213 FC standard (FCS) datafiles corresponding to umbilical cord and peripheral blood samples from healthy and patient volunteers, stained with the 14-color 18-antibody EuroFlow BIgH-...
The BIgH-IMM antibody panel allowed identification of 117 different B-lymphocyte and PC subsets. Samples from 36 healthy donors were stained and 14 of the datafiles that fulfilled strict inclusion cri...
Our results show that compared to conventional FC data analysis strategies, the here proposed AGI tool is a faster, more robust, reproducible, and standardized approach for in-depth analysis of B-lymp...
Protective immune responses to many pathogens depend on the development of high-affinity antibody-producing plasma cells (PC) in germinal centers (GCs). Transgenic models suggest that there is a strin...
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein [M-protein], and skin changes) is a rare systemic disorder characterized by various symptoms caused by underlying plasm...
Intratumoral B cell responses are associated with more favorable clinical outcomes in human pancreatic ductal adenocarcinoma (PDAC). However, the antigens driving these B cell responses are largely un...
Rheumatoid arthritis (RA) is a clinically heterogeneous and complex autoimmune disease, making the prediction of therapeutic responses a significant challenge. This study aims to assess the role of cl...
This single-center prospective study included 56 RA patients who had an inadequate response to methotrexate (MTX). At baseline, comprehensive assessments including complete blood count, liver and kidn...
Out of the participants, 24 (42.9%) failed to achieve ACR20 with adalimumab treatment. Non-responders exhibited higher infiltration of plasma cells in the synovium. Multivariate logistic regression an...
Inadequate responses to adalimumab in RA patients were associated with increased plasma cell infiltrations in the synovium. These findings suggest a promising target for tailored therapies in rheumato...
Both antibody-mediated rejection and recurrence of kidney disease are major causes of allograft loss. A possible strategy to address the former is donor-specific antibody (DSA) monitoring. In this pat...
BACKGROUND Fluid overload-associated large B-cell lymphoma (FO-LBCL) is a recently described malignant lymphoma that presents with serous effusions in the pleura, peritoneum, and/or pericardium but wi...
The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, represents one of the most significant global health crises in recent history. Despite extensive research into the immune mechanisms and ...
