questionsmedicales.fr
Disciplines des sciences naturelles
Disciplines des sciences biologiques
Biologie
Microbiologie
Virologie
Virologie : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Infections virales
Diagnostic médical
Polymerase Chain Reaction
Infections virales
Grippe
Diagnostic médical
Symptômes
Infections virales
Symptômes
5
Hépatite virale
Symptômes
Complications
5
Virus Ebola
Complications
Facteurs de risque
5
Grippe
Facteurs de risque
Hépatite C
Facteurs de risque
COVID-19
Facteurs de risque
Varicelle
Facteurs de risque
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Virologie : Questions médicales les plus fréquentes",
"headline": "Virologie : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Virologie : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-01-15",
"dateModified": "2025-04-09",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Virologie"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Microbiologie",
"url": "https://questionsmedicales.fr/mesh/D008829",
"about": {
"@type": "MedicalCondition",
"name": "Microbiologie",
"code": {
"@type": "MedicalCode",
"code": "D008829",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "H01.158.273.540"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Virologie",
"alternateName": "Virology",
"code": {
"@type": "MedicalCode",
"code": "D014773",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Anice C Lowen",
"url": "https://questionsmedicales.fr/author/Anice%20C%20Lowen",
"affiliation": {
"@type": "Organization",
"name": "Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA."
}
},
{
"@type": "Person",
"name": "Arturo Casadevall",
"url": "https://questionsmedicales.fr/author/Arturo%20Casadevall",
"affiliation": {
"@type": "Organization",
"name": "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA."
}
},
{
"@type": "Person",
"name": "Andrew Mehle",
"url": "https://questionsmedicales.fr/author/Andrew%20Mehle",
"affiliation": {
"@type": "Organization",
"name": "Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA."
}
},
{
"@type": "Person",
"name": "Andrew Pekosz",
"url": "https://questionsmedicales.fr/author/Andrew%20Pekosz",
"affiliation": {
"@type": "Organization",
"name": "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA."
}
},
{
"@type": "Person",
"name": "Felicia Goodrum",
"url": "https://questionsmedicales.fr/author/Felicia%20Goodrum",
"affiliation": {
"@type": "Organization",
"name": "Department of Immunobiology, University of Arizona, Tucson, Arizona, USA."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Barrier proteins and eosinophilic esophagitis in children: the role of E-cadherin and filaggrin.",
"datePublished": "2022-07-01",
"url": "https://questionsmedicales.fr/article/35789411",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.15586/aei.v50i4.588"
}
},
{
"@type": "ScholarlyArticle",
"name": "PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes.",
"datePublished": "2023-04-28",
"url": "https://questionsmedicales.fr/article/37156706",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jdermsci.2023.04.007"
}
},
{
"@type": "ScholarlyArticle",
"name": "Filaggrin gene variants among Saudi patients with ichthyosis vulgaris.",
"datePublished": "2023-10-23",
"url": "https://questionsmedicales.fr/article/37872553",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12920-023-01700-x"
}
},
{
"@type": "ScholarlyArticle",
"name": "Evaluation of OVOL1 and Filaggrin immunohistochemical expression and clinical relevance in psoriasis.",
"datePublished": "2024-06-21",
"url": "https://questionsmedicales.fr/article/38907248",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13000-024-01491-4"
}
},
{
"@type": "ScholarlyArticle",
"name": "Rare Filaggrin Variants Are Associated with Pustular Skin Diseases in Asians.",
"datePublished": "2024-06-12",
"url": "https://questionsmedicales.fr/article/38928170",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/ijms25126466"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Disciplines des sciences naturelles",
"item": "https://questionsmedicales.fr/mesh/D010811"
},
{
"@type": "ListItem",
"position": 3,
"name": "Disciplines des sciences biologiques",
"item": "https://questionsmedicales.fr/mesh/D001690"
},
{
"@type": "ListItem",
"position": 4,
"name": "Biologie",
"item": "https://questionsmedicales.fr/mesh/D001695"
},
{
"@type": "ListItem",
"position": 5,
"name": "Microbiologie",
