questionsmedicales.fr
Acides nucléiques, nucléotides et nucléosides
Nucléosides
Ribonucléosides
Uridine
Tétrahydrouridine
Tétrahydrouridine : Questions médicales fréquentes
Diagnostic
2
Tétrahydrouridine
Tests de laboratoire
Biomarqueurs
Évaluation clinique
Symptômes
2
Effets secondaires
Nausées
Symptômes
Traitements anticancéreux
Prévention
2
Prévention
Surveillance médicale
Traitements
2
Administration orale
Intraveineuse
Chimiothérapie
Médicaments anticancéreux
Complications
2
Gestion des complications
Suivi médical
Facteurs de risque
2
Facteurs de risque
Maladies hépatiques
Interactions médicamenteuses
Effets indésirables
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 20/12/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Cleveland Clinic, Case Western Reserve University, Cleveland, Ohio, USA.
Publications dans "Tétrahydrouridine" :
2 publications dans cette catégorie
Affiliations :
Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
2 publications dans cette catégorie
Affiliations :
Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
2 publications dans cette catégorie
Affiliations :
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
EpiDestiny, Inc., Akron, Ohio, USA.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Precision Medicine, Biomarkers & Diagnostic Centre of Expertise, Novo Nordisk A/S, Søborg, Denmark.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Precision Medicine, Biomarkers & Diagnostic Centre of Expertise, Novo Nordisk A/S, Søborg, Denmark.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Cleveland Cytometry Services Company, Novelty, Ohio, USA.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Development ADME, Novo Nordisk A/S, Måløv, Denmark. Electronic address: cxls@novonordisk.com.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
SOLVO Biotechnology a Charles River Company, Budapest, Hungary.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
SOLVO Biotechnology a Charles River Company, Budapest, Hungary.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH. Electronic address: hillb2@ccf.edu.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
1 publication dans cette catégorie
Affiliations :
Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Tétrahydrouridine" :
Sickle cell disease (SCD) is caused by an inherited structural abnormality of adult hemoglobin causing polymerization. Fetal hemoglobin interferes with polymerization but is epigenetically silenced by...
The pharmacokinetics and pharmacodynamics of three oral combination formulations of THU and decitabine, with different coatings producing different delays in decitabine release, were investigated in h...
Tetrahydrouridine and decitabine were rapidly absorbed into the systemic circulation after a single combination oral dose, with relative bioavailability of decitabine ≥74% in fasted males compared wit...
Combination oral formulations of THU with decitabine produced pharmacokinetics and pharmacodynamics suitable for oral DNMT1-targeted therapy....
One mechanism by which lymphoid malignancies resist standard apoptosis-intending (cytotoxic) treatments is genetic attenuation of the p53/p16-CDKN2A apoptosis axis. Depletion of the epigenetic protein...
Oxidized methylcytidines 5-hydroxymethyl-2'deoxycytidine (5hmdC) and 5-formy-2'deoxycytidine (5fdC) are deaminated by cytidine deaminase (CDA) into genome-toxic variants of uridine, triggering DNA dam...
Targeting the epigenome of cancerous diseases represents an innovative approach, and the DNA methylation inhibitor decitabine is recommended for the treatment of hematological malignancies. Although e...
Decitabine caused marked repression of the DNMT1 protein. Conversely, PBA treatment of CCCL recovered acetylation of histone 3 lysine residues, and this enabled an open chromatin state. Unlike single ...
The combined decitabine/PBA/THU drug treatment improved drug potency considerably, and given their existing regulatory approval, our findings merit prospective clinical trials for the triple combinati...
Arylamine N-acetyltransferase 1 (NAT1), a phase II metabolic enzyme, is frequently upregulated in breast cancer. Inhibition or depletion of NAT1 leads to growth retardation in breast cancer cells in v...
The cells were treated with (1) inhibitors of dihydroorotate dehydrogenase or CDA (e.g., teriflunomide and tetrahydrouridine); (2) pyrimidine/nucleoside analogs (e.g., gemcitabine and 5-azacytidine); ...
Although NAT1 KO cells failed to show differential sensitivity to nucleoside analogs that are metabolized by CDA, they were markedly more sensitive to 5fdC which induces DNA damage in the presence of ...
The present findings suggest a novel therapeutic strategy to treat breast cancer with elevated NAT1 expression. For instance, NAT1 inhibition may be combined with cytotoxic nucleosides (e.g., 5fdC) fo...
Following promising responses to the DNA methyltransferase (DNMT) inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) combined with tetrahydrouridine (THU) in phase 1 testing, we initiated a non-randomized ph...
Patients in histology-specific strata (breast, head and neck [H&N], or non-small cell lung cancers [NSCLC] or urothelial transitional cell carcinoma) were administered FdCyd (100 mg/m...
Ninety-three eligible patients were enrolled (29 breast, 21 H&N, 25 NSCLC, and 18 urothelial). There were three partial responses. All strata were terminated early due to insufficient responses (H&N, ...
Further study of FdCyd + THU is potentially warranted in urothelial carcinoma but not NSCLC or breast or H&N cancer. Increase in the proportion of p16-expressing cytokeratin-positive CTCs is a pharmac...
1. NDec is a novel, oral, fixed-dose formulation of decitabine and tetrahydrouridine that is currently being developed for the treatment of patients with sickle cell disease. Here, we examine the pote...
Pentatricopeptide repeat (PPR) proteins with C-terminal DYW domains are present in organisms that undergo C-to-U editing of organelle RNA transcripts. PPR domains act as specificity factors through el...
DNA methyltransferase 1 (DNMT1) is scientifically validated as a molecular target to treat chemo-resistant pancreatic ductal adenocarcinoma (PDAC). Results of clinical studies of the pyrimidine nucleo...
In preclinical studies, 5-fluoro-2'-deoxycytidine (FdCyd), an inhibitor of DNA methyltransferase and DNA hypermethylation, has shown treatment efficacy against multiple malignancies by suppressing epi...