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"description": "Comment diagnostiquer une anomalie des sulfoglycosphingolipides ?\nQuels tests sont utilisés pour évaluer les sulfoglycosphingolipides ?\nLes imageries sont-elles utiles dans le diagnostic ?\nY a-t-il des marqueurs spécifiques pour ces lipides ?\nLe diagnostic nécessite-t-il une consultation spécialisée ?",
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"description": "Quels traitements sont disponibles pour les troubles liés aux sulfoglycosphingolipides ?\nLes médicaments peuvent-ils aider à gérer les symptômes ?\nY a-t-il des traitements expérimentaux disponibles ?\nLa diététique joue-t-elle un rôle dans le traitement ?\nLes traitements sont-ils personnalisés selon le patient ?",
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"headline": "Complications sur Sulfoglycosphingolipides",
"description": "Quelles complications peuvent survenir avec ces troubles ?\nLes complications sont-elles réversibles ?\nY a-t-il un risque accru de maladies associées ?\nLes complications affectent-elles la qualité de vie ?\nComment gérer les complications à long terme ?",
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"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Sulfoglycosphingolipides",
"description": "Quels sont les principaux facteurs de risque ?\nL'environnement joue-t-il un rôle dans ces troubles ?\nLes habitudes alimentaires influencent-elles le risque ?\nY a-t-il des groupes à risque particulier ?\nLe mode de vie affecte-t-il le risque de troubles ?",
"url": "https://questionsmedicales.fr/mesh/D013433?mesh_terms=Early+Detection+of+Cancer&page=1000#section-facteurs de risque"
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie des sulfoglycosphingolipides ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic se fait par des tests biochimiques et génétiques pour évaluer les niveaux de sulfoglycosphingolipides."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les sulfoglycosphingolipides ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des analyses de sang et des biopsies tissulaires peuvent être effectuées pour mesurer les niveaux."
}
},
{
"@type": "Question",
"name": "Les imageries sont-elles utiles dans le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques d'imagerie peuvent aider à visualiser les effets des anomalies sur les organes."
}
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{
"@type": "Question",
"name": "Y a-t-il des marqueurs spécifiques pour ces lipides ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs biochimiques spécifiques peuvent indiquer des déséquilibres dans les sulfoglycosphingolipides."
}
},
{
"@type": "Question",
"name": "Le diagnostic nécessite-t-il une consultation spécialisée ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une consultation avec un spécialiste en métabolisme lipidique est souvent nécessaire."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une dysfonction des sulfoglycosphingolipides ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent inclure des troubles neurologiques, des problèmes de peau et des douleurs abdominales."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent se manifester différemment selon l'âge et le stade de la maladie."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques à surveiller ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes comme des troubles cognitifs ou des anomalies de la peau doivent être surveillés."
}
},
{
"@type": "Question",
"name": "Les symptômes sont-ils toujours présents ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certains patients peuvent avoir des symptômes intermittents ou légers."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils s'aggraver avec le temps ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, sans traitement, les symptômes peuvent s'aggraver progressivement."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les troubles liés aux sulfoglycosphingolipides ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est difficile, mais un diagnostic précoce et un suivi régulier peuvent aider."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives recommandées ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des conseils génétiques et un suivi médical régulier sont recommandés pour les familles à risque."
}
},
{
"@type": "Question",
"name": "L'éducation des patients est-elle importante ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'éducation sur les symptômes et les risques peut aider à une détection précoce."
}
},
{
"@type": "Question",
"name": "Les tests de dépistage sont-ils utiles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests de dépistage peuvent identifier les personnes à risque avant l'apparition des symptômes."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie influencent-elles la prévention ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes de vie saines peuvent contribuer à réduire le risque de complications."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les troubles liés aux sulfoglycosphingolipides ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des thérapies enzymatiques et des approches symptomatiques."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider à gérer les symptômes ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent soulager les symptômes associés aux déséquilibres lipidiques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux disponibles ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements expérimentaux, comme la thérapie génique, sont en cours d'évaluation."
}
},
{
"@type": "Question",
"name": "La diététique joue-t-elle un rôle dans le traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut aider à gérer certains symptômes et à améliorer la santé globale."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés selon le patient ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements sont souvent adaptés en fonction des besoins spécifiques de chaque patient."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec ces troubles ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles neurologiques graves et des problèmes d'organes."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de maladies associées ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients peuvent avoir un risque accru de maladies métaboliques et cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les complications affectent-elles la qualité de vie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent significativement affecter la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications à long terme ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une gestion multidisciplinaire et un suivi régulier sont essentiels pour les complications à long terme."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs de risque incluent des antécédents familiaux et des mutations génétiques spécifiques."
}
},
{
"@type": "Question",
"name": "L'environnement joue-t-il un rôle dans ces troubles ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs environnementaux peuvent influencer l'expression des troubles lipidiques."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en graisses saturées peut augmenter le risque de complications."
}
},
{
"@type": "Question",
"name": "Y a-t-il des groupes à risque particulier ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes avec des antécédents familiaux de troubles lipidiques sont à risque accru."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il le risque de troubles ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et le stress peuvent augmenter le risque de complications."