"item": "https://questionsmedicales.fr/mesh/D008829"
},
{
"@type": "ListItem",
"position": 6,
"name": "Virologie",
"item": "https://questionsmedicales.fr/mesh/D014773"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Virologie - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Virologie",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-14",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Virologie",
"description": "Comment diagnostique-t-on une infection virale ?\nQuels tests sont utilisés pour le VIH ?\nQu'est-ce qu'un test PCR ?\nComment identifier une grippe virale ?\nQuels symptômes indiquent une infection virale ?",
"url": "https://questionsmedicales.fr/mesh/D014773?mesh_terms=Filaggrin+Proteins#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Virologie",
"description": "Quels sont les symptômes de l'hépatite virale ?\nComment se manifeste le COVID-19 ?\nQuels signes d'infection par le virus de la varicelle ?\nQuels symptômes d'une infection à rhinovirus ?\nQuels symptômes d'une infection par le virus Ebola ?",
"url": "https://questionsmedicales.fr/mesh/D014773?mesh_terms=Filaggrin+Proteins#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Virologie",
"description": "Comment prévenir l'infection par le VIH ?\nQuelles vaccins pour prévenir la grippe ?\nComment éviter la transmission du COVID-19 ?\nQuelles mesures pour prévenir l'hépatite A ?\nComment prévenir la varicelle ?",
"url": "https://questionsmedicales.fr/mesh/D014773?mesh_terms=Filaggrin+Proteins#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Virologie",
"description": "Quels traitements pour le VIH ?\nComment traiter une grippe ?\nY a-t-il un traitement pour l'hépatite C ?\nComment traiter une infection à coronavirus ?\nQuels sont les traitements pour la varicelle ?",
"url": "https://questionsmedicales.fr/mesh/D014773?mesh_terms=Filaggrin+Proteins#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Virologie",
"description": "Quelles complications de l'hépatite B ?\nQuelles complications du virus Ebola ?\nQuels risques liés à la grippe ?\nQuelles complications du COVID-19 ?\nQuelles complications de la varicelle ?",
"url": "https://questionsmedicales.fr/mesh/D014773?mesh_terms=Filaggrin+Proteins#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Virologie",
"description": "Quels sont les facteurs de risque pour le VIH ?\nQui est à risque de grippe sévère ?\nQuels facteurs augmentent le risque d'hépatite C ?\nQuels sont les facteurs de risque pour le COVID-19 ?\nQui est à risque de varicelle ?",
"url": "https://questionsmedicales.fr/mesh/D014773?mesh_terms=Filaggrin+Proteins#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostique-t-on une infection virale ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur des tests PCR, sérologiques et parfois des cultures virales."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour le VIH ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests de dépistage incluent les tests ELISA et les tests de charge virale."
}
},
{
"@type": "Question",
"name": "Qu'est-ce qu'un test PCR ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "C'est un test qui amplifie l'ADN viral pour détecter la présence de virus."
}
},
{
"@type": "Question",
"name": "Comment identifier une grippe virale ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests rapides et des cultures de virus peuvent confirmer une grippe."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une infection virale ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, fatigue, douleurs musculaires et symptômes respiratoires sont courants."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes de l'hépatite virale ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Jaunisse, fatigue, douleurs abdominales et perte d'appétit sont fréquents."
}
},
{
"@type": "Question",
"name": "Comment se manifeste le COVID-19 ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, toux, essoufflement et perte de goût sont des symptômes clés."
}
},
{
"@type": "Question",
"name": "Quels signes d'infection par le virus de la varicelle ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éruption cutanée, démangeaisons et fièvre sont typiques de la varicelle."
}
},
{
"@type": "Question",
"name": "Quels symptômes d'une infection à rhinovirus ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Congestion nasale, éternuements et maux de gorge sont courants."
