Titre : Trifluorothymidine

Trifluorothymidine : Questions médicales fréquentes

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment la trifluorothymidine est-elle administrée ?

Elle est généralement administrée par voie topique ou intraveineuse selon l'indication.
Administration de médicaments Voie d'administration
#2

Quels tests sont nécessaires avant traitement ?

Des tests de fonction hépatique et rénale sont souvent requis avant le traitement.
Tests de laboratoire Fonction hépatique
#3

La trifluorothymidine est-elle utilisée pour tous les cancers ?

Non, elle est principalement utilisée pour certains cancers comme le cancer colorectal.
Cancer colorectal Oncologie
#4

Quels signes indiquent une infection virale ?

Les symptômes incluent fièvre, fatigue, et éruptions cutanées, nécessitant un diagnostic.
Infections virales Symptômes
#5

Comment évaluer l'efficacité du traitement ?

L'efficacité est évaluée par des examens d'imagerie et des marqueurs tumoraux.
Imagerie médicale Marqueurs tumoraux

Symptômes 5

#1

Quels effets secondaires peuvent survenir ?

Les effets secondaires incluent des nausées, des vomissements et des réactions cutanées.
Effets secondaires Réactions cutanées
#2

La trifluorothymidine cause-t-elle de la fatigue ?

Oui, la fatigue est un effet secondaire courant du traitement par trifluorothymidine.
Fatigue Effets indésirables
#3

Quels symptômes indiquent une réaction allergique ?

Des démangeaisons, un gonflement ou des difficultés respiratoires peuvent indiquer une allergie.
Réaction allergique Symptômes
#4

Y a-t-il des symptômes spécifiques aux infections ?

Oui, des symptômes comme des douleurs musculaires et des maux de tête peuvent survenir.
Infections virales Symptômes
#5

Comment reconnaître une surdose de trifluorothymidine ?

Des symptômes tels que des vomissements sévères et des troubles neurologiques peuvent indiquer une surdose.
Surdosage Symptômes neurologiques

Prévention 5

#1

Comment prévenir les infections virales ?

La vaccination et l'hygiène personnelle sont essentielles pour prévenir les infections virales.
Prévention des infections Vaccination
#2

Y a-t-il des mesures préventives pour le cancer ?

Oui, un mode de vie sain, une alimentation équilibrée et l'évitement du tabac sont recommandés.
Prévention du cancer Mode de vie sain
#3

La trifluorothymidine peut-elle prévenir les infections ?

Non, elle est utilisée pour traiter les infections, pas pour les prévenir.
Infections virales Traitement
#4

Quels comportements à risque doivent être évités ?

Éviter les contacts non protégés et le partage d'aiguilles peut réduire le risque d'infection.
Comportements à risque Prévention des infections
#5

Les dépistages réguliers sont-ils importants ?

Oui, des dépistages réguliers peuvent aider à détecter précocement le cancer et les infections.
Dépistage Prévention du cancer

Traitements 5

#1

La trifluorothymidine est-elle efficace contre le cancer ?

Oui, elle est utilisée pour traiter certains types de cancers, notamment le cancer colorectal.
Traitement du cancer Efficacité thérapeutique
#2

Peut-on combiner trifluorothymidine avec d'autres traitements ?

Oui, elle peut être combinée avec d'autres agents anticancéreux pour une meilleure efficacité.
Thérapies combinées Oncologie
#3

Quel est le schéma posologique standard ?

Le schéma varie selon l'indication, mais il est souvent administré plusieurs fois par semaine.
Posologie Administration de médicaments
#4

Y a-t-il des alternatives à la trifluorothymidine ?

Oui, d'autres antiviraux et agents chimiothérapeutiques peuvent être utilisés selon le cas.
Antiviraux Chimiothérapie
#5

Comment surveiller les effets du traitement ?

Des suivis réguliers avec des analyses sanguines et des examens cliniques sont nécessaires.
Suivi médical Analyses sanguines

Complications 5

#1

Quelles complications peuvent survenir avec le traitement ?

Des complications comme des infections secondaires et des troubles hématologiques peuvent survenir.
Complications Infections secondaires
#2

La trifluorothymidine peut-elle causer des dommages aux organes ?

Oui, elle peut entraîner des effets néfastes sur le foie et les reins en cas d'utilisation prolongée.
Toxicité Dommages aux organes
#3

Comment gérer les complications du traitement ?

La gestion inclut l'ajustement de la posologie et le traitement des effets secondaires.
Gestion des complications Effets secondaires
#4

Y a-t-il des risques de résistance virale ?

Oui, une utilisation inappropriée peut entraîner une résistance virale aux traitements.
Résistance virale Antiviraux
#5

Quels sont les signes d'une complication grave ?

