Le diagnostic repose sur l'examen clinique et des tests d'imagerie comme l'échographie.
SialadéniteÉchographieExamen clinique
#2
Quels tests de laboratoire sont utiles ?
Des analyses de sang et des cultures de salive peuvent aider à identifier l'infection.
Analyses de sangCulture de saliveInfection
#3
Quels signes cliniques indiquent une sialadénite ?
Douleur, gonflement et rougeur au niveau de la glande salivaire sont des signes clés.
SialadéniteDouleurGonflement
#4
La biopsie est-elle nécessaire ?
Une biopsie est rarement nécessaire, sauf si une tumeur est suspectée.
BiopsieTumeurSialadénite
#5
Peut-on utiliser l'imagerie par résonance magnétique ?
Oui, l'IRM peut être utilisée pour évaluer les complications ou les obstructions.
IRMObstructionComplications
Symptômes
5
#1
Quels sont les symptômes courants de la sialadénite ?
Les symptômes incluent douleur, enflure, sécheresse buccale et parfois fièvre.
SialadéniteFièvreSécheresse buccale
#2
La douleur est-elle constante ?
La douleur peut être intermittente, souvent aggravée par la mastication ou la déglutition.
DouleurMasticationDéglutition
#3
Y a-t-il des signes de pus ?
Oui, un écoulement purulent peut se produire si l'infection est sévère.
Écoulement purulentInfectionSialadénite
#4
Les symptômes varient-ils selon l'âge ?
Oui, les enfants peuvent présenter des symptômes différents, comme une irritabilité accrue.
EnfantsIrritabilitéSialadénite
#5
Peut-on avoir des symptômes systémiques ?
Oui, des symptômes comme fatigue et malaise général peuvent accompagner l'inflammation.
FatigueMalaiseSialadénite
Prévention
5
#1
Comment prévenir la sialadénite ?
Maintenir une bonne hygiène buccale et s'hydrater régulièrement aide à prévenir.
Hygiène buccaleHydratationPrévention
#2
Les massages des glandes salivaires sont-ils utiles ?
Oui, masser doucement les glandes peut stimuler la production de salive.
MassageGlandes salivairesProduction de salive
#3
Faut-il éviter certains aliments ?
Éviter les aliments acides ou irritants peut réduire le risque d'inflammation.
Aliments acidesIrritationSialadénite
#4
Les infections buccales augmentent-elles le risque ?
Oui, les infections buccales non traitées peuvent favoriser le développement de sialadénite.
Infections buccalesSialadéniteRisque
#5
Le stress a-t-il un impact ?
Le stress peut affecter la santé buccale et augmenter le risque d'infections salivaires.
StressSanté buccaleInfections salivaires
Traitements
5
#1
Quels traitements sont recommandés ?
Le traitement inclut des antibiotiques, des anti-inflammatoires et des soins locaux.
AntibiotiquesAnti-inflammatoiresSoin local
#2
Les compresses chaudes sont-elles efficaces ?
Oui, les compresses chaudes peuvent soulager la douleur et favoriser l'écoulement salivaire.
Compresses chaudesSoulagement de la douleurSialadénite
#3
Quand faut-il envisager une intervention chirurgicale ?
Une chirurgie peut être nécessaire en cas d'abcès ou d'obstruction persistante.
ChirurgieAbcèsObstruction
#4
Les médicaments en vente libre aident-ils ?
Oui, des analgésiques en vente libre peuvent aider à gérer la douleur.
AnalgésiquesVente libreSialadénite
#5
Faut-il changer son alimentation ?
Une alimentation douce et hydratante est recommandée pour réduire l'irritation.
AlimentationHydratationIrritation
Complications
5
#1
Quelles complications peuvent survenir ?
Les complications incluent l'abcès, la déshydratation et la propagation de l'infection.
ComplicationsAbcèsInfection
#2
L'abcès nécessite-t-il une intervention ?
Oui, un abcès peut nécessiter un drainage chirurgical pour soulager la pression.
AbcèsDrainageChirurgical
#3
Peut-on avoir des séquelles à long terme ?
Des séquelles comme des douleurs chroniques peuvent survenir après une sialadénite sévère.
SéquellesDouleurs chroniquesSialadénite
#4
Y a-t-il un risque de récidive ?
Oui, les personnes ayant eu une sialadénite peuvent être à risque de récidive.
RécidiveSialadéniteRisque
#5
Les infections systémiques sont-elles possibles ?
Oui, une sialadénite non traitée peut entraîner des infections systémiques graves.
Infections systémiquesSialadéniteGraves
Facteurs de risque
5
#1
Quels sont les facteurs de risque principaux ?
Les facteurs incluent la déshydratation, l'âge avancé et les maladies buccales.
DéshydratationÂge avancéMaladies buccales
#2
Les personnes âgées sont-elles plus à risque ?
Oui, les personnes âgées ont un risque accru en raison de la sécheresse buccale fréquente.
Personnes âgéesRisque accruSécheresse buccale
#3
Les maladies auto-immunes augmentent-elles le risque ?
Oui, des maladies comme le syndrome de Sjögren augmentent le risque de sialadénite.
Maladies auto-immunesSyndrome de SjögrenRisque
#4
Le tabagisme est-il un facteur de risque ?
Oui, le tabagisme peut contribuer à la sécheresse buccale et à l'inflammation des glandes.
TabagismeSécheresse buccaleInflammation
#5
Les infections virales jouent-elles un rôle ?
Oui, certaines infections virales, comme les oreillons, peuvent déclencher une sialadénite.
Infections viralesOreillonsSialadénite
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"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut contribuer à la sécheresse buccale et à l'inflammation des glandes."
}
},
{
"@type": "Question",
"name": "Les infections virales jouent-elles un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections virales, comme les oreillons, peuvent déclencher une sialadénite."
}
}
]
}
]
}
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
Center of Stomatology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China.
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
Center of Stomatology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China.
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
2022-06-09
Department of Oral and Maxillofacial Radiology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key laboratory of Digital Stomatology, Beijing 100081, China.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
2022-06-09
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
2022-06-09
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
2022-06-09
To compare the ability of immunohistochemistry (IHC), multiparameter flow cytometry (MFC) and fluorescence in situ hybridisation (FISH) to detect clonal plasma cells. We also attempted to outline a te...
A retrospective review was performed on 278 CD138+sorted FISH studies from November 2019 to December 2020 along with their concurrent IHC and MFC results. A p value was computed using McNemar's test f...
Using the Mc Nemar's test for paired data, CD138+sorted FISH studies achieved the highest proportion of positive results and was significantly greater than MFC (63% vs 53%, p=0.01). FISH had more posi...
While CD138+sorted FISH is primarily used for prognostication, it may be employed as a single test for detection and monitoring clonality in certain scenarios. Further studies are needed to monitor th...
Plasma cell vulvitis is a rare inflammatory disorder of the vulva with an unknown aetiology, characterised by mucosal inflammation. It commonly manifests as pain, itching, dyspareunia, and dysuria and...
case report; immunosuppressant; platelet-rich plasma; vulvitis....
The evaluation of plasma cell (PC) compartment is influenced by the quality of bone marrow aspirate (BMA). Herein, we evaluated the impact of sequence of pull on quality of clinical assessment in plas...
Histomorphology along with smears from first pull and second pull BMA and flow cytometric immunophenotyping (FCMI) data from second pull aspirate were evaluated for cellularity and PC%....
Of the 484 samples, BMA smears were adequate in 87.4% of first pull (median PC = 7%; IQR = 2-25%) and 51.2% of second pull samples (median PC = 2%; IQR = 0.5-12%; p < 0.001). Recovery of PC was least ...
First pull BMA smears were of superior quality but inadequate in one-tenth of samples. Second pull smears underreported PC% and recovery of PC compartment was poorest on FCMI. Concurrent bone marrow b...
Next-generation sequencing (NGS) detects somatic mutations in a high proportion of plasma cell dyscrasias (PCD), but is currently not integrated into diagnostic routine. We correlated NGS data with de...
Of the 90 patients the diagnoses comprised multiple myeloma (n = 77), MGUS (n = 7), AL-amyloidosis (n = 4) or solitary plasmocytoma (n = 2). The NGS panel included eight genes CCND1, DIS3, EGR1, FAM46...
Mutations were detected in 64/90 (71%) of cases. KRAS (29%), NRAS (16%) and DIS3 (16%) were most frequently mutated. At least one mutation/sample corresponded to a higher degree of BM involvement with...
The probability of detecting a mutation by NGS in the BM was highest in samples with > 10% clonal PC by MFC, or > 20% PC by BMC/ BMH. We propose further evaluation of these thresholds as a practical c...
Plasma cells (PCs) are essential for the quality and longevity of protective immunity. The canonical humoral response to vaccination involves induction of germinal centers in lymph nodes followed by m...
Plasma cell gingivitis (PCG) is an inflammatory condition that affects the gingival mucosa of the oral cavity. It is characterized by polyclonal dense plasma cell infiltrate in the connective tissue. ...
Primary plasma cell leukemia (PCL) is the most aggressive monoclonal gammopathy. It was formerly characterized by ≥ 20% circulating plasma cells (CTCs) until 2021, when this threshold was decreased to...
We assessed the levels of CTCs by multiparameter flow cytometry in 395 patients with newly diagnosed transplant-ineligible MM to establish a cutoff for CTCs that identifies the patients with ultra-hig...
Newly diagnosed transplant-ineligible patients with MM with 2%-20% CTCs had significantly shorter progression-free survival (3.1...
Our study uncovers that ≥ 2% CTCs is a biomarker of hidden primary PCL and supports the assessment of CTCs by flow cytometry during the diagnostic workup of MM....
Autoantibody (autoAbs) production in osteoarthritis (OA), coupled with evidence of disturbed B-cell homoeostasis, suggest a potential role for B-cells in OA. B-cells can differentiate with T-cell help...
B-cells were isolated from OA and HC. Standardised in vitro models of B-cell differentiation were used comparing T-dep (CD40 (cluster of differentiation-40/BCR (B-cell receptor)-ligation) versus TLR-d...
Compared to HC, circulating OA B-cells showed an overall more mature phenotype. The gene expression profile of synovial OA B-cells resembled that of PCs. Circulating B-cells differentiated under both ...
Our findings suggest that OA B-cells present an altered capacity for proliferation and differentiation while remaining able to produce antibodies, notably in synovium. These findings may partly contri...
A recent study shows that the SNARE protein Sec22b plays a key role in antibody-secreting plasma cell accrual. Without Sec22b, antibody titres were diminished, and plasma cells rare to undetectable. T...
In recent decades, our understanding of periodontitis has evolved from that based on a gross/histologic level to one on a cellular/molecular level. Previous landscape studies have explored molecular s...