}
},
{
"@type": "Question",
"name": "Quels symptômes d'une infection par le virus Ebola ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, vomissements, diarrhée et hémorragies peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'infection par le VIH ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Utiliser des préservatifs et des traitements prophylactiques comme le PrEP."
}
},
{
"@type": "Question",
"name": "Quelles vaccins pour prévenir la grippe ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le vaccin antigrippal est recommandé chaque année pour réduire le risque."
}
},
{
"@type": "Question",
"name": "Comment éviter la transmission du COVID-19 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Porter un masque, se laver les mains et se faire vacciner sont essentiels."
}
},
{
"@type": "Question",
"name": "Quelles mesures pour prévenir l'hépatite A ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Vaccination et hygiène alimentaire sont cruciales pour prévenir l'hépatite A."
}
},
{
"@type": "Question",
"name": "Comment prévenir la varicelle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "La vaccination est le moyen le plus efficace de prévenir la varicelle."
}
},
{
"@type": "Question",
"name": "Quels traitements pour le VIH ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antirétroviraux sont utilisés pour contrôler l'infection par le VIH."
}
},
{
"@type": "Question",
"name": "Comment traiter une grippe ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antiviraux comme l'oseltamivir peuvent réduire la durée des symptômes."
}
},
{
"@type": "Question",
"name": "Y a-t-il un traitement pour l'hépatite C ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antiviraux à action directe peuvent guérir l'hépatite C."
}
},
{
"@type": "Question",
"name": "Comment traiter une infection à coronavirus ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des antiviraux et des soins de soutien selon la gravité."
}
},
{
"@type": "Question",
"name": "Quels sont les traitements pour la varicelle ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antihistaminiques et des antiviraux peuvent soulager les symptômes."
}
},
{
"@type": "Question",
"name": "Quelles complications de l'hépatite B ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Cirrhose et cancer du foie peuvent survenir chez les patients chroniques."
}
},
{
"@type": "Question",
"name": "Quelles complications du virus Ebola ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles hémorragiques et des défaillances organiques."
}
},
{
"@type": "Question",
"name": "Quels risques liés à la grippe ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des pneumonies et des exacerbations d'asthme peuvent survenir chez les vulnérables."
}
},
{
"@type": "Question",
"name": "Quelles complications du COVID-19 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des problèmes respiratoires chroniques et des troubles neurologiques peuvent apparaître."
}
},
{
"@type": "Question",
"name": "Quelles complications de la varicelle ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections bactériennes secondaires et pneumonie peuvent survenir chez les adultes."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour le VIH ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les rapports non protégés et l'utilisation de drogues injectables augmentent le risque."
}
},
{
"@type": "Question",
"name": "Qui est à risque de grippe sévère ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées, les jeunes enfants et les immunodéprimés sont plus à risque."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'hépatite C ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'utilisation de drogues injectables et les transfusions sanguines non sécurisées sont des risques."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour le COVID-19 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, les maladies chroniques et l'obésité augmentent le risque de complications."
}
},
{
"@type": "Question",
"name": "Qui est à risque de varicelle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes non vaccinées et celles ayant un système immunitaire affaibli sont à risque."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 09/04/2025
Contenu vérifié selon les dernières recommandations médicales
5 publications dans cette catégorie
Affiliations :
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
Publications dans "Virologie" :
5 publications dans cette catégorie
Affiliations :
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Publications dans "Virologie" :
5 publications dans cette catégorie
Affiliations :
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Publications dans "Virologie" :
5 publications dans cette catégorie
Affiliations :
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Microbiology, Ohio State University, Wooster, Ohio, USA.
Viruses and Emerging Pathogens Program, Infectious Diseases Institute, Ohio State University, Wooster, Ohio, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
School of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Microbiology and Immunology, Columbia University, New York, New York, USA.
Department of Physiology, Columbia University, New York, New York, USA.
Department of Biophysics, Columbia University, New York, New York, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Publications dans "Virologie" :
4 publications dans cette catégorie
Affiliations :
Department of Microbiology and Immunology, SUNY Upstate Medical Center, Syracuse, New York, USA.
Publications dans "Virologie" :
This study aimed to assess the protein expression of E-cadherin and filaggrin (FLG) in the oesophagus of paediatric and adolescent patients diagnosed with eosinophilic esophagitis (EoE). It is a cross...
Difamilast, a topical phosphodiesterase 4 (PDE4) inhibitor, has been shown to be effective for treating atopic dermatitis (AD), but the molecular mechanism involved is unclear. Since skin barrier dysf...
To elucidate the mechanism by which difamilast regulates FLG and LOR expression via CREB in human keratinocytes....
We analyzed normal human epidermal keratinocytes (NHEKs) treated with difamilast....
We observed increases of intracellular cAMP levels and CREB phosphorylation in difamilast (5 μM)-treated NHEKs. Next, we found that difamilast treatment increased mRNA and protein levels of FLG and LO...
These findings may provide further guidance for therapeutic strategies in the treatment of AD using difamilast....
Ichthyoses are a heterogeneous group of cornification disorders. The most common form of ichthyoses is ichthyosis vulgaris (IV) ([OMIM] #146,700), which can be inherited as autosomal semi-dominant mut...
Psoriasis is a disease of overactive immune system. OVOL1 and Filaggrin have been associated with many inflammatory skin lesions. To the best of our knowledge, the correlation between OVOL1 and Filagg...
Slides cut from paraffin blocks of 30 psoriasis cases and 30 control subjects were stained with OVOL1 and Filaggrin. Clinicopathological data were correlated with the results of staining....
OVOL1 and Filaggrin expression in epidermis showed a significant gradual reduction from normal skin to peri-lesional and psoriasis biopsies (P < 0.001). In contrast, psoriasis dermis showed a signific...
OVOL1 and Filaggrin might be involved in psoriasis-associated inflammation and skin hyperproliferation. OVOL1 might have a protective barrier function in the skin and could be used to stratify progres...
Reactive pustular eruptions (RPEs) can manifest in a variety of conditions, including pustular psoriasis (PP) and adult-onset immunodeficiency syndrome due to anti-interferon-γ autoantibody (AOID). Th...
The World Allergy Organization recommends probiotics in the prevention of atopic dermatitis in high-risk populations. Mutations in the filaggrin gene (FLG) result in an increased risk of atopic dermat...
Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements again...
Staphylococcus aureus (S. aureus) is frequently detected in the skin of patients with atopic dermatitis (AD). AD skin-derived strains of S. aureus (AD strain) are selectively internalized into keratin...
The pathogenesis of melasma remains unclear. Interleukin (IL)-17, a proinflammatory mediator, disturbs barrier function. Filaggrin (FLG) is a protein involved in epidermal barrier homeostasis and may ...
To evaluate epidermal barrier function in malar melasma and its association with the expression of FLG, IL-17, and IL-33....
Twenty patients with malar melasma were included in this study. Colorimetric and transepidermal water loss (TEWL) was measured in lesional and adjacent unaffected skin at baseline and 30 minutes after...
After the stripping test, the erythema and TEWL values were higher in the melasma than in the unaffected skin ( P = 0.01). Thirty minutes later, TEWL diminished, but it remained higher than in the per...
This study found subclinical inflammation in the skin adjacent to the melasma, dysfunction of the epidermal barrier in lesions associated with chronic inflammation, and an abnormal differentiation pro...
The filaggrin (FLG) protein, encoded by the FLG gene, is an intermediate filament-associated protein that plays a crucial role in the terminal stages of human epidermal differentiation. Loss-of-functi...
For the preparation of SMRTbell libraries to be sequenced using PacBio technology, we focused on optimizing a 2-step long-range PCR protocol to generate 13-kb amplicons covering the whole FLG exon 3 s...
Taken together, our findings suggested that the PrimeSTAR protocol is suitable for producing the amplicons of the 13-kb FLG whole exon 3 to prepare SMRTbell libraries. We suggest that sequencing the g...