Des signes comme des douleurs abdominales sévères ou des saignements doivent être signalés immédiatement.
Complications graves Signes cliniques

Facteurs de risque 5

#1

Quels facteurs augmentent le risque de cancer ?

Les antécédents familiaux, le tabagisme et l'obésité sont des facteurs de risque connus.
Facteurs de risque Cancer
#2

Les infections virales sont-elles un facteur de risque ?

Oui, certaines infections virales peuvent augmenter le risque de développer des cancers.
Infections virales Facteurs de risque
#3

L'âge influence-t-il le risque de cancer ?

Oui, le risque de cancer augmente généralement avec l'âge.
Âge Cancer
#4

Le mode de vie affecte-t-il le risque d'infection ?

Oui, un mode de vie sain peut réduire le risque d'infections virales.
Mode de vie Infections virales
#5

Y a-t-il des risques liés à l'environnement ?

Oui, l'exposition à des substances chimiques et à la pollution peut augmenter le risque de cancer.
Environnement Facteurs de risque
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Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale


Validation scientifique effectuée le 06/06/2026

Contenu vérifié selon les dernières recommandations médicales

Auteurs principaux

Josep Tabernero

6 publications dans cette catégorie

Affiliations :
  • From the Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna (G.W.P.); the Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC Cancer Research for Personalized Medicine, Université Paris Cité, Paris (J. Taieb), the Department of Oncology, University Hospital, Brest (P.-G.P.), and Servier, Suresnes (N.A., C.L., L.V.) - all in France; City of Hope Comprehensive Cancer Center, Duarte, CA (M.F.); Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples (F.C.), and the Unit of Medical Oncology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa (C.C.) - both in Italy; the Department of Digestive Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium (E.V.C.); the Department of Medical Oncology, Vall d'Hebron Hospital Campus and Institute of Oncology, International Oncology Bureau-Quiron, Barcelona (E.E., J. Tabernero); Núcleo de Pesquisa e Ensino da Rede São Camilo, São Paulo (F.M.C.); the Department of Oncology and Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (L.W.); Moscow City Oncology Hospital, Moscow Healthcare Department, Moscow (D.S.); the Department of Oncology, Hungarian Defense Forces Medical Center, Budapest, Hungary (Z.P.); the Department of Oncology, Regional Hospital West Jutland, Herning, Denmark (G.L.); Dnipro State Medical University, Dnipro, Ukraine (I.B.); the Medical Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin (D.P.M.); and Taiho Oncology, Princeton, NJ (K.A.B.).

Kohei Shitara

5 publications dans cette catégorie

Affiliations :
  • Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Takeshi Wakasa

4 publications dans cette catégorie

Affiliations :
  • Translational Research Laboratory, Taiho Pharmaceutical Co. Ltd., Tokushima, Japan.
  • Department of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Hiroyuki Kitao

4 publications dans cette catégorie

Affiliations :
  • Department of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. hkitao@phar.kyushu-u.ac.jp.

Eiji Oki

4 publications dans cette catégorie

Affiliations :
  • Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Yoshihiko Maehara

4 publications dans cette catégorie

Affiliations :
  • Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.

Yasutoshi Kuboki

4 publications dans cette catégorie

Affiliations :
  • Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan. ykuboki@east.ncc.go.jp.
  • Department of Experimental Therapeutics, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. ykuboki@east.ncc.go.jp.

Hiroya Taniguchi

4 publications dans cette catégorie

Affiliations :
  • Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
  • Translational Research Support Section, Translational Research Management Division, Clinical Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.

Julien Taieb

4 publications dans cette catégorie

Affiliations :
  • From the Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna (G.W.P.); the Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC Cancer Research for Personalized Medicine, Université Paris Cité, Paris (J. Taieb), the Department of Oncology, University Hospital, Brest (P.-G.P.), and Servier, Suresnes (N.A., C.L., L.V.) - all in France; City of Hope Comprehensive Cancer Center, Duarte, CA (M.F.); Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples (F.C.), and the Unit of Medical Oncology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa (C.C.) - both in Italy; the Department of Digestive Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium (E.V.C.); the Department of Medical Oncology, Vall d'Hebron Hospital Campus and Institute of Oncology, International Oncology Bureau-Quiron, Barcelona (E.E., J. Tabernero); Núcleo de Pesquisa e Ensino da Rede São Camilo, São Paulo (F.M.C.); the Department of Oncology and Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (L.W.); Moscow City Oncology Hospital, Moscow Healthcare Department, Moscow (D.S.); the Department of Oncology, Hungarian Defense Forces Medical Center, Budapest, Hungary (Z.P.); the Department of Oncology, Regional Hospital West Jutland, Herning, Denmark (G.L.); Dnipro State Medical University, Dnipro, Ukraine (I.B.); the Medical Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin (D.P.M.); and Taiho Oncology, Princeton, NJ (K.A.B.).