}
}
]
}
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}
Phosphatase and tensin homolog (PTEN) loss is associated with adverse outcomes in prostate cancer and can be measured via immunohistochemistry. The purpose of the study was to establish the clinical a...
In patients with existing ovarian function, there are some special aspects to adjuvant endocrine therapy in premenopausal patients with hormone receptor-positive, HER2-negative (HR pos./HER2 neg.) bre...
Trastuzumab has been the standard of care for the treatment of patients with ERBB2-positive breast cancer; however, cardiac events have been reported. This long-term follow-up study provides clinical ...
To compare cardiac safety and efficacy between SB3 and TRZ for patients with ERBB2-positive early or locally advanced breast cancer after up to 6 years of follow-up....
This prespecified secondary analysis of a randomized clinical trial, conducted from April 2016 to January 2021, included patients with ERBB2-positive early or locally advanced breast cancer from a mul...
In the original trial, patients were randomized to either SB3 or TRZ with concomitant neoadjuvant chemotherapy for 8 cycles (4 cycles of docetaxel followed by 4 cycles of fluorouracil, epirubicin, and...
The primary outcomes were the incidence of symptomatic congestive heart failure and asymptomatic, significant decrease in left ventricular ejection fraction (LVEF). The secondary outcomes were event-f...
A total of 538 female patients were included (median age, 51 years [range, 22-65 years]). Baseline characteristics were comparable between the SB3 and TRZ groups. Cardiac safety was monitored for 367 ...
In this secondary analysis of a randomized clinical trial, SB3 demonstrated cardiac safety and survival comparable to those of TRZ after up to 6 years of follow-up in patients with ERBB2-positive earl...
ClinicalTrials.gov Identifier: NCT02771795....
Molecular assessment using circulating tumor DNA (ctDNA) has not been well-defined. We recruited 61 pancreatic cancer (PC) patients who underwent initial computed tomography (CT) imaging study during ...
The boost to the tumor bed improves local control in breast cancer and it is an important part of the breast conserving therapy. However, information about the use of a hypofractionated boost is spars...
A total of 96 women with early breast cancer undergoing breast-conserving surgery and hypofractionated whole breast irradiation (WBI) were retrospectively analyzed divided into hypofractionated boost ...
The median follow-up was 49.5 months (26-67). Median age was 57 years (36-82). Sixty-six patients (68.7%) were younger than 60 years at the time of boost and 30 (31.2%) were older than 60 years who re...
Hypofractionated WBI associated with HB treatment is a viable option in the management of conservative breast therapy given the good tolerance and similar local control....
Lymph node status is an important factor in determining the prognosis of patients with early gastric cancer (EGC) and preoperative diagnosis of lymph node metastasis (LNM) has some limitations. This s...
Clinicopathological data of EGC patients was collected from the public Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate logistic regression was used to identify...
A total of 3993 EGC patients were randomly allocated to a training cohort (n=2797) and a validation cohort (n=1196). An external cohort of 106 patients from the Second Hospital of Lanzhou University w...
In this study, we identified risk factors and independent prognostic factors for the development of LNM in EGC patients, and developed a relatively accurate model to predict the development of LNM in ...
This study was designed to compare the effects of endoscopic submucosal dissection (ESD) and laparoscopic distal radical surgery (LDRS) on patient rehabilitation and quality of life (QoL) in patients ...
The clinical data of 52 patients with early GC admitted to Wuhan Union Hospital from January 2018 to December 2020 were retrospectively analyzed. Among them, 32 patients who underwent LDRS were assign...
The laparoscopic group showed a significantly lower complete resection rate than the endoscopic group (P=0.030). The endoscopic group experienced notably less intraoperative blood loss and operation t...
With significantly better efficacy than that of LDRS, ESD is beneficial to postoperative rehabilitation and can improve the QoL of patients, and both schemes cause no significant effect on the recurre...
Tumor metastasis is a hallmark of colorectal cancer (CRC), in which exosome plays a crucial role with its function in intercellular communication. Plasma exosomes were collected from healthy control (...
Breast cancer patients who are positive for hormone receptor typically exhibit a favorable prognosis. It is controversial whether chemotherapy is necessary for them after surgery. Our study aimed to e...
In this study, differentially expressed genes (DEGs) were identified between relapse and nonrelapse breast cancer groups based on RNA sequencing. Gene set enrichment analysis (GSEA) was performed to i...
A total of 234 out of 487 patients were enrolled in this study, and 1588 DEGs were identified between the relapse and nonrelapse groups. GSEA results showed that immune-related pathways were enriched ...
A multigene model was established from RNA-sequencing data to direct risk classification and predict relapse of hormone receptor-positive breast cancer in Chinese patients. Utilization of the model co...
Today, the decision to treat patients with chemotherapy for early breast cancer (EBC) is made based on the patient's individual risk stratification and tumor biology. In cases with chemotherapy indica...
The study separately analyzed chemotherapy use among six age cohorts of EBC patients who had been treated at 104 German breast units between January 2008 and December 2017....
In total, 124,084 patients were included, 46,279 (37.3%) of whom had received chemotherapy. For 44,765 of these cases, detailed information on treatment was available. Within this cohort, chemotherapy...
The data from the nationwide German cohort reveal relevant age-dependent discrepancies concerning the use of chemotherapy for EBC....