Titre : Carence en vitamine B12

Carence en vitamine B12 : Questions médicales fréquentes

Termes MeSH sélectionnés :

Complement C5
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peut-elle être asymptomatique ?\nQuel rôle joue l'historique médical dans le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+C5&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Carence en vitamine B12", "description": "Quels sont les symptômes courants de la carence en B12 ?\nLa carence en B12 peut-elle causer des problèmes neurologiques ?\nComment la carence affecte-t-elle la peau ?\nY a-t-il des symptômes digestifs associés ?\nLes symptômes varient-ils selon l'âge ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+C5&page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Carence en vitamine B12", "description": "Comment prévenir la carence en vitamine B12 ?\nLes personnes âgées doivent-elles prendre des suppléments ?\nLes végétaliens peuvent-ils éviter la carence ?\nLes tests réguliers sont-ils recommandés ?\nLes maladies digestives augmentent-elles le risque ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+C5&page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Carence en vitamine B12", "description": "Comment traiter une carence en vitamine B12 ?\nQuelle est la durée du traitement ?\nLes aliments peuvent-ils aider à corriger la carence ?\nLes personnes végétariennes sont-elles à risque ?\nLes traitements sont-ils différents pour les enfants ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+C5&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Carence en vitamine B12", "description": "Quelles complications peuvent survenir ?\nLa carence peut-elle entraîner des problèmes cognitifs ?\nY a-t-il un risque accru de maladies cardiovasculaires ?\nLes complications sont-elles réversibles ?\nLa carence en B12 peut-elle affecter la grossesse ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+C5&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Carence en vitamine B12", "description": "Qui est le plus à risque de carence en B12 ?\nLes maladies auto-immunes augmentent-elles le risque ?\nLes médicaments peuvent-ils influencer le risque ?\nLes troubles digestifs sont-ils un facteur de risque ?\nLes antécédents familiaux jouent-ils un rôle ?", "url": "https://questionsmedicales.fr/mesh/D014806?mesh_terms=Complement+C5&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une carence en vitamine B12 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un diagnostic se fait par des analyses sanguines mesurant les niveaux de vitamine B12." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour confirmer la carence ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests incluent la mesure de la vitamine B12, de l'homocystéine et de la méthylmalonyl-CoA." } }, { "@type": "Question", "name": "Quels signes cliniques indiquent une carence ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des signes comme l'anémie, la fatigue, et des troubles neurologiques peuvent indiquer une carence." } }, { "@type": "Question", "name": "La carence en B12 peut-elle être asymptomatique ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines personnes peuvent avoir une carence sans présenter de symptômes visibles." } }, { "@type": "Question", "name": "Quel rôle joue l'historique médical dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'historique médical aide à identifier des facteurs de risque comme des troubles d'absorption." } }, { "@type": "Question", "name": "Quels sont les symptômes courants de la carence en B12 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent fatigue, faiblesse, engourdissements et troubles de l'humeur." } }, { "@type": "Question", "name": "La carence en B12 peut-elle causer des problèmes neurologiques ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des troubles neurologiques comme des démences ou des neuropathies." } }, { "@type": "Question", "name": "Comment la carence affecte-t-elle la peau ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Elle peut provoquer des changements cutanés comme une pâleur ou des lésions cutanées." } }, { "@type": "Question", "name": "Y a-t-il des symptômes digestifs associés ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme des nausées, des diarrhées ou des troubles digestifs peuvent survenir." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent être plus prononcés chez les personnes âgées en raison de l'absorption réduite." } }, { "@type": "Question", "name": "Comment prévenir la carence en vitamine B12 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée incluant des sources de B12 et des suppléments si nécessaire aide." } }, { "@type": "Question", "name": "Les personnes âgées doivent-elles prendre des suppléments ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes âgées peuvent avoir besoin de suppléments en raison d'une absorption réduite." } }, { "@type": "Question", "name": "Les végétaliens peuvent-ils éviter la carence ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Ils doivent prendre des suppléments de B12 ou consommer des aliments enrichis pour éviter la carence." } }, { "@type": "Question", "name": "Les tests réguliers sont-ils recommandés ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests réguliers sont conseillés pour les personnes à risque de carence." } }, { "@type": "Question", "name": "Les maladies digestives augmentent-elles le risque ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme la maladie de Crohn peuvent affecter l'absorption de la vitamine B12." } }, { "@type": "Question", "name": "Comment traiter une carence en vitamine B12 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement inclut des suppléments oraux ou des injections de vitamine B12 selon la gravité." } }, { "@type": "Question", "name": "Quelle est la durée du traitement ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "La durée dépend de la gravité, mais peut durer de quelques mois à plusieurs années." } }, { "@type": "Question", "name": "Les aliments peuvent-ils aider à corriger la carence ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, consommer des aliments riches en B12 comme la viande, le poisson et les produits laitiers aide." } }, { "@type": "Question", "name": "Les personnes végétariennes sont-elles à risque ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent être à risque en raison d'un apport alimentaire limité en vitamine B12." } }, { "@type": "Question", "name": "Les traitements sont-ils différents pour les enfants ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements sont similaires, mais les doses peuvent varier selon l'âge et le poids." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent l'anémie mégaloblastique, des troubles neurologiques et des problèmes cardiaques." } }, { "@type": "Question", "name": "La carence peut-elle entraîner des problèmes cognitifs ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une carence prolongée peut causer des troubles cognitifs et des pertes de mémoire." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de maladies cardiovasculaires ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une carence en B12 peut augmenter le risque de maladies cardiovasculaires en élevant l'homocystéine." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non." } }, { "@type": "Question", "name": "La carence en B12 peut-elle affecter la grossesse ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut entraîner des complications pendant la grossesse, comme des malformations congénitales." } }, { "@type": "Question", "name": "Qui est le plus à risque de carence en B12 ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les personnes âgées, les végétariens, et ceux ayant des troubles d'absorption sont à risque." } }, { "@type": "Question", "name": "Les maladies auto-immunes augmentent-elles le risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des maladies comme la gastrite atrophique peuvent affecter l'absorption de la B12." } }, { "@type": "Question", "name": "Les médicaments peuvent-ils influencer le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains médicaments comme les inhibiteurs de la pompe à protons peuvent réduire l'absorption." } }, { "@type": "Question", "name": "Les troubles digestifs sont-ils un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles comme la maladie cœliaque peuvent nuire à l'absorption de la vitamine B12." } }, { "@type": "Question", "name": "Les antécédents familiaux jouent-ils un rôle ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de carence peuvent augmenter le risque chez certains individus." } } ] } ] }