Eric Van Cutsem

4 publications dans cette catégorie

Affiliations :
  • From the Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna (G.W.P.); the Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC Cancer Research for Personalized Medicine, Université Paris Cité, Paris (J. Taieb), the Department of Oncology, University Hospital, Brest (P.-G.P.), and Servier, Suresnes (N.A., C.L., L.V.) - all in France; City of Hope Comprehensive Cancer Center, Duarte, CA (M.F.); Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples (F.C.), and the Unit of Medical Oncology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa (C.C.) - both in Italy; the Department of Digestive Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium (E.V.C.); the Department of Medical Oncology, Vall d'Hebron Hospital Campus and Institute of Oncology, International Oncology Bureau-Quiron, Barcelona (E.E., J. Tabernero); Núcleo de Pesquisa e Ensino da Rede São Camilo, São Paulo (F.M.C.); the Department of Oncology and Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (L.W.); Moscow City Oncology Hospital, Moscow Healthcare Department, Moscow (D.S.); the Department of Oncology, Hungarian Defense Forces Medical Center, Budapest, Hungary (Z.P.); the Department of Oncology, Regional Hospital West Jutland, Herning, Denmark (G.L.); Dnipro State Medical University, Dnipro, Ukraine (I.B.); the Medical Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin (D.P.M.); and Taiho Oncology, Princeton, NJ (K.A.B.).

Nadia Amellal

4 publications dans cette catégorie

Affiliations :
  • From the Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna (G.W.P.); the Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC Cancer Research for Personalized Medicine, Université Paris Cité, Paris (J. Taieb), the Department of Oncology, University Hospital, Brest (P.-G.P.), and Servier, Suresnes (N.A., C.L., L.V.) - all in France; City of Hope Comprehensive Cancer Center, Duarte, CA (M.F.); Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples (F.C.), and the Unit of Medical Oncology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa (C.C.) - both in Italy; the Department of Digestive Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium (E.V.C.); the Department of Medical Oncology, Vall d'Hebron Hospital Campus and Institute of Oncology, International Oncology Bureau-Quiron, Barcelona (E.E., J. Tabernero); Núcleo de Pesquisa e Ensino da Rede São Camilo, São Paulo (F.M.C.); the Department of Oncology and Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (L.W.); Moscow City Oncology Hospital, Moscow Healthcare Department, Moscow (D.S.); the Department of Oncology, Hungarian Defense Forces Medical Center, Budapest, Hungary (Z.P.); the Department of Oncology, Regional Hospital West Jutland, Herning, Denmark (G.L.); Dnipro State Medical University, Dnipro, Ukraine (I.B.); the Medical Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin (D.P.M.); and Taiho Oncology, Princeton, NJ (K.A.B.).

Daisuke Kotani

3 publications dans cette catégorie

Affiliations :
  • Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Yoshiaki Nakamura

3 publications dans cette catégorie

Affiliations :
  • Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
  • Translational Research Support Section, Translational Research Management Division, Clinical Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.

Akihito Kawazoe

3 publications dans cette catégorie

Affiliations :
  • Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

Gerald W Prager

3 publications dans cette catégorie

Affiliations :
  • From the Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna (G.W.P.); the Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC Cancer Research for Personalized Medicine, Université Paris Cité, Paris (J. Taieb), the Department of Oncology, University Hospital, Brest (P.-G.P.), and Servier, Suresnes (N.A., C.L., L.V.) - all in France; City of Hope Comprehensive Cancer Center, Duarte, CA (M.F.); Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples (F.C.), and the Unit of Medical Oncology, Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa (C.C.) - both in Italy; the Department of Digestive Oncology, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium (E.V.C.); the Department of Medical Oncology, Vall d'Hebron Hospital Campus and Institute of Oncology, International Oncology Bureau-Quiron, Barcelona (E.E., J. Tabernero); Núcleo de Pesquisa e Ensino da Rede São Camilo, São Paulo (F.M.C.); the Department of Oncology and Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (L.W.); Moscow City Oncology Hospital, Moscow Healthcare Department, Moscow (D.S.); the Department of Oncology, Hungarian Defense Forces Medical Center, Budapest, Hungary (Z.P.); the Department of Oncology, Regional Hospital West Jutland, Herning, Denmark (G.L.); Dnipro State Medical University, Dnipro, Ukraine (I.B.); the Medical Department of Hematology, Oncology, and Cancer Immunology, Charité-Universitätsmedizin Berlin, Berlin (D.P.M.); and Taiho Oncology, Princeton, NJ (K.A.B.).

Sources (41 au total)

Trifluridine-tipiracil plus bevacizumab versus trifluridine-tipiracil monotherapy for chemorefractory metastatic colorectal cancer: a systematic review and meta-analysis.

Colorectal cancer is the leading cause of cancer death worldwide. The first and second lines of treatment for metastatic colorectal cancer (mCRC) include chemotherapy based on 5-fluorouracil. However,...

Efficacy and safety of trifluridine/tipiracil plus ramucirumab in comparison with trifluridine/tipiracil monotherapy for patients with advanced gastric cancer-single institutional experience.

Trifluridine/tipiracil plus VEGF inhibition with ramucirumab (RAM) for advanced gastric cancer (AGC) demonstrated clinical activity with an acceptable toxicity profile in previous phase II trial. Howe... We retrospectively investigated efficacy and safety of trifluridine/tipiracil plus RAM and trifluridine/tipiracil monotherapy as third or later line treatment for AGC patients.... Forty-one patients receiving trifluridine/tipiracil plus RAM and 60 patients receiving trifluridine/tipiracil monotherapy were analyzed. The objective response rate (ORR) and the disease control rate ... Trifluridine/tipiracil plus RAM might show favorable anti-tumor activity with an acceptable toxicity profile in comparison with trifluridine/tipiracil monotherapy, suggesting one treatment option for ...

Subgroup analyses from patients with pre-treated metastatic colorectal cancer receiving trifluridine/tipiracil: results of the TALLISUR trial.

In the pivotal phase III RECOURSE trial, trifluridine/tipiracil (FTD/TPI) improved progression-free and overall survival (PFS, OS) of patients with pre-treated metastatic colorectal cancer (mCRC). Sub... In this prospective, multi-centre, Germany-wide, phase IV study, patients with pre-treated mCRC were given the choice to receive either FTD/TPI or best supportive care (BSC). To assess the primary end... Of 195 patients, 186 decided to receive FTD/TPI and 9 to receive BSC. The low number of patients in the BSC-arm did not allow statistically meaningful analyses. Treatment with FTD/TPI was associated w... Treatment of patients suffering from pre-treated mCRC with FTD/TPI was associated not only with prolonged survival and delayed progression, but also with maintained QoL. Independent of other baseline ... EudraCT-Number 2017-000292-83, first registration 19/06/2017....

Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer.

The TRUSTY study evaluated the efficacy of second-line trifluridine/tipiracil (FTD/TPI) plus bevacizumab in metastatic colorectal cancer (mCRC).... This exploratory biomarker analysis of TRUSTY investigated the relationship between baseline plasma concentrations of angiogenesis-related factors and cell-free DNA (cfDNA), and the efficacy of FTD/TP... The disease control rate (DCR) and progression-free survival (PFS) were compared between baseline plasma samples of patients with high and low plasma concentrations (based on the median value) of angi... Baseline characteristics (n = 65) were as follows: male/female, 35/30; median age, 64 (range 25-84) years; and RAS status wild-type/mutant, 29/36. Patients in the hepatocyte growth factor (HGF)-low an... Low baseline plasma concentrations of HGF and IL-8 may predict better DCR and PFS in patients with mCRC receiving FTD/TPI plus bevacizumab, however further studies are warranted.... jRCTs031180122....

Efficacy and safety of trifluridine/tipiracil plus bevacizumab versus trifluridine/tipiracil monotherapy for refractory metastatic colorectal cancer: a retrospective cohort study.

Several studies demonstrated trifluridine/tipiracil (TAS-102) plus bevacizumab (BEV) had better efficacy than the monotherapy of TAS-102 in refractory metastatic colorectal cancer (mCRC). However, it ... This retrospective cohort study enrolled patients (any age) with refractory mCRC from Hunan Cancer Hospital. The main inclusion criteria were histopathologically and/or radiographically confirmed refr... A total of 90 patients were enrolled, including 58 patients who received TAS-102 plus BEV and another 32 patients who received TAS-102 monotherapy. The known baseline characteristics were comparable (... There was a trend in favor of the combination of BEV plus TAS-102 regarding OS and DCR, without reaching statistical significance, and it means that there was no clear advantage of one over the other ...

Prognostic impact of severe neutropenia in colorectal cancer patients treated with TAS-102 and bevacizumab, addressing immortal-time bias.

Several studies have reported an association between severe neutropenia and long-term survival in patients treated with trifluridine-tipiracil (TAS-102). Because some of these studies failed to addres... We conducted a single-center retrospective cohort study in patients with colorectal cancer who received Bmab + TAS-102. We compared overall survival (OS) between patients who developed grade ≥ 3 neutr... Median OS was 15.3 months [95% CI: 14.1-NA] in patients with grade ≥ 3 neutropenia and 10.0 months [95% CI: 8.1-NA] in those without. In time-varying Cox regression, onset grade ≥ 3 neutropenia was si... We identified an association between long-term survival and the development of severe neutropenia during the early cycle of Bmab + TAS-102 using an approach that addressed immortality time bias....