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"name": "Comment évaluer la taille de la pupille ?",
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"text": "La taille de la pupille est mesurée en millimètres à l'aide d'un ophtalmoscope."
}
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"@type": "Question",
"name": "Quelles anomalies pupillaires peuvent indiquer une maladie ?",
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"text": "Des pupilles asymétriques ou non réactives peuvent signaler des troubles neurologiques."
}
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"@type": "Question",
"name": "Quel test évalue la réactivité de la pupille ?",
"position": 3,
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"text": "Le test de la lumière évalue la réactivité de la pupille à la lumière."
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"name": "Comment détecter un réflexe pupillaire ?",
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"@type": "Question",
"name": "Quels symptômes indiquent une dilatation anormale de la pupille ?",
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"@type": "Question",
"name": "Que signifie une pupille réactive à la lumière ?",
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"text": "Une pupille réactive indique un bon fonctionnement du nerf optique et du système nerveux."
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"@type": "Question",
"name": "Quels signes peuvent indiquer une pupille non réactive ?",
"position": 8,
"acceptedAnswer": {
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"text": "Une pupille non réactive peut signaler une lésion cérébrale ou une intoxication."
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"name": "Comment la douleur oculaire affecte-t-elle la pupille ?",
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"text": "La douleur oculaire peut entraîner une constriction ou une dilatation de la pupille."
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"name": "Quels symptômes accompagnent une anisocorie ?",
"position": 10,
"acceptedAnswer": {
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"text": "L'anisocorie peut s'accompagner de vision double ou de maux de tête."
}
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{
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"name": "Comment prévenir les troubles pupillaires ?",
"position": 11,
"acceptedAnswer": {
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"text": "Évitez les traumatismes oculaires et consultez régulièrement un ophtalmologiste."
}
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"name": "Quels examens réguliers sont recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens ophtalmologiques réguliers aident à détecter précocement les anomalies pupillaires."
}
},
{
"@type": "Question",
"name": "Comment protéger les yeux des UV ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Portez des lunettes de soleil avec protection UV pour prévenir les dommages oculaires."
}
},
{
"@type": "Question",
"name": "Quels aliments favorisent la santé des yeux ?",
"position": 14,
"acceptedAnswer": {
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"text": "Les légumes à feuilles vertes, les carottes et les poissons gras sont bénéfiques pour les yeux."
}
},
{
"@type": "Question",
"name": "Comment éviter la fatigue oculaire ?",
"position": 15,
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"text": "Faites des pauses régulières lors de l'utilisation d'écrans pour réduire la fatigue oculaire."
}
},
{
"@type": "Question",
"name": "Comment traiter une pupille dilatée ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement dépend de la cause sous-jacente, comme des médicaments ou une intervention chirurgicale."
}
},
{
"@type": "Question",
"name": "Quels médicaments affectent la taille de la pupille ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les mydriatiques peuvent provoquer une dilatation de la pupille."
}
},
{
"@type": "Question",
"name": "Quand une intervention chirurgicale est-elle nécessaire ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une chirurgie peut être nécessaire en cas de traumatisme ou de maladies oculaires graves."
}
},
{
"@type": "Question",
"name": "Comment traiter une pupille non réactive ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement vise à traiter la cause, comme une infection ou une lésion cérébrale."
}
},
{
"@type": "Question",
"name": "Quels remèdes naturels peuvent aider la santé des yeux ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des compléments comme la lutéine et des aliments riches en antioxydants peuvent être bénéfiques."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une pupille non réactive ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications neurologiques graves peuvent survenir, nécessitant une attention médicale urgente."
}
},
{
"@type": "Question",
"name": "Comment une infection peut-elle affecter la pupille ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une infection oculaire peut entraîner une inflammation et des changements dans la taille de la pupille."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés à une chirurgie de la pupille ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les risques incluent l'infection, les saignements et des complications de la vision."
}
},
{
"@type": "Question",
"name": "Comment une lésion cérébrale affecte-t-elle la pupille ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une lésion cérébrale peut provoquer des changements dans la réactivité et la taille de la pupille."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires des médicaments peuvent affecter la pupille ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains médicaments peuvent provoquer une dilatation ou une constriction anormale de la pupille."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de troubles pupillaires ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents familiaux, les traumatismes oculaires et certaines maladies neurologiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "Comment le stress affecte-t-il la pupille ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress peut provoquer une dilatation temporaire de la pupille en raison de la réponse au stress."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont des facteurs de risque pour la pupille ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les médicaments comme les antidépresseurs et les mydriatiques peuvent affecter la pupille."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'âge dans la santé de la pupille ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Avec l'âge, la réactivité de la pupille peut diminuer, augmentant le risque de troubles."
}
},
{
"@type": "Question",
"name": "Comment les maladies systémiques influencent-elles la pupille ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies comme le diabète peuvent affecter la santé des nerfs oculaires et la pupille."
}
}
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Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene expression. AS misregulation, caused by either dysregulation or mutation of splicing factors, has been shown ...
Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of ...
We recently performed transcriptome and proteome profiling of human lung epithelial cells ectopically expressing oncogenic KRAS and another cancer-associated Ras GTPase, RIT1. Unbiased analysis of pho...
Mass spectrometry data showed widespread downregulation of splicing factor phosphorylation in lung epithelial cells expressing mutant KRAS compared to cells expressing wild-type KRAS. We observed alte...
Proteomic and transcriptomic profiling of lung epithelial cells uncovered splicing factor phosphorylation and mRNA splicing events regulated by oncogenic KRAS. These data suggest that in addition to w...
Serine- and arginine-rich splicing factors are pivotal modulators of constitutive splicing and alternative splicing that bind to the cis-acting elements in precursor mRNAs and facilitate the recruitme...
Alternative splicing (AS) is a dynamic RNA processing step that produces multiple RNA isoforms from a single pre-mRNA transcript and contributes to the complexity of the cellular transcriptome and pro...
Identification of cancer sub-types is a pivotal step for developing personalized treatment. Specifically, sub-typing based on changes in RNA splicing has been motivated by several recent studies. We t...
Serine/arginine-rich splicing factor 3 (SRSF3) is an RNA binding protein that most often regulates gene expression at the splicing level. Although the role of SRSF3 in mRNA splicing in the nucleus is ...
Splicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the al...
Malignant pleural mesothelioma (MPM) is a rare and highly malignant thoracic tumor. Although alternative splicing (AS) is associated with tumor prognosis, the prognostic significance of AS in MPM is u...
Transcriptomic data, clinical information, and splicing percentage values for MPM were obtained from The Cancer Genome Atlas (TCGA) and TCGA SpliceSeq databases. Least absolute shrinkage and selection...
The LASSO/multivariate Cox analysis identified 41 AS events and 2 SFs that were mostly associated with survival. Nine prognostic prediction models (i.e., seven types of AS model, total AS model, and S...
This study provides the first comprehensive analysis of the prognostic value of AS events and SFs in MPM. The SF-AS regulatory network established in this study and our drug sensitivity analysis using...
Light signals perceived by a group of photoreceptors have profound effects on the physiology, growth, and development of plants. The red/far-red light-absorbing phytochromes (phys) modulate these aspe...
Precursor messenger RNA splicing is a highly regulated process, mediated by a complex RNA-protein machinery, the spliceosome, that encompasses several hundred proteins and five small nuclear RNAs in h...