Sources (1719 au total)

The case for complement component 5 as a target in neurodegenerative disease.

Complement-based drug discovery is undergoing a renaissance, empowered by new advances in structural biology, complement biology and drug development. Certain components of the complement pathway, par... We will discuss the evidence supporting C5 as a target in neurodegenerative disease, along with the current progress in developing different classes of C5 inhibitors and the gaps in knowledge that wil... Validation of C5 as a therapeutic target for neurodegenerative disease would represent a major step forward for complement therapeutics research and has the potential to furnish disease-modifying drug...

Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation.

The complement system is a key component of the innate immune system, and its aberrant activation underlies the pathophysiology of various diseases. Zilucoplan is a macrocyclic peptide that binds and ... The interaction of zilucoplan with C5, including for clinical C5 R885 variants, was investigated using surface plasmon resonance (SPR), hemolysis assays, and ELISA. The interference of C5b6 formation ... Zilucoplan specifically bound human complement C5 with high affinity, competitively inhibited the binding of C5 to C3b, and blocked C5 cleavage by C5 convertases and the assembly of the cytolytic memb... Our findings demonstrate that zilucoplan uses a dual mode of action to potently inhibit the activation of C5 and terminal complement pathway including wild-type and clinical R885 variants that do not ...

Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi-protein cascade of the complement system.

Over a century after the discovery of the complement system, the first complement therapeutic was approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). It was a long-acting monoclon...

Plasma levels of Complement components C5 and C9 are associated with thrombin generation.

The thrombin generation assay (TGA) evaluates the potential of plasma to generate thrombin over time, providing a global picture of an individual's hemostatic balance.... This study aimed to identify novel biological determinants of thrombin generation using a multi-omics approach.... Associations between TGA parameters and plasma levels of 377 antibodies targeting 236 candidate proteins for cardiovascular risk were tested using multiple linear regression analysis in 770 individual... Eighteen proteins were associated (p<1.33x10-4) with at least three TGA parameters in MARTHA, among which 13 demonstrated a similar pattern of associations in EFS-AM. Complement proteins C5 and C9 had... This study identified complement proteins C5 and C9 as potential determinants of thrombin generation. Further studies are warranted to establish causality and elucidate the underlying mechanisms....

Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.

African Trypanosomes have developed elaborate mechanisms to escape the adaptive immune response, but little is known about complement evasion particularly at the early stage of infection. Here